Acute Childhood Malnutrition: Taking Science Where It Is Needed

Acute childhood malnutrition:
Taking science where it is needed
Dr Tahmeed Ahmed
Senior Director
Nutrition & Clinical Services Division
icddr,b
Professor, Public Health Nutrition

James P. Grant School of Public Health
BRAC University
Outline
• Status of complementary feeding and acute

malnutrition in Bangladesh
• The work we have done to improve diets for
preventing and treating acute malnutrition
• Our ongoing work
Stunting, wasting, underweight still major
childhood problems in Bangladesh
Stunting Underweight
36% Severe wasting 33%
3%
Trends in Nutritional Status of Under-five Children
in Bangladesh, 2004-2014
Trends in Nutritional Status of Under-five Children
in Bangladesh, 2004-2014
• Substantial reduction in stunting and

underweight over the last one decade
• But little improvement in wasting
MDD: fed at least 4 out of 7 food groups
MAD: given milk or milk products, foods from the recommended

food groups, fed at least the recommended minimum no. of times
Bangladesh
MDD: fed at least 4 out of 7 food groups
MAD: given milk or milk products, foods from the recommended

food groups, fed at least the recommended minimum no. of times
Bangladesh
Even among the highest wealth

quintile, only 33% receive
appropriate feeding
Development of Ready to Use Complementary
Foods from locally available food ingredients
 IRB approval of proposal
 Market survey since Jan 2011
 Establishment of Food Processing Lab
 Technical committee
 Experiments, evaluations
 Shelf life (sensory and laboratory evaluation)
 Identification of local food industries
Development of recipes
Rice-Lentil
+
based RUSF
Rice Lentil
Milk powder Sugar

Oil
Chickpea based
RUSF
Chickpea
Establishing the Food Processing Lab in icddr,b
Formation of Technical Committee
• GoB, NGO (national, international), Pediatricians,

academia, international agencies, scientists
Testing shelf life of the diets
• Panelists at icddr’b, laboratory testing

The study results suggest that rice-lentil and chickpea-based
RUSF are well accepted by children
50
45
44.2 43.7 44.3 Growth deceleration occurred from 6
40.3
40
39.1 to 18 months of age
35 Growth deceleration occurred from 6 to 18 months of age 29.5
30 Deceleration in LAZ was lower (by
% Stunted
26.5
25.1 25
25 23.1 0.02–0.04/month) in the Plumpy’doz
20
Deceleration in LAZ was lower (by 0.02–0.04/month)
(p=0.02), rice-lentilin the
(p=< 0.01), and
15 chickpea (p=< 0.01) groups
10 Plumpy’doz (p=0.02), rice-lentil (p=< 0.01), and
relative chickpea
to control
5
0
(p=< 0.01) groups relative to control
Control Plumpy'doz Rice-lentil Chickpea WSB++
Baseline Endline
Stunting reduced by 5-6%
Complementary foods and doses
Nutrition counseling
 One-on-one counseling was provided
 9 sessions over 12 months, 45 min/session
 11 age specific messages: kind & amount of food to

eat, responsive feeding, feeding sick children, hygiene
Effects on stunting & wasting and attained
length, LAZ at 18 months of age
Summary
• Local RUCF provided daily to children from 6-18 months of
age significantly reduced linear growth deceleration and
the prevalence of stunting at 18 months of age by 4-6%
over and above nutrition counseling alone
• Scaling up will depend upon the context

– Bulk production locally
– Targeted distribution through the lowest tiers of health
system
– Distribution through social safety nets
– Social marketing
Severe Acute Malnutrition
• WH<-3 SD
• Edema both feet
• MUAC <11.5 cm
At risk of death from

• Hypoglycemia
• Hypothermia
• Infections
Severe Acute Malnutrition
• WH<-3 SD
• Edema both feet
• MUAC <11.5 cm
At risk of death from

• Hypoglycemia
• Hypothermia
• Infections
Affects 19 million and

kills ~1 million each year
Management of SAM
• Stabilization, hospital-based, only ~5-10%

• Community-based nutritional rehabilitation
• Prevention through food security and
health care programs
Ready-to-Use Therapeutic Food
• Energy dense: 500 kcal/92g
• Same formula as F100 (except
it contains iron)
• No microbial growth even when
opened
• Safe & easy for home use
• Is given after breast milk
• Safe drinking water should be
provided
• Well liked by children
Local diets for treatment of SAM
Development at kitchen scale Development in industry

