This document provides information on the antibiotic clindamycin hydrochloride, including its classification, uses, side effects, dosage, nursing considerations, and contraindications. It is used to treat serious respiratory, skin, soft tissue, abdominal, and bone/joint infections caused by anaerobes and certain streptococci, staphylococci, and pneumococci. Major side effects include diarrhea, pseudomembranous colitis, nausea, and rashes. Nursing considerations include monitoring for diarrhea and assessing the extent and improvement of infections. Clindamycin use is contraindicated in cases of hypersensitivity or history of antibiotic-associated colitis.
This document provides information on the antibiotic clindamycin hydrochloride, including its classification, uses, side effects, dosage, nursing considerations, and contraindications. It is used to treat serious respiratory, skin, soft tissue, abdominal, and bone/joint infections caused by anaerobes and certain streptococci, staphylococci, and pneumococci. Major side effects include diarrhea, pseudomembranous colitis, nausea, and rashes. Nursing considerations include monitoring for diarrhea and assessing the extent and improvement of infections. Clindamycin use is contraindicated in cases of hypersensitivity or history of antibiotic-associated colitis.
This document provides information on the antibiotic clindamycin hydrochloride, including its classification, uses, side effects, dosage, nursing considerations, and contraindications. It is used to treat serious respiratory, skin, soft tissue, abdominal, and bone/joint infections caused by anaerobes and certain streptococci, staphylococci, and pneumococci. Major side effects include diarrhea, pseudomembranous colitis, nausea, and rashes. Nursing considerations include monitoring for diarrhea and assessing the extent and improvement of infections. Clindamycin use is contraindicated in cases of hypersensitivity or history of antibiotic-associated colitis.
This document provides information on the antibiotic clindamycin hydrochloride, including its classification, uses, side effects, dosage, nursing considerations, and contraindications. It is used to treat serious respiratory, skin, soft tissue, abdominal, and bone/joint infections caused by anaerobes and certain streptococci, staphylococci, and pneumococci. Major side effects include diarrhea, pseudomembranous colitis, nausea, and rashes. Nursing considerations include monitoring for diarrhea and assessing the extent and improvement of infections. Clindamycin use is contraindicated in cases of hypersensitivity or history of antibiotic-associated colitis.
condition. 4. Reserve for serious infections. Side-Effects:
Classification: Antibiotic, lincosamide
1. Diarrhea 2. Pseudomembranous colitis
Uses:
3. Tinnitis 1. Treatment of serious respiratory tract infections caused by anaerobes 2. Treatment of serious skin and soft
4. Nausea and vomiting
5. Slin rashes 6. Dry skin
tissue infections, septicemia and
7. Burning
abdominal infections
8. Itching
3. Serious infections caused by
9. Skin erythema
Streptococci/ Staphylocicci/
10.Peeling
Pneumococci
11.Oily skin
4. Adjunct to surgery for chronic
bone/joint infections
12.Cardiopulmonary arrest 13.Anaphylaxis
5. Treatment of acne vulgaris
14.Agranulocytosis
6. Treatment of bacterial vaginosis
15.Aplastic anemia Dosage:
Actions: 1. Suppresses protein synthesis by
Per Orem: 150-300mg q6h. For severe
microorganisms by binding to
infections: 300-450mg q6h.
ribosomes
Life-threatening infections: 4.8 grams/IV
2. Prevents peptide formation
Topical: Apply a thin film on the affected area.
3. Does not diffuse adequately to the
CSF
Nursing Considerations:
Contraindications: 1. Use parenteral form for anaerobic 1. Hypersensitivity 2. Use in treating minor bacterial infections 3. Use in clients with a history of regional enteritis, ulcerative colitis,
infections 2. Reduce dosage in severe renal impairment 3. Give parenteral dosage for hospitalized clients only
meningitis, antibiotic-associated
4. Administer IV over 20-60 minutes
colitis
5. Assess for diarrhea and possible
4. Use for treating viral infections
5. Lactation Special Concerns:
colitis 6. Assess extent of infections and if improvement occurs 7. Monitor liver and renal function
1. Systemic use may cause severe and
possibly fatal colitis. 2. Diarrhea and pseudomembranous colitis may occur up to several weeks.
8. With IV, keep in bed for 30 min.
following infusion to prevent hypotension 9. Take orally with a full glass of water to prevent stomach distress
10.If diarrhea occurs, do not use
Route & Dosage
antiperistaltic agents 11.If using vaginal cream, it weakens latex-containing condoms due to the
Intraabdominal Infections
Adult: IV 1 g q8h Child: IV 3 mo, 20 mg/kg q8h (max: 1 g q8h)
mineral oil content
12.Do not use peeling agents on affected acne areas
Actions Broad-spectrum carbapenem antibiotic that inhibits the cell wall synthesis of gram-positive and gramnegative bacteria by its strong affinity for penicillinbinding proteins of bacterial cell wall.
Therapeutic Effects Effective against both gram-positive and gramnegative bacteria. High resistance to most bacterial beta-lactamases. Do not use to treat methicillinresistant Staphylococci (MRSA).
Uses Complicated appendicitis and peritonitis, bacterial meningitis caused by susceptible bacteria, complicated skin infections.
Unlabeled Uses Other intraabdominal infections, skin/soft tissue infections, febrile neutropenia.
Contraindications Hypersensitivity to meropenem, other carbapenem antibiotics including imipenem, penicillins, cephalosporins, or other beta-lactams; lactation.
Cautious Use History of asthma or allergies, renal impairment, epileptics, history of neurologic disorders, older adult, pregnancy (category B). Safety and effectiveness in infants <3 mo not established.
Bacterial Meningitis
Adult: IV 2 g q8h Child: IV 3 mo, 40 mg/kg q8h (max: 2 g q8h) Complicated Skin Infection
water for injection to yield approximately 50 mg/mL. Shake to dissolve and let stand until clear. IV Infusion: Further dilute in 50100 mL of D5W, NS, or D5/NS. ADMINISTER: Direct: Give over 35 min. IV Infusion:
diluted IV solutions should generally be used within 1 h of preparation.
Adverse Effects ( 1%)
GI: Diarrhea, nausea, vomiting, constipation. Other: Inflammation at injection site,
phlebitis, thrombophlebitis. CNS: Headache. Skin: Rash, pruritus, diaper rash. Body as a Whole: Apnea, oral moniliasis, sepsis, shock. Hematologic: Anemia.
Interactions
Drug: Probenecid will delay meropenem excretion;
may decrease valproic acid serum levels.
Pharmacokinetics
Discontinue drug and immediately report
S&S of hypersensitivity (see Appendix F).
Report S&S of superinfection or
pseudomembranous colitis (see Appendix F).
Monitor for seizures especially in older
adults and those with renal insufficiency.
Distribution: Attains high concentrations in bile,
bronchial secretions, cerebrospinal
fluid. Metabolism: Undergoes renal and extrarenal metabolism via dipeptidases or nonspecific degradation. Elimination:Excreted primarily in urine. Half-Life: 0.81 h.
Nursing Implications
Patient & Family Education
Learn S&S of hypersensitivity,
superinfection, and pseudomembranous colitis; report any of these to physician promptly.
Do not breast feed while using this drug.
Assessment & Drug Effects
Lab tests: Perform C&S tests prior to
therapy. Monitor periodically liver and kidney function. Determine history of hypersensitivity reactions to other beta-lactams, cephalosporins, penicillins, or other drugs.
