WHO The Management and Prevention of Diarrhoea
WHO The Management and Prevention of Diarrhoea
WHO The Management and Prevention of Diarrhoea
and prevention of
diarrhoea
Practical guidelines
Third edition
ed.
3.Diarrhea-prevention
The World Health Organization welcomes requests for permission to reproduce or translate its publications, in part or in full. Applications and enquiries should be addressed to the Office of Publications.
World Health Organization, 1211 Geneva 27, Switzerland, which will be giad to provide the latest
information on any changes made to the text, plans for new editions, and reprints and translations already
available.
Contents
Foreword
5
5
6
8
9
9
9
10
11
12
16
16
16
17
22
22
M A N A G E M E N T A N D PREVENTION O F DIARRHOEA
26
26
27
27
27
28
28
30
31
Annexes
1 . Diarrhoea management chart
32
38
39
40
42
45
50
Foreword
This book is intended for health workers who are concerned with the management and
prevention of diarrhoea, and for their supervisors and trainers. It is a revised and
updated version of The treatment and prevention of acute diarrhoea. Practical
guidelines (second edition, Geneva, World Health Organization, 1989). The guidelines
are based on the chart Management of the patient with diarrhoea (segments of which
are reproduced in Annex l ) , and form the technical basis of the module entitled
Management of the patient with diarrhoea (1992) in the Supervisory skills training
course of the WHO Programme for Control of Diarrhoeal Diseases.'
The book is divided into eight sections. Each of the first seven sections is followed by a
list of points of essential skills and knowledge required by health workers for the
management and prevention of acute diarrhoea. All 17 points of essential skills and
knowledge are summarized in Annex 7. The segments of the chart Management of the
patient with diarrhoea given in Annex 1 summarize the approach to management of
diarrhoea explained in this book (and are referred to collectively as the "diarrhoea
management chart" throughout the remainder of the book). The chart may be
adapted to local conditions and should be available to health workers for reference at
all times.
Although this book refers mainly to diarrhoea in children, its recommendations apply
equally to adults.
Supervisory skills training course and the separate module Management of the patient with
diarrhoea are ava~lableon request from the Programme for Control of Diarrhoeal Diseases, World Health
Organization, 121 1 Geneva 27, Switzerland.
SECTION 1
What is diarrhoea?
The number of stools normally passed in a day varies with an individual's diet and age.
When there is diarrhoea, stools contain more water than usual-they are often called
loose or watery stools. They may also contain visible blood, in which case the illness is
called dysentery.
Mothers usually know when their children have diarrhoea. When diarrhoea occurs,
mothers may say that the stools smell strong or pass noisily, as well as being loose and
watery. Talking to mothers often reveals one or more useful local definitions of
diarrhoea. For practical purposes, diarrhoea is defined as three or more loose or
watery stools in a day (24 hours).
Diarrhoea is most common in children, especially those between 6 months and 2 years
of age. It is also common in babies under the age of 6 months who are drinking cow's
milk or infant feeding formulas.
Frequent passing of normal stools is not diarrhoea
Babies who are taking only breast milk commonly have frequent soft stools; this is not
diarrhoea.
To prevent malnutrition, children with diarrhoea should be given food as soon as they
will eat, and should be given extra food after diarrhoea stops.
7
\
Child improves
Diarrhoea
starts
Prevention of dehydration
Dehydration can usually be prevented in the home if the child drinks extra fluids as
soon as the diarrhoea starts. A child should be given one of the fluids recommended
locally for home treatment of diarrhoea. These include: oral rehydration salts (ORS)
solution, food-based fluids (such as soup, rice water, and yoghurt drinks), and plain
water. If possible, food-based fluids should contain a small amount of salt. ORS
solution can be used for both prevention and treatment of dehydration, and should
also be given in the circumstances described in Treatment Plan A (see Annex 1,
Diarrhoea management chart). If the child is under 6 months old and is not yet taking
solid food, ORS solution or water should be given rather than a food-based fluid.
Treatment of dehydration
If dehydration occurs, the child should be taken to a community health worker or
health centre for treatment. The best treatment for dehydration is oral therapy with a
solution made with ORS. ORS solution can be used alone to rehydrate 95% or more of
patients with dehydration. Patients with severe dehydration require rehydration with
intravenous (IV) fluids at first, but should be given ORS solution in addition to IV fluids
as soon as they can drink. ORS solution should be used alone when the signs of severe
dehydration are gone.
Feeding
Feeding during diarrhoea provides nutrients the child needs to grow and be strong,
and prevents weight loss. Fluids given to prevent or treat dehydration, such as the
recommended home fluid or ORS solution, do not provide the required nutrients;
frequent feeding with adequate amounts of nutritious food is essential.
