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    Helicobacter Pylori: What Is Helicobacter Pylori Infection and Who Is Affected by It?

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    Helicobacter pylori (H. pylori) is a common bacterial infection that infects the lining of the stomach and duodenum. It is the leading cause of peptic ulcers and can also cause gastritis and in rare cases, stomach cancer. H. pylori infection is diagnosed through breath, stool, or blood tests and treated with a combination of antibiotics and acid-suppressing medications for one week. Eradication therapy successfully clears the infection in about 90% of cases. While most infected individuals do not experience problems, H. pylori can cause ulcers, non-ulcer dyspepsia, and increases the risk of stomach cancer in a small percentage of people.

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    Helicobacter Pylori: What Is Helicobacter Pylori Infection and Who Is Affected by It?

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    Helicobacter pylori (H. pylori) is a common bacterial infection that infects the lining of the stomach and duodenum. It is the leading cause of peptic ulcers and can also cause gastritis and in rare cases, stomach cancer. H. pylori infection is diagnosed through breath, stool, or blood tests and treated with a combination of antibiotics and acid-suppressing medications for one week. Eradication therapy successfully clears the infection in about 90% of cases. While most infected individuals do not experience problems, H. pylori can cause ulcers, non-ulcer dyspepsia, and increases the risk of stomach cancer in a small percentage of people.

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    Helicobacter pylori (H. pylori) is a common bacterial infection that infects the lining of the stomach and duodenum. It is the leading cause of peptic ulcers and can also cause gastritis and in rare cases, stomach cancer. H. pylori infection is diagnosed through breath, stool, or blood tests and treated with a combination of antibiotics and acid-suppressing medications for one week. Eradication therapy successfully clears the infection in about 90% of cases. While most infected individuals do not experience problems, H. pylori can cause ulcers, non-ulcer dyspepsia, and increases the risk of stomach cancer in a small percentage of people.

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    © All Rights Reserved
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    18 views3 pages

    Helicobacter Pylori: What Is Helicobacter Pylori Infection and Who Is Affected by It?

    Uploaded by

    BBD BBD
    Helicobacter pylori (H. pylori) is a common bacterial infection that infects the lining of the stomach and duodenum. It is the leading cause of peptic ulcers and can also cause gastritis and in rare cases, stomach cancer. H. pylori infection is diagnosed through breath, stool, or blood tests and treated with a combination of antibiotics and acid-suppressing medications for one week. Eradication therapy successfully clears the infection in about 90% of cases. While most infected individuals do not experience problems, H. pylori can cause ulcers, non-ulcer dyspepsia, and increases the risk of stomach cancer in a small percentage of people.

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    of 3

    Page 1 of 3

    View this article online at: patient.info/digestive-health/dyspepsia-indigestion/helicobacter-pylori

    Helicobacter Pylori
    Infection with Helicobacter pylori (H. pylori) is the cause of most stomach and duodenal ulcers. H. pylori also causes
    some cases of non-ulcer dyspepsia. Infection with H. pylori can be confirmed by a test done on a sample of stools
    (faeces), by a breath test, by a blood test, or from a biopsy sample taken during a gastroscopy (endoscopy). A one-
    week course of two antibiotic medicines plus an acid-suppressing medicine will usually clear the H. pylori infection. This
    should prevent the return of a duodenal or stomach ulcer that had been caused by this infection.

    What is Helicobacter pylori infection and who is affected by it?


    Helicobacter pylori (commonly just called H. pylori) is a germ (bacterium). It can infect the lining of the stomach and duodenum (the first
    part of the intestine). Over half the world's population has it. It is more common in developing countries. Why and when people become
    infected is unknown. It is sometimes present in children and some scientists believe we acquire it at a very young age. About 15 in 100
    people are infected in the UK and it is becoming less common as time goes by. Once you are infected, unless treated, the infection
    usually stays for the rest of your life.

    Who should be tested for Helicobacter pylori and treated if it is found?


