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    PhysioEx - Activity 5

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    i1011221013
    The document summarizes the results of an experiment examining fatigue in isolated skeletal muscle. In the experiment, a muscle was stimulated at different frequencies with varying rest periods between stimuli. The muscle was able to sustain maximal tension for longer periods when brief rest periods were given compared to continuous stimulation. This occurred because the rest periods allowed intracellular concentrations of ADP, Pi, and other fatigue byproducts to decline before stimulation resumed. The student correctly answered pre-lab and post-lab quiz questions about muscle fatigue and the experimental results matched the student's prediction that longer rest periods would prolong the time of sustained maximal tension.

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    PhysioEx - Activity 5

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    i1011221013
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    The document summarizes the results of an experiment examining fatigue in isolated skeletal muscle. In the experiment, a muscle was stimulated at different frequencies with varying rest periods between stimuli. The muscle was able to sustain maximal tension for longer periods when brief rest periods were given compared to continuous stimulation. This occurred because the rest periods allowed intracellular concentrations of ADP, Pi, and other fatigue byproducts to decline before stimulation resumed. The student correctly answered pre-lab and post-lab quiz questions about muscle fatigue and the experimental results matched the student's prediction that longer rest periods would prolong the time of sustained maximal tension.

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    PhysioEx_Activity 5

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    The document summarizes the results of an experiment examining fatigue in isolated skeletal muscle. In the experiment, a muscle was stimulated at different frequencies with varying rest periods between stimuli. The muscle was able to sustain maximal tension for longer periods when brief rest periods were given compared to continuous stimulation. This occurred because the rest periods allowed intracellular concentrations of ADP, Pi, and other fatigue byproducts to decline before stimulation resumed. The student correctly answered pre-lab and post-lab quiz questions about muscle fatigue and the experimental results matched the student's prediction that longer rest periods would prolong the time of sustained maximal tension.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    11 views5 pages

    PhysioEx - Activity 5

    Uploaded by

    i1011221013
    The document summarizes the results of an experiment examining fatigue in isolated skeletal muscle. In the experiment, a muscle was stimulated at different frequencies with varying rest periods between stimuli. The muscle was able to sustain maximal tension for longer periods when brief rest periods were given compared to continuous stimulation. This occurred because the rest periods allowed intracellular concentrations of ADP, Pi, and other fatigue byproducts to decline before stimulation resumed. The student correctly answered pre-lab and post-lab quiz questions about muscle fatigue and the experimental results matched the student's prediction that longer rest periods would prolong the time of sustained maximal tension.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 5

    Name: Kelompok 3D

    Exercise 2: Skeletal Muscle Physiology: Activity 5: Fatigue in Isolated Skeletal Muscle Lab Report

    Pre-lab Quiz Results


    You scored 100% by answering 4 out of 4 questions correctly.

    1. When skeletal muscle twitches fuse so that the peaks and valleys of each twitch become indistinguishable from each
    other, the muscle is in a state known as
    You correctly answered: d. complete (fused) tetanus.

    2. When the stimulus frequency reaches a value beyond which no further increase of skeletal muscle force can occur, the
    muscle has reached its
    You correctly answered: c. maximal tetanic tension.

    3. A decline in a muscle's ability to maintain a constant level of force, or tension, after prolonged, repetitive stimulation is
    called
    You correctly answered: c. fatigue.

    4. Which of the following is not thought to be a contributing factor to the development of fatigue?
    You correctly answered: a. buildup of Ca2+ in the muscle fibers

    11/07/23 page
    Experiment Results
    Predict Question:
    Predict Question: If the stimulator is briefly turned off for defined periods of time, what will happen to the length of time that
    the muscle is able to sustain maximal developed tension when the stimulator is turned on again?
    Your answer : b. The length of the rest period will proportionately increase the length of time for sustained muscle tension.

    Stop & Think Questions:


    Why does the stimulated muscle force begin to decrease over time despite the maintained stimuli? (Note that a decrease in
    maximal force indicates muscle fatigue is developing.)
    You correctly answered: d. More than one of these answers could be correct.

    Why did the length of the intervening rest period affect the length of time the skeletal muscle can maintain maximum tension
    once the stimulator is turned on again?
    You correctly answered: c. Intracellular concentrations of ADP and Pi declined during the rest period.

    Experiment Data:

    Voltage Stimuli/sec Rest Period (sec) Active Force (g) Sustained Maximal Force
    (sec)
    8.5 120 0 5.86 10
    8.5 120 0 5.86 10
    8.5 120 12 5.86 1.80
    8.5 120 22 5.86 5.80

    11/07/23 page
    11/07/23 page 3
    Post-lab Quiz Results
    You scored 100% by answering 5 out of 5 questions correctly.