Breast-fed children should be offered the breast frequently. Other children should
receive their usual milk. Children of 6 months or older (or infants who are already
taking solid food) should frequently be offered small amounts of nutritious, easily
digestible food. After the diarrhoea has stopped, an extra meal should be given each
day for 2 weeks to help children regain weight lost during the illness.
Other treatments
There are no drugs available at present that will safely and effectively help to stop
diarrhoea.
Antibiotics are not effective against most organisms that cause diarrhoea. They rarely
help and can make some people sicker in the long term. Their indiscriminate use
increases the resistance to antibiotics of many disease-causing organisms. In addition,
antibiotics are costly, so money is wasted. Antibiotics should therefore not be used
routinely. Their appropriate use for dysentery and cholera is described in Section 6 and
in Annex 6.
Antidiarrhoeal drugs and antiemetics should never be given to children and infants.
These include adsorbents (such as kaolin, attapulgite, and activated charcoal),
antimotility drugs (such as codeine, tincture of opium, diphenoxylate, and loperamide),
and drugs to treat vomiting (such as chlorpromazine and promethazine). None has
proven value in treating diarrhoea and some can be dangerous. Some of these drugs
can cause paralysis of the gut or make children abnormally sleepy, and some can be
fatal, especially in infants, if used improperly.
SECTION 2
high-fibre or bulky foods, such as coarse fruits and vegetables, fruit and vegetable
peels, and whole grain cereals-these are hard to digest
foods and drinks with a lot of sugar-these foods can make diarrhoea worse.
fever
blood in the stool.
SECTION 3
Are the child's eyes normal, sunken, or very sunken and dry?
Does the child have tears when he or she cries?
e Are the child's mouth and tongue wet, dry, or very dry?
When offered a drink, does the child:
- drink normally or seem not thirsty?
- drink eagerly and seem thirsty?
- drink poorly or seem unable to drink?
Feel for the following
When the skin of the abdomen is pinched, does it go back quickly, slowly, or very
slowly (longer than 2 seconds)?
Select the approprlate treatment plan based on the degree of dehydration. These
treatment plans are described on the diarrhoea management chart (Annex 1).
An example of how a health worker has selected the appropr~atetreatment plan for a
child Wth diarrhoea is given On page 12.
Example of assessment
A mother took her 4-month-old son, Tomi, to a health worker because he had
diarrhoea for several days and was not getting better. The health worker looked and
felt for signs of dehydration. The health worker's findings are circled on the table
Assess your patient for dehydration below.
Tomi had no signs in Column C, so he was not severely dehydrated. Two signs are
circled in Column B, sunken eyes and thirsty. Since these two signs included one key
sign, the health worker concluded that Tomi had some dehydration and needed
Treatment Plan B.
1. LOOK AT
CONDITION
EYES
Restless, irritable
Absent
Absent
2. FEEL.
Lethargic or unconscious;
floppy*
Very sunken and dry
Normal
TEARS
THIRST
Very dry
Drlnks normally,
not thlrsty
SKIN PINCH
3. DECIDE
4. TREAT
SECTION 4
In addition to assessing for dehydration, the health worker should ask about and look
for signs of other problems, such as dysentery or severe malnutrition. The section of
the diarrhoea management chart entitled Then, for otherproblems, shown on page 14
and in Annex 1, shows what to ask about and look for, and how to treat or refer any
problems discovered.
Ask about the following:
Blood in the stool. This will tell you whether the patient has dysentery, which requires
treatment with an antibiotic as described in Annex 6.
Duration of diarrhoea. If the patient's diarrhoea has lasted for 14 days or more, it is
persistent diarrhoea and should be treated as shown on the chart.
Look for the following:
Signs of severe malnutrition. If a child appears very wasted, like "skin and bones", he
or she has severe marasmus. If there is generalized swelling of the body and thin,
sparse hair, the child has kwashiorkor. Children with either of these types of severe
malnutrition should be referred for nutritional management.
Generally, you will be able to tell whether a child is severely malnourished just by
looking for the above signs. However, if you are unsure, you can also measure the
circumference of the child's upper arm to determine the degree of malnutrition, as
described in Annex 3.
Ask about fever and take temperature:
Ask the mother whether the child has had a fever (felt abnormally hot) at any time in
the past 5 days. If fever is present, it is important to know the age of the child. If the child
is under 2 months of age, the treatment of fever is different from that for a child of 2
months or more (see the diarrhoea management chart).
IF BLOOD IS PRESENT:
Treat for 5 days with an oral antibiotic recommended for
Shigella in your area.
