Chapter 15 The Chromosomal Basis of Inheritance

Campbell Biology, 11e
Chapter 15 The Chromosomal Basis of Inheritance
15.1 Multiple-Choice Questions
1) When Thomas Hunt Morgan crossed his red-eyed F1 generation flies to each other, the F2
generation included both red- and white-eyed flies. Remarkably, all the white-eyed flies were
male. What was the explanation for this result?
A) The gene involved is located on the Y chromosome.
B) The gene involved is located on the X chromosome.
C) The gene involved is located on an autosome, but only in males.
D) Other male-specific factors influence eye color in flies.
2) Which of the following statements correctly describes the meaning of the chromosome theory
of inheritance as expressed in the early 20th century?
A) Individuals inherit particular chromosomes attached to genes.
B) Mendelian genes are at specific loci on the chromosome and, in turn, segregate during
meiosis.
C) No more than a single pair of chromosomes can be found in a healthy normal cell.
D) Natural selection acts on certain chromosome combinations rather than on genes.
3) Why are males more often affected by sex-linked traits than females?
A) Male hormones such as testosterone often alter the effects of mutations on the X
chromosome.
B) Female hormones such as estrogen often compensate for the effects of mutations on the X
chromosome.
C) X chromosomes in males generally have more mutations than X chromosomes in females.
D) Males are hemizygous for the X chromosome.
4) The SRY gene is best described as ________.

A) a gene present on the X chromosome that triggers female development
B) an autosomal gene that is required for the expression of genes on the Y chromosome
C) a gene present on the Y chromosome that triggers male development
D) an autosomal gene that is required for the expression of genes on the X chromosome
5) In cats, black fur color is determined by an X-linked allele; the other allele at this locus
determines orange color. The heterozygote is tortoiseshell. What kinds of offspring would you
expect from the cross of a black female and an orange male?
A) tortoiseshell females; tortoiseshell males
B) black females; orange males
C) tortoiseshell females; black males
D) orange females; black males
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6) Red-green color blindness is a sex-linked recessive trait in humans. Two people with normal
color vision have a color-blind son. What are the genotypes of the parents?
A) XnXn and XnY
B) XNXN and XnY
C) XNXN and XNY
D) XNXn and XNY
7) Cinnabar eye color is a sex-linked, recessive characteristic in fruit flies. If a female having
cinnabar eyes is crossed with a wild-type male, what percentage of the F1 males will have
cinnabar eyes?
A) 0%
B) 25%
C) 50%
D) 100%
8) Generally, only female cats have the tortoiseshell phenotype for fur color. Which of the
following statements explains this phenomenon?
A) A male inherits only one allele of the X-linked gene controlling hair color.
B) The Y chromosome has a gene blocking orange coloration.
C) Only males can have Barr bodies.
D) Multiple crossovers on the Y chromosome prevent orange pigment production.
9) In birds, sex is determined by a ZW chromosome scheme. Males are ZZ and females are ZW.
A recessive lethal allele that causes death of the embryo is sometimes present on the Z
chromosome in pigeons. What would be the sex ratio in the offspring of a cross between a male
that is heterozygous for the lethal allele and a normal female?
A) 2:1 male to female
B) 1:2 male to female
C) 1:1 male to female
D) 3:1 male to female
10) Sex determination in mammals is due to the SRY gene found on the Y chromosome. Which
of the following situations could allow a person with an XX karyotype to develop a male
phenotype?
A) the loss of the SRY gene from an autosome
B) translocation of SRY to an X chromosome
C) the presence of an extra autosomal chromosome
D) the presence of one normal and one shortened (deleted) X
11) In humans, clear gender differentiation occurs not at fertilization, but after the second month
of gestation. Which of the following statements describes the first event of this differentiation?
A) formation of testosterone in male embryos
B) formation of estrogens in female embryos
C) activation of SRY in male embryos and masculinization of the gonads
D) activation of SRY in females and feminization of the gonads
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12) Duchenne muscular dystrophy is a serious condition caused by a recessive allele of a gene on
the human X chromosome. The patients have muscles that weaken over time because they have
absent or decreased dystrophin, a muscle protein. They rarely live past their 20s. How likely is it
for a woman to have this condition?
A) Women can never have this condition.
B) One-fourth of the daughters of an affected man would have this condition.
C) One-half of the daughters of an affected father and a carrier mother could have this condition.
D) Only if a woman is XXX could she have this condition.
13) All female mammals have one active X chromosome per cell instead of two. What causes
this to happen?
A) activation of the XIST gene on the X chromosome that will become the Barr body
B) activation of the BARR gene on one X chromosome, which then becomes inactive
C) inactivation of the XIST gene on the X chromosome derived from the male parent
D) attachment of methyl (-CH3) groups to the X chromosome that will remain active
14) A man who is a dwarf with achondroplasia and normal vision marries a color-blind woman
of normal height. The man's father was six feet tall, and both the woman's parents were of
average height. Dwarfism caused by achondroplasia is autosomal dominant, and red-green color
blindness is X-linked recessive. How many of their daughters might be expected to be color-
blind with achondroplasia?
A) none
B) half
C) one out of four
D) three out of four
15) A man who is a dwarf with achondroplasia and normal vision marries a color-blind woman
of normal height. The man's father was six feet tall, and both the woman's parents were of
average height. Dwarfism caused by achondroplasia is autosomal dominant, and red-green color
blindness is X-linked recessive. What proportion of their sons would be color blind and of
normal height?
A) none
B) half
C) one out of four
D) all
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16) Pseudohypertrophic muscular dystrophy is a human disorder that causes gradual
deterioration of the muscles. Only boys are affected, and they are always born to phenotypically
normal parents. Due to the severity of the disease, the boys die in their teens. Is this disorder
likely to be caused by a dominant or recessive allele? Is the inheritance of this trait sex-linked or
autosomal?
A) dominant, sex-linked
B) recessive, autosomal
C) recessive, sex-linked
D) incomplete dominant, sex-linked
17) A recessive allele on the X chromosome is responsible for red-green color blindness in
humans. A woman with normal vision whose father is color blind marries a color-blind male.
What is the probability that this couple's first son will be color blind?
A) 1/4
B) 1/2
C) 2/3
D) 3/4
18) Which of the following individuals will inherit an X-linked allele from a man who carries it?
A) all of his daughters
B) half of his daughters
C) all of his sons
D) all of his children
記19) Glucose-6-phosphate dehydrogenase deficiency (G6PD) is inherited as an X-linked