    1. During cross bridge cycling in skeletal muscle, force is created by the


    You correctly answered: c. power stroke of the myosin heads.

    2. The term tetanus refers to


    You correctly answered: b. sustained muscle tension due to repetitive stimuli.

    3. A decline in a muscle's ability to maintain a constant level of force, or tension, after prolonged, repetitive stimulation is
    called
    You correctly answered: c. fatigue.

    4. During fatigue
    You correctly answered: c. the number of active cross bridges begins to decline although the rate of stimulus delivery
    (frequency) remains constant.

    5. If an intervening rest period is imposed on active skeletal muscle


    You correctly answered: c. the development of fatigue will be delayed.

    11/07/23 page
    Review Sheet Results
    1. When a skeletal muscle fatigues, what happens to the contractile force over time?
    Your answer:
    Ketika otot rangka mengalami fatigue atau kelelahan, kekuatan kontraktil akan berkurang seiring waktu. Fatigue atau
    kelelahan otot terjadi ketika otot mencapai tegangan maksimumnya, tidak akan ada lagi peningkatan kekuatan kontraksi
    otot.

    Sumber: Wan JJ, Qin Z, Wang PY, Sun Y, Liu X. Muscle fatigue: general understanding and treatment. Exp Mol Med. 2017
    Oct 6;49(10):e384. doi: 10.1038/emm.2017.194. PMID: 28983090; PMCID: PMC5668469.

    2. What are some proposed causes of skeletal muscle fatigue?


    Your answer:
    Penyebab dari kelelahan pada otot rangka yaitu adanya penumpukan ADP, Pi, dan asam laktat di otot sebagai hasil dari
    penggunaan ATP yang diperlukaan saat kontraksi. Penggunaan otot yang terus-menerus memerlukan pasokan oksigen
    dan glukosa agar dapat terjadi respirasi aerobik yang menghasilkan ATP untuk kontraksi otot. Apabila kontraksi otot terjadi
    terus-menerus, energi akan dihasilkan melalui proses respirasi lain, yaitu respirasi anaerob. Respirasi anaerob inilah yang
    akan menghasilkan penumpukan asam laktat pada otot.

    Sumber: Wan JJ, Qin Z, Wang PY, Sun Y, Liu X. Muscle fatigue: general understanding and treatment. Exp Mol Med. 2017
    Oct 6;49(10):e384. doi: 10.1038/emm.2017.194. PMID: 28983090; PMCID: PMC5668469.

    3. Turning the stimulator off allows a small measure of muscle recovery. Thus, the muscle will produce more force for a
    longer time period if the stimulator is briefly turned off than if the stimuli were allowed to continue without interruption.
    Explain why this might occur. How well did the results compare with your prediction?
    Your answer:
    Ketika stimulator dimatikan, akan terjadi fase istirahat antara stimulus satu dengan stimulus selanjutnya, sehingga akan
    mengulur terjadinya kelelahan atau fatigue pada otot, sehingga tidak terjadi penumpukan ADP, Pi, dan asam laktat. Oleh
    karena itu, tegangan pada otot terus-menerus dapat dipertahankan lebih lama.Sehingga, sesuai dengan prediksi yang telah
    dibuat, durasi waktu istirahat akan berbanding lurus dengan waktu yang digunakan untuk tegangan otot yang
    terus-menerus.

    Sumber: Sherwood L. Human physiology: from cells to systems. Cengage learning; 2015.

    4. List a few ways that humans could delay the onset of fatigue when they are vigorously using their skeletal muscles.
    Your answer:
    Dengan latihan fisik yang cukup, kapasitas metabolisme otot dapat berubah sehingga menunda timbulnya kelelahan otot.
    Otot yang digunakan untuk latihan anaerobik intensitas tinggi akan mensintesis lebih banyak enzim glikolitik, sedangkan
    otot untuk latihan aerobik dengan daya tahan lama akan mengembangkan lebih banyak kapiler dan mitokondria. Latihan
    dengan repetisi ringan juga dapat melatih ketahanan otot, karena terdapat jarak antar kontraksi otot.

    Sumber: Wan JJ, Qin Z, Wang PY, Sun Y, Liu X. Muscle fatigue: general understanding and treatment. Exp Mol Med. 2017
    Oct 6;49(10):e384. doi: 10.1038/emm.2017.194. PMID: 28983090; PMCID: PMC5668469.

    11/07/23 page

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