Pharmacology Summary Notes
Pharmacology Summary Notes
Pharmacology Summary Notes
1
directly w/o metabolism - Many drugs compete for the same binding site
- Major organ for excretion is kidney, TISSUE BINDING
intestine, biliary system & lungs - Some drugs bound to certain tissue due to special
- Unabsorbed portion of orally administered affinity
drugs are eliminated thru feces - Tissue binding delays excretion & prolongs duration
- Liver transfers unionized molecules into action
bile for specific transport - Serves as a reservoir to drugs
- Some drugs get absorbed in lower gut & BLOOD-BRAIN BARRIER (BBB)
carried back to liver thru enterohepatic - Brain capillaries & glial cells form BBB
circulation (prolong duration of dug action) - Lipid soluble, unionized frugs can cross BBB
- Lungs main route of excretion for gases & PLACENTA BARRIER
volatile liquids - Lipid soluble, unionized drugs readily cross placenta
- Small amounts drugs are eliminated thru - Drugs taken by mom can cause unwanted effects in
sweat & saliva fetus
FACTORS INFLUENCING ABSORPTION OF DRUGS PHARMACODYNAMIC: Study of action & mechanism
1. Disintegration & dissolution time of action of drugs on the body
Oral drugs should break & dissolve in order *Drugs produce effects by interacting with the
to be absorb physiology systems of body
Liquids absorb faster ACTIONS OF DRUGS
S/C & I/M injections have to dissolve in 1. Stimulation
tissue fluids - > activity of specialized cells (adrenaline
2. Pharmaceutical preparation stimulates heart)
Drugs formulated to produce required 2. Depression
absorption - < activity of specialized cells (barbiturate
3. Particle size depress CNS)
Smaller size better absorbed 3. Irritation
Drug has to act on the gut & its absorption - Occurs on all types of tissues & result in
is not required, then size should be big inflammation, corrosion & necrosis of cells
4. Lipid solubility 4. Replacement
Lipid soluble drugs absorbed better & faster - Drugs used for replacement when there’s
by phospholipids of cell membrane deficiency of natural substances like
5. pH & Ionization hormone/nutrients
Ionized drugs poorly absorbed as compared 5. Anti-infective or Cytotoxin action
to unionized drugs - Drugs act by specifically destroying
6. Area & vascularity of the absorbing surface infective organisms cytotoxin effect on
The larger & more vascular the surface cancer cells
area, better the absorption 6. Modification of the immune system
7. GIT motility - Vaccines act by improving immunity while
If gastric emptying fast, drug will be immune-suppressants act by depressing
absorbed faster in intestine immunity
8. Presence of food SITE & MECHANSIISM OF DRUGS ACTION
Foods delay stomach emptying & dilute 1. Locally
drug & delay absorption - Acts on site application (skin, eyes, GIT
9. Metabolism mucosa, nasal mucous membrane,
Some drugs maybe degraded in gut like respiratory mucosa)
insulin - Preparations such as cream, drops, inhaler,
10. Health status enema
Disease of gut like malabsorption will < 2. Systematically
absorption - Maybe absorb into blood & act
FACTORS INFLUENCING DISTRIBUTION systematically
1. Lipid solubility - Produce effects by binding to specific target
2. Ionization proteins (receptors, enzymes, ion channel
3. Blood flow & act on cell membrane)
4. Plasma protein binding FUNDAMENTAL MECHANISM OF DRUGS ACTION
5. Cellular proteins 1. Through receptors
PLASMA PROTEIN BIDNING - Receptor is a site on cell which drug binds
- Acid drugs bind to albumin & basic drugs bind to to bring out a change
alpha acid glycoprotein - It’s protein present in cytoplasm or on
- Free/unbound fraction drug is only form available nucleus
for action, metabolism & excretion but protein bound - It has to identify compound, once they
form serves as reservoir bind, it will cause a response
- Protein binding prolongs duration of action of drugs - Drug binds to receptor & produce response
