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    Enzyme Commission Number

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    Claudia Muñoz
    The Enzyme Commission Number (EC number) is a system that numerically classifies enzymes based on the chemical reactions they catalyze. EC numbers provide a recommended name for each enzyme and classify enzymes based on a four-number code that describes the specific reaction catalyzed. While EC numbers classify reactions, not enzymes directly, different enzymes that catalyze the same reaction will receive the same EC number. The four numbers in an EC code represent a hierarchical classification, from the broadest category to the most specific reaction. For example, EC 3.4.11.4 indicates an enzyme that acts on peptide bonds and cleaves the amino-terminal amino acid from a tripeptide.

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    Enzyme Commission Number

    Uploaded by

    Claudia Muñoz
    17 views4 pages
    The Enzyme Commission Number (EC number) is a system that numerically classifies enzymes based on the chemical reactions they catalyze. EC numbers provide a recommended name for each enzyme and classify enzymes based on a four-number code that describes the specific reaction catalyzed. While EC numbers classify reactions, not enzymes directly, different enzymes that catalyze the same reaction will receive the same EC number. The four numbers in an EC code represent a hierarchical classification, from the broadest category to the most specific reaction. For example, EC 3.4.11.4 indicates an enzyme that acts on peptide bonds and cleaves the amino-terminal amino acid from a tripeptide.

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    Clasificacion de las enzimas

    Original Title

    Enzimas

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    The Enzyme Commission Number (EC number) is a system that numerically classifies enzymes based on the chemical reactions they catalyze. EC numbers provide a recommended name for each enzyme and classify enzymes based on a four-number code that describes the specific reaction catalyzed. While EC numbers classify reactions, not enzymes directly, different enzymes that catalyze the same reaction will receive the same EC number. The four numbers in an EC code represent a hierarchical classification, from the broadest category to the most specific reaction. For example, EC 3.4.11.4 indicates an enzyme that acts on peptide bonds and cleaves the amino-terminal amino acid from a tripeptide.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    17 views4 pages

    Enzyme Commission Number

    Uploaded by

    Claudia Muñoz
    The Enzyme Commission Number (EC number) is a system that numerically classifies enzymes based on the chemical reactions they catalyze. EC numbers provide a recommended name for each enzyme and classify enzymes based on a four-number code that describes the specific reaction catalyzed. While EC numbers classify reactions, not enzymes directly, different enzymes that catalyze the same reaction will receive the same EC number. The four numbers in an EC code represent a hierarchical classification, from the broadest category to the most specific reaction. For example, EC 3.4.11.4 indicates an enzyme that acts on peptide bonds and cleaves the amino-terminal amino acid from a tripeptide.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 4

    Enzyme Commission Number

    The Enzyme Commission number (EC number) is a numerical classification scheme for
    enzymes, based on the chemical reactions they catalyze. As a system of enzyme nomenclature,
    every EC number is associated with a recommended name for the respective enzyme.

    Strictly speaking, EC numbers do not specify enzymes, but enzyme-catalyzed reactions. If


    different enzymes (for instance from different organisms) catalyze the same reaction, then they
    receive the same EC number. Furthermore, through convergent evolution, completely different
    protein folds can catalyze an identical reaction and therefore would be assigned an identical EC
    number (these are called non-homologous isofunctional enzymes, or NISE). By contrast,
    UniProt identifiers uniquely specify a protein by its amino acid sequence.

    Format of number
    Every enzyme code consists of the letters "EC" followed by four numbers separated by periods.
    Those numbers represent a progressively finer classification of the enzyme. Preliminary EC
    numbers exist and have an 'n' as part of the fourth (serial) digit (e.g. EC 3.5.1.n3).

