Tosoh Automated

Glycohemoglobin Analyzer

Variant Analysis Mode  

 ● First results become available after start-up in 2.0 min
● Analysis time is only 1.0 min/sample
● Throughput is 60 samples/hr *1

● Easy to exchange the column & filter

● Guide screen to support operator’s handling
片観音 断ち

● Handy barcode scanner (Option)

● Flag function
● User account management
● Reagent & Maintenance management
　

● Good reproducibility below 1.0 % CV

● NGSP certification / IFCC certification

● Sample Loaders (90SL or 290SL)

HLC−723G11 90SL
Up to 9 sample racks
(90 Samples) at a time
HLC−723G11 290SL
Up to 29 sample racks
(290 Samples) at a time

Two types of sample

loaders to choose
Fast but precise and accurate HbA1c
measurement by HPLC method

Contributing to prevention of
complications by monitoring and control of diabetes

Variant Analysis Mode

High speed 1.0 min/sample & First report 2.0 min *1

START REPORT
Pre-action Measurement

G8 1.9 min 1.6 min 3.5 min

G11 1.0 min 1.0 min 2.0 min

0 1.0 2.0 3.0 4.0 min
Elapsed time
Simplified Handy Barcode Scanner *2
replacement of filter Reading barcode ID for STAT measurement,
element Calibration value, Reagent lot No. and expiration date
Filter element can be easily can be input by handy barcode scanner.
replaced by newly-applied
filter handle.

Replacement of the
printer paper
Replacement of the printer
paper is easily done in
one-step. Management of
Reagent Information
Guide Screen REAGENT INFO screen
“Column Replacement”, “Elution Buffer Replacement”, displays lot number, start
“Filter Replacement”, “Printer Paper Replacement”, date being used and
“Drain Valve Open/Close” can be checked on Guide. expiration date of the
(Example) Column Replacement
elution buffers/column.

Management of
User Account
You can input user name.
User name is also printed
on the results.

STAT Assay Detection of abnormal

Blood tube or sample cup is automatically recognized chromatogram by Flag
on STAT port. setting
●Dilution ratio can be selected Supporting the judgment of the
from DEFAULT (by 201 times),
result by Flag setting.
DECREASE (by 401 times) or
●Effective for detecting abnormal Hb.
INCREASE (by 101 times), for
small quantity sample or low
Hb sample.

*1) The time lapse after sampling and before printing the results. *2) Handy Barcode Scanner is an option (0022944) *3) NGSP (National Glycohemoglobin Standardization Progr
 Performance Data
■ Sample Chromatogram

Best-in-class measurement precision

HPLC method is the gold standard for HbA1c
measurement. G11 acquires good within-run
reproducibility and between-run reproducibility.
Within-run reproducibility (n=10) s-A1c (%)
Sample Mean(%) SD(%) CV(%)

片観音 断ち
Low level sample 4.99 0.03 0.63
High level sample 9.80 0.00 0.00

Between-run reproducibility (n=10) s-A1c (%)

Sample Mean(%) SD(%) CV(%) HbF

Low level sample 4.90 0.05 0.96 HbA1c

High level sample 9.83 0.05 0.49
In house data
HbAo

NGSP and IFCC certifications

　
■ Correlation (vs. G8)
HLC-723 series have been and are NGSP*3
Variant Analysis Mode
and IFCC*4 certified. 25
s-A1c (%)
y = 0.9791x + 0.1590
R 2 = 0.9996
n = 129
20
HLC-723G11

