PHR112: QUALITY CONTROL 1: DRUG TESTING ASSAY

1. Another name of Ferric ammonium sulfate

a. Ferric alum
b. Fe NH4 (SO4)2
c. Fe (NH4)2(SO4)2
d. A and B
e. A and C

2. The following is/are example/s of metal-ion indicators.

I. Murexide III. Pyrocathecol violet

II. Calmagite IV. Ferric alum

a. I only
b. I and II only
c. I, II, and III
d. I, II, III and IV

3. Assay of diluted HCl is expressed in:

a. % w/w
b. % w/v
c. Both a and b
d. None of the choices

4. Standard solution in precipitation method od analysis

a. Disodium edetate
b. Silver nitrate
c. Sodium Methoxide
d. Perchloric acid

5. Argentometric titration is titration with ______ ion.

a. Magnesium
b. Sodium
c. Silver
d. Potassium
6. Fajans titration uses ____ indicator.

a. Acid-base
b. Adsorption
c. Metal-ion
7. Solutions containing all the reagents and solvents used in the analysis, but no deliberately
added analyte.
PHR112: QUALITY CONTROL 1: DRUG TESTING ASSAY

a. Blank solution
b. Solution with sample
c. Standard solution
d. Test solution

8. Primary standard in the standardization of perchloric acid

a. Potassium hydrogen phthalate

b. Calcium carbonate
c. Benzoic acid
d. Sodium carbonate
9. Ferric ammonium sulfate is used as indicator in the standardization of:

a. Silver nitrate
b. Ammonium thiocyanate
c. Edetate disodium
d. All of the choices
10. The end point of using number ferric ammonium sulfate is:

a. White precipitate
b. Red-brown color
c. Pink color
d. Blue color
11. Standard solution in non-aqueous titrimetric analysis-acidimetry

a. perchloric acid
b. hydrogen bromide
c. both a and b
d. none of the choices
12. If starch is used as an indicator, the end point is/are:

a. appearance of intense blue color

b. disappearance of intense blue color
c. both of the choices
d. none of the choices
13. Types of chemical reaction used in the volumetric analysis

a. redox
b. neutralization
c. diazotization
d. all of the choices
e. a and b only

14. Use of KI in the preparation of iodine solution.

a. Solubilizing agent
b. Change in pH of the solution
PHR112: QUALITY CONTROL 1: DRUG TESTING ASSAY

c. As preservative
d. All of the choices
15. Indicator in iodometric method of analysis.
a. KMnO4
b. Methyl red TS
c. Methyl orange TS
d. Starch TS
16. A substance which gains electrons in a redox reaction.

a. Oxidizing agent
b. Reducing agent
c. Both a and c
d. None of the choices

17. Developed in 1883, this method of analysis remains as one of the accurate and widely used
method for determining nitrogen in substance.

a. Non-aqueous titrimetry
b. Precipitation
c. Redox itration
d. Kjeldahl method

18. Most suitable indicator to use in titration of organic acids

a. Methyl red TS
b. Methyl orange TS
c. Phenolphthalein
d. All of the choices

19. Indicator/s used in nonaqueous titrimetry

I. Nile blue
II. Crystal violet
III. Malachite green
IV. Phenolphthalein

a. I only
b. I and II only
c. I, II, and III only
d. I, II, III and IV

20. Standard solutions in nonaqueous alkalimetry.

a. Lithium methoxide
b. Perchloric acid
PHR112: QUALITY CONTROL 1: DRUG TESTING ASSAY

c. Hydrogen bromide
d. Sodium hydroxide

21. The used of sodium bicarbonate in the standardization of iodine solution ______.

a. Increase the solubility

b. as buffer
c. As preservative
d. To prevent bacterial growth
22. To keep samples moisture free, the appropriate apparatus to use is:

a. Desiccator
b. Separatory funnel
c. Furnace
d. Incubator

23. A 0.2185 g sample of NaCl was assayed using Volhard method using 50 mL of 0.998N silver
nitrate and 11.9 mL of 0.1350N ammonium thiocyanate. Calculate the NaCl in the sample. MW
NaCl = 58.45
a. 42.6
b. 62.4
c. 90.5
d. 6.24
24. A 4.59 mL sample of HCl, specific gravity 1.3, required 50.5 mL of 0.9544N NaOH in a
titration. Calculate the % w/w HCl.
a. 29%
b. 1%
c. 92%
d. 69%
25. Sulfamic acid (H3NSO3) is a primary standard that can be used to standardized sodium
hydroxide. What is the molarity if 33.26 mL reacts with 0.3337 g sulfamic acid. MW=97
a. 0.304
b. 0.1004
c. 0.1005
d. 0.403
26. What is the titer value for 0.05 M calcium chloride with 2 moles of water? MW= 142.9
a. 3.57 mg
b. 7.15 mg
c. 73.5 mg
d. 53.7 mg
27. A 10 mL sample of sulfuric acid solution required 16.85 mL of NaOH solution in a titration.
Each mL of the NaOH solution was equivalent to 0.2477 g of potassium hydrogen phthalate.
Calculate the sulfuric acid content in %w/v. MW=98
PHR112: QUALITY CONTROL 1: DRUG TESTING ASSAY

