Scribd Logo
Upload

Welcome to Scribd!

  • 30 views

    Alphacoronavirus From Wikipedia, The Free Encyclopedia Jump To Navigationjump To Search

    Uploaded by

    Alexadner
    Alphacoronaviruses are a genus of coronaviruses that infect humans and mammals. They have spherical virions with club-shaped surface projections and a viral envelope. Their genome is a positive-sense, single-stranded RNA that is 27 to 29 kilobases in length. Alphacoronaviruses are classified into several subgenera based on phylogeny, including Tegacovirus which includes canine coronavirus and feline coronavirus.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd

    Alphacoronavirus From Wikipedia, The Free Encyclopedia Jump To Navigationjump To Search

    Uploaded by

    Alexadner
    30 views8 pages
    Alphacoronaviruses are a genus of coronaviruses that infect humans and mammals. They have spherical virions with club-shaped surface projections and a viral envelope. Their genome is a positive-sense, single-stranded RNA that is 27 to 29 kilobases in length. Alphacoronaviruses are classified into several subgenera based on phylogeny, including Tegacovirus which includes canine coronavirus and feline coronavirus.

    Original Description:

    corona

    Original Title

    Alpha

    Copyright

    © © All Rights Reserved

    Available Formats

    DOCX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Alphacoronaviruses are a genus of coronaviruses that infect humans and mammals. They have spherical virions with club-shaped surface projections and a viral envelope. Their genome is a positive-sense, single-stranded RNA that is 27 to 29 kilobases in length. Alphacoronaviruses are classified into several subgenera based on phylogeny, including Tegacovirus which includes canine coronavirus and feline coronavirus.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    30 views8 pages

    Alphacoronavirus From Wikipedia, The Free Encyclopedia Jump To Navigationjump To Search

    Uploaded by

    Alexadner
    Alphacoronaviruses are a genus of coronaviruses that infect humans and mammals. They have spherical virions with club-shaped surface projections and a viral envelope. Their genome is a positive-sense, single-stranded RNA that is 27 to 29 kilobases in length. Alphacoronaviruses are classified into several subgenera based on phylogeny, including Tegacovirus which includes canine coronavirus and feline coronavirus.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 8

    Alphacoronavirus

    From Wikipedia, the free encyclopedia

    Jump to navigationJump to search

    Alphacorona
    virus

    Porcine
    epidemic
    diarrhea
    virus  genom
    e and virion
    structure

    Virus
    classification

    ( V
    u i
    n r
    r u
    a s
    n
    k
    e
    d
    )
    :

    R R
    e i
    a b
    l o
    m v
    : i
    r
    i
    a

    K O
    i r
    n t
    g h
    d o
    o r
    m n
    : a
    v
    i
    r
    a
    e

    P P
    h i
    y s
    l u
    u v
    m i
    : r
    i
    c
    o
    t
    a

    C P
    l i
    a s
    s o
    s n
    : i
    v
    i
    r
    i
    c
    e
    t
    e
    s

    O N
    r i
    d d
    e o
    r v
    : i
    r
    a
    l
    e
    s

    F C
    a o
    m r
    i o
    l n
    y a
    : v
    i
    r
    i
    d
    a
    e

    S O
    u r
    b t
    f h
    a o
    m c
    i o
    l r
    y o
    : n
    a
    v
    i
    r
    i
    n
    a
    e

    G A
    e l
    n p
    u h
    s a
    : c
    o
    r
    o
    n
    a
    v
    i
    r
    u
    s

    Subgenera
    and species

    See text

    Alphacoronaviruses  (Alpha-CoV) are members of the first of the four genera


    (Alpha-,  Beta-,  Gamma-, and  Delta-) of  coronaviruses. They are  positive-sense,
    single-stranded  RNA viruses  that infect both humans and  mammals. They have
    spherical virions with club-shaped  surface projections  and a  viral envelope.

