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    Trisomy 21

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    Kevin
    Trisomy 21, also known as Down syndrome, is caused by the triplication or translocation of chromosome 21. This alters gene expression on chromosome 21 and other chromosomes, leading to mitochondrial dysfunction, oxidative damage, energy depletion, neuronal dysfunction, and neuronal death - potentially resulting in dementia or Alzheimer's. Predisposing factors include having a parent who is a carrier of a genetic translocation or having a previous child with Down syndrome, while smoking, alcohol, and advanced maternal age are precipitating factors that can increase the risk.

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    Trisomy 21

    Uploaded by

    Kevin
    28 views1 page
    Trisomy 21, also known as Down syndrome, is caused by the triplication or translocation of chromosome 21. This alters gene expression on chromosome 21 and other chromosomes, leading to mitochondrial dysfunction, oxidative damage, energy depletion, neuronal dysfunction, and neuronal death - potentially resulting in dementia or Alzheimer's. Predisposing factors include having a parent who is a carrier of a genetic translocation or having a previous child with Down syndrome, while smoking, alcohol, and advanced maternal age are precipitating factors that can increase the risk.

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    1. Trisomy 21

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    Trisomy 21, also known as Down syndrome, is caused by the triplication or translocation of chromosome 21. This alters gene expression on chromosome 21 and other chromosomes, leading to mitochondrial dysfunction, oxidative damage, energy depletion, neuronal dysfunction, and neuronal death - potentially resulting in dementia or Alzheimer's. Predisposing factors include having a parent who is a carrier of a genetic translocation or having a previous child with Down syndrome, while smoking, alcohol, and advanced maternal age are precipitating factors that can increase the risk.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    28 views1 page

    Trisomy 21

    Uploaded by

    Kevin
    Trisomy 21, also known as Down syndrome, is caused by the triplication or translocation of chromosome 21. This alters gene expression on chromosome 21 and other chromosomes, leading to mitochondrial dysfunction, oxidative damage, energy depletion, neuronal dysfunction, and neuronal death - potentially resulting in dementia or Alzheimer's. Predisposing factors include having a parent who is a carrier of a genetic translocation or having a previous child with Down syndrome, while smoking, alcohol, and advanced maternal age are precipitating factors that can increase the risk.

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    CHROMOSOMAL ABERRATION/TRISOMY 21

    PRECIPITATING PREDISPOSING
    FACTORS: FACTORS:
    -Smoking and Alcohol -Carrier Parents of
    Consumption during genetic translocation.
    pregnancy -Having one child with
    -Maternal age 35< down syndrome

    Triplication, mosaicism, or translocation of


    CHROMOSOME 21

    1. Altered Chromosome 21 gene expression


    2. Deregulation of genes on other chromosomes

    Mitochondrial Dysfunction Oxydative damage B- Amyloid

    Energy Depletion

    Neuronal Dysfunction

    Neuronal Death

    Dementia/Alzheimers

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