HT TP: //qpa Pe R.W But .Ac .In: 2010-11 Pharmacology

Name : ……………………………………………………………
htt
Roll No. : …………………………………………………………
Invigilator's Signature : ………………………………………..

CS/B.Pharm(OLD)/SEM-5/PT-508/2010-11
p:/
2010-11
PHARMACOLOGY
Time Allotted : 3 Hours Full Marks : 70
/q
The figures in the margin indicate full marks.
Candidates are required to give their answers in their own words
pap
as far as practicable.
GROUP – A
( Multiple Choice Type Questions )
1. Choose the correct alternatives for any ten of the following :
er.
10 × 1 = 10
i) When Valproate is administered with phenytoin
a) Plasma level of valproate increases
b) Plasma level of phenytoin increases
wb
c) Both (a) and (b)

d) None of these.
ii) In case of four point bioassay, potency ratio of an
ut .
unknown substance can be calculated by using the

formula
a) s /t
1 1
x antilog (T 2
–S +T –S /T –T +S –S
2 1 1 2 1 2 1 ) x log s /s
2 1
b)
a c.
s 1 /t 1 x antilog s 1 /s 2
c) s 1 /t 1 x antilog ( T2 – S2 + T1 – S1 / T2 – T1 + S2 – S1 ) x log s 1
/s 2
d) s 1 /t 1 x log s 1 /s 2 .
in
5440 [ Turn over

iii) Transport of two substrates through membrane, via

receptor in same direction is termed as
htt
a) across transport
b) symport or cotransport
p:/
c) antiport
d) none of these.
iv) The therapeutic use of amantadine is

/q
a) anti-viral b) anti-Parkinson
c) both (a) and (b) d) none of these.

pap
v) The fall in Blood Pressure caused by d-tuboeurarine is
due to
a) reduced venous pressure
b) ganglionic blockade
er.
c) histamine release
d) all of these.
wb
vi) The preferred drug for status epilepticus is
a) I.V. diazepam b) I.V. phenytoin sodium
c) I.M. phenobarbitone d) rectal paraldehyde.

ut .
vii) An antidote for acute morphine poisoning is
a) ferrous sulphate b) nitrazepam
c) naloxone d) ketamine.
a c.
viii) Levodopa and carbidopa produce
a) antagonistic effect b) supradditive effect
c) additive effect d) none of these.

in
5440 2
ix) Which of the following is Mydriatic agent ?

htt
a) Pilocarpine b) Homoatropine
c) Aspirin d) Tropicamide.
x) The drug having affinity to receptor but it shows

p:/
negative efficacy, is known as
a) agonist b) partial agonist
c) inverse agonist d) antagonist.

/q
xi) “Child dose” = { Age/ ( Age + 12 ) } ∞ adult dose. This
formula is known as
pap
a) Dilling's formula b) Young's formula
c) Clerck's formula d) Jacob's formula.
xii) Paracetamol is known as

er.
a) Para amino phenol b) Phenacetin
c) Acetaminophen d) Para-acetaminophen.
wb
GROUP – B
( Short Answer Type Questions )
Answer any three of the following. 3 × 5 = 15
2. What are sedative and hypnotic ? Write briefly on acute

ut .
barbiturate poisoning.
3. Write briefly on Drug Tolerance.

a c.
4. Write briefly about the transport of drug through membrane.
5. Write a short note on the blood brain barrier.
6. Define “Biological Half Life” and explain its significance.

in
5440 3 [ Turn over

GROUP – C
htt
( Long Answer Type Questions )
Answer any three of the following. 3 × 15 = 45
7. a) Define biotransformation.
p:/
b) Briefly discuss about phase II reaction with eample.
c) What is prodrug ? Discuss various applications of

prodrug in drug therapy with example.
/q
8. What do you mean by analgesic, antipyretic and anti-
inflammatory drugs ? Classify non-selective COX-inhibitors
pap
with example. What is the pharmacokinetic property of
paracetamol. Write briefly about acute paracetamol poisoning
( dose, symptoms, mechanism of toxicity and treatment )
3+3+2+7
er.
9. What is Epilepsy ? Classify the drugs used for the

management of epilepsy with examples. Describe in detail
about phenytoin as antiepileptic drug. 2+5+8
wb
10. What are the differences betwen general anaesthetic and

local anaesthetic ? Write in brief about the mechanism of
action of general anaesthesia. What is pre-anaesthetic
medication ? What are the common complications that occur
ut .
with general anaesthesia ? 2+4+5+4
11. Define receptor and classify it with proper example. Describe

in detail about Adenylyl cyclase :
a c.
CMP pathway and phospholipase C : IP3 DAG pathway.

1+8+6
in
5440 4

HT TP: //qpa Pe R.W But .Ac .In: 2010-11 Pharmacology

Uploaded by

Copyright:

Available Formats

HT TP: //qpa Pe R.W But .Ac .In: 2010-11 Pharmacology

Uploaded by

Document Information

Original Description:

Original Title

Copyright

Available Formats

Share this document

Share or Embed Document

Sharing Options

Did you find this document useful?

Is this content inappropriate?

Copyright:

Available Formats

HT TP: //qpa Pe R.W But .Ac .In: 2010-11 Pharmacology

Uploaded by

Copyright:

Available Formats

Name : ……………………………………………………………

Invigilator's Signature : ………………………………………..

c) Both (a) and (b)

unknown substance can be calculated by using the

5440 [ Turn over

iii) Transport of two substrates through membrane, via

iv) The therapeutic use of amantadine is

c) both (a) and (b) d) none of these.

a) reduced venous pressure

vi) The preferred drug for status epilepticus is

a) I.V. diazepam b) I.V. phenytoin sodium

c) I.M. phenobarbitone d) rectal paraldehyde.

vii) An antidote for acute morphine poisoning is

a) ferrous sulphate b) nitrazepam

viii) Levodopa and carbidopa produce

a) antagonistic effect b) supradditive effect

c) additive effect d) none of these.

ix) Which of the following is Mydriatic agent ?

x) The drug having affinity to receptor but it shows

a) agonist b) partial agonist

c) inverse agonist d) antagonist.

a) Dilling's formula b) Young's formula

c) Clerck's formula d) Jacob's formula.

xii) Paracetamol is known as

a) Para amino phenol b) Phenacetin

2. What are sedative and hypnotic ? Write briefly on acute

3. Write briefly on Drug Tolerance.

4. Write briefly about the transport of drug through membrane.

5. Write a short note on the blood brain barrier.

6. Define “Biological Half Life” and explain its significance.

5440 3 [ Turn over

c) What is prodrug ? Discuss various applications of

9. What is Epilepsy ? Classify the drugs used for the

10. What are the differences betwen general anaesthetic and

with general anaesthesia ? 2+4+5+4

11. Define receptor and classify it with proper example. Describe

CMP pathway and phospholipase C : IP3 DAG pathway.

You might also like