Teach the mother to feed the child as described in Plan A.
See the child again after 2 days if:
under l year of age
initially dehydrated
there is still blood in the stool
not getting better
Example of assessment
A mother took her 3-year-old daughter, Rania, to a clinic because she had diarrhoea.
The clinic worker looked and felt for signs of dehydration. The clinic worker's findings
are circled on the table Assess your patient for dehydration below.
Since Rania had no signs from Column C and only one sign from Column B, the clinic
worker decided that she had no signs of dehydration. He selected Treatment Plan A to
prevent Rania from becoming dehydrated.
The clinic worker also asked about and looked for symptoms and signs of other
problems. He found that Rania had blood in her stool and that the diarrhoea had
started about 5 days earlier. Rania appeared to be well nourished. She had a slight
fever (38C).
Because Rania had blood in her stool, the clinic worker diagnosed dysentery and gave
the mother an appropriate antibiotic for the child. (This was trimethoprim-sulfamethoxazole, to which most shigellae in the area were known to be sensitive.) Since
there was no known malaria in the area, Rania was not given an antimalarial for her
fever. The clinic worker assumed that the fever was caused by the dysentery since no
other cause was apparent.
EYES
Sunken
TEARS
Absent
Dry
Rllraty, drlnka crgcrly
FEEL
3 DECIDE
SKIN PINCH
G m bask slowly.
II
II
Il
11
Drlnka poorly or
nol able to drlnk.
(.
~oea
back vwy .lorrfy +
algn *, me.0
1s
SEVERE
DEHYDRATION
II
Absent
Very dry
I
I
SECTION 5
Dehydration is treated with a solution of oral rehydration salts (ORS). All health
workers should know how to prepare ORS solution from water and ORS.
Ingredient
Amount
(in grams)
20
3.5
2.9
2.5
Potassium chloride
1.5
Packets generally contain these ingredients in the correct amounts for mixing with
1 litre of drinking-water.
Note: Some packets of ORS are made for smaller volumes of water; they contain
smaller amounts of the same ingredients. It is critical that the correct amount of
water is used to mix with any packet. If too little water is used, the solution will be
too strong and may be dangerous. If too much water is used, the solution will be
too dilute and may not be as effective.
When ORS packets are not available, an oral rehydration fluid can be made by
following the instructions given in Annex 4.
p
....
..-..
.. :...
....
...
..
;
.....
..:
..,..
...
1 LITE
OC
WATER
Mix fresh ORS solution each day in a clean container. Keep the container covered. The
solution can be kept and used for one day (24 hours). Throw away any solution
remaining from the day before.
Remember
All children wlth d~arrhoeawill be treated w ~ t hPlan A, Including both'
ch~ldrenwho have not developed slgns of dehydrat~on,and
ch~ldrenwho have already been treated for dehydrat~on,and have improved.
Remember that ~tIS Important to give ORS solut~onIn small amounts at a steady pace
(a teaspoonful every 1-2 mlnutes), and that, after recelvlng ORS solut~anfor 4 hours
l
sufflc~entlyto be treated accord~ngto Plan A.
(on Plan B), most children w ~ l Improve
If a c h ~ l dbeg~nsto vom~twhlle belng glven ORS solut~on,w a ~ 10
t minutes then contlnue
glvlng the solut~on,but more slowly, a teaspoon every 2-3 mlnutes. Some chlldren may
want to d r ~ n ktoo qulckly. Thls may make them vomlt.
TREATMENT PLAN A
TO TREAT DIARRHOEA AT HOME
2,
Continue to breast-teedfrequently.
If the child is not breast-fed, glve the usual mllk
If the chlld IS 6 months or older, or already taklng sol~dfood.
- Also give cereal or another starchy food m~xed,d possible, wtth pulses,
vegetables, and meat or fish Add 1 or 2 teaspoonfuls of vegetable o ~to
l each
3. TAKE THE CHILD TO THE HEALTH WORKER IF THE CHlLD OOES NOT GET
BElTER IN 3 DAYS OR DEVELOPS ANY QF THE FOLLOWING:
* Many watery stools
Eatlng or drlnktng poorly
Repeated vomltlng
* Fever
Marked th~rst
Blood ~nthe stool
Descnbe and show the amount to be gtven after each stool using a local measure.
TREATMENT PLAN B
TO TREAT DEHYDRATION
APPROXIMATE AMOUNT OF ORS SOLUTION TO GlVE IN THE FIRST 4 HOURS:
Use the patient's age only when you do not know the weight. The approximate amount of ORS required
(In ml) can also be calculated by multiplying the patient's weight (in kg) times 75.