recessive allele in humans. A woman whose father suffered from G6PD marries a normal man.
What proportion of their sons is expected to be G6PD?
A) 100%
B) 1/4
C) 1/2
D) zero
記20) Glucose-6-phosphate dehydrogenase deficiency (G6PD) is inherited as an X-linked

recessive allele in humans. A woman whose father suffered from G6PD marries a man who has
the disease. What proportion of their sons would have the disease?
A) 100%
B) 1/2
C) 1/4
D) zero
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21) Use the following information to answer the question.
In a Drosophila experiment, a cross was made between homozygous wild-type females and
yellow-bodied males. All of the resulting F1s were phenotypically wild type. However, adult
flies of the F2 generation (resulting from matings of the F1s) had the characteristics shown in the
figure. How is the mutant allele for yellow body inherited?
A) It is recessive.
B) It is codominant.
C) It is dominant.
D) It is incompletely dominant.
In a Drosophila experiment, a cross was made between homozygous wild-type females and
yellow-bodied males. All of the resulting F1s were phenotypically wild type. However, adult
flies of the F2 generation (resulting from matings of the F1s) had the characteristics shown in the
figure. How is the mutant allele for yellow body inherited?
A) It is not X-linked.
B) It is X-linked.
C) It is inherited by X inactivation.
D) It is Y-linked.
23) Which of the following statements regarding gene linkage is correct?

A) The closer two genes are on a chromosome, the lower the probability that a crossover will
occur between them.
B) The observed frequency of recombination of two genes that are far apart from each other has
a maximum value of 100%.
C) All of the traits that Mendel studied—seed color, pod shape, flower color, and others—are due
to genes linked on the same chromosome.
D) Linked genes are found on different chromosomes.
24) Which of the following statements would explain a testcross involving F1 dihybrid flies in
which more parental-type offspring than recombinant-type offspring are produced?
A) The two genes are closely linked on the same chromosome.
B) The two genes are linked but on different chromosomes.
C) Recombination did not occur in the cell during meiosis.
D) Both of the characters are controlled by more than one gene.
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25) What does a recombination frequency of 50% indicate?
A) The two genes are likely to be located on different chromosomes.
B) All of the offspring have combinations of traits that match one of the two parents.
C) The genes are located on sex chromosomes.
D) Abnormal meiosis has occurred.
26) Which of the following phrases correctly defines what one map unit is?
A) the physical distance between two linked genes
B) a 1% frequency of recombination between two genes
C) 1 nanometer of distance between two genes
D) the recombination frequency between two genes assorting independently
27) Which of the following occurrences describes how recombination between linked genes
comes about?
A) Nonrecombinant chromosomes break and then rejoin with one another.
B) Independent assortment sometimes fails.
C) Linked genes travel together at anaphase.
D) Crossovers between these genes result in chromosomal exchange.
28) What is an adaptive advantage of recombination between linked genes?