a. 10%
b. 20%
c. 30%
d. 40%
28. Limestone consists mainly of the mineral calcite, CaCO 3. The carbonate content of 0.5413 g of
powdered limestone was measured by suspending the powder in water, adding 10 mL of 1.392
M HCl and heating to dissolve the solid and expel CO2. The excess acid required 39.96 mL of
0.1004 M NaOH for complete titration to a phenolphthalein end point. Find the weight % of the
calcite in the limestone. MW=100
a. 29%
b. 39%
c. 92%
d. 96%

29. The Kjeldahl procedure was used to analyzed 256µL of a solution containing 37.9 mg
protein/mL. The liberated ammonia was collected in 5 mL of 0.0336 M HCl, and the remaining
acid required 6.34 mL of 0.010 M NaOH for complete titration. What is the weight % of
nitrogen in the protein? MW= 14

a. 3.86
b. 15.1
c. 51.5
d. 5.65

30. How many grams of Cupric (II) Sulfate pentahydrate should be dissolves in a volume of 500 ml
to make 8 X 10-3 M solution?
MW= 249.54
a. 0.998
b. 9.98
c. 99.8
d. 109.1

31. The molarity of concentrated HCl purchased in the laboratory is approximately 12.1 M. How
many mL of this reagent should be diluted to 2 L to make 0.1 M?

a. 1.65
b. 6.53
c. 16.53
d. 165.3

32. A solution with a final volume of 500 mL was prepared by dissolving 25 mL of methanol
(density= 0.7914 g/mL) in chloroform. Calculate the molarity of methanol in the solution. MW=
32.
PHR112: QUALITY CONTROL 1: DRUG TESTING ASSAY

a. 0.12
b. 1.24
c. 12.4
d. 124
33. What is the use of HgI2 in the preparation of starch TS?
a. To increase the solubility of starch
b. To impart color
c. As a preservative
d. To stabilize the pH
34. Also known as Eosin Y.
a. Dichlorofluorescein
b. Tetrabromophenolpthalein
c. Tetrabromofluorescein
d. Xylenol orange
35. The 0.1 N iodine solution is standardized using
a. Potassium permanganate
b. Potassium hydrogen phthalate
c. Arsenic trioxide
d. Sodium carbonate

36. Iodimetry is an indirect analysis of:

a. Oxidizing agent
b. Reducing agent
c. Acid
d. Base
37. Koettsdorfer number is also known as:
a. Acid value
b. Saponification value
c. Ester value
d. Iodine value
38. To determine the total ash, the sample is incinerated at a temperature of 675 + - 25°C.
This temperature is represented by:
a. Very dull heat
b. Dull red heat
c. White red heat
d. Bright red heat
39. Perchloric acid in glacial acetic acid and perchloric acid in dioxane are volumetric solution
used in what type of analysis?
a. Direct acidimetry
b. Direct alkalimetry
c. Non-aqueous acidimetry
d. Non-aqueous alkalimetry
40. Hydrolysis products of ASA
PHR112: QUALITY CONTROL 1: DRUG TESTING ASSAY

a. Acetic acid + sodium hydroxide

b. Acetic acid + salicylic acid
c. Salicylic acid + sodium hydroxide
d. Sodium salicylate + water
41. To remove stain of KMnO4, the most effective chemical substance is :
a. Oxalic acid
b. Sodium thiosulfate
c. Vinegar
d. Bromine solution
42. The oxidation number of Mn in KMnO4 is:
a. +2
b. +1
c. +5
d. +7
43. The process in which the exact concentration of solution is determined.
a. Neutralization
b. Standardization
c. Titration
d. Complexation

