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    FORMULATION AND EVALUATION OF PHENYTOIN SODIUM FAST DISSOLVING TABLETS BY DIRECT COMPRESSION METHOD USING VARIOUS CONCENTRATIONS OF SUPERDISINTEGRANTS

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    Kumar 0 List of Tables DDDD

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    Vamsi Sakhamuri
    42 views4 pages
    FORMULATION AND EVALUATION OF PHENYTOIN SODIUM FAST DISSOLVING TABLETS BY DIRECT COMPRESSION METHOD USING VARIOUS CONCENTRATIONS OF SUPERDISINTEGRANTS

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    Kumar 0 List of Tables Dddd

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    FORMULATION AND EVALUATION OF PHENYTOIN SODIUM FAST DISSOLVING TABLETS BY DIRECT COMPRESSION METHOD USING VARIOUS CONCENTRATIONS OF SUPERDISINTEGRANTS

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    42 views4 pages

    Kumar 0 List of Tables DDDD

    Uploaded by

    Vamsi Sakhamuri
    FORMULATION AND EVALUATION OF PHENYTOIN SODIUM FAST DISSOLVING TABLETS BY DIRECT COMPRESSION METHOD USING VARIOUS CONCENTRATIONS OF SUPERDISINTEGRANTS

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 4

    TABLE OF CONTENTS

    Chapter

    Title

    Page
    No.

    INTRODUCTION

    II

    AIM, OBJECTIVE & PLAN OF


    WORK

    35

    III

    LITERATURE REVIEW

    37

    IV

    DRUG PROFILE

    40

    EXCIPIENTS PROFILE

    44

    VI

    MATERIALS AND METHODS

    48

    VII

    RESULTS& DISCUSSION

    56

    VIII

    SUMMARY& CONCLUSION

    65

    IX

    FUTURE WORK PROPOSED

    66

    BIBLIOGRAPHY

    67

    LIST OF TABLES
    TABLE NO.
    1

    TITLE OF THE TABLE


    Excipientsand their uses in the manufacture of ODT using Freeze

    PAGENO.
    6

    2
    3

    drying technique
    Various pre-blend compositions and drugs used in floss process
    List Of Suitable Drug Candidates For MDT

    10
    20

    Comparison of Conventional Solid Dosage Forms and ODTs

    21

    List of Patented Technologies Based Branded Products

    21

    ODTS UNDER DEVELOPMENT

    22

    List of Superdisintegrants

    25

    weight variation tolerances for uncoated tablets

    26

    Materials used

    48

    10
    11
    12

    Equipments used
    CalibrationdataofPhenytoin Sodium
    Formulae for ODT
    Pre-Compression Parameters

    48
    56
    57

    Results of general appearance evaluation


    Post-Compression Parameters For The Formulations
    In-vitro Dissolution studies
    Comparison of dissolution profile of formulation F5 with Dilantin

    58
    59
    61
    64

    13
    14
    15
    16
    17

    58

    LIST OF FIGURES
    FIGURENO.

    TITLE OF FIGURE

    PAGENO.

    1
    2

    Steps involved in sublimation


    Disintegration of tablet by wicking and swelling

    9
    23

    Disintegration of tablet by deformation and repulsion

    24

    4
    5
    6

    Measurement of wetting time and water absorption ratio of a tablet.


    Structure for Phenytoin Sodium
    UVSpectrumof Phenytoin Sodium(max)
    Calibrationcurve for Phenytoin Sodium using Phosphate Buffer pH

    28
    40
    56

    57

    8
    9
    10

    6.8
    Wetting Time Chart
    Disintegration Time Chart
    Comparative Zero Order Plots For Formulations F1-F9

    11

    Comparative First Order Plots For Formulations F1-F9

    62

    12

    Comparative Higuchi Plots For Formulations F1-F9

    63

    13

    Comparative Korsmeyer Peppas Plots For Formulations F1-F9

    63

    14

    ComparativeIn-vitro Dissolution Profiles of F5, Dilantin

    64

    61
    62
    62

    LIST OF ABBREVATIONS
    %
    % CDR

    : Percentage
    : Percentage cumulative drug release

    :
    :
    :
    :
    :
    :
    :
    :
    :
    :
    :
    :
    :
    :
    :
    :
    :
    :

    C
    CCS
    CRP
    DT
    ODT
    FTIR
    GI
    Gm
    H
    IR
    Lit
    Mg
    Mcg
    MCC
    Meq
    Min
    Ml
    N
    RDT
    RPM
    SD
    Sec
    SSG
    UV
    USP
    WHO
    Wt
    W/W
    W/V

    :
    :
    :
    :
    :
    :
    :
    :
    :

    Degree Celsius/ Degree Centrigrade


    Cross carmellose sodium
    Cross povidone
    Disintegration time
    Oral disintegrating tablets
    Fourier Transformer Infra Red
    Gastro intestinal
    Gram
    Hour
    Infra red
    Litre
    Milligram
    Microgram
    Micro crystalline cellulose
    Milliequivalent
    Minutes
    Milliter
    Normality
    Rapid dissolving tablets
    Revolution per minute
    Standard deviation
    second
    Sodium starch glycolate
    Ultra violet
    United states pharmacopoeia
    World health organisation
    Weight
    Weight by weight
    Weight by volume

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