Doxofyllinee

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DRUG NAME MECHANISM OF INDICATION CONTRAINDICATIONS SIDE EFFECTS/ADVERSE EFFECTS NURSING CONSIDERATION

ACTION
GENERIC The main mechanism Indicated for  acute  CNS: Headache, Before:
of action of the treatment of myocardial
NAME:
infarction
restlessness.  History taking and physical
doxofylline is chronic
Doxofylline
obstructive  low blood  Cardiovascular: Palpitation examination of patients taking
unclear. One of the pressure , tachycardia. bronchodilators or antiasthmatics.
pulmonary
mechanisms of action (hypotension)
Skin: Pallor, local burning
disease   Assess for possible contraindications
of is thought to arise  lactating women
(COPD), patients allergic and stinging. or cautions: any known allergies to
from the inhibition of bronchial

phosphodiesterase
to  GU: Decreased renal prevent hypersensitivity reactions;
asthma and DOXOFYLLINE
activity thus formation. cigarette use which affects the
pulmonary
increasing the levels disease with  Respiratory: Rebound metabolism of the drug; peptic ulcer,
of cAMP and spastic congestion with nasal gastritis, renal or hepatic dysfunction,
promoting smooth bronchial inhalation. and coronary disease, all of which
muscle relaxation.  component.  Misc: Fear, anxiety. could be exacerbated and require
cautious use; and pregnancy and
The interaction of lactation, which are contraindications
doxofylline with because of the potential for adverse
beta-2 adrenoceptors effects on the fetus or nursing baby.
was demonstrated by
a study using
 Perform a physical examination to
nonlinear establish baseline data for assessing
chromatography, the effectiveness of the drug and the
frontal analysis and occurrence of any adverse effects
molecular docking 8. associated with drug therapy.
Serine 169 and serine  Perform a skin examination,
173 residues in the including color and the presence of
receptor are thought lesions, to provide a baseline as a
to be critical binding reference for drug effectiveness.
sites for doxofylline
 Monitor blood pressure, pulse,
where hydrogen
bonds are formed 8. cardiac auscultation, peripheral
Via mediating the perfusion, and baseline
actions of beta-2 electrocardiogram to provide a
adrenoceptors, baseline for effects on
doxofylline induces the cardiovascular system.
blood vessel  Assess bowel sounds and do a
relaxation and airway
liver evaluation and monitor liver and
smooth muscle
relaxation. renal function tests to provide a
baseline for renal and hepatic
function tests.

During:
 Take it with or without food as advised by the
doctor.
 Swallow it as a whole with a glass of water.
 Do not break, crush or chew it.

After:
 Evaluate serum theophylline levels to
provide a baseline reference and
identify conditions that may require
caution in the use of xanthines.
 Evaluate urinary output and
prostate palpation as appropriate to
monitor anticholinergic effects.
 Evaluate orientation, affect, and
reflexes to evaluate CNS effects.

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