2
called “agonist” 3. Minerals
- Drugs bind to receptor & prevents action of - Iron, Mg sulphates, Al hydroxide
agonist on receptor called “antagonist” 4. Microorganism
2. Through enzymes & pumps - Antibacterial agents obtained from bacteria
- Acts by inhibition of enzymes by altering & fungi such as penicillin
enzyme reaction or inhibit membrane 5. Human
pumps - Immunoglobulin from blood & chorionic
3. Through ion channel gonadotrophins from urine of pregnant
- Interfere with movement ions across mom
specific channels SYNTHETICS
4. By physical action 1. Cell cultures
- Act due to its physical properties (activated - Urokinase from human kidney cells
charcoal for absorption) 2. Recombination DNA technology
5. By chemical interaction - Human insulin (some from cow)
- Acts by its chemical reactions (antacid to 3. Hybridoma technique
neutralized gastric acid) - Monoclonal antibodies
6. By altering metabolic process DRUG INFORMATION SOURCES
- Alter metabolic pathway in microbes 1. Official compendia
resulting in destruction of microbes - Pharmacopeia
FACTORS INFLUENCING ACTION OF DRUGS - Drug formulary
1. Body weight 2. No-official compendia
- recommended dose is calculated to - Textbooks
medium build person, obese & - Journals
underweight & has to calculate individually - Periodicals
2. Age 3. Medline
- Pharmacokinetics of drugs change with age E-source
resulting in altered response in extremes of LIQUID CATEGORY
age 1. Solutions: Prepared by diluting liquid
3. Gender concentrated/powder
- Hormonal effects & smaller body size 2. Tintures: Extracted using alcohol
influence drugs response in woman 3. Suspension: Liquid drug with solid drug particles
4. Diet 4. Spirits: Alcohol
- Food interferes the absorption of drugs 5. Emulsions: Oily substance mixed
5. Route of administration 6. Elixirs: Mixture of alcohol & water
- Occasionally route of administration 7. Syrups: Sweetened solutions
influence response PARTS OF DRUG LABEL
6. Genetics factors 1. Trade name (brand name)
- Difference response to drugs due to genetic 2. Generic name (official name of drug)
mediated 3. Dosage strength (amount/weight)
7. Dose 4. Form (indicate how drug’s supplied)
- Dose >, response > till “maximum” is 5. Route (indicate how drug to be administered)
reached 6. Direction (instruction to follow)
8. Disease UNIT 2.1 - DOSAGE CALCULATION
- Presence of certain disease can influence Dose required X Stock volume
drug response Dose in stock
9. Repeated doses : Volume to be given
- Result in toxicity & tolerance
DRUG CALCULATION
(accumulation)
1. Tab calculation
10. Psychological factor
2. Syrup calculation
- Doctor-patient & nursing care may
3. Parental calculation
influence the response
4. IV flow rate calculation
11. Presence of other drugs
5. Inotrops calculation
- Concurrent use of 2 or > drugs may
UNIT 2.2 - PRINCIPLE OF DRUG ADMINISTRATION
influence response of each other
7 RIGHTS OF DRUG ADMINISTRATION
UNIT 2 - PHARMACEUTICAL PREPARATIONS
1. Right patient
Sources of drugs:
2. Right drug
(i) Natural sources
3. Right dose
(ii) Synthetics
4. Right time
NATURAL SOURCES
5. Right route
1. Plants
6. Right documentation
- Atropine, morphine, quinine, digoxin
7. Right to refuse by client
2. Animals
KOZIER 10 PRINCIPLES OF DRUG ADMINISTRATION
- Insulin, heparin
3
1. Right client DISADVANTAGE OF ENTERAL ROUTE
Med given to intended client 1. Onset of action is slower
Ask client name 2. Irritant & unpalatable drugs can’t be given
Check wrist band 3. Some maybe destroyed by stomach acid/enzyme
2. Right drug 4. Irritation leads to vomit
Med given was right 5. Irregularities in absorption
Check with doc’s prescription 6. Can’t be given to unconscious & uncooperative pt
Check 3 time (b4, during, after) 7. Pt forget to take med
3. Right time 8. Some maybe undergo extensive 1st pass
Given in right frequency metabolism in liver