OBSERVE THE CHILD CAREFULLY AND HELP THE MOTHER GlVE ORS SOLUTION:
Show her how much solution to give her child.
Show her how to give it - a teaspoonful every 1-2 minutes for a child under 2 years,
frequent sips from a cup for an older child.
Check from time to time to see if there are problems.
If the child vomits, wait 10 minutes and then continue giving ORS, but more slowly,
for example, a spoonful every 2-3 minutes.
If the child's eyelids become puffy, stop ORS and give plain water or breast milk.
Give ORS according to Plan A when the puffiness is gone.
AFTER 4 HOURS, REASSESS THE CHILD USING THE ASSESSMENT CHART. THEN
SELECT PLAN A, B, OR C TO CONTINUE TREATMENT.
If there are no signs of dehydration, shift to Plan A. When dehydration has been
corrected, the child usually passes urine and may also be tired and fall asleep.
If signs indicating some dehydration are still present, repeat Plan B, but start to
offer food, milk and juice as described in Plan A.
If signs indicating severe dehydration have appeared, shift to Plan C.
r
TREATMENT PLAN C
TO TREAT
SEVERE DEHYDRATlON QUICKLY
FOLLOW THE ARROWS. IF ANSWER IS "YES", GO ACROSS. IF "NO', G 0 DOWN
START HERE
IYES
intravenous (IV)
flulds Immedlately?
I,
First give
30 ml/kg in:
Then ghre
70 mlkg In:
1 hour
5 hours
30 minutes
2 112 hours
available nearby,
(within 30 minutes)?
use a naso-gastric
(NG) tube for
rehydration?
drink?
If possible, observe the patient at least 6 hours after rehydration to be sure the
mother can maintain hydration givlng ORS solution by mouth.
If the patient is above 2 years and there is cholera in your area, give an
appropriate oral antibiotic after the patient is alert.
SECTION 6
The section of the diarrhoea management chart entitled Then, for other problems,
shown on page 14 and in Annex l , describes
dysentery (that is, diarrhoea with blood in the stools)
persistent diarrhoea (that is, diarrhoea lasting for 14 days or more)
severe malnutrition
fever.
There is also a section of the chart entitled Use of drugs for children with diarrhoea.
This is shown on page 24 and in Annex 1. Drugs are very rarely needed in the treatment
of diarrhoea. However, antibiotics should be used for dysentery and for suspected
cholera with severe dehydration. A list of suitable antibiotics is given in Annex 6.
Dysentery
Presence of blood in the stools is an indication of infection with microbes that invade
the walls of the intestine; Shigella is the most common of those that cause dysentery in
children. Other microbes rarely cause dysentery; antibiotic treatment is not required
and illness usually subsides without serious complications.
If a patient has blood in the stools, it should be treated as suspected sh~gellosls.
Practical empirical therapy for dysentery involves the following antibiotic therapy.
F~rst,an ant~btot~c
to w h ~ c hmost sh~gellaeIn the area are sensltlve IS glven for 2 days If
the patlent Improves, the drug IS contrnued for 5 days If there IS no ~mprovementIn the
patlent's cond~tlon,a second ant~blotlcknown to be effectlve agalnst shlgellae IS glven
for 2 days If the patlent Improves, treatment IS continued for 5 days If there IS no
~rnprovement-or ~fat any time trophozo~tesof Entamoeba hwtolyt~cacontarnlng red
patrent should be treated emplrlcally for
blood cells are seen In the faeces-the
amoeb~as~s
E hwtolyt~caIS a very rare cause of dysentery In chlldren The cllnlcal presentat~onof
amoeblasls IS slow onset of diarrhoea, whlch IS In marked contrast to the abrupt or
acute onset of shlgella dysentery Early treatment of sh~gelloslswlth appropriate
antlblotlcs IS Important to decrease the seventy, duratron, and compl~cat~ons
of the
lnfectlon Routlne treatment (metron~dazole)for E h~stolyt~ca
should never be glven ~t
IS tneffectlve agalnst sh~gellae,has adverse slde-effects, and Increases the cost of
treatment Treatment for amoeb~aslsshould be glven only ~fthe patlent wlth dysentery
falls to Improve after consecutlve treatment wlth two antlblotlcs, each glven for 2 days,
or when trophozo~tesof E hwtolyt~cacontalnlng red blood cells are seen In fresh
stools
Cholera
Cholera is an important cause of acute diarrhoea in which, as for acute diarrhoea of
other origin, rehydration is the cornerstone of effective case management. However,
dehydration may be more severe in cholera than in other types of diarrhoea. An adult
with cholera may lose 15 litres of fluid in a 24-hour period, and a child with severe
cholera may die from dehydration within a few hours of the onset of diarrhoea.
