In Vitro Dissolution Testing Models: DR Rajesh Mujariya
In Vitro Dissolution Testing Models: DR Rajesh Mujariya
In Vitro Dissolution Testing Models: DR Rajesh Mujariya
Models
Dr Rajesh Mujariya
CONTENTS
Introduction.
References.
NEED FOR DISSOLUTION TESTING
App no IP BP USP
1 Paddle Basket Rotating basket
6 Rotating cylinder
7 Reciprocating disk
Name of Apparatus Drug Product
Reservoir of medium
Pump that forcing medium through the cell
holding test sample
Flow rate from 4 to 16 mL/min.
For modified release dosage forms, containing
active ingredients with limited solubility.
Laminar flow by pulse less pump
Dissolution medium may be fresh or recirculated
Fresh medium ,dissolution rate at any moment
can be obtained.
Flow through cell
5) Paddle over disk method
1. Better reproducibility
2. For capsules as they tend to float at
surface thus minimizing area exposed
to dissolution fluid
Disadvantage
Tumbling method
Rotating disk method
Rotating bottle method
Intrinsic dissolution method
Peristalsis method
Sartorius apparatus
Beaker method
Dialysis method
Tumbling method
In this method dosage form is placed in tubes or
bottles which are rotated using revolving drum
JW= PWCW
JW Drug flux through intestinal wall at any position & time