Med given within 30 mins b4/after ADVANTAGES OF PARENTAL ROUTE
schedule time is acceptable 1. Action more rapid & predictable
4. Right route 2. Can be given to unconscious & uncooperative pt
Give med by the ordered route 3. Gastric irritants can be given
Check doc’s prescription 4. Can be given to pt with vomiting & unable to
5. Right dose swallow
Appropriate dose ordered 5. Digestion by digestive juices & 1st pass metabolism
Double check calculation can be avoided
6. Right client education DISADVANTAGES OF PARENTAL ROUTE
Explain about the med to client (name, 1. Asepsis must maintain
function, side effects) 2. Injection maybe painful
7. Right documentation 3. More expensive, less safe & inconvenient
Document med administration after giving 4. Injury to nerve & other tissue may occur
med NOT B4 (date, time, sign) TYPES OF PARENTAL ROUTE
8. Right client to refuse 1. Injection
Nurses have to ensure that client is fully ID (10-15’)
informed of potential consequences of - into layer of skin by raising bleb
refusal to health care provider - ex: BCG vaccine
9. Right assessment SC (45’)
Some med required specific assessment - deposit in s/c tissue
prior to administration (vital sign) - < vascular, absorption < & uniform &
10. Right evaluation make drugs long acting
Monitor pt’s response to med - ex: insulin
Desired effect achieved or not? IM (90’)
Did pt experienced any side effects? - absorption into plasma by simple
UNIT 2.3 - ROUTES OF DRUGS ADMINISTRATION diffusion & larger molecules thru lymphatic
Type of routes: vessels
(i) Enteral - absorption rapid & quite uniform bcs
Common, oldest, safest route muscle is vascular
Surface, difference pH helps effective - need to draw plunger to make sure
absorption needle is not in blood vessel
Acid & enzyme secreted & biochemical - shouldn’t > 10ml, deltoid only 1-2ml
activity of bacteria flora can destroy drugs IV (25’)
(ii) Parental - use when immediate response is needed
Drugs directly delivered to into tissue 2. Inhalation
fluids/blood Metered dose inhaler
ADVANTAGES OF ENTERAL ROUTE - inhale into lungs in aerosol form to act
1. Safest locally within respiratory system
2. Most convenient Nebulizer
3. Most economical - convert liquid med to mist to inhale it
4. Can be self-administered easily & inhale to lungs to act locally
5. Non-invasive route 3. Transdermal route
TYPES OF ENTERAL DRUGS Adhesive patch
1. Oral (PO) - waterproof adhesive patch applied on
site to release med over a long period
Given by mouth & usually swallowed but
some have to chew or suck Creams/ointment
2. Sublingual (SL) - direct apply on skin & will be absorbed
Drug placed under tongue & left to absorb Eye drop
- instilled into pt’s lower eyelid
Frequent used will affect on heart
4. Transmucosal route
3. Per rectum (PR)
- Intranasal, buccal, rectal & sublingual
Administered into rectum as
enema/suppository DISADVANTAGES OF SC INJECTION
4
1. Rich supply of nerves, irritant drugs can’t be 3. Keep & Store of Dangerous & Psychotropic Drug
injected Keep drugs in DDA cupboard with double
2. In shock, absorption not dependable due to lock at all time
vasoconstriction Keep DDA par level at all times (Periodic
3. Repeated injections site can cause lipoatrophy Automatic Replacement – indicate min.
(loss fat locally) amount of stock to avoid shortage &
FACTORS INFLUENCE ACTION OF DRUGS overstocking & ensure a consistent supply
1. Age level while reducing waste)
Infants - immature enzymatic drug Keep empty ampoules for exchange
inactivation Broke/missing ampoules to be reported
Children - hyper-reactive to certain drugs immediately to pharmacist & sister
Older adults - have impaired liver & kidney 4. Recording of controlled drugs
function & likely suffer from toxic reaction Immediately document drugs used
2. Body weight Document particulars
Concentration of drug will depend on dose - pt name
per kg of body - RN num.
