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Safety Data Sheet

acc. to OSHA HCS
Printing date 04/09/2020 Revision date 04/09/2020

1 Identification
· Product identifier
· Trade name: Cephalexin
· Synonym
(6R,7R)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-
carboxylic acid
· Article number: 9002009, 012586
· CAS Number:
15686-71-2
· EC number:
239-773-6
· Application of the substance / the mixture For research use only - not for human or veterinary use.
· Details of the supplier of the safety data sheet
· Manufacturer/Supplier:
Cayman Chemical Co.
1180 E. Ellsworth Rd.
Ann Arbor, MI 48108
USA
· Information department: Product safety department
· Emergency telephone number:
During normal opening times: +1 (734) 971-3335
US/CANADA: 800-424-9300
Outside US/CANADA: 703-741-5970

* 2 Hazard(s) identification
· Classification of the substance or mixture

~
d GHS08 Health hazard

Resp. Sens. 1 H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled.

~
d GHS07

Skin Sens. 1 H317 May cause an allergic skin reaction.

· Label elements
· GHS label elements
The substance is classified and labeled according to the Globally Harmonized System (GHS).
· Hazard pictograms

~
d
GHS08

· Signal word Danger

(Contd. on page 2)
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· Hazard-determining components of labeling:

Cephalexin
· Hazard statements
May cause allergy or asthma symptoms or breathing difficulties if inhaled.
May cause an allergic skin reaction.
· Precautionary statements
Avoid breathing dust/fume/gas/mist/vapors/spray
Contaminated work clothing must not be allowed out of the workplace.
Wear protective gloves.
[In case of inadequate ventilation] wear respiratory protection.
If on skin: Wash with plenty of water.
If inhaled: If breathing is difficult, remove person to fresh air and keep comfortable for breathing.
If skin irritation or rash occurs: Get medical advice/attention.
Specific treatment (see on this label).
If experiencing respiratory symptoms: Call a poison center/doctor.
Wash contaminated clothing before reuse.
Dispose of contents/container in accordance with local/regional/national/international regulations.
· Classification system:
· NFPA ratings (scale 0 - 4)

Health = 1
0 Fire = 0
1 0 Reactivity = 0

· HMIS-ratings (scale 0 - 4)
HEALTH *1 Health = *1
FIRE 0 Fire = 0
REACTIVITY 0 Reactivity = 0

· Other hazards
· Results of PBT and vPvB assessment
· PBT: Not applicable.
· vPvB: Not applicable.

3 Composition/information on ingredients
· Chemical characterization: Substances
· CAS No. Description
15686-71-2 Cephalexin
· Identification number(s)
· EC number: 239-773-6

* 4 First-aid measures
· Description of first aid measures
· After inhalation:
Supply fresh air and to be sure call for a doctor.
In case of unconsciousness place patient stably in side position for transportation.
· After skin contact: Immediately wash with water and soap and rinse thoroughly.
· After eye contact: Rinse opened eye for several minutes under running water.
· After swallowing: If symptoms persist consult doctor.
(Contd. on page 3)
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· Information for doctor:
· Most important symptoms and effects, both acute and delayed
May cause anemia, cough, CNS depression, drowsiness, headache, heart damage, lassitude
(weakness, exhaustion), liver damage, narcosis, reproductive effects, teratogenic effects.
No further relevant information available.
· Indication of any immediate medical attention and special treatment needed
No further relevant information available.

5 Fire-fighting measures
· Extinguishing media
· Suitable extinguishing agents:
Use fire fighting measures that suit the environment.
A solid water stream may be inefficient.
· Special hazards arising from the substance or mixture No further relevant information available.
· Advice for firefighters
· Protective equipment: No special measures required.

6 Accidental release measures

· Personal precautions, protective equipment and emergency procedures Not required.
· Environmental precautions: Do not allow to enter sewers/ surface or ground water.
· Methods and material for containment and cleaning up:
Dispose contaminated material as waste according to item 13.
Ensure adequate ventilation.
· Reference to other sections
See Section 7 for information on safe handling.
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.
· Protective Action Criteria for Chemicals
· PAC-1:
Substance is not listed.
· PAC-2:
Substance is not listed.
· PAC-3:
Substance is not listed.

7 Handling and storage

· Handling:
· Precautions for safe handling Ensure good ventilation/exhaustion at the workplace.
· Information about protection against explosions and fires: No special measures required.
· Conditions for safe storage, including any incompatibilities
Keep container tightly closed.
Store in accordance with information listed on the product insert.
· Storage:
· Requirements to be met by storerooms and receptacles: No special requirements.
· Information about storage in one common storage facility: Not required.
· Further information about storage conditions: None.
(Contd. on page 4)
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· Specific end use(s) No further relevant information available.

