Mcqs Haematology

MCQs Haematology
1 Regarding the reversal of Heparins with Protamine, which is FALSE?
A IV Protamine administration is associated with hypotension and bradycardia
B Protamine is ineffective in the reversal of LMWH
C The dose of Protamine needed decreases with increasing length of time

elapsed since Heparin administration
D Protamine is derived from fish sperm and is contraindicated in fish allergies
Answer
2 All of the following statements regarding haemophilia are true,

EXCEPT:
A In Christmas disease, there is a deficiency of clotting factor IX
B In haemophilia, there is a deficiency of clotting factor proteins which

are essential to the normal intrinsic coagulation pathway
C Both haemophilia A and haemophilia B have an autosomal dominant

inheritance pattern
D A patient with 10% of normal clotting factor VIII level is considered to

suffer a mild form of haemophilia
Answer
3 A 50 year old male presents with Haematemesis. His coagulation studies

show PT of 50 seconds, APTT 80 seconds. This is MOST consistent with
A Liver failure
B Factor VII deficiency
C Haemophilia
D Warfarin toxicity
Answer
4 In a patient with von Willebrand's Disease the MOST appropriate initial
treatment for active bleeding is
A DDAVP
B Factor VII
C Aminohippuric acid
D Vitamin K
Answer
5 All of the following are reactions to blood transfusion EXCEPT:
A haemolysis
B hypothermia
C hypercalcaemia
D increased haemoglobin oxygen affinity
Answer
6 With regards to transfusion medicine, which of the following is FALSE?
A In the context of massive transfusion, a platelet count below 50 warrants

replacement therapy.
B Dextrose is compatible with all blood products.
C The main indication for transfusion is a severe reduction in oxygen carrying

capacity.
D FFP is accepted treatment for TTP.
Answer
Which of the following red cell morphologies would be typically seen
7 following splenectomy?
A Burr cells
B Howell Jolly Bodies
C Target Cells
D Schistocytes
Answer
8 Indications for FFP transfusion include all of the following EXCEPT
A Fibrinogen deficiency
B HUS
C Massive transfusion
D Acute DIC
Answer
9 Which is FALSE with regards the coagulation profile?
A Black snake bite causes an elevated APTT
B Isolated factor VII deficiency gives a normal PT
C High dose heparin affects PT
D DIC causes elevated APTT and PT
Answer
10 Which one of the following statements regarding thrombocytopaenia
is TRUE?
A Clopidogrel is a cause of thrombocytopaenia
B Post-transfusion purpure occurs due to dilution of platelets following

massive transfusion
C In HIV, thrombocytopaenia is mostly the result of bone marrow

suppression
D Phenytoin is associated with immune-mediated thrombocytopaenia
Answer
11 Which process is directly responsible for the formation of D-dimers?
A Primary haemostasis.
B TPA activity on plasminogen.
C Plasmin activity on fibrinogen.
D Plasmin activity on fibrin polymer.
Answer
12 Which of the following activated factors does NOT complex with

Antithrombin 3 in the process of inhibiting haemostasis.
A F2a.
B F3a
C F9a
D F11a.
Answer
13 Concerning blood products:
A The first blood bank was established in Moscow in 1932
B Landsteiner demonstrated the rhesus system in 1900
C In the 1970’s, Massive transfusion was defined as more than 10 units of

blood transfused over 24 hours
D William Harvey discovered in 1728 that blood and not ill humours circulated
the body
Answer
Answers
1. B Dunn et al. Chapter 12: Haematology

2. C Cameron, p. 521 A: Christmas disease = haemophilia B. C: Both
have X-linked inheritance, which is why males are affected (female
carriers may have a mild deficiency) D: Patients with 6-30% of factor
levels experience no spontaneous bleeds, only bleeding after
interventions/trauma) E: Prothrombin time measures primarily factors
II, V, VII and X.
3. A
4. A
5. C
6. B saline is
rd
7. B Dunn 3 edition p 264
8. A Cameron, p495
9. B
10. A Cameron, 3rd ed.: A: table 13.3.1 p 518. Apart from its effect on
platelet function, clopidogrel can cause severe thrombocytopaenia
(see text). B: p.518 – presents about a week after transfusion; due to
platelet-specific allo-antibodies. C: Table 13.3.1: immune-related
(EBV, Rubella and Dengue fever cause marrow suppression) D: Table
13.3.1 Carbamazepine and valproic acid are anticonvulsants that
cause thrombocytopaenia E: Plasma exchange has reduced the
mortality from 90% to less than 20%
11. D
12. B
13. C

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MCQs Haematology

1 Regarding the reversal of Heparins with Protamine, which is FALSE?

A IV Protamine administration is associated with hypotension and bradycardia

B Protamine is ineffective in the reversal of LMWH

C The dose of Protamine needed decreases with increasing length of time

D Protamine is derived from fish sperm and is contraindicated in fish allergies

2 All of the following statements regarding haemophilia are true,

A In Christmas disease, there is a deficiency of clotting factor IX

B In haemophilia, there is a deficiency of clotting factor proteins which

C Both haemophilia A and haemophilia B have an autosomal dominant

D A patient with 10% of normal clotting factor VIII level is considered to

3 A 50 year old male presents with Haematemesis. His coagulation studies

B Factor VII deficiency

5 All of the following are reactions to blood transfusion EXCEPT:

D increased haemoglobin oxygen affinity

6 With regards to transfusion medicine, which of the following is FALSE?

A In the context of massive transfusion, a platelet count below 50 warrants

B Dextrose is compatible with all blood products.

C The main indication for transfusion is a severe reduction in oxygen carrying

D FFP is accepted treatment for TTP.

B Howell Jolly Bodies

8 Indications for FFP transfusion include all of the following EXCEPT

9 Which is FALSE with regards the coagulation profile?

A Black snake bite causes an elevated APTT

B Isolated factor VII deficiency gives a normal PT

C High dose heparin affects PT

D DIC causes elevated APTT and PT

A Clopidogrel is a cause of thrombocytopaenia

B Post-transfusion purpure occurs due to dilution of platelets following

C In HIV, thrombocytopaenia is mostly the result of bone marrow

D Phenytoin is associated with immune-mediated thrombocytopaenia

11 Which process is directly responsible for the formation of D-dimers?

B TPA activity on plasminogen.

C Plasmin activity on fibrinogen.

D Plasmin activity on fibrin polymer.

12 Which of the following activated factors does NOT complex with

A The first blood bank was established in Moscow in 1932

B Landsteiner demonstrated the rhesus system in 1900

C In the 1970’s, Massive transfusion was defined as more than 10 units of

1. B Dunn et al. Chapter 12: Haematology

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