Methods
 Double blind randomized clinical trial
 Study sites: 3 sites
Dhaka Hospital Terre des Hommes, SNU Radda MCH FP Center

icddr,b, Dhaka Kurigram Mirpur Dhaka
Flow chart of study participant enrolment
and intervention
Receive the
Anthropometric
standard WHO Recover from
measurements of
management for acute phase
admitted or OPD
SAM during acute
patients
phase
Achieves the Continue study Randomize and

discharge criteria intervention @ appetite test by
and discharge with 200 kcal/kg/day in intervention diet,
advice 7 divided meals if passed
Primary objective and outcome variable
To compare the efficacy in terms of rate of weight gain

(g/kg per day) of children with SAM treated with the
different diets
Sample size
Considering a standard deviation of the mean of the rate

of weight gain to be 5.3, power 80%, α of 0.05, and
accommodating for 20% dropout, the sample size was
estimated to be a total of 327 participants (109 in each of
three arms)
Study activities in Terre des Homes, Kurigram
A 11 month old girl randomized
to one of the three RUTFs, on day 1
On day 18 when she was discharged

Summary of therapeutic diet studies
 Daily weight gain & duration of stay to achieve the discharge

criteria were comparable among all the intervention groups
 We conclude that both the local diets, i.e. Sharnali-1 & Sharnali-2
are as good as Plumpy’Nut in treating children suffering from SAM
Current treatment is not effective
Sphere standard OTP SFP
Length of ≤60 d in OTP 70 days 71.5 days

stay, days ≤90 d in SFP
Mean rate >5 g/kg/d for OTP 2 g/kg/d 1.75 g /kg/d

of weight >3 g/kg/d for SFP
gain
Pakistan country case study, UNICEF 2012

Current treatment is not effective
Diet group WLZ score WLZ score on WLZ score

enrolment 15% wt gain follow up
n=224
n=183 n=99
Halwa/ -3.96 ± 0.79 -2.86 ± 0.92 -2.24 ± 1.03
khichuri
RUTFs -3.85 ± 0.64 -2.66 ± 0.68 -2.18 ± 0.97
First POC study – Children with MAM
CP, peanut, banana, soyflour

Above without milk
CP, SF without milk
Outcome measures:
• Repair of microbiota immaturity (MAZ score)
• Impact on enteropathogen burden
• Anthropometry
• Serum biomarkers [e.g., metabolites indicative of metabolic
flexibility; insulin, leptin, IGF-1, bone formation (P1NP, CTX,
IL-6, osteoprotegerin); trp/kyn etc.]
Requirements for such studies
Study population Appropriate trial design
Health care clinic

Local dissemination
Collection of stool
within 20 minutes of
production and put it
into dry shippers
Our experience with

the last 70 samples:
~7 minutes
Log_Microbiota_MAL_ED_29_02_16.xlsx
Track record with RUSF and RUTF
The Study Team
Dr Ishita Mostofa Dr Muttaquina Hossain

Dr Imtiaz Mahmud Dr KM Shahunja
Dr Md. Iqbal Hossain Dr Sayeeda Haq
Dr Md. Munirul Islam Dr Mustafa Mahfuz
Ms Nuzhat Choudhury Dr Santhia Ireen
Dr Shafiqul Alam Sarker Dr John Clemens
Dr Michael Barratt Dr Jeffery Gordon
Dr Tahmeed Ahmed

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Acute childhood malnutrition:

Taking science where it is needed

Professor, Public Health Nutrition

• Status of complementary feeding and acute

• Substantial reduction in stunting and

MAD: given milk or milk products, foods from the recommended

MAD: given milk or milk products, foods from the recommended

Even among the highest wealth

Milk powder Sugar

• GoB, NGO (national, international), Pediatricians,

• Panelists at icddr’b, laboratory testing

 One-on-one counseling was provided

 9 sessions over 12 months, 45 min/session

 11 age specific messages: kind & amount of food to

• Scaling up will depend upon the context

At risk of death from

At risk of death from

Affects 19 million and

• Stabilization, hospital-based, only ~5-10%

Development at kitchen scale Development in industry

Dhaka Hospital Terre des Hommes, SNU Radda MCH FP Center

Achieves the Continue study Randomize and

To compare the efficacy in terms of rate of weight gain

Considering a standard deviation of the mean of the rate

On day 18 when she was discharged

 Daily weight gain & duration of stay to achieve the discharge

Sphere standard OTP SFP

Length of ≤60 d in OTP 70 days 71.5 days

Mean rate >5 g/kg/d for OTP 2 g/kg/d 1.75 g /kg/d

Pakistan country case study, UNICEF 2012

Diet group WLZ score WLZ score on WLZ score

CP, peanut, banana, soyflour

Study population Appropriate trial design

Health care clinic

Our experience with

Dr Ishita Mostofa Dr Muttaquina Hossain

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