Endocrine System
Endocrine System
Endocrine System
Neurocrine
- Secreted in neurons and released into
extracellular space
Neuroendocrine
- Secreted in neurons and released from nerve
endings
ctolenada@feu.edu.ph
CLINICAL CHEMISTRY 2
ctolenada@feu.edu.ph
CLINICAL CHEMISTRY 2
ctolenada@feu.edu.ph
CLINICAL CHEMISTRY 2
ctolenada@feu.edu.ph
CLINICAL CHEMISTRY 2
ctolenada@feu.edu.ph
CLINICAL CHEMISTRY 2
PITUITARY TUMORS
• ProlacCn-secreCng pituitary tumors
(Most common)
• NonfuncFoning or null cell tumors
A. Anterior Pituitary (Adenohypophysis) • Tumors that secrete GH,
- True Endocrine gland gonadotropins, ACTH, or TSH
- Released and producFon of hormones • Atypical pituitary tumors
such as ProlacFn, GH, Gonadotropins • MIB-1 proliferaFve index
(FSH, LH), TSH, and ACTH greater than 3%
5 TYPES OF CELLS BY IMMUNOCHEMICAL • MIB-1 : monoclonal anFbody
TEST that is used to detect the Ki-
Somatotrophs: secrete GH 67 anFgen
Lactotrophs or mammotrophs: secrete • marker of cell proliferaFon
prolacFn • high “proliferaCon index” suggests
Thyrotrophs: secrete TSH higher degree of atypia
Gonadotrophs: secrete LH and FSH • excessive p53
CorCcotrophs: Secretes immunoreacFvity
prooplomelanocorFn • increased mitoFc acFvity
• macroadenomas (i.e., >1 cm
in diameter)
ctolenada@feu.edu.ph
CLINICAL CHEMISTRY 2
ctolenada@feu.edu.ph
CLINICAL CHEMISTRY 2