3. Route of administration (> : faster) - date & time
IV > liq > powder > cap > tab > coated tab - drug used
4. Psychological taste - dosage given
Anxious pt requires > dose of general - stock balance
anesthesia - name & initial of SN
5. Disease taste - name of consultant who ordered drug
Drug metabolism is depressed in liver - 2 SN to counter check drugs
failure Document drugs & dosage in pt’s med chart
Drug excretion is < in damaged kidney & time
UNIT 3 - DANGEROUS DRUG ACT (DDA) For outpatient: report in pt’s case note
List of drugs under control of DDA act 1952: 5. Replenishment of controlled drugs indenting
1. Analgesics (Narcotic) Indent drug in DDA indent book (write
Morphine Sulphate (10mg/ml) balance & amount required to indent)
Morphine HCL (10mg/5ml solution) Send items to pharmacy when indenting:
Pethidine HCL (50mg/ml) - DDA indent book
- DDA record book
- Empty ampoules of injections
2. Analgesics medium
Follow indent schedule as given by
Dehydrocodeine Tartrate (30mg/tab) (DF
pharmacist
118)
6. Collecting drugs
Nalbuphine HCL (10mg/ml injection)
Only SRN to collect drugs
(Nubain)
Check following when collecting drugs:
- amount supplied tally with requisition
3. Tranquillisers/Hypnotics/Sedatives note
Midazolam (7.5mg/tab) (Dormicum) - total drug supplied
Midazolam (5mg/ml injection) (Dormicum) Sign at columns to indicate receipt:
Diazepam (5mg/tab) (Valium) - DDA indent book
Diazepam (10mg/2ml injection) (Valium) - DDA record book
Syrup Chloral Hydrate (200mg/ml) 7. Missing of drugs
Report immediately if inaccurate count
4. Anticonvulsants Remain on duty & search for missing
Phenobarbitone (30mg/tab) (Luminal) narcotics
Phenobarbitone Sodium (200mg/ml Fill up incident report & sign with witness
injection) (Gardenal) (special precautions used to help control
NURSING RESPONSIBILITIES IN HANDLING DDA drug abuse)
1. Checking of controlled drugs Breakage of drug ampoule must be
Check DDA every shift for balance of drugs documented in DDA book:
as documented in DDA record book (date, - date
time, pt name, RN num.) - reason of waste
Check expiry date (send to pharmacy if 3 - amount waste
months b4 due date) - sign of SN
2. Passing over controlled drugs - sign of witness SN
Pass over from shift to shift regarding drugs UNIT 4.1 - ANALGESICS
used & balance DEFINITION – Medications that relieve different type
Check & receive balance & document in of pain, includes inflammatory
DDA record book CLASSIFICATION OF ANALGESIC
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1. Opioid 4. Take drug with food to prevent GIT bleeding
2. Non-opioid NON-OPIOID ACETAMINOPHEN
(i) Salicylates - Example
(ii) Acetaminophen Paracetamol
(iii) NSAIDs - Indications
OPIOID Mild-moderate pain as analgesia
- Derivatives from opium plant/synthetic drug that Fever as antipyretic
imitates natural narcotics - Function
- Example: < fever by effect on hypothalamus leading
Codeine to sweating & vasodilation
Morphine Inhibit effect of pyrogens on heat-
Pethidine regulating centre on hypothalamus
Fentanyl Inhibit CNS prostaglandin synthesis as an
- Indication: analgesia
Moderate-severe pain - Side effects
- Side effects: Skin rash
CNS (analgesia, euphoria, drowsiness, Hepatotoxicity