8 Exposure controls/personal protection

· Additional information about design of technical systems: No further data; see item 7.
· Control parameters
· Components with limit values that require monitoring at the workplace:
The following constituent is the only constituent of the product which has a PEL, TLV or other
recommended exposure limit.
The following constituents are the only constituents of the product which have a PEL, TLV or other
recommended exposure limit.
At this time, the remaining constituent has no known exposure limits.
At this time, the other constituents have no known exposure limits.
· Additional information: The lists that were valid during the creation were used as basis.
· Exposure controls
· Personal protective equipment:
· General protective and hygienic measures:
Keep away from foodstuffs, beverages and feed.
Immediately remove all soiled and contaminated clothing.
Wash hands before breaks and at the end of work.
· Breathing equipment:
In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer
exposure use respiratory protective device that is independent of circulating air.
· Protection of hands:

S
_ Protective gloves

The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.
Due to missing tests no recommendation to the glove material can be given for the product/ the
preparation/ the chemical mixture.
Selection of the glove material on consideration of the penetration times, rates of diffusion and the
degradation
· Material of gloves
The selection of the suitable gloves does not only depend on the material, but also on further marks of
quality and varies from manufacturer to manufacturer.
· Penetration time of glove material
The exact break through time has to be found out by the manufacturer of the protective gloves and has
to be observed.
· Eye protection: Not required.

* 9 Physical and chemical properties

· Information on basic physical and chemical properties
· General Information
· Appearance:
Form: Crystalline
Color: Not determined.
· Odor: Characteristic
· Structural Formula C16H17N3O4S
(Contd. on page 5)
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· Molecular Weight 347.4

· Odor threshold: Not determined.
· pH-value: Not applicable.
· Change in condition
Melting point/Melting range: Undetermined.
Boiling point/Boiling range: Undetermined.
· Flash point: Not applicable.
· Flammability (solid, gaseous): Product is not flammable.
· Decomposition temperature: Not determined.
· Auto igniting: Not determined.
· Danger of explosion: Product does not present an explosion hazard.
· Explosion limits:
Lower: Not determined.
Upper: Not determined.
· Vapor pressure: Not applicable.
· Density: Not determined.
· Relative density Not determined.
· Vapor density Not applicable.
· Evaporation rate Not applicable.
· Solubility in / Miscibility with
Water: Soluble.
· Partition coefficient (n-octanol/water): Not determined.
· Viscosity:
Dynamic: Not applicable.
Kinematic: Not applicable.
SOLUBILITY ~2 mg/ml in PBS (pH 7.2); ~25 mg/ml in 1M ammonium
hydroxide
VOC content: 0.00 %
Solids content: 100.0 %
· Other information No further relevant information available.

* 10 Stability and reactivity

· Reactivity No further relevant information available.
· Chemical stability
· Thermal decomposition / conditions to be avoided:
No decomposition if used according to specifications.
· Possibility of hazardous reactions No dangerous reactions known.
· Conditions to avoid No further relevant information available.
· Incompatible materials: strong oxidizing agents
· Hazardous decomposition products: carbon oxides, nitrogen oxides; sulfur oxides
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11 Toxicological information
· Information on toxicological effects
· Acute toxicity:
· LD/LC50 values that are relevant for classification:
ATE (Acute Toxicity Estimate)
Oral LD50 1,495 mg/kg (mouse)
15686-71-2 Cephalexin
Oral TDLO 14 ml/kg (hmn)
LD50 1,495 mg/kg (mouse)
>20,000 mg/kg (rat)
Intraperitoneal LD50 400 mg/kg (mouse)
4,000 mg/kg (rat)
Subcutaneous LD50 1,150 (mouse)
6,100 mg/kg (rat)
· Primary irritant effect:
· on the skin: No irritant effect.
· on the eye: No irritating effect.
· Sensitization:
Sensitization possible through inhalation.
Sensitization possible through skin contact.
· Additional toxicological information:
· Carcinogenic categories
· IARC (International Agency for Research on Cancer)
Substance is not listed.
· NTP (National Toxicology Program)
Substance is not listed.
· OSHA-Ca (Occupational Safety & Health Administration)
Substance is not listed.

