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    SEARCH QUERY

    'gut microbiota kidney transplant' OR (('gut'/exp OR gut) AND ('microbiota'/exp OR


    microbiota) AND ('kidney'/exp OR kidney) AND ('transplant'/exp OR transplant))

    RECORD 1
    TITLE
    Clinical Significance of Gastrointestinal Carriage of Klebsiella
    Pneumoniae-Producing Extended-Spectrum Beta-Lactamases in
    Kidney Graft Recipients
    AUTHOR NAMES
    Wilkowski P.; Gajko K.; Marczak M.; Hryniewiecka E.; Wojtowicz M.; Dobrzaniecka
    K.; Mlynarczyk G.; Paczek L.; Ciszek M.
    AUTHOR ADDRESSES
    (Wilkowski P.; Gajko K.; Marczak M.; Hryniewiecka E.; Wojtowicz M.; Paczek L.;
    Ciszek M., [email protected]) Department of Immunology, Transplant Medicine and
    Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
    (Hryniewiecka E.) Department of Clinical Nursing, Medical University of Warsaw,
    Warsaw, Poland.
    (Dobrzaniecka K.; Mlynarczyk G.) Chair and Department of Medical Microbiology,
    Medical University of Warsaw, Warsaw, Poland.
    (Paczek L.) Department of Bioinformatics, Institute of Biochemistry and Biophysics,
    Polish Academy of Sciences, Warsaw, Poland.
    CORRESPONDENCE ADDRESS
    M. Ciszek, Department of Immunology, Transplant Medicine and Internal Diseases,
    Medical University of Warsaw, 59 Nowogrodzka St, Warsaw, Poland. Email:
    [email protected]
    AiP/IP ENTRY DATE
    2018-07-31
    FULL RECORD ENTRY DATE
    2018-11-05
    SOURCE
    Transplantation Proceedings (2018) 50:6 (1874-1877). Date of Publication: 1 Jul 2018
    SOURCE TITLE
    Transplantation Proceedings
    PUBLICATION YEAR
    2018
    VOLUME
    50
    ISSUE

    Record downloaded - Sun 2 05 19:47:56 UTC 2023 Page 1


    6
    FIRST PAGE
    1874
    LAST PAGE
    1877
    DATE OF PUBLICATION
    1 Jul 2018
    PUBLICATION TYPE
    Article
    ISSN
    1873-2623 (electronic)
    0041-1345
    BOOK PUBLISHER
    Elsevier USA
    ABSTRACT
    The burden of Klebsiella pneumoniae (KP) producing extended-spectrum beta-
    lactamases (ESBL+) urinary tract infections (UTIs) is a growing problem after kidney
    transplantation (KTX). The study was aimed at evaluating the incidence of KP ESBL+
    gut colonization in KTX recipients and its correlation with clinical outcomes with special
    regard to UTIs. The study included all KTX patients hospitalized in our department
    between January 2014 and December 2016. During this period 2018 KTX patients were
    admitted: 605 in 2014, 750 in 2015, and 663 in 2016, respectively. Screening for drug-
    multiresistant Enterobacteriaceae gut carriage was performed in 104 patients (2014),
    122 (2015), and 166 (2016). In 2014, 2015, and 2016, 18 (17.3%), 26 (21.3%), and 30
    (18.1%) patients had positive test results, and 44 (42.3%), 36 (29.5%), and 45 (27.4%)
    KTX patients were diagnosed with KP ESBL+ UTI. In 2014, KP ESBL+ UTI was
    diagnosed in 30 (34.9%) cases with negative anal swab and in 14 patients (77.8%) with
    positive test result (P =.0008). In 2015, KP ESBL+ UTI was diagnosed in 21 patients
    (21.9%) with negative anal swab and in 15 (57.7%) with positive test result (P =.0004).
    In 2016, KP ESBL+ UTI was diagnosed in 24 patients (17.8%) with negative anal swab
    and in 21 (72.4%) with positive test result (P =.000001). In conclusion, we have
    revealed a strong association between gut K. pneumoniae colonization, female sex, and
    MPA intake and KP ESBL+ urinary tract infections in kidney transplant recipients. Our
    results indicate the very important role of KP ESBL+ screening, while strategies of
    identified carriers require further research.
    EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
    extended spectrum beta lactamase producing Klebsiella pneumoniae; graft recipient;
    intestine flora; kidney graft
    EMTREE MEDICAL INDEX TERMS
    adult; article; bacterial colonization; clinical outcome; correlational study; female;

    Record downloaded - Sun 2 05 19:47:56 UTC 2023 Page 2


    gender; human; incidence; major clinical study; male; middle aged; multidrug
    resistance; priority journal; trend study; urinary tract infection
    EMBASE CLASSIFICATIONS
    Urology and Nephrology (28)
    Microbiology: Bacteriology, Mycology, Parasitology and Virology (4)
    LANGUAGE OF ARTICLE
    English
    LANGUAGE OF SUMMARY
    English
    EMBASE ACCESSION NUMBER
    20180518609
    MEDLINE PMID
    30056919 (http://www.ncbi.nlm.nih.gov/pubmed/30056919)
    PUI
    L2000979369
    DOI
    10.1016/j.transproceed.2018.03.114
    FULL TEXT LINK
    http://dx.doi.org/10.1016/j.transproceed.2018.03.114
    EMBASE LINK
    https://www.embase.com/search/results?subaction=viewrecord&id=L2000979369&from
    =export
    COPYRIGHT
    Copyright 2018 Elsevier B.V., All rights reserved.

    Record downloaded - Sun 2 05 19:47:56 UTC 2023 Page 3

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