    For example, the tripeptide aminopeptidases have the code "EC 3.4.11.4", whose components
    indicate the following groups of enzymes:

    EC 3 enzymes are hydrolases (enzymes that use water to break up some other molecule)
    EC 3.4 are hydrolases that act on peptide bonds
    EC 3.4.11 are those hydrolases that cleave off the amino-terminal amino acid from a
    polypeptide
    EC 3.4.11.4 are those that cleave off the amino-terminal end from a tripeptide

    Rojin Hematian Ashrafian Page 1


    Top level codes

    EC 1. Oxidoreductases
    EC 1.1 Acting on the CH-OH group of donors
    EC 1.2 Acting on the aldehyde or oxo group of donors
    EC 1.3 Acting on the CH-CH group of donors
    EC 1.4 Acting on the CH-NH2 group of donors
    EC 1.5 Acting on the CH-NH group of donors
    EC 1.6 Acting on NADH or NADPH
    EC 1.7 Acting on other nitrogenous compounds as donors
    EC 1.8 Acting on a sulfur group of donors
    EC 1.9 Acting on a heme group of donors
    EC 1.10 Acting on diphenols and related substances as donors
    EC 1.11 Acting on a peroxide as acceptor
    EC 1.12 Acting on hydrogen as donor
    EC 1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
    EC 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
    EC 1.15 Acting on superoxide as acceptor
    EC 1.16 Oxidizing metal ions

    Rojin Hematian Ashrafian Page 2


    EC 1.17 Acting on CH or CH2 groups
    EC 1.18 Acting on iron-sulfur proteins as donors
    EC 1.19 Acting on reduced flavodoxin as donor
    EC 1.20 Acting on phosphorus or arsenic in donors
    EC 1.21 Acting on X-H and Y-H to form an X-Y bond
    EC 1.97 Other oxidoreductases
    EC 1.98 Enzymes using H2 as reductant
    EC 1.99 Other enzymes using O2 as oxidant

    EC 2. Transferases
    EC 2.1 Transferring One-Carbon Groups
    EC 2.2 Transferring Aldehyde or Ketonic Groups
    EC 2.3 Acyltransferases
    EC 2.4 Glycosyltransferases
    EC 2.5 Transferring Alkyl or Aryl Groups, Other than Methyl Groups
    EC 2.6 Transferring Nitrogenous Groups
    EC 2.7 Transferring Phosphorus-Containing Groups
    EC 2.8 Transferring Sulfur-Containing Groups
    EC 2.9 Transferring Selenium-Containing Groups

    EC 3. Hydrolases
    EC 3.1 Acting on Ester Bonds
    EC 3.2 Glycosylases
    EC 3.3 Acting on Ether Bonds
    EC 3.4 Acting on peptide bonds (Peptidases)
    EC 3.5 Acting on Carbon-Nitrogen Bonds, other than Peptide Bonds
    EC 3.6 Acting on Acid Anhydrides
    EC 3.7 Acting on Carbon-Carbon Bonds
    EC 3.8 Acting on Halide Bonds
    EC 3.9 Acting on Phosphorus-Nitrogen Bonds
    EC 3.10 Acting on Sulfur-Nitrogen Bonds
    EC 3.11 Acting on Carbon-Phosphorus Bonds
    EC 3.12 Acting on Sulfur-Sulfur Bonds
    EC 3.13 Acting on Carbon-Sulfur Bonds

    EC 4. Lyases
    EC 4.1 Carbon-Carbon Lyases
    EC 4.2 Carbon-Oxygen Lyases
    EC 4.3 Carbon-Nitrogen Lyases
    EC 4.4.4.4[1] Carbon-Sulfur Lyases
    EC 4.5 Carbon-Halide Lyases
    EC 4.6 Phosphorus-Oxygen Lyases
    EC 4.99 Other Lyases

    Rojin Hematian Ashrafian Page 3


    EC 5. Isomerases
    EC 5.1 Racemases and Epimerases
    EC 5.2 cis-trans-Isomerases
    EC 5.3 Intramolecular Oxidoreductases
    EC 5.4 Intramolecular Transferases
    EC 5.5 Intramolecular Lyases
    EC 5.99 Other Isomerases

    EC 6. Ligases
    EC 6.1 Forming Carbon-Oxygen Bonds
    EC 6.2 Forming Carbon-Sulfur Bonds
    EC 6.3 Forming Carbon-Nitrogen Bonds
    EC 6.4 Forming Carbon-Carbon Bonds
    EC 6.5 Forming Phosphoric Ester Bonds
    EC 6.6 Forming Nitrogen—Metal Bonds

    Rojin Hematian Ashrafian Page 4

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