Scribd Logo
Upload

Welcome to Scribd!

  • 64 views

    Pathophysiology of Tetanus: Precipitating Factors: Predisposing Factors

    Uploaded by

    Pernel Jose Alam Micubo
    Tetanus is caused by Clostridium tetani bacteria entering the body through a wound. The bacteria release toxins that travel through the bloodstream and nervous system to the spinal cord and neuromuscular junctions. The toxins block inhibitory neurotransmitters in the nervous system, causing unregulated muscle contractions that lead to lockjaw, difficulty breathing, and potentially death from respiratory failure.

    Copyright:

    © All Rights Reserved
    Download as DOC, PDF, TXT or read online from Scribd

    Pathophysiology of Tetanus: Precipitating Factors: Predisposing Factors

    Uploaded by

    Pernel Jose Alam Micubo
    64 views2 pages
    Tetanus is caused by Clostridium tetani bacteria entering the body through a wound. The bacteria release toxins that travel through the bloodstream and nervous system to the spinal cord and neuromuscular junctions. The toxins block inhibitory neurotransmitters in the nervous system, causing unregulated muscle contractions that lead to lockjaw, difficulty breathing, and potentially death from respiratory failure.

    Original Description:

    Pathophysio

    Original Title

    Tetanus Pathophysio

    Copyright

    © © All Rights Reserved

    Available Formats

    DOC, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Tetanus is caused by Clostridium tetani bacteria entering the body through a wound. The bacteria release toxins that travel through the bloodstream and nervous system to the spinal cord and neuromuscular junctions. The toxins block inhibitory neurotransmitters in the nervous system, causing unregulated muscle contractions that lead to lockjaw, difficulty breathing, and potentially death from respiratory failure.

    Copyright:

    © All Rights Reserved
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    64 views2 pages

    Pathophysiology of Tetanus: Precipitating Factors: Predisposing Factors

    Uploaded by

    Pernel Jose Alam Micubo
    Tetanus is caused by Clostridium tetani bacteria entering the body through a wound. The bacteria release toxins that travel through the bloodstream and nervous system to the spinal cord and neuromuscular junctions. The toxins block inhibitory neurotransmitters in the nervous system, causing unregulated muscle contractions that lead to lockjaw, difficulty breathing, and potentially death from respiratory failure.

    Copyright:

    © All Rights Reserved
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    You are on page 1of 2

    PATHOPHYSIOLOGY OF TETANUS

    Precipitating Factors: Predisposing Factors:

     Exposure to bacteria  Age


    (laceration at left foot)  Gender (Male)
     Unknown history oftetanus
    imunization

    Clostridium tetani bacteria containing virulence


    plasmids enter wound

    Toxins produced by growing cells

    Spores germinate under anaerobic


    conditions (3-21 days incubation)

    Cell lysis occurs

    Fever
    Release of bacterial endotoxins into surrounding tissues

    Inflammatory Stimulation of
    Tetanospasmin
    response hypothalamus

    Toxin circulated around the body through bloodstream and lymphatic system

    Autonomic
    Enter Central Nervous System (CNS) along peripheral nerves
    Dysfunction

    Toxin makes its way to spinal cord Tachycardia

    Toxin taken up by neuromuscular junction

    Irreversibly binds to gangliosides at presynaptic inhibitory motor nerve endings

    Taken up by preganglionic neuron axon through endocytosis

    Blocks the release of inhibitory neurotransmitters (glycine and GABA)

    Excitatory activities unregulated

    Generalized tonic muscle spasms occur


    Generalized tonic muscle spasms occur

    Pharynx Masseter muscle Respiratory


    muscles

    Aspiration of oral Lock Jaw


    secretions Dyspnea Chest wall rigidity

    Cough Retractions Asphyxiation

    DEATH Respiratory failure

    You might also like