A) Recombination is required for independent assortment.
B) Recombination must occur or genes will not assort independently.
C) New allele combinations are acted upon by natural selection.
D) The forces on the cell during meiosis II result in recombination.
29) Map units on a linkage map cannot be relied upon to calculate physical distances on a
chromosome for which of the following reasons?
A) The frequency of crossing over varies along the length of the chromosome.
B) The relationship between recombination frequency and map units is different in every
individual.
C) Physical distances between genes change during the course of the cell cycle.
D) The gene order on the chromosomes is slightly different in every individual.
30) Use the following map of four genes on a chromosome to answer the question.
Between which two genes would you expect the highest frequency of recombination?
A) A and W
B) E and G
C) A and E
D) A and G
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In a series of mapping experiments, the recombination frequencies for four different linked genes
of Drosophila were determined as shown in the figure. Based on this information, what is the
order of these genes on a chromosome map?
A) rb-cn-vg-b
B) cn-rb-b-vg
C) b-rb-cn-vg
D) vg-cn-b-rb
A plantlike organism on the planet Pandora can have three recessive genetic traits: bluish leaves,
due to an allele (a) of gene A; a feathered stem, due to an allele (b) of gene B; and hollow roots
due to an allele (c) of gene C. The three genes are linked and recombine.
A geneticist performed a testcross with an organism that had been found to be heterozygous for
the three recessive traits, and she was able to identify progeny of the following phenotypic
distribution (+ = wild type):
Phenotypes Leaves Stems Roots Number

1 a + + 14
2 a + c 0
3 a b + 32
4 a b c 440
5 + b + 0
6 + b c 16
7 + + c 28
8 + + + 470
Total 1000
Which of the following are the phenotypes of the parents in this cross?
A) 2 and 5
B) 1 and 6
C) 4 and 8
D) 3 and 7
7

1 a + + 14
2 a + c 0
3 a b + 32
4 a b c 440
5 + b + 0
6 + b c 16
7 + + c 28
8 + + + 470
Total 1000
Which of the progeny phenotypes will require recombination between genes A and B?
A) 1, 2, 5, and 6
B) 1, 3, 6, and 7
C) 2, 4, 5, and 8
D) 2, 3, 5, and 7
8

1 a + + 14
2 a + c 0
3 a b + 32
4 a b c 440
5 + b + 0
6 + b c 16
7 + + c 28
8 + + + 470
Total 1000
If recombination frequency is equal to distance in map units, what is the approximate distance
between genes A and B?
A) 3 map units
B) 6 map units
C) 15 map units
D) 30 map units
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1 a + + 14
2 a + c 0
3 a b + 32
4 a b c 440
5 + b + 0
6 + b c 16
7 + + c 28
8 + + + 470
Total 1000
What is the greatest benefit of having used a testcross for this experiment?
A) The homozygous recessive parents are obvious to the naked eye.
B) The homozygous parents are the only ones whose crossovers make a difference.
C) The phenotypes of the progeny reveal the allelic content of the gamete from the heterozygous
parent.
D) All of the progeny will be heterozygous.
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1 a + + 14
2 a + c 0
3 a b + 32
4 a b c 440
5 + b + 0
6 + b c 16
7 + + c 28
8 + + + 470
Total 1000
The greatest distance among the three genes is between a and c. What does this mean?
A) Gene c is between a and b.
B) Genes are in the order: a-b-c.
C) Gene a is not recombining with c.
D) Gene a is between b and c.
37) Which of the following statements correctly describes the reason that closely linked genes
are typically inherited together?
A) They are located close together on the same chromosome.
B) The number of genes in a cell is greater than the number of chromosomes.
C) Alleles are paired together during meiosis.
D) Genes align that way during metaphase I of meiosis.
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38) A homozygous tomato plant with red fruit and yellow flowers was crossed with a
homozygous tomato plant with golden fruit and white flowers. The F1 all had red fruit and
yellow flowers. The F1 were testcrossed by crossing them to homozygous recessive individuals,
and the following offspring were obtained:
Red fruit and yellow flowers—41

Red fruit and white flowers—7
Golden fruit and yellow flowers—8
Golden fruit and white flowers—44
How many map units separate these genes?