mood change, mental clouding, deep sleep) NURSING RESPONSIBILITY ON SERVING
Respiratory system (depress respiration, ACETAMINOPHEN
depress cough reflex) 1. Aware the max dose is 1g 6 hourly
GIT (nausea, vomit, < peristaltic motility) 2. Administer b4 fever & pain
Others (vasodilation hypotension, pupil 3. Monitor signs of allergic reaction (hives, skin rash,
constriction) swelling face)
NURSING RESPONSIBILITY ON SERVING OPIOID 4. Give N- acetyleystine for toxicity to prevent
1. Remind pt to be careful when getting out of bed & hepatic damage by inactivating acetaminophen
walking metabolites which cause liver effect
2. Monitor pt RR (RR < 12, withhold med) NON-OPIOID NSAIDs
3. Administer med b4 pain arise - Example
4. Administer antiemetics b4 nausea & vomit Diclofenac Sodium (Voltaren)
5. Give Naloxone (Narcan) for toxicity - used to Indomethacin (Indocid)
reverse respiratory depression due to overdose Ibuprofen (Brufen)
NON-OPIOID SALICYLATES - Indications
- Example RA
Aspirin Osteoarthritis
- Indication Gout
Control pain Musculoskeletal disease
Reduce fever & inflammation Severe toothache
- Function - Function
Relief pain by inhibit synthesis of < prostaglandin synthesis
prostaglandin - Side effects
Reduce fever by stimulate hypothalamus & Peptic & duodenal ulcer
produce peripheral blood vessel dilation & GI bleeding
> sweating Nausea & vomit
Inhibit platelets aggregation (clumping of Tinnitus
platelets to form clot) Loss of hearing
- Side effects NURSING RESPONSIBILITY ON SERVING NSAIDs
Hearing loss 1. Take with milk/meal/antacids to < GIT bleeding
Bleeding tendencies 2. Report sign of GI bleeding
GIT upset 3. Instruct pt to report sign of bleeding, blurring
- Contraindications vision, tinnitus, rashes
Hypersensitivity to salicylates UNIT 4.2 – ORAL HYPOGLYCEMIA AGENTS
Asthma DEFINITION – Any of various agents that < level of
Pre/post-surgery glucose in blood & used un treatment for DM
Bleeding disorder (hemophilia) *Type 2 diabetes (disorder involving < insulin
GIT bleeding production or insulin resistance to secrete insulin)
Peptic ulcer
NURSING RESPONSIBILITY ON SERVING SALICYLATES CLASSIFICATIONS
1. Avoid use to children may trigger Reye’s Syndrome 1. Sulfonylureas
(swelling in liver & brain) 2. Biguanides
2. Avoid use for surgery pt, discontinue 1 week b4 3. Alpha-glucosidase inhibitors
surgery due to risk of post-op bleeding 4. Thiazolidinediones
3. Watch signs of bleeding (gum bleeding) 5. Dipeptidyl peptidase-4 enzyme inhibitors
6
SULFONYLUREAS 1. Take with meals
2. Monitor side effects of stomach bloating
GENERIC NAME TRADE NAME 3. Monitor liver function (carb. metabolism)
Glimepiride Amaryl 4mg THIAZOLIDINEDIONES
Glibenclamide Daonil 5mg
Gliclazide Diamicron MR 30mg GENERIC NAME TRADE NAME
Diamicron 80mg Rosiglitazone Avandia 4mg
Glyade 80mg Pioglitazone Actos
Glipizide Minidiab 5mg
- Function
- Function > sensitivity of tissue to insulin action
Stimulate insulin secretion from pancreatic - Side effects
B-cells > adiposity (weight gain)
- Side effects Peripheral edema (hands/legs)
Hypoglycemia > risk of fracture
Stomach upset NURSING RESPONSIBILITY
Weight gain (insulin > appetite) 1. Monitor blood glucose
NURSING RESPONSIBILITY 2. Monitor liver function
1. Monitor pt signs of hypoglycemia 3. Don’t serve to heart failure pt
