An Ayurvedic Protocol To Manage Retinitis Pigmentosa - A Case Report
An Ayurvedic Protocol To Manage Retinitis Pigmentosa - A Case Report
An Ayurvedic Protocol To Manage Retinitis Pigmentosa - A Case Report
DOI: http://dx.doi.org/10.31782/IJCRR.2020.12135
ABSTRACT
Introduction: Retinitis pigmentosa (RP) is a clinically and genetically heterogeneous group of inherited retinal disorders that
almost invariably occur in both eyes and often result in blindness in the middle-age and advanced age groups. According to
Ayurveda, the cardinal symptoms of night blindness and diminished vision seen in RP may be correlated with Kapha-Vidagdha
Drishti, a Drishtigata Roga or disease of vision.
Case: A 38-year-old male presenting with blurring of vision since 2017 and diminished night vision since childhood is presented
here.
Intervention: The patient underwent two courses of in-patient Ayurvedic management consisting of Panchakarma (bio-purifica-
tion) therapy, oral medicines, and external therapies for the eyes and head.
Results: Assessment showed improvement in both unaided distant visual acuity (DVA) and visual field analysis.
Conclusion: The main aim of management was to preserve and give a better quality of vision for the patient. The results indicate
the potential of Ayurvedic treatments to manage and maintain vision in retinitis pigmentosa.
Key Words: Case report, Retinitis pigmentosa, Kriyakalpa, Panchakarma therapy
INTRODUCTION METHODOLOGY
Retinitis pigmentosa is a genetically pre-determined retinal The efficacy of an Ayurvedic treatment protocol to manage
dystrophy characterized by progressive degeneration of rod a case of RP was assessed in this report. It was prepared ac-
photoreceptors, cone photoreceptors, and retinal pigment cording to the Case Report (CARE) guidelines to ensure
epithelium in that order. Inflammation, implied by the term transparency and effectiveness in reporting4. Although in-
is not a part of its pathophysiology. The prevalence of RP stitutional ethical clearance was not required for this study,
amounts to one case in every 4000 persons.1 A search on written informed consent was obtained from the patient be-
RP in PubMed amounted to 7000 references and was char- fore detailing his case.
acterized by desirability for both experimental and clinical
research.2 Occurrence may be either isolated or either au-
tosomal dominant, autosomal recessive, or X-linked by in- CASE PRESENTATION
heritance. Apart from genetic predisposition, there are no
other known risk factors.3 RP’s primary symptom is night A 38-year-old non-diabetic and non-hypertensive male pre-
blindness, with advanced cases presenting with a ring-like sented to the OPD of Sreedhareeyam Ayurvedic Eye Hospi-
scotoma in the visual field that gradually progresses to “tun- tal and Research Center, with blurring of vision since 2017
nel” vision. As there is no definite cure for RP in allopathic and difficulty in night vision since childhood. He was born to
medicine, alternative management options may be explored. non-consanguineous parents and his mother had a full-term,
normal delivery (FTND) with no postpartum complications.
Corresponding Author:
Dr. Aravind Kumar, M.S. (Ay), Sreedhareeyam Ayurvedic Research and Development Institute Nelliakkattu Mana, Kizhakombu Koothat-
tukulam, Ernakulam Dt., Kerala, 686662; Phone:9400630608; Email: [email protected]
ISSN: 2231-2196 (Print) ISSN: 0975-5241 (Online)
Received: 02.05.2020 Revised: 05.06.2020 Accepted: 18.06.2020 Published: 05.07.2020
He started to gradually develop difficulty in night vision cation through the nasal route), Anjana, Sirodhara (thera-
around the age of 3, for which he was prescribed vitamin peutic streaming over the head), Ascyotana (eye drops),
A tablets. He developed pain in distant vision around the Siro-veshtanam (application of paste over the head on a
age of 7, for which he was diagnosed with myopia and pre- Cora cloth), Bandhana (bandaging), Mukha Dhanya Pinda
scribed corrective spectacles. The glass power progressively Sveda (facial sudation by applying poultice made from sour
increased over time, for which he was prescribed cylindri- grains), Drishti Prasadana (massage over the eyelids using
cal lenses in 2014. In 2018, he was diagnosed with retinitis ghee), and Netra Tarpana (lubrication of the eye) (Table 4)
pigmentosa after a complete ophthalmic and genetic exami- were prescribed during the two courses of treatment.