Rehydration with ORS solution for patients with some dehydration and with intravenous fluids for patients with severe dehydration is therefore life-saving.
Whereas acute diarrhoea is normally more prevalent in young children, cholera
outbreaks affect adults as well. The use of suitable antibiotics in severe cases of
cholera will shorten the duration of disease and thus reduce the period during which
patients may spread cholera to others.
USE OF DRUGS
FOR CHILDREN WITH DIARRHOEA
ANTIBIOTICS should ONLY be used for dysentery and for suspected cholera cases
with severe dehydration. Otherwise, they are ineffective and should NOT be given.
ANTIPARASITIC drugs should ONLY be used for:
Amoebiasis, after antibiotic treatment of bloody diarrhoea for Shigella has failed or
trophozoites of E. histolytica containing red blood cells are seen in the faeces.
- Giardiasis, when diarrhoea has lasted at least 14 days and cysts or trophozoites of
Giardia are seen in faeces or small bowel fluid.
SECTION 7
Prevention of diarrhoea
An important part of the health worker's job is to help prevent diarrhoea by convincing
and helping community members to adopt and maintain certain preventive practices.
These preventive practices are:
breast-feeding
improved weaning
use of plenty of water for hygiene and clean water for drinking
hand-washing
use of latrines
proper disposal of the stools of young children
immunization against measles.
The health worker can teach, encourage, and set a good example to influence
community members to adopt these preventive practices.
Some simple facts that people in the community should know about each preventive
practice are presented on the following pages.
Breast-feeding
Mothers should give only breast milk to their babies for the first 4-6 months and
then continue breast-feeding up to 2 years of age or beyond, while giving other
foods.
A new mother should be taught how to hold the baby for breast-feeding and how to
place the breast in the baby's mouth. This is best done by a female health worker or
another woman who has successfully breast-fed her own children.
To breast-feed most effectively, mothers should:
- start breast-feeding as soon as possible after the baby is born
- breast-feed on demand (increased sucking increases milk supply)
- express milk manually to avoid engorgement of the breasts during periods of
separation from the baby
- not give their babies other fluids, such as water, sugar water, or milk formula,
during the first 4-6 months of life; however, if the baby develops diarrhoea, extra
fluids should be given as described on page 6.
If the mother works outside the home and it is not possible for her to take the baby
with her, she should breast-feed before leaving home, on returning at night, and at
any other time when she is with the baby.
A mother should continue breast-feeding when her baby is ill, and after the illness.
This is especially important if the baby has diarrhoea.
Use of plenty of water for hygiene and clean water for drinking
Use the most readrly available water for personal and domestic hygiene,
Water for drtnklng should be collected from the cleanest avarlabie source,
Water sources should be protected by: keeprng anrrnals away; tocatrng latrines more
than 10 metres away from the source, and downhtl!; and d~gglngdrarnage drfchea
uphill from the source to channel, storm-water away.
PREVENTION OF DIARRHOEA
Use of latrines
a
a
a
All families should have a clean and functioning latrine. The latrine should be used
by all family members who are old enough to use it.
The latrine should be kept clean by regular washing of dirty surfaces.
If there is no latrine, family members should:
- defecate at a distance from the house, paths, or areas where children play, and
at least 10 metres from the water supply
- avoid going barefoot to defecate
- not allow a child to visit the defecation area alone.
The stool of a young child or baby should be collected quickly, wrapped in a leaf or
newspaper, and buried or put into the latrine.
PREVENTION OF DIARRHOEA
The rules for home treatment of diarrhoea given on pages 6-8 are also useful when
teaching about prevention.
4. Support breast-feeding
A health worker who attends the birth of a baby can help the mother begin breastfeeding by doing the things listed below. Health workers can also encourage traditional birth attendants or family members attending a birth to do these things.
Give the infant to the mother to begin breast-feeding immediately, or as soon as
possible, after delivery.
Let the mother and infant stay in the same room or bring the infant to breast-feed
when hungry.
Do not give feeds other than breast milk to a newborn baby.
Show the mother the best way to breast-feed, and how to avoid problems with
breast-feeding.
Health workers can encourage breast-feeding mothers to form a breast-feeding
support group who meet together to discuss any problems they may be having.
improvements to water sources if health workers can tell them exactly what should be
done.
Build a fence or wall around the water source to keep animals away.
Dig drainage ditches uphill from an open well to prevent storm-water from flowing
into it.
Do not allow washing in the water source.
Do not allow children to play in or around the water source.
Do not locate latrines uphill from, or within 10 metres of, the water source.
Install a simple pulley device and bucket to make it easier to raise water from a well.
