Chemistry in Everyday Life

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CHEMISTRY IN

EVERYDAY LIFE
1.1 DRUGS
A drug is a chemical substance of low molecular mass which exerts an abnormal
effect on certain body functions. It interacts with macromolecular targets and
produces a biological response.

1.2 MEDICINE
When the biological response is therapeutic and useful, a drug is referred to as a
medicine.

The chemicals which cause therapeutical biological response and may be useful
in diagnosis, prevention and cure of diseases are termed as medicines.

1.3 THERAPEUTIC ACTION OF DIFFERENT


CLASSES OF DRUGS
1.3.1 ANTACIDS
Chemical substances which remove the excess acid and raise the
pH to an appropriate level in stomach are called antacids.

Examples: Mg (OH)2 , MgCO3 , NaHCO3

It was discovered that histamine, a chemical released in the cells


stimulates acidity in the stomach. Inspired by the discovery, a drug
called cimetidine (Tegamet) was formulated to prevent the action
of histamine in the stomach.
Due to its importance, cimetidine remained the largest selling drug
in the world until another drug ranitidine (Zantac) was discovered.
Recently, omeprazole and lansoprazole have been introduced as
antacids.

MORE ON HISTAMINES
 Stimulates the secretion of pepsin and hydrochloric acid
 Contracts the smooth muscles in the bronchi and relaxes
other muscles
 Responsible for nasal congestion due to common cold or
allergic response.

1.3.2 ANTIHISTAMINES
The drugs used to combat the allergic effects of histamine are
called antihistamines. Antihistamines interfere with the natural
action of histamine by competing with histamine for binding sites
of receptors where histamine exerts its effect.
Examples: brompheniramine (Dimetapp), terfenadine (Seldane),
promethazine.

MORE ON ANTIHISTAMINES
 Have a sedative effect
 Lead to drowsiness, dizziness and dryness of the nasal and
buccal mucosa
 Their effective dose is small
 Therefore, cause low toxicities
 Do not affect secretion of acid in the stomach

1.3.3 NEUROLOGICALLY ACTIVE DRUGS


The drugs which affect the message transfer mechanism form nerve
to receptor are called neurologically active drugs.
Tranquilizers and analgesics are such drugs.

1.3.3.1 TRANQUILIZERS
The chemical substances used for the treatment of
stress, mild and severe mental diseases. Tranquilizers
relieve anxiety, stress, irritability or excitement by
including a sense of well-being. Tranquilizers are the
constituents of sleeping pills.
Examples: Noradrenaline, Valium, serotonin

Noradrenaline is one of the several neurotransmitters


that plays a role in mood changes.

Commonly used tranquilizers are derivatives of


barbituric acid, e.g., veronal, amytal, nembutal,
luminal, Seconal. These are called barbiturates and
they are hypnotic, i.e., sleep producing agents.

Chlordiazepoxide, meprobamate and equanil are non-


hypnotic tranquilizers.
Chlordiazepoxide and meprobamate are mild, while
equanil has strong tranquilizing effect.

ANTIDEPRESSANT DRUGS
Antidepressant drugs inhibit the enzymes which
catalyse the degradation of noradrenaline.
These relieves the person from depression.
Examples: Iproniazid, phenelzine.

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