nation. He was advised to protect his eyes from ultraviolet
During Snehapana, the patient was advised to observe strict
radiation, avoid smoking, and take plenty of fruits, vegeta-
rest and abstain from consuming oily and fried foods. A total
bles, and foods rich in omega-3 fatty acids. Genetic coun-
of 5 Vegas (urges) were noted between 6:30am and 11:30am
seling was also recommended. He had his first consultation
during Virecana, after which, Peya (thin gruel of rice) was
at Sreedhareeyam Eye Hospital in September 2018.
administered as Samsarjana Krama (post-therapy dietetic
His sister also suffered from night blindness. His bowel, ap- regimen for revival).
petite, and micturition were normal and his sleep was sound.
All medicines, except Septillin tablet, were manufactured
He occasionally consumes alcohol. Review of systems and
at Sreedhareeyam Farmherbs India, Pvt. Ltd., the hospital’s
vital signs were normal. He weighed 90kg and was 172cm
GMP-certified drug manufacturing unit. Septillin Tablet was
tall. His Dasavidha Pariksha (ten parameters of examina-
manufactured by The Himalaya Company, based in Bengal-
tion)5 findings are listed in Table 1.
uru, Karnataka, India.
Unaided distant visual acuity (DVA) was LogMAR 0.602 in
both eyes (OU). Aided DVA was LogMAR 0.477 in the right
eye (OD) and LogMAR 0.301 in the left eye (OS), which RESULT
was improvable to LogMAR 0.301 OU with a cylindrical
lens of 1 diopter OD and 1.25 diopter OS. Near vision was DVA was LogMAR 0.477 OU, which was improvable to
N6 OU. Anterior segment examination was normal OU. Di- LogMAR 0.176 OU with cylindrical lenses of -1.25D OD
rect and consensual pupillary reflexes were normal OU. and -0.5D OS after the first course of treatment on October
15th, 2018. NVA was maintained at N6 OU. The same visual
Posterior segment examination by direct ophthalmoscopy acuity was maintained at admission to, and at discharge af-
showed a slightly cloudy foveal reflex OU, pale optic disc ter, the second course of treatment. Refraction at discharge
OU, normal macula OU, and some bony corpuscles in the after the second course of treatment demonstrated LogMAR
peripheral retina OU. Visual field analysis OU showed 0 OU with cylinder lenses of -1.25D OD and -0.5D OS.
marked constriction in the peripheral visual fields (Figures Fundus examination by ophthalmoscopy showed no further
1 and 2). The findings were suggestive of RP. progression in the attenuated blood vessels and bony corpus-
The intervention adopted reflected the treatment for Timira cles. Visual field analysis showed markedly wider peripheral
and Kacha according to Vagbhata, viz., administrations of visual fields OU (Figures 3 and 4).
Snehana (therapeutic oleation), Asra-visravana (blood-let- A timeline of events for this case is provided in Table 5.
ting), Reka (purgation), Nasya (medication through the na-
sal route), Anjana(collyrium), Murdha-basti (retention of oil
over the head region), Basti Kriya (therapeutic enema), Tar- DISCUSSION
pana (lubrication of the eye), Lepa (anointment), and Seka
(ocular therapy by streaming).6 Ayurveda explains that genetic diseases, which are a result
of abnormalities in the Bija (sperm or ovum) brought about
The patient’s first round of treatment was from 25/09/2018
by improper activities of the parents and divine providence,
- 15/10/2018, and his second round of treatment was from
increase all the Doshas and the resultant condition, as well
12/08/2019 - 22/08/2019. Oral medicines such as Kvatha
as all hereditary conditions, is Asadhya (incurable).12 Heredi-
(decoction), Ghrta (clarified butter), and tablets (Table 2);
tary defects in an organ happen when it is vitiated due to the
Panchakarma therapies such as Snehapana (therapeutic
part of the Bija responsible for the formation of that organ
oleation), Svedana (sudation therapy), Virecana (therapeutic
becoming vitiated itself.13 In this patient, a genetic defect
purgation), and Marsa Nasya (high dose medication through
resulting in retinitis pigmentosa occurred despite a normal
the nose) (Table 3); and external therapies for the eye (Netra
pregnancy and delivery course.