SECTION 8
The most important aspects of managing a patient with diarrhoea are preventing or
treating dehydration and maintaining good nutrition.
Antidiarrhoeal drugs should never be used; antibiotics should be given only for
dysentery and for suspected cholera with severe dehydration in children over 2
years of age.
Health workers should teach family members how to treat diarrhoea. The three rules
for home treatment of diarrhoea are as follows:
The health worker should be able to describe what families can do to prevent
diarrhoea, including breast-feeding, improved weaning practices, use of plenty of
clean water for hygiene and clean water for drinking, use of latrines, proper disposal
of the stools of young children, and immunization against measles.
Some things that health workers can do to support preventive practices include:
use good educational techniques
set a good example
- participate in community projects to improve preventive practices
- support breast-feeding
- build and maintain a latrine at the health facility
- tell community members where the clean water sources are and how to improve
water sources.
-
ANNEX 1
The next six pages contain segments of the WHO chart, Management of the patient
with diarrhoea (1992). This is a poster-sized chart for hanging on the wall. It is available
on request from the Programme for Control of Diarrhoea1 Diseases, World Health
Organization, 1211 Geneva 27, Switzerland, and from WHO Regional Offices.
CONDITION
Restless. Initabla
EYES
Sunken
TEARS
THIRST
FEEL
3 DECIDE
4. TREAT
SKIN PINCH
Dr~nksnormally,
.
I.
Lnhargk
fk4PPY.
or uneonulous;
II
Absent
Absent
II
'.
~ Y-ly
Goes b . ~ kV
ANNEX l
IF BLOOD IS PRESENT
Treat for 5 days with an oral antibiotic recommended for
Shlgella in your area.
Teach the mother to feed the child as described in Plan A.
See the child again after 2 days if:
- under l year of age
- initially dehydrated
- there is still blood in the stool
- not getting better
If the stool is still bloody after 2 days, change to a second
oral antibiotic recommended for Shigella in your area.
Give it for 5 days.
TREATMENT PLAN A
TO TREAT DIARRHOEA AT HOME
U S E THIS P L A N TO T E A C H T H E MOTHER TO-:
Continue to treat at home her child's current episode of diarrhoea.
Glve early treatment for future episodes of diarrhoea.
Age
50-100 ml
500 mllday
2 up to l0 years
100-200ml
1000 mllday
10 years or more
As much as wanted
2000 mllday
Describe and show the amount to be given after each stool using a local measure.
ANNEX l
TREATMENT PLAN B
TO TREAT DEHYDRATION
APPROXIMATE AMOUNT OF ORS SOLUTION TO GIVE IN THE FIRST 4 HOURS:
Use the patient'sage only when you do not know the weight. The approximate amount of ORS required
(in ml) can also be calculated by multiplyingthe patient's weight (in kg) times 75.
AfTER 4 HOURS, REASSESS THE CHILD USING THE ASSESSMENT CHART. THEN
SELECT PLAN A, B, OR C TO CONTINUE TREATMENT.
If there are no signs of dehydration, shift to Plan A. When dehydration has been
corrected, the child usually passes urine and may also be tired and fall asleep.
If signs indicating some dehydration are still present, repeat Plan B, but start to
offer food, milk and juice as described in Plan A.
If signs indicating severe dehydration have appeared, shift to Plan C.
TREATMENT PLAN C
TO TREAT
SEVERE DEHYDRATlON QUICKLY
FOLLOW THE ARROWS. IF ANSWER IS "YES", G 0 ACROSS. IF "NO", GO DOWN
START HERE
W=
I)
intravenous (iV)
Age
Infants
(under 12 months)
Older
First give
30 mVkg in:
1 hour
30 minutes '
Then give
70 mlkg in:
S hours
2 112 hours
eESI,
available nearby,
(within 30 minutes)?
use a naso-gastric
(NG) tube for
rehydration?
drink?
NG treatment
If possible, observe the patient at least 6 hours after rehydration to be sure the
mother can mainta~nhydration giving ORS solution by mouth.
If the patient is above 2 years and there is cholera in your area, give an
appropriate oral antibiotic after the patient is alert.
ANNEX l
USE OF DRUGS
FOR CHILDREN WITH DIARRHOEA
ANTIBIOTICS should ONLY be used for dysentery and for suspected cholera cases
with severe dehydration. Otherwise, they are ineffective and should NOT be given.
ANTIPARASITIC drugs should ONLY be used for:
Amoebiasis, after antibiotic treatment of bloody diarrhoea for Shigella has failed or
trophozoites of E. histolytica containing red blood cells are seen in the faeces.