    If you have repeated indigestion symptoms (recurring dyspepsia)
    If you have recurring dyspepsia (dyspepsia which clears up and then comes back again), it is common practice to test for H. pylori
    before doing any other tests. If H. pylori is found, eradication treatment is often given. The exact diagnosis may not be known. For
    example, it might not be clear if the dyspepsia is caused by a duodenal or stomach ulcer, or non-ulcer dyspepsia. These can only be
    confirmed by having a look down into the gut with a test called gastroscopy (endoscopy). However, if symptoms go after treatment for H.
    pylori then that is the end of the matter. You do not need further tests such as gastroscopy. You will not know exactly what caused the
    symptoms but this does not matter if the symptoms have gone.

    Other reasons for testing


    If you are in one of the following groups, you may be offered a test for H. pylori and offered treatment with eradication therapy if it is
    found. If you:

    Have a duodenal or stomach ulcer. Eradication therapy will usually cure the ulcer.
    Have non-ulcer dyspepsia. Eradication therapy may work and clear symptoms but it does not in most cases.
    Have a first-degree relative (mother, father, brother, sister or child) who has been diagnosed with stomach cancer. Treatment
    is advised even if you do not have any symptoms. The aim is to reduce your future risk of stomach cancer.
    Are taking, or are about to take, long-term anti-inflammatory medication such as ibuprofen, diclofenac, aspirin, etc. The
    combination of these medicines and H. pylori increases the risk of developing a stomach ulcer.
    Have a MALToma.
    Have inflammation of the stomach lining (atrophic gastritis).
    Have had an operation to remove a stomach cancer.
    Have unexplained iron-deficiency anaemia.
    Have a condition called chronic idiopathic thrombocytopenic purpura. This is an uncommon blood condition where the
    number of platelets in the blood becomes very low. Some research suggests a possible connection between H. pylori
    infection and this condition.

    What problems does Helicobacter pylori cause?


    Commonly there are no problems
    Most people who are infected with H. pylori have no symptoms or problems caused by the infection. These people do not know that they
    are infected. A number of H. pylori germs (bacteria) may just live harmlessly in the lining of the stomach and duodenum.

    Stomach and duodenal ulcers


    H. pylori is the most common cause of duodenal ulcers and stomach (gastric ulcers). About 3 in 20 people who are infected with H.
    pylori develop an ulcer. An ulcer occurs where the lining of the stomach or duodenum is damaged by the acid made in the stomach and
    the underlying tissue is exposed.

    In some people H. pylori causes inflammation in the lining of the stomach or duodenum. This is called gastritis and may lead to other
    conditions such as vitamin B12 deficiency. In gastritis the mucous defence barrier appears to be disrupted in some way (and in some
    cases the amount of acid to be increased). This seems to allow the acid to cause inflammation and ulcers.
    Page 2 of 3

    Non-ulcer dyspepsia
    This is a condition where you have recurrent bouts of indigestion (dyspepsia) which are not caused by an ulcer or inflammation. It is
    sometimes called functional dyspepsia. H. pylori is sometimes found in people with non-ulcer dyspepsia. Getting rid of H. pylori cures
    some cases but makes no difference in most cases. The cause of most cases of non-ulcer dyspepsia is not known.

    Stomach cancer
    The risk of developing stomach cancer is thought to be increased with long-term infection with H. pylori. However, it has to be stressed
    that the vast majority of people with H. pylori do not get stomach cancer. The increased risk is small. Your risk may be greater if you
    have H. pylori in addition to having a first-degree relative (mother, father, brother, sister or child) who has been diagnosed with stomach
    cancer.

    Gastric mucosa-associated lymphoid tissue lymphoma - a MALToma


    This is a rare and unusual type of stomach cancer. Infection with H. pylori is thought play a role in this condition developing.

    How is Helicobacter pylori diagnosed?