2. Monitor blood glucose & urine ketone to assess DIPEPTIDYL PEPTIDASE-4 ENZYME INHIBITORS
effectiveness
3. Taking beta-adrenergic blocking agent may mask GENERIC NAME TRADE NAME
warning signs of hypoglycemia Linagliptin Tradjenta
4. Avoid alcohol Saxagliptin Onglyza
BIGUANIDES Sitagliptin Januvia
- Function
< glucose production by liver
> insulin sensitivity at tissue
> glucose transport into cells
- Side effects
Nausea
Anorexia
Diarrhea
NURSING RESPONSIBILITY
1. Monitor renal function bcs it can cause lactic
acidosis hyperglycemia
2. > risk of acute renal failure with use of iodinated
contrast for diagnostics studies NURSING RESPONSIBILITY
ALPHA-GLUCOSIDASE INHIBITORS 1. Monitor blood glucose level
2. Watch signs of side effects
GENERIC NAME TRADE NAME UNIT 4.3 - INSULIN THERAPY
Acarbose Glucobay 50mg Essential for Type I DM
Glucobay 100mg Required for Type II DM
- When meal planning & OHA (orally
administered anti-hyperglycemia agent)
- Function
ineffective
Slow digestion pf CO2 & delay glucose
- During illness, infection, pregnancy, surgery
absorption
- Side effects
Flatulence (passing gas from digestive
system out back passage) TYPES OF INSULIN
Stomach bleeding
NURSING RESPONSIBILITY
7
(vi) Anti-platelets
CLASSIFICATION EXAMPLE (vii) Anti-lipemics (< lipids)
1. Rapid acting Novorapid INOTROPES
(eat 5-15mins after
injection) +VE INOTROPIC -VE INOTROPIC
2. Short acting Actrapid Epinephrine Flecainide
(administer 20-10mins Norepinephrine Verapamil
b4 meals) Dopamine Cibenzoline
3. Intermediate acting Monotard, Humalin L, Dobutamine Clonidine
(eat within 15mins Humalin N, Insulatard Levosimendan Atenolol
after injection) Milrinone Disopyramide
4. Long acting Levemir, Lantus Amrinon Sunitinib
(absorb slowly in 24h) Enoximone Itraconazole
8
Constipation Keep tab in dark glass bottle
Dry mouth Instruct pt if chest pain, put tab under
Nervousness tongue. If not relieve in 5min, take 2nd tab.
Nausea If not relieve after 5min, take 3rd tab & rush
Blurry vision to hosp
Diarrhea 2. Transdermal Nitroglycerin
Sweating Apply when wake up in morning & remove
CARDIA GLYCOSIDASE b4 bedtime
- Functions Avoid hairy skin
> output force of heart Don’t stand near microwave oven
< its rate of contractions by inhibit cellular 3. Assess baseline BP prior to administration of
sodium-potassium ATPase pump nitrates (SBP<90Hg, withhold drug)
- Example 4. IV nitrates should never stop suddenly. Sudden
Digoxin (Cardoxin & Lanoxin) withdrawal can aggravate angina
Digitalis (Digitoxin) ANTI-HYPERTENSIVE
- Indication - Med that brings BP down in various ways
Heart failure
Atrial fibrillation (AF) GROUPS OF DRUGS DRUGS
- Contraindication Diuretics Thiazides:
Hypertropic obstructive cardiomyopathy - Hydrochlorothiazide,
Heart blocks - Chlorthalidone
Bradycardia High loop diuretics:
- Side effects of Digoxin toxicity -Furosemide
Bradycardia Torsemide K+ Sparing:
Nausea & vomit - Amiloride
Headache ACE inhibitors Captopril, Enalapril,
Blurred vision Ramipril, Lisinopril
MANAGEMENT OF DIGOXIN TOXICITY Angiotensin I (AT1 Losartan, Telmisartan,
1. Withhold dose receptor blockers) Valsartan
2. Monitor vital sign (Angiotensin II
3. Administer anti-emetics for nausea & vomit receptor antagonists)