12 Ecological information
· Toxicity
· Aquatic toxicity: No further relevant information available.
· Persistence and degradability No further relevant information available.
· Behavior in environmental systems:
· Bioaccumulative potential No further relevant information available.
· Mobility in soil No further relevant information available.
· Additional ecological information:
· General notes:
Water hazard class 1 (Self-assessment): slightly hazardous for water
Do not allow undiluted product or large quantities of it to reach ground water, water course or sewage
system.
· Results of PBT and vPvB assessment
· PBT: Not applicable.
· vPvB: Not applicable.
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· Other adverse effects No further relevant information available.

13 Disposal considerations
· Waste treatment methods
· Recommendation:
Must not be disposed of together with household garbage. Do not allow product to reach sewage
system.
· Uncleaned packagings:
· Recommendation: Disposal must be made according to official regulations.
· Recommended cleansing agent: Water, if necessary with cleansing agents.

* 14 Transport information
· UN-Number
· DOT, IMDG, IATA not regulated
· UN proper shipping name
· DOT, IMDG, IATA not regulated
· Transport hazard class(es)
· DOT, ADN, IMDG, IATA
· Class not regulated
· Packing group
· DOT, IMDG, IATA not regulated
· Environmental hazards: Not applicable.
· Special precautions for user Not applicable.
· Transport in bulk according to Annex II of
MARPOL73/78 and the IBC Code Not applicable.

* 15 Regulatory information
· Safety, health and environmental regulations/legislation specific for the substance or mixture
· Sara
· Section 355 (extremely hazardous substances):
Substance is not listed.
· Section 313 (Specific toxic chemical listings):
Substance is not listed.
· TSCA (Toxic Substances Control Act):
Substance is not listed.
· Hazardous Air Pollutants
Substance is not listed.
· Proposition 65
· Chemicals known to cause cancer:
Substance is not listed.
(Contd. on page 8)
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· Chemicals known to cause reproductive toxicity for females:
Substance is not listed.
· Chemicals known to cause reproductive toxicity for males:
Substance is not listed.
· Chemicals known to cause developmental toxicity:
Substance is not listed.
· Carcinogenic categories
· EPA (Environmental Protection Agency)
Substance is not listed.
· TLV (Threshold Limit Value established by ACGIH)
Substance is not listed.
· NIOSH-Ca (National Institute for Occupational Safety and Health)
Substance is not listed.
· GHS label elements
The substance is classified and labeled according to the Globally Harmonized System (GHS).
· Hazard pictograms

~
d
GHS08

· Signal word Danger

· Hazard-determining components of labeling:
Cephalexin
· Hazard statements
May cause allergy or asthma symptoms or breathing difficulties if inhaled.
May cause an allergic skin reaction.
· Precautionary statements
Avoid breathing dust/fume/gas/mist/vapors/spray
Contaminated work clothing must not be allowed out of the workplace.
Wear protective gloves.
[In case of inadequate ventilation] wear respiratory protection.
If on skin: Wash with plenty of water.
If inhaled: If breathing is difficult, remove person to fresh air and keep comfortable for breathing.
If skin irritation or rash occurs: Get medical advice/attention.
Specific treatment (see on this label).
If experiencing respiratory symptoms: Call a poison center/doctor.
Wash contaminated clothing before reuse.
Dispose of contents/container in accordance with local/regional/national/international regulations.
· Chemical safety assessment: A Chemical Safety Assessment has not been carried out.

16 Other information
This information is based on our present knowledge. However, this shall not constitute a guarantee for
any specific product features and shall not establish a legally valid contractual relationship.
· Department issuing SDS: Environment protection department.
· Contact: -
· Date of preparation / last revision 04/09/2020 / -
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· Abbreviations and acronyms:
IMDG: International Maritime Code for Dangerous Goods
DOT: US Department of Transportation
IATA: International Air Transport Association
ACGIH: American Conference of Governmental Industrial Hygienists
EINECS: European Inventory of Existing Commercial Chemical Substances
CAS: Chemical Abstracts Service (division of the American Chemical Society)
NFPA: National Fire Protection Association (USA)
HMIS: Hazardous Materials Identification System (USA)
VOC: Volatile Organic Compounds (USA, EU)
LC50: Lethal concentration, 50 percent
LD50: Lethal dose, 50 percent
PBT: Persistent, Bioaccumulative and Toxic
vPvB: very Persistent and very Bioaccumulative
NIOSH: National Institute for Occupational Safety
OSHA: Occupational Safety & Health
TLV: Threshold Limit Value
PEL: Permissible Exposure Limit
REL: Recommended Exposure Limit
Resp. Sens. 1: Respiratory sensitisation – Category 1
Skin Sens. 1: Skin sensitisation – Category 1
· * Data compared to the previous version altered.
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