A) 17.6
B) 15
C) 17.1
D) 18.1
39) In Drosophila melanogaster, vestigial wings are determined by a recessive allele of a gene
that is linked to a gene with a recessive allele that determines black body color. T. H. Morgan
crossed black-bodied, normal-winged females and gray-bodied, vestigial-winged males. The F1
were all gray bodied, normal winged. The F1 females were crossed to homozygous recessive
males to produce testcross progeny. Morgan calculated the map distance to be 17 map units.
Which of the following information is correct about the testcross progeny?
A) black-bodied, normal-winged flies = 17% of the total
B) black-bodied, normal-winged flies plus gray-bodied, vestigial-winged flies = 17% of the total
C) gray-bodied, normal-winged flies plus black-bodied, vestigial-winged flies = 17% of the total
D) black-bodied, vestigial-winged flies = 17% of the total
40) If cell X enters meiosis, and nondisjunction of one chromosome occurs in one of its daughter
cells during meiosis II, how will this affect the gametes at the completion of meiosis?
A) All the gametes descended from cell X will be diploid.
B) Half of the gametes descended from cell X will be n + 1, and half will be n - 1.
C) One-quarter of the gametes descended from cell X will be n + 1, one-quarter will be n - 1, and
half will be n.
D) Two of the four gametes descended from cell X will be haploid, and two will be diploid.
41) One possible result of chromosomal breakage is for a fragment to join a nonhomologous
chromosome. What is this type of chromosomal alteration called?
A) deletion
B) inversion
C) translocation
D) duplication
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42) Which of the following statements correctly describes what happens to a chromosome after a
nonreciprocal translocation occurs?
A) A deletion of part of the chromosome occurs.
B) A duplication of part of the chromosome occurs.
C) Nondisjunction of pairs of homologous occurs.
D) A chromosome transfers a fragment but receives none in return.
43) Of the following human aneuploidies, which is the one that generally has the most severe
impact on the health of the individual?
A) 47, trisomy 21
B) 47, XXY
C) 47, XXX
D) 45, X
44) A phenotypically normal prospective couple seeks genetic counseling because the man
knows that he has a translocation of a portion of his chromosome 4, which has been exchanged
with a portion of his chromosome 12. Although his translocation is balanced, he and his wife
want to know the probability that his sperm will be abnormal. What is your prognosis regarding
his sperm?
A) One-quarter will carry the two normal chromosomes, 4 and 12, one-quarter will have only the
two translocation chromosomes and no normal chromosomes 4 and 12, and half will have one
normal and one translocated chromosome.
B) All will carry the same translocation as the father.
C) None will carry the translocation.
D) Half will be normal, and the rest will have the father's translocation.
45) Abnormal chromosomes are frequently found in malignant tumors. Errors such as
translocations may place a gene in close proximity to different control regions. Which of the
following events might then occur to make the cancer worse?
A) an increase in nondisjunction
B) expression of inappropriate gene products
C) a decrease in mitotic frequency
D) failure of the cancer cells to multiply
46) A couple has a child with Down syndrome. The mother is 39 years old at the time of delivery.
Which of the following is the most probable cause of the child's condition?
A) The woman inherited this tendency from her parents.
B) The mother had a chromosomal duplication.
C) One member of the couple underwent nondisjunction in somatic cell production.
D) One of the gametes in the mother most likely underwent nondisjunction during meiosis.
47) What is a syndrome?

A) a characteristic facial appearance
B) a trait that leads to cancer at some stage in life
C) a group of traits typically found in conjunction with a particular chromosomal aberration or
gene mutation
D) a specific characteristic that appears in conjunction with one specific aneuploidy
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48) Which of the following correctly describes a Philadelphia chromosome?
A) a human chromosome 22 that has had a specific translocation
B) a human chromosome 9 that is found only in one type of cancer
C) an animal chromosome found primarily in the mid-Atlantic area of the United States
D) a chromosome found only in mitochondria
49) Which of the following statements is generally true of aneuploidies in newborns?