4. Check serum Digoxin & potassium level a adrenergic blocker Terazosin, Prazosin,
NURSING RESPONSIBILITY Phentolamine,
1. Assess HR by counting apical pulse b4 Phenoxybenzamine
administration B adrenergic blocker Atenolol, Propanolol,
2. Assess ECG, if heart block, withhold drug & inform Metoprolol
doc a+B adrenergic Labetalol, Carvedilol
3. Review serum potassium level, if <, withhold drug blocker
& inform doc Calcium channel Verapamil, Nifedipine,
4. Observe signs & symptoms of digoxin toxicity blocker Amlodipine, Diltiazem,
CARDIAC VASODILATOR - NITRATES Felodipine
- Function Central Clonidine, Methyldopa
Vasodilation of arteries that used to trat Sympatholytics
angina pains Vasodilators Arteriolar=Minoxidil,
- Example Diazoxide, Hydralazine
Sublingual Glyceryl Trinitrate (GTN) Arteriolar+Venus=Sodium
Isordil Nitroprusside
Isosorbide Dinitrate Direct renin inhibitors Aliskiren
Transdermal nitroglycerin (Nitrodisc)
- Indication
Angina pectoris DIURETICS
Unstable angina
- Function
Myocardial angina
Get rid of Na & H2O, < amount of fluid in
Hypersensitive crisis blood vessels & < BP
- Side effects
Treat hypertension
Hypotension
Fluid volume excess & edema (congested
Tachycardia heart failure, cirrhosis of liver or renal
Headache dysfunction)
Facial flushing - Side effects
NURSING RESPONSIBILITY Hypotension
1. Sublingual GTN Dry mouth
9
Thirst effectiveness or potency
- Adverse reactions of diuretics ANGIOTENSIN (AT1 RECEPTOR BLOCKER)
Hypokalemia - Produce arteriolar & venous dilation & block
- weakness aldosterone secretion, thus < BP & < salt & H2O
- muscle cramps/pain retention
- muscular fatigue - Similar pharmacological effects to ACE inhibitor
- dysrhythmia a ADRENERGIC BLOCKERS
Hyponatremia - < BP by keeping hormone norepinephrine from
- lethargy (lack energy) tightening muscles in walls of smaller arteries & veins
- drowsiness - Alpha-blocker mainly used in combination with
- restlessness other hypertensive in order to trat high BP
Confusion B ADRENERGIC BLOCKERS
Seizures - < BP by blocking effects of hormone epinephrine
NURSING RESPONSIBILITY - Function
1. Administer with milk/foods < HR
2. Administer IV diuretics slowly (fast infusion cause < heart contractility
sudden & severe changes in electrolyte balance) - Indication
3. Educate pt about function & side effects adverse Hypertension
reactions in order to empower safe self-administer of Angina pectoris (low blood supply to heart)
med Myocardial infarction
4. Encourage proper hydration but remind pt to Heart failure
follow the prescribed oral fluid restriction (excessive - Side effects
fluids intake will nullify the diuretics goal to eliminate Hypotension
excessive fluid in body) Bradycardia
5. If pt has dry mouth, encourage to rinse mouth with Heart blocks
cold H2O & spit it out Diarrhea
6. Administer oral diuretics early morning & avoid Nausea & vomit
giving in evening to < tendency to urinate during NURSING RESPONSIBILITY
sleeping hour
1. Assess vital sign b4 & after (if SBP<90mmHg &
7. Check blood glucose routinely especially diabetic
HR<45, withhold drugs)
(Thiazide diuretics may change serum glucose level)
2. Observe side effects
ACE INHIBITOR 3. Sudden withdrawal of drug can aggravate angina
- Blocking conversion of Angiotensin I to Angiotensin a+B ADRENERGIC BLOCKERS