Giardiasis, when diarrhoea has lasted at least 14 days and cysts or trophozoites of
Giardia are seen in faeces or small bowel fluid.
ANNEX 3
H o w to determine whether
a child is malnourished by using
arm circumference
The upper arm has a bone, muscles, and fat. When babies are about 1 year old, they
have quite a lot of fat under the skin of their arms. When they are 5 years old, there is
much less fat and more muscle. The distance around the upper arm remains almost
the same between the ages of 1 and 5 years. If a child is malnourished, this distance is
reduced, and the arm becomes thin. This is due to reduction in muscle and fat. By
placing a special measuring strip around the upper arm you can find out whether a
child between the ages of 1 and 5 years is malnourished or not.
This measuring strip is called a tri-coloured arm strip and looks like this:
YELLOW
GREEN
I
You can make a measuring strip from a string or strip of material that does not stretch
Take care that the markings are accurate.
To use this strip:
Put the strip around the mid upper arm
of the child and see which colour is
touched by the 0 cm mark on the strip.
If the green part is touched, the child
is well nourished.
If the yellow part is touched, the child
is moderately malnourished.
If the red part is touched, the child is
severely malnourished.
This method of measuring the arm is
useful because the health worker can
identify malnutrition in a child without
using a scale or knowing the child's age.
However, since it only shows large
changes in a child's nutrition, it is not
suitable for determining whether the
child is improving or becoming worse.
ANNEX 4
The health worker should understand the routine procedures for ordering ORS
packets and the procedure for obtaining emergency supplies quickly.
If ORS packets are not available and it is necessary to prepare and dispense large
quantities of an oral rehydration fluid, ingredients can be measured in bulk and mixed
thoroughly in an appropriate volume of drinking-water. The cleanest available
drinking-water should be used. Boiled water, cooled before use, or chlorinated water is
best. However, the prepared fluid should not be kept for more than 24 hours and
should not be dispensed in quantities exceeding the 24-hour volume requirement.
The following table shows how to make an oral rehydration fluid in large quantities; the
example given is 5 litres.
Ingredients
Amount required
for 1 litre of
oral rehydration
fluid
Amount required
for 5 litres of
oral rehydration
fluid1
Notes
Water
1 litre
1 litre X 5 = 5 litres
Sodium chloride
(common salt)
3.5 g
3.5 g
Glucose
or
sucrose
(common sugar)
20 g
or
2Ogx5=lOOg
or
40 g
40 g
Trisodium citrate
dihydrate, or
sodium bicarbonate
2.9 g
or
2.5 g
2.9 g x 5 = 14.5 g
or
2.5 g X 5 = 12.5 g
Potassium chloride
1.5 g
1.5gx5=7.5 g
5 = 17.5 g
5 = 200 g
'If larger volumes of the fluid are prepared, the amount of each ingredient should be increased
proportionally.
The ingredients should be measured accurately using scales (which may be available
in a local pharmacy). This is especially important in measuring potassium chloride:
errors in potassium measurements are dangerous.
ANNEX 4
If accurate scales are not available, the fluid should be prepared without potassium
chloride. In this case, and if the child is already taking solid food, the mother should be
advised to give fruit juice or mashed banana to provide potassium.
Do not mix the salts and sugar in dry form without adding the appropriate amounts of
water when they are measured in bulk. You cannot ensure the uniformity of mixing of
dry ingredients, and this could be dangerous.
ANNEX 5
Preferred solution
Ringer's lactate solution. This is also called Hartmann's solution for injection. It is the
best commercially available solution. It supplies an adequate concentration of sodium,
and sufficient lactate, which is metabolized to bicarbonate for correction of acidosis
(a condition resulting from a relative excess of acid in the blood, primarily due to loss of
alkali in the stool). The solution can be used for patients in all age groups to treat
ANNEX 5
dehydration due to acute diarrhoea of any cause. Early provision of ORS solution and
early resumption of feeding will provide the required amounts of potassium and
glucose.
Acceptable solutions
Use of any of the following solutions should be supplemented by ORS solution given by
mouth as soon as the patient can drink. The ORS solution will provide the potassium,
bicarbonate, and sodium that may be lacking in the intravenous solutions.
Normal saline. This solution is also called isotonic or physiological saline, and is often
readily available. It will not correct acidosis and will not replace potassium losses.
Sodium bicarbonate or sodium lactate and potassium chloride can be added to the
solution, but quantities must be carefully calculated and the solutions must be sterile.
Half-strength Darrow's solution. This solution is also called lactated potassic saline. It
contains less sodium chloride than is needed for efficient correction of the sodium
deficit in severe dehydration.