A) A monosomy is more frequent than a trisomy.
B) Monosomy X is the only viable monosomy known to occur in humans.
C) Human aneuploidy usually conveys an adaptive advantage in humans.
D) An aneuploidy resulting in the deletion of a chromosome segment is less serious than a
duplication.
50) A woman is found to have 47 chromosomes, including three X chromosomes. Which of the
following statements describes her expected phenotype?
A) a female with masculine characteristics such as facial hair
B) an apparent male who is sterile
C) healthy female of slightly above-average height
D) a sterile female
51) Which of the following is an example of monosomy in humans?

A) Turner syndrome
B) Klinefelter syndrome
C) Down syndrome
D) trisomy X
52) Genomic imprinting is generally due to the addition of methyl (-CH3) groups to C
nucleotides and chemical histone changes to silence a given gene. If this depends on the sex of
the parent who transmits the gene, which of the following statements must be true?
A) Genes required for early development stages must not be imprinted.
B) Methylation of this kind must occur more in males than in females.
C) Methylation must be reversible in ovarian and testicular cells.
D) The imprints are transmitted only to gamete-producing cells.
53) German scientist Carl Correns found that the inheritance of variegated color on the leaves of
certain plants was determined only by the maternal parent. What phenomenon explains this
pattern of inheritance?
A) ribosome structure
B) inheritance of plastid genes
C) genomic imprinting
D) sex linkage
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54) Mitochondrial DNA is primarily involved in coding for proteins needed for protein
complexes of the electron transport chain and ATP synthase. Therefore, mutations in
mitochondrial genes would most affect which of the following processes?
A) DNA synthesis in cells of the immune system
B) the movement of oxygen into erythrocytes
C) generation of ATP in muscle cells
D) the storage of urine in the urinary bladde
r
55) Use the following figure to answer the question.
The pedigree in the figure shows the transmission of a trait in a particular family. Based on this
pattern of transmission, the trait is most likely ________.
A) mitochondrial
B) sex-linked dominant
C) sex-linked recessive
D) autosomal dominant
56) A certain kind of snail can have a right-handed direction of shell coiling (DD or Dd) or left-
handed coiling (dd). However, if direction of coiling is due to a protein deposited by the mother
in the egg cytoplasm, then a Dd egg-producing snail and a dd sperm-producing snail will have
offspring of which genotype(s) and phenotype(s)?
A) 1/2 Dd:1/2 dd; all right-coiling
B) all Dd; all right-coiling
C) 1/2 Dd: 1/2 dd; half right-coiling and half left-coiling
D) all Dd; half right-coiling and half left-coiling
57) During meiosis, a defect occurs in a cell that results in the failure of spindle microtubules
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binding at the kinetochores. Which of the following statements describes the most likely result of
such a defect?
A) New microtubules with more effective binding capabilities to kinetochores will be
synthesized to compensate for the defect.
B) Excessive cell divisions will occur resulting in cancerous tumors and an increase in the
chromosome numbers known as polyploidy.
C) The defect will be bypassed in order to ensure normal chromosome distribution in the new
cells.
D) The resulting cells will not receive the correct number of chromosomes in the gametes, a
condition known as aneuploidy.
58) Inheritance patterns cannot always be explained by Mendel's models of inheritance. If a pair
of homologous chromosomes fails to separate during meiosis I, select the choice that shows the
chromosome number of the four resulting gametes with respect to the normal haploid number
(n)?
A) n + 1; n + 1; n - 1; n - 1
B) n + 1; n - 1; n; n
C) n + 1; n - 1; n - 1; n - 1
D) n + 1; n + 1; n; n
19.20.
題目無敘述媽媽是否得病,由答案推媽媽是無得病,這兩題要記
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Campbell Biology, 11e

Chapter 15 The Chromosomal Basis of Inheritance

15.1 Multiple-Choice Questions

4) The SRY gene is best described as ________.

記19) Glucose-6-phosphate dehydrogenase deficiency (G6PD) is inherited as an X-linked

記20) Glucose-6-phosphate dehydrogenase deficiency (G6PD) is inherited as an X-linked

22) Use the following information to answer the question.

23) Which of the following statements regarding gene linkage is correct?

28) What is an adaptive advantage of recombination between linked genes?

32) Use the following information to answer the question.

Phenotypes Leaves Stems Roots Number

Phenotypes Leaves Stems Roots Number

Phenotypes Leaves Stems Roots Number

Phenotypes Leaves Stems Roots Number

Phenotypes Leaves Stems Roots Number

Red fruit and yellow flowers—41

How many map units separate these genes?

47) What is a syndrome?

49) Which of the following statements is generally true of aneuploidies in newborns?

51) Which of the following is an example of monosomy in humans?

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