44. Methyl orange in base medium is colored:

a. Yellow
b. Pink
c. Colorless
d. Green
45. Assay of zinc oxide is what type of analysis?
a. Alkalimetric residual
b. Acidimetric direct
c. Acidimetric residual
d. Alkalimetric direct
46. The indicator used if weak acid is titrated with strong alkali.
a. Methyl orange
b. Methyl red
c. Phenol red
d. Phenolphthalein
47. Phenolphthalein in alkali medium is colored:
a. Yellow
b. Pink
c. Colorless
d. Blue
48. This analysis is done by dissolving the substance under examination in an accurately measured
quantity of standard solution known to be in excess and back titrating the excess solution with
another standard solution.
PHR112: QUALITY CONTROL 1: DRUG TESTING ASSAY

a. Gravimetric analysis
b. Acidimetric analysis
c. Direct alkalimetric analysis
d. Residual titration
49. When the alcoholic KOH is used to neutralize the acid and saponify the ester of 1 gram of the
oil or fat, the constant determined is:
a. Acid value
b. Ester value
c. Hydroxyl value
d. Saponification value
50. Analysis in which separation of the constituents from the sample is done and then weighing
the product is:
a. Volumetric analysis
b. Instrumental method of analysis
c. Gravimetric analysis
d. Special method of analysis
51. The end point of iodometry using starch TS as indicator is:
a. Intense blue color
b. Disappearance of blue color
c. Greenish-blue color
d. Disappearance of green-blue color

52. Which of the following standard solutions is not used in redox titration?
a. Sodium thiosulfate solution
b. Iodine solution
c. Bromine solution
d. Sodium hydroxide solution
53. Assay of ASA (raw material) is an example of what method of analysis?
a. Direct alkalimetry
b. Residual alkalimetry
c. Direct acidimetry
d. Residual acidimetry
54. Assay of sodium nitrite is an example of what method of analysis?
a. Direct titration – Redox
b. Indirect titration – Redox
c. Residual titration – Redox
d. Iodimetry
55. Two substances reacting upon reaching the end point must have the same
a. Normality
b. Volume
c. Number of mEq
d. Weight
56. Most of the official drugs containing Calcium and Magnesium are determine by:
PHR112: QUALITY CONTROL 1: DRUG TESTING ASSAY

a. Gravimetric
b. Complexometry
c. Bioassay
d. Non-aqueous matter
57. Type of titration used in volumetric analysis:
a. Direct
b. Residual
c. Indirect
d. AOTA
58. The measurement of a base of a given sample by titration with the standard acid is:
a. Acidimetry
b. Alkalimetry
c. Complexometry
d. Redox
59. Analysis where separation of the constituent from the sample is done that weighing the
products is:
a. Volumetric
b. Gravimetric
c. Special
d. Gasometric method
60. Adsorption indicators are used in:
a. Complexometric reaction
b. Acidimetry
c. Volumetric precipitation
d. Alkalimetry
61. Titer is an expression of concentration in terms of:
a. g of solute per 100 mL
b. g or mg of solute per mL
c. g per liter
d. A and C
62. Iodimetry is what type of titration?
a. Direct
b. Indirect
c. Residual
d. A and C
63. Which is not considered as a primary packaging component?
a. Bottles
b. Vials
c. Caps
d. Packer boxes
64. The chemical factor used in calculation of percent purity of a substance in volumetric analysis:
a. mEq weight
b. Molarity
c. Titer
d. A and C
PHR112: QUALITY CONTROL 1: DRUG TESTING ASSAY

65. The assay procedures in volumetric precipitation were introduced by the following scientist
EXCEPT:
a. Arrhenlus
b. Fajan
c. Mohr
d Volhard
66. The color of phenolphthalein in vinegar.
a. Pink
b. Colorless
c. Yellow
d. Orange
67. The titrant most commonly used for direct compleximetry titration.
a. Zinc sulfate
b. Silver nitrate
c. EDTA
d. HClO4
68. Assay of sodium nitrite is an example of:
a. Neutralization
b. Complexation
c. Precipitation
d. Redox method

69. Based on the stability of raw materials, reassay date assigned to flavoring agent is:
a. 6 months
b. 24 months
c. 12 months
d. 36 months
70. The type of chromatography where the cellulose of the filter paper is used as the adsorbent is:
a. Column
b. Paper
c. TLC
d. Gas
71. Which of the following is an oxidizing agent?
a. Ascorbic acid
b. KMnO4
c. Sodium thiosulfate
d. Sodium nitrite

72. A Soda Lime glass becomes a Treated Soda Lime glass through
a. Dealkilation
b. Oxidation
c. Hydrolysis
d. None of the above
73. Find the acid value of oleic acid sample weighing 2g which require 45mL 0f 0.1102 NaOH to
bring about the end point.
a. 196
PHR112: QUALITY CONTROL 1: DRUG TESTING ASSAY

b. 200
c. 345
d. 139
74. If a sample of white wax is found to have an ester value of 65.7 and a saponification value of
74.2, what is the acid value of the sample?
a. 8.5
b. 86.5
c. 186.5
d. 56.5
75. A 50 mL aliquot of solution containing .450g of magnesium sulfate in 0.5L required 37.6 mL of
EDTA solution for titration. How many mg of calcium carbonate will react with 1 mL of this
EDTA solution? MW magnesium sulfate = 120.37; MW CaCO3 = 100
a. 0.9943 mg
b. 9.99 mg
c. 99.94 mg
d. 9943 mg