Half-normal saline in 5% dextrose. Like normal saline, this solution will not correct
acidosis or replace potassium losses. It also contains less sodium chloride than is
needed for efficient correction of the sodium deficit in severe dehydration.
Unsuitable solutions
Plain glucose or dextrose solution. These solutions should not be used as they provide
only water and sugar. They do not contain electrolytes and thus do not correct the
electrolyte deficits or acidosis.
ANNEX 6
Severe
cholera2
Oral
antibiotic'
Doxycycline3
Tablet or capsule,
300 mg
Tetracycline
Tablet or capsule,
250 mg
Recommended dose
Children
Adults
Not suitable
for children
under l 2 years
12.5 mglkg
4 times a day
for 3 days
500 mg
4 times a day
for 3 days
112
tablet
Adults
Severe
cholera2
Oral
antibiotic1
Recommended dose
Children
Adults
Paediatric tablet,
TMP 20 rng and
SMX 100 rng
Syrup, TMP 40 mg
and SMX 200 rng
in 5 rnl
Trimethoprimsulfamethoxazole
(TMP-SMX)4
Adult tablet
TMP 80 rng and
SMX 400 rng
114
tablet
112
tablet
Adults
Disease
Oral
antibiotic1
Severe
cholera2
Furazolidone5
Tablet, l 0 0 mg
Dysentery7
Trimethoprirnsulfamethoxazole
(TMP-SMX)
Adult tablet,
TMP 80 mg and
SMX 400 mg
Recommended dose
Children
Adults
1.25 mglkg
4 times a day
for 3 days
l 0 0 mg
4 times a day
for 3 days
114
tablet
114
tablet
112
tablet
Paed~atrictablet,
TMP 20 mg and
SMX 100 mg
Syrup, TMP 40 mg
and SMX 200 mg
in 5 ml
Children
Adults
114
tablet
112
tablet
Oral
antibiotic'
Recommended dose
Children
~ysentery'
Nalidixic acid
Tablet, 250 mg
Ampicillin
Tablet or capsule,
250 mg
Adults
Children
Adults
34kg
69kg
10-14kg
15-19kg
20-29kg
15 mglkg
4 tlmes a day
for 5 days
lg
4 t~mesa day
for 5 days
114
tablet
112
tablet
25 mglkg
4 times a day
for 5 days
1g
4 times a day
for 5 days
112
tablet
'Antibiotics are recommended for patients older than 2 years wlth suspected cholera and severe dehydration
Doxycycline is the antimicrobial of choice for adults because only one dose is required. (See footnote 5 for treatment of pregnant women.)
4Trimethoprim sulfamethoxazole (also named CO-trimoxazole) IS the antimicrobial of c h o ~ c efor children. Tetracycline is equally effective; however, it is not
recommended for paediatric use in some countries.
Furazolidone is the antimicrobial of choice for pregnant women
6 0 t h e r choices include erythromycin and chloramphen~col
' Shigella is the most important cause of dysentery in young children. An antimicrobial to which most Shigella in the area are sensitive should be selected. If the stool is still
bloody after two days, the antimicrobial should be stopped and a different one used. In many areas, trimethoprim-sulfamethoxazole
acid is a n alternative. Resistance to ampiclllin is frequent.
IS
Oral
antimicrobial
Recommended dose
Children
Amoebic
dysentery'
Metronidazole
Tablet, 250 mg
~iardiasis'
Metronidazole
Tablet, 250 mg
Adults
10 mglkg
3 times a day
for 5 days
(10 days for
severe disease)
750 mg
3 times a day
for 5 days
(10 days for
severe disease)
5 mglkg
3 times a day
for 5 days
250 mg
3 times a day
for 5 days
Children
Adults
3-5kg
6-9kg
10-14kg
15-19kg
20-29kg
1I 4
tablet
112
tablet
1I 2
tablet
1I 4
tablet
1I 4
tablet
112
tablet
1I 2
tablet
' Amoeblasis is a n unusual cause of dysentery in young children. Metronidazole should be given only when trophozoites of Entamoeba histolytica contanlng red blood
cells are seen In the faeces or when bloody stools perslst after consecutive treatment with two antimicroblals (each given for two days) that are usually effective for
Shigeila In the area.
Treatment for g~ardiasisshould be given only when diarrhoea IS pers~stent(lasting at least 14 days) and cysts or trophozoites of Giardia are seen In faeces or small
bowel f u d Tlnidazole and ornldazole are also effect~ve.Tlnidazole is given in a single dose of 50 mglkg, with a maximum dose of 2 g. Ornidazole should be used
a c c o r d n g to the manufacturer's lnstructons.
ANNEX 7
P -