    Alphacoronaviruses are in the subfamily  Orthocoronavirinae  of the


    family  Coronaviridae. Both the  Alpha- and  Betacoronavirus  lineages descend from
    the  bat viral gene pool.[1][2][3]  Alphacoronaviruses were previously known as
    "phylogroup  1 coronaviruses".

    Etymology

    The name alphacoronavirus is derived from Ancient Greek ἄλφα (álpha, "the first
    letter of the Greek alphabet"), and κορώνη (korṓnē, “garland, wreath”), meaning
    crown, which describes the appearance of the surface projections seen under
    electron microscopy that resemble a solar corona.[4]

    Structure

    The virion is enveloped and spherical measuring 120–160 nm in diameter and a core
    shell of about 65 nm. Glycoproteins and trimers form large surface projections which
    create the appearance of solar corona. This genus, like other coronaviruses, has a
    spike protein with a type II fusion machine (S2) and a receptor-binding domain (S1). It
    assembles into a trimer. Unlike beta- and gammacoronaviruses, this protein is not
    cleaved into two halves.[5]

    Genome

    Genetic relationships between the different feline coronaviruses (FCov) and canine
    coronaviruses (CCoV) genotypes. Recombination at arrows.[6]

    The genome is positive-sense, single-stranded RNA with a length of 27 to 29 kilobases


    and a 3’-polyA tail. Two large, overlapping ORFs at the 5'-end of the genome encode
    the major non-structural proteins expressed as a fusion protein by ribosomal
    frameshift. These include regions with protease, helicase and RNA polymerase motifs.
    There are seven other genes downstream which encode structural proteins. These are
    expressed from a 3'-coterminal nested set of subgenomic mRNAs.

    Recombination

    Both types of Alphacoronavirus 1, feline coronavirus (FCoV) and canine coronavirus


    (CCoV), are known to exist in two serotypes. Serotype II targets Aminopeptidase N,
    while the receptor for Serotype I is unknown. The difference is due to a different spike
    protein.[7] There is a common ancestor for FCoV and CCoV. This ancestor gradually
    evolved into FCoV I and CCoV I. An S protein from an unknown virus was recombined
    into the ancestor and gave rise to CCoV II. CCoV II once again recombined with FCoV
    to create FCoV II. CCoV II gradually evolved into TGEV. A spike deletion in TGEV
    creates PRCV. All these viruses are sorted into the subgenus Tegacovirus.[7]

    Classification

    Phylogentic tree of the genus Alphacoronaviruses with host animals indicated on the
    right hand side.

    The following subgenera and species are recognized:[8]

    Colacovirus

    Bat coronavirus CDPHE15

    Decacovirus

    Bat coronavirus HKU10

    Rhinolophus ferrumequinum alphacoronavirus HuB-2013

    Duvinacovirus

    Human coronavirus 229E

    Luchacovirus

    Lucheng Rn rat coronavirus

    Coronavirus

    H1N1 virus

    Types[show]

    Vaccines[show]

    Epidemics[show]

    Outbreaks[show]

    See also[show]

    vte

    Minacovirus
    Mink coronavirus 1

    Ferret coronavirus

    Minunacovirus

    Miniopterus bat coronavirus 1

    Miniopterus bat coronavirus HKU8

    Myotacovirus

    Myotis ricketti alphacoronavirus Sax-2011

    Nyctacovirus

    Nyctalus velutinus alphacoronavirus SC-2013

    Pipistrellus kuhlii coronavirus 3398

    Pedacovirus

    Porcine epidemic diarrhea virus

    Scotophilus bat coronavirus 512

    Rhinacovirus

    Rhinolophus bat coronavirus HKU2

    Setracovirus

    Human coronavirus NL63

    NL63-related bat coronavirus strain BtKYNL63-9b

    Soracovirus

    Sorex araneus coronavirus T14

    Sunacovirus

    Suncus murinus coronavirus X74

    Tegacovirus

    Alphacoronavirus 1

    Canine coronavirus

    Feline coronavirus
    Transmissible gastroenteritis coronavirus

    You might also like