76. The following is/are true about auxillary complexing agent.

I. Eriochrome black is an example of an auxillary complexing agent
II. Auxillary complexing agents are also ligands
III. Auxillary complexIng agents binds the metal strong enough to prevent the hydroxide
from precipitating, but weakly enough to give up the metal ion when EDTA is added.
IV. It is used to permit many metals to be titrated in alkaline solution with EDTA.
a. I only
b. II and III
c. II, III, and IV
d. III, and IV
e. I, II, III and IV
77. Which of the statement/s is/are correct?
I. Direct titration of a reducing agent with iodine is called iodometry.
II. In iodimetry, an oxidizing agent is added to excess I - to produce iodine which us then
titrated with sodium thiosulfate.
III. In iodimetry, starch TS can be added at the beginning of the titration.
IV. In iodometry, starch TS can be added at the beginning of the titration.
a. I only
b. II only
c. III only
d. IV only
e. I, II, III, and IV
78. Koppeschaar’s solution is also known as:
a. 0.1 N Iodine solution
b. 0.1 N Bromine solution
PHR112: QUALITY CONTROL 1: DRUG TESTING ASSAY

c. 0.1 M sodium nitrite solution

d. 0.1 N sodium thiosulfate solution
79. Assay of sulfa drugs can be determined by this reaction with sodium nitrite.
a. Neutralization
b. Complexation
c. Precipitation
d. Diazotization
80. 0.1 N Bromine is employed as:
a. Oxidizing agent
b. Reducing agent
c. Masking agent
d. Demasking agent
81. Residual titration method is also known as:
a. Direct titration
b. Indirect titration
c. Back titration
d. Redox titration

82. Microbial assay of an antibiotics maybe performed using the following except:
a. Test tube inoculation
b. Cylinder plate method
c. Paper disk method
d. Titration process

83. The ester value determination of substance is applicable to the following except:
a. Fats
b. Volatile oil
c. Alcohols
d. Fatty oils
84. All of the following are optical devices except:
a. pH meter
b. Spectrophotometer
c. Colorimeter
d. Filter photometer
85. Which of the following is an oxidizing agent?
a. Ascorbic acid
b. KMnO4
c. Sodium thiosulfate
d. Sodium nitrite

86. The water attack test determines the chemical resistance to water of what type of
glass?
PHR112: QUALITY CONTROL 1: DRUG TESTING ASSAY

a. Type I
b. Type II
c. Type III
d. NP
87. The type of glass most suitable for parenteral preparation is
a. Type I
b. Type II
c. Type III
d. NP

. 88. Ability of the formulation to remain within its physical, chemical, therapeutic and toxicological
specifications.
a. Endurance
b. Stability
c. Purity
d. Friability

89. May be defined as the weight of a substance chemically equivalent to 1 ml of the standard
solution.
a. Titrant
b. Equivalent weight
c. Molarity
d. Titer
90. Salt and water are always the products in ___ reaction.
a. Neutralization
b. Precipitation
c. Complexation
d. Redox

. 91. When a weak acid is titrated with strong alkali, the indicator of choice is:
a. Methyl red
b. Phenolphthalein
c. Methyl orange
d. No indicator can be used
92. Standardization can be optional to:
a. 0.1 N oxalic acid
b. 0.1 N ceric sulfate
c. 0.1 N potassium dichromate
d. 0.1 N silver nitrate
93. Metal ion indicator is used in:
a. Precipitimetry
b. Compleximetry
c. Fajan method
d. Ceremetry
94. Used to prevent one element from interfering in the analysis of another element:
PHR112: QUALITY CONTROL 1: DRUG TESTING ASSAY

a. Nitrobenzene
b. Evaporation
c. Masking
d. Buffering
95. Assay of sodium nitrite can be done using:
a. Indirect permanganometry
b. Diazotization
Iodometry
c. All of the above

96. The end point using this indicator is illustrated by the formation of a secondary colored
precipitate in:
a. Potassium chromate
b. Fluorescein
c. Ferric alum
d. Thiosulfate

97. Which of the following is added to maintain the pH of thiosulfate solution in optimum range for
the stability of the solution?
a. Sodium carbonate
b. Thymol
c. Sodium bicarbonate
d. Chloroform

98. If starch TS is used as indicator, end point is illustrated by:

a. Appearance of blue color
b. Either
c. Disappearance of blue color
d. Neither

99. The oxidation number of sulfur in sodium thiosulfate is:

a. 1
b. 3
c. 2
d. 4

100. Drugs containing Ca can be assayed by:

a. Gravimetric method
b. Complexometric method
c. Compleximetry
d. All of the above
PHR112: QUALITY CONTROL 1: DRUG TESTING ASSAY