For the use of a Registered Medical Practitioner or a Hospital or a Laboratory Only.

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RABIES VACCINE B.P 'Rab/Vac' 1 dose for Human Use TO
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Purified Vero Cell Rabies Vaccine RANGE

Abhayrab
Purified Inactivated Rabies Vaccine prepared on Vero cells. For the prophylactic or ADMINISTRATION
post exposure immunization. Prepared using L.Pasteur 2061/Vero Rabies strain. Reconstitute the freeze-dried vaccine with the diluent supplied along with the vaccine.
Clinical studies with Abhayrab shows neutralizing antibody responses both after primary Administer the reconstituted vaccine (entire quantity of the vial) by deep intramuscular
and secondary immunizations. route in the deltoid region or by subcutaneous route. The reconstituted vaccine is to
be used immediately and shall not be stored for administration later.
COMPOSITION PER SINGLE DOSE
Freeze-dried Vaccine : 1 immunizing dose contains the protective activity of equal to INCOMPATIBILITIES
or greater than 2.5 International Units (IU) even after exposure at 37oC for one month. None

Rabies Virus (L.Pasteur 2061/VERO) propogated on Vero cell line inactivated with CONTRAINDICATIONS
beta-propiolactone. Thiomersol @ 0.01% added as preservative. Post-exposure immunization
As Rabies is a dreaded disease; no contraindications are to be considered in case of
Maltos : q.s. per immunizing dose. post-bite therapy.
Human Serum Albumin : q.s. per immunizing dose. Pre-exposure immunization
In case of pregnancy or acute febrile illness, the vaccination should be postponed.
The antibiotics Neomycin, Kanamycin and Polymixin B sulphate used in the cell and
virus cultures are eliminated to the greatest extent during purification procedures and SPECIAL CONDITIONS
cannot be detected in the final vaccine. Use In Pregnancy
Pregnancy Category C. Animal reproductive studies have not been conducted with
INDICATIONS Abhayrab. It is also not known whether Abhayrab can cause fetal abnormalities when
administered to a pregnant women or can affect reproduction capacity. Abhayrab should
- For active immunization against Rabies both for prophylaxis and post-bite therapy
be given to a pregnant women only If clearly needed.
in all age groups of humans
Use In Lactation: - As Rabies is always fatal in humans, there are no contraindications.
- For immunizing against Rabies after exposure (after contact with a rabid or It can be used in lactation in case of suspected rabid contamination.
suspected rabid animal). See Table-1 for W.H.O. recommendations Use In Children's: - As Rabies is always fatal, there is no age limitation. It can be used
- For prophylactic immunization of all high risk group of persons such as in all ages of children's in case of suspected rabid contamination.
Veterinarians, Municipal workers, Medical and Paramedical personnel, Forest
and Zoo personnel, Hunters, Laboratory personnel working with suspected CAUTIONS
Rabies materials and Pet owners. 1. Concurrent use of immunosuppressive agents like corticosteroids shall be avoided
as it may hamper in the development of protective antibodies.
DOSAGE 2. In case of severe bites and at the site of injuries, nearer to head local infiltration of
Prophylaxis: Three immunizing doses on 0, 7 and 21 or 28 days followed by annual the wounds with antirabies immunoglobulins is recommended.
booster. Post-Exposure: One immunizing dose on post exposure days 0, 3, 7, 14, 28 3. Delay in the commencement of post-bite therapy, incomplete and irregular therapy
and 90 each. can cause failure of protection.
Continued
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RANGE

STORAGE
Table 1 Guide for post exposure treatment (W.H.0. Recommendations)
To be stored at temperatures between +2OC to +8OC. Do not freeze.
Category Type of contact with the Course of action to be followed
PRESENTATION
suspected or confirmed
Box of 1 dose vial along with Diluent Ampoule (0.5 ml), Sterile disposable syringe with
rabid animal
needle and vaccination card.
I Touching or feeding of animal, None, if reliable case history
Rabies Antiserum I.P
licks on intact skin available
AbhayRIG
II Nibbling of uncovered skin, Administer vaccine immediately.
minor scratches or abrasion Stop the treatment if the
without bleeding, licks on animal remains healthy for
broken skin a period of 10 days or
has been killed humanely
and found to be negative for
Rabies by appropriate laboratory
techniques.

III Single or Multiple transdermal Administer rabies

bites or scratches with saliva immunoglobulins and
(i.e.licks) vaccine immediately.
Stop treatment if the animal
remains healthy throughout the
observation period of 10 days or
if animal is killed humanely and
found to be negative for rabies by
appropriate laboratory
techniques.

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