15

10

0
0 5 10 15 20 25
HLC-723G8
In house data

■ Effects of Coexisting Substances

No interference from coexisting substances
up to the concentrations below.
Glucose ∼ 1000 mg/dL
Sodium cyanate (Kidney disorder) ∼ 25 mg/dL
Acetaldehyde (alcohol drinking) ∼ 25 mg/dL
Acetylsalicylic acid (Aspirin) ∼ 50 mg/dL
Free bilirubin ∼ 20 mg/dL
Conjugated bilirubin ∼ 20 mg/dL
Triglyceride ∼ 500 mg/dL
Ascorbic acid ∼ 250 mg/dL

ram *4) IFCC (International Federation of Clinical Chemistry and Laboratory Medicine)
SPECIFICATIONS PART NUMBERS / DESCRIPTION
Analytes HbA1c (s-A1c), HbF 0023850 HLC-723G11 (Main Unit)

Applicable samples Whole blood and diluted samples 0023851 HLC-723G11LA (Main Unit) *

Assay principle Ion exchange high performance liquid chromatography 0023852 G11-90SL (90 Sample Loader)

Detection method 2-wavelength absorbance (detection wavelength: 415 nm) 0023853 G11-290SL (290 Sample Loader)

Processing throughput 1.0 min/sample * Possible to connect with Laboratory Automation Belt line
Variant Analysis Mode
Main unit
Column connection Finger-tight-type 0023478 TSKgel G11 Variant (Analysis Column)

Sampling volume 3 µL for whole blood and 150 µL for diluted samples 0023479 G11 Variant Elution Buffer No. 1 (S)
Sample aspiration by Nozzle 0028480 G11 Variant Elution Buffer No. 2 (S)
0028481 G11 Variant Elution Buffer No. 3 (S)
Pump unit Single plunger pump
0018431 HSi Hemolysis & Wash Solution (L)
System control / Data processing
0019550 HSi Hemolysis & Wash Solution (LL)
Display 320 × 240 dot matrix color LCD
0018767 Hemoglobin A1c Calibrator Set
Input Pressure-sensitive touch panel / operation keys
0021974 Hemoglobin A1c Control Set
Output Thermal printer
Storage USB stick Analysis Column Elution Buffers and
Hemolysis & Wash Solutions
Data processing unit RS-232C serial communication port (bi-directional)
Data storage by internal memory (for up to 800 samples)
Recalculation (reprinting) of achieved result
Automatic startup by timer
Error flag function for abnormal results
Calibration 2-point calibration by calibrators
Data extraction Extract by date or sample type (max 800 samples)
Control for quality control Distinguished by barcode ID (max 4 controls) Hemoglobin A1c Calibrator Set Hemoglobin A1c Control Set

Sampling unit
Sample loading capacity 90 samples or 290 samples
Sample rack 10 primary tubes or cups per rack
Sample dilution Dilution by Hemolysis & Wash Solution in the dilution port
Sample tubes or cups 12 - 15 mm diameter × 75 - 100 mm primary tubes / Sample cups
Sample ID recognition Barcode with maximum of 20 digits
Barcode specifications NW-7 (Codabar), CODE39, ITF and CODE128 (initial setting), or JAN
OPTIONS
(UPC/EAN), Industrial 2 of 5 and COOP 2 of 5 (requires setting change)
0022944 Handy Barcode scanner
Temperature 15 - 30 °C
0023294 Base for Handy Barcode scanner
Power requirement AC100 - 240 V, 50 / 60 Hz, 200 VA

Dimensions / weight 90SL model : 530 (W) × 515 (D) × 482 (H) mm / 37 kg

290SL model : 1120 (W) × 530 (D) × 482 (H) mm / 54 kg

* “HLC-723” and “TSKgel” are the registered trademarks of Tosoh
Corporation in Japan, etc.
“G11” is the registered trademark of Tosoh Corporation in Japan.
* Specifications and design may be changed without prior notice.

TOSOH CORPORATION
Bioscience Division
3-8-2 Shiba, Minato-ku, Tokyo 105-8623, Japan
Phone : +81 3 5427 5181
Fax : +81 3 5427 5220

This brochure may not be reprinted or copied in whole or

in part without written consent from Tosoh Corporation.
Copyright 2016 by Tosoh Corporation

Printed in Japan 3701GX- Cat.No.0992351 A