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    Coagulation Tests

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    UWIMANA Jean Claude
    The document discusses various coagulation tests including PT, APTT, reptilase time, echis time, TCT, euglobulin lysis time, bleeding time, factor 13 solubility test, antithrombin 3 assay, protein C & S, APC resistance, procoagulant screen, D-dimer, and FDPs. These tests measure different parts of the coagulation cascade, identify coagulation factor deficiencies, and detect hypercoagulable states.

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    Coagulation Tests

    Uploaded by

    UWIMANA Jean Claude
    19 views1 page
    The document discusses various coagulation tests including PT, APTT, reptilase time, echis time, TCT, euglobulin lysis time, bleeding time, factor 13 solubility test, antithrombin 3 assay, protein C & S, APC resistance, procoagulant screen, D-dimer, and FDPs. These tests measure different parts of the coagulation cascade, identify coagulation factor deficiencies, and detect hypercoagulable states.

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    The document discusses various coagulation tests including PT, APTT, reptilase time, echis time, TCT, euglobulin lysis time, bleeding time, factor 13 solubility test, antithrombin 3 assay, protein C & S, APC resistance, procoagulant screen, D-dimer, and FDPs. These tests measure different parts of the coagulation cascade, identify coagulation factor deficiencies, and detect hypercoagulable states.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    19 views1 page

    Coagulation Tests

    Uploaded by

    UWIMANA Jean Claude
    The document discusses various coagulation tests including PT, APTT, reptilase time, echis time, TCT, euglobulin lysis time, bleeding time, factor 13 solubility test, antithrombin 3 assay, protein C & S, APC resistance, procoagulant screen, D-dimer, and FDPs. These tests measure different parts of the coagulation cascade, identify coagulation factor deficiencies, and detect hypercoagulable states.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    of 1

    - activated partial thromboplastin time

    - PT or APTT after an equal volume of a control specimen (with 50% normal APTT - a test of the intrinsic coagulation pathway
    normal coagulation factors) is added to the patients blood APTT and PT
    - prothrombin time
    - assists with differentiation of causes of an increased TCT - a test of the extrinsic coagulation pathway
    - reptilase is a thrombin-lie molecule that converts fibrinogen
    reptilase
    to fibrin but is not inhibited by antithrombin III or FDPs time PT - the international normalised ratio (INR) is the PT
    expressed as a ratio of the control used by the specific
    laboratory (usually for monitoring of warfarin therapy)
    - differentiates liver dysfunction for vitamin K deficiency
    - Echis carinatum venom converts pre-prothrombin to prothrombin echis - thrombin clotting time
    - in vitamin K deficiency the venom corrects the PT where in liver time
    dysfunction the PT remains unchanged
    TCT - tests the final common pathway of the coagulation cascade
    which converts fibrinogen to fibrin

    - a shortened time indicates the presence euglobulin coagulation - most often used to detect the presence of qualitative
    of systemic fibrinolytic pathway activators lysis time platelet dysfunction and capillary defects
    tests - ristocetin-induced platelet aggregation is another
    bleeding useful test of qualitative platelet function
    urea time - the Hess test is a clinical test where a tourniquet is
    - factor 13 stabilises fibrin applied to the patient's arm and petechiae are noted to
    - if it is deficient 5M urea will dissolve it solubility
    arise under and distal to the cuff in conditions causing
    test a prolonged bleeding time

    (i) antithrombin 3 assay


    - specific for fibrin breakdown
    (ii) protein C & protein S
    (iii) argon plasma coagulation (APC) resistance D-dimer - increased in postoperative states, trauma, sepsis, venous
    - factor V (Leiden) gene mutation
    procoagulant thrombosis & malignancies
    (iv) lupus anticoagulant & anticardiolipin antibodies screen
    (v) G20210A prothrombin gene mutation - fibrin degradation products
    (vi) fasting homocystein assay FDPs - markers of fibrin & fibrinogen breakdown

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