Kriyakalpa) and head such as Netradhara (ocular therapy
by streaming), Hasta Pada Abhyanga (therapeutic massage Kapha Vidagdha Drishti occurs when the person perceives
over the hands and feet), Pratimarsa Nasya (low-dose medi- objects as white due to the Doshas lodging in the first and
second Patalas (layers of the eyeball). When the Doshas ad- maintain vision and prolonging further progression of the
vance to the 3rd Patala, the person sees during the day and not disease. The results obtained in this case may be validated
at night because of Kapha Dosha.14 and analyzed by large-scale studies and trials.
Snehapana was done as a Samana Cikitsa (pacifying treat-
ment) for this patient, with 30mL of ghee administered each Abbreviations:
day so as to not increase Kapha further. Avipattikara Yoga RP: retinitis pigmentosa
was selected for Virecana as it is apt for all Pitta (Dosha DVA: distant visual acuity
responsible for regulating body temperature and metabolic NVA: near visual acuity
activities) conditions. The ingredients of Jivantyadi Taila OD: oculus dexter
pacified Vata and Pitta. Saptamrta Lauha is Tridosha Prasa-
mana (pacifies the Tridosha), Rakta Prasadana (enhancing OS: oculus sinister
the quality of blood tissue), Rasayana (rejuvenative), and OU: oculus uterque
Cakshushya (Dravya or intervention good for eyesight).
Asvagandha is Kapha-Vata Samana (pacifies Kapha and
Vata), Balya (strength, stamina, and immunity promoter), ACKNOWLEDGMENT
Rakta Prasadana, and Rasayana. These medicines enhanced
The authors thank Sreedhareeyam Ayurvedic Eye Hospital
blood quality, relieved Tridosha, and prolonged the retinal
and Research Center, and Sreedhareeyam Farmherbs India
dystrophy by revitalizing the tissue. Bharngyadi Kvatha is
Pvt. Ltd., for their help in preparing this case report. The
Vata-Kapha Samana, Dipana, and Srotosodhana (cleansing
authors acknowledge the immense help received from the
the structural or functional channels). Dasamula Katutraya
scholars whose articles are cited and included in references
Kvatha is Vata-Kapha Samana, Dipana, and Lekhana (thera-
of this manuscript. The authors are also grateful to the au-
peutic scraping). Sudarsanam Tablet, the tablet form of the
thors/editors/publishers of all those articles, journals, and
original Curna, is Tridosa Prasamana, Amapacana (enhanc-
books from where the literature for this article has been re-
ing digestion). The combined effect of these three medicines
viewed and discussed.
helped to enhance digestion, reduce Doshas, and make avail-
able essential nutrients by clearing the channels. Local exter- Conflicts of Interest: None declared
nal treatments enabled efficient absorption and transport of
Sources of Funding: None declared
the medicines to the target tissue, the retina, by obviating the
blood-aqueous, blood-vitreous, and blood-retinal barriers.
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Table 5: (Continued)
Date Event
August 19th, 2019 Drishti Prasadana is stopped.
August 20 , 2019
th
Ascyotana with Ananta Ghrta* and Jatavedha Ghrta* is done, with Bandhana for 1 hour with jasmine
flowers.
Tarpana with Ananta Ghrta* and Jatavedha Ghrta* is started.
August 26th, 2019 All treatments and oral medicines are stopped.
Unaided DVA: 6/18 Snellen (LogMAR 0.477) OU
Aided DVA: LogMAR 0.176 OU
Refraction: LogMAR 0 OU with cylinder lenses of -1.25D OD and -0.5D OS.
NVA: N6 OU
Visual Fields: Widened peripheral fields OU