II
- Used to treat high BP
- Indication
- Side effects
Hypertension
Fatigue & dizziness
Heart failure
Poor circulation
Myocardial infarction
GIT symptoms
- Side effects
Sexual dysfunction
Dry cough
Weight gain
Hyperkalemia
CALCIUM CHANNEL BLCOKER
Fatigue
- < BP by preventing Ca2+ from entering cells of
Dizziness due to low BP
arteries & heart that causes to contract strongly
Headache
- Indication
Loss of taste
Hypertension
NURSING RESPINSIBILITY
Angina
1. Administer on empty stomach, 1-2h prior to main Myocardial infarction
meals (ensure optimal absorption & therapeutical - Side effects
action)
Hypotension
2. Med review to ensure pt doesn’t take with NSAIDs
Heart failure
(may lower effectiveness of ACE inhibitor)
Bradycardia
3. Educate pt about function, indication, side effects
NURSING RESPONSIBILITY
& adverse reactions & how to self-administer (to
1. Assess vital sign b4 & after (if SBP<90, withhold
empower safely self-administer of med)
drug)
4. Monitor pt input & output & stool chart (cause
2. Observe sign & symptoms of side effects
diarrhea)
5. Discourage intake of fish oil, banana, orange & CENTRAL SYMPATHOLYTICS
other potassium-rich foods (cause hyperkalemia) - < BP by < sympathetic nerve activity & neuronal
6. Encourage reduction of alcohol (cause release norepinephrine to heart & peripheral
hypotension)7. Encourage pt to change position circulation
slowly (prevent orthostatic hypotension)
7. ACE inhibitor usually be crushed w/o affecting
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VASODILATORS - Function
- < BP by producing vascular smooth muscle < hyperlipidemia that lead to additional
relaxation, primarily in arteries & arterioles result in < health prob (stroke, myocardial infarction,
in peripheral resistance angina & heart failure)
DIRECT RENIN INHIBITORS - Example
- Directly inhibits renin Statins
- Act in RAAS, then ACE inhibitors & angiotensin - < LDL-C
blocker - Lovastatin, Pravastatin, Simvastatin,
ANTI-COAGULANT Atorvastatin
- Function Fibrates
> time take to clot - < triglycerides & > HDL-C
Prevent clot formation - Gemfibrozil
- Example - Indication
Heparin For hyperlipidemia & prevention of
Warfarin cardiovascular disease
Clexane & Fraxiparine (Low molecular
weight heparin)
- Indication
Heparin
- Myocardial infarction
- Unstable angina
- Pulmonary embolism (obstruction of
artery due to blood clot/air bubble)
Warfarin
- Atrial fibrillation
- Post heart valve surgery
- Side effect
Bruising
Hemorrhage
NURSING RESPONSIBILITY
1. Monitor coagulation profile, INR, aPPT, PT
2. Observe for active bleeding (gum, hematuria,
melanic stool)
3. Inform pt to report to doc if any bleeding occurred
4. Antidote:
Heparin: Protamine Sulphate/ Transfusion
of Fresh Frozen Plasma (FFP)
Warfarin: Vitamin K/ Transfusion of Fresh
Frozen Plasma (FFP)
ANTI-PLATELETS
- Function
Inhibits platelets aggregation/sticking
together
- Example
Aspirin
Clopidogrel (Plavix)
Ticlopidine (Ticlid)
- Indication
Angina pectoris
Myocardial infarction
- Side effects
Heart burn
GIT bleeding
Thrombocytopenia (lack of thrombocytes)
NURSING RESPONSIBILITY
1. Serve with meals to avoid GIT irritation
2. Observe pt for unusual bruising & bleeding
ANTI-LIPEMICS
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