    Various tests can detect H. pylori:

    A breath test can confirm that you have a current H. pylori infection. A sample of your breath is analysed after you take a
    special drink. Note: prior to this test you should not have taken any antibiotics for at least four weeks. Also, you should not
    have taken a proton pump inhibitor (PPI) or H2-receptor antagonist medicine for at least two weeks. (These are acid-
    suppressing medicines.) Also, you should not eat anything for six hours before the test. The reason for these rules is
    because the medication and food can affect the test result.
    An alternative test is the stool antigen test. In this test you give a pea-sized sample of your stools (faeces) which is tested for
    H. pylori. Note: prior to this test you should not have taken any antibiotics for at least four weeks. Also, you should not have
    taken a PPI or H2-receptor antagonist acid-suppressing medicine for at least two weeks.
    A blood test can detect antibodies to H. pylori. This is sometimes used to confirm that you are, or have been, infected with H.
    pylori. However, it can take up to a year for this test to become negative once the infection has cleared. So, it is no use to
    confirm whether treatment has cleared the infection (if this needs to be known). If needed, the breath test or stool antigen test
    is usually used to check if an infection has cleared following treatment.
    Sometimes a small sample (biopsy) of the lining of the stomach is taken if you have a gastroscopy (endoscopy). The sample
    can be tested for H. pylori.

    How is Helicobacter pylori cleared from the stomach and duodenum?


    H. pylori is killed by certain antibiotics. However, a combination of medicines is needed to get rid of it completely. This is referred to as
    combination therapy although because it gets rid of (eradicates) the germ it is also referred to as eradication therapy. You need to take
    two antibiotics at the same time. In addition, you need to take a medicine to reduce the acid in the stomach. This allows the antibiotics to
    work well in the stomach. You need to take eradication therapy for a week. It is important to take all the medication exactly as directed
    and to take the full course.

    Eradication therapy clears H. pylori in up to 9 in 10 cases if it is taken correctly for the full course. If you do not take the full course
    then the chance of clearing the infection is reduced. A second course of eradication therapy, using different antibiotics, will usually work
    if the first course does not clear the infection.

    Eradication therapy is sometimes called triple therapy as it involves three medicines - two antibiotics and an acid-suppressing medicine.

    Follow-up
    If you have indigestion (dyspepsia), it is usually only necessary to check to see if the H. pylori has gone if your symptoms come back
    after treatment. If you have a gastric or duodenal ulcer, testing is usually done 6-8 weeks after treatment.

    Are there any side-effects of eradication therapy?


    Up to 3 in 10 people develop some side-effects when they take eradication therapy. These include indigestion (dyspepsia), feeling sick
    (nausea), diarrhoea and headaches. However, it is worth persevering with the full course if side-effects are not too bad. A switch to a
    different set of medicines may be advised if the first combination does not clear the H. pylori, or if it caused bad side-effects and you had
    to stop taking it.

    Further reading & references


    Gastro-oesophageal reflux disease and dyspepsia in adults: investigation and management; NICE Clinical Guideline (Sept 2014 - last updated
    October 2019)
    Diaconu S, Predescu A, Moldoveanu A, et al; Helicobacter pylori infection: old and new. J Med Life. 2017 Apr-Jun;10(2):112-117.
    Dore MP, Pes GM, Bassotti G, et al; Dyspepsia: When and How to Test for Helicobacter pylori Infection. Gastroenterol Res Pract. 2016;2016:8463614.
    doi: 10.1155/2016/8463614. Epub 2016 Apr 28.
    Dyspepsia - proven functional; NICE CKS, October 2018 (UK access only)
    Dyspepsia - proven peptic ulcer; NICE CKS, October 2019 (UK access only)
    Page 3 of 3

    Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. Egton
    Medical Information Systems Limited has used all reasonable care in compiling the information but makes no warranty as to its
    accuracy. Consult a doctor or other healthcare professional for diagnosis and treatment of medical conditions. For details see our
    conditions.

    Author: Peer Reviewer:


    Dr Laurence Knott Dr Hayley Willacy

    Document ID: Last Checked: Next Review:


    4266 (v43) 14/04/2020 13/04/2025

    View this article online at: patient.info/digestive-health/dyspepsia-indigestion/helicobacter-pylori


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