INTRODUCTION

IT IS WIDELY KNOWN THAT ALCOHOL CONSUMPTION

SIGNIFICANTLY IMPAIRS DRIVING PERFORMANCE,
1-6
and driving with a blood alcohol concentration (BAC) in excess
of 0.05 to 0.08 g/dL is considered in many countries to be dan-
gerous and is punishable by law (except for several US states
where a BAC of 0.1 while driving is acceptable). There is
increasing awareness that sleepiness resulting from inadequate
sleep or sleep disorders (eg, sleep apnea) also impairs driving
performance and increases crash risk.
7
This awareness has led to
an increased punitive approach to sleepiness while driving, as
demonstrated following the train disaster in Selby, United
Kingdom,
8
caused by a sleep-deprived driver and the introduc-
tion of new laws in New Jersey, USA, where driving while sleep
deprived constitutes reckless driving (Maggies Law
9
).
Additionally, studies have shown that sleep deprivation and alco-
hol interact, with sleepiness exacerbating the sedating effects of
alcohol.
3,5,6,10
Given the interactive effects of sleepiness and alcohol, it is
possible that even low (legal) levels of BAC may adversely affect
driving performance. Some research suggests that low levels of
alcohol consumption, not considered to constitute a serious risk
(eg, 0.02 g/dL BAC), in combination with factors such as sleep
deprivation and circadian timing, can affect performance tasks
(eg, visual tracking and divided attention).
11-13
A recent study by
Horne et al
12
examined the combined effects of low alcohol con-
sumption and mild sleep deprivation on driving simulator perfor-
mance and perception of sleepiness in the afternoon. They found
that performance was significantly impaired compared to base-
line. This study however did not examine subjects perception of
crash risk nor did they investigate sex differences.
While driving with a high (illegal) BAC or after total sleep
deprivation does occur in our communities and is recognized to
constitute a serious risk for an accident, driving after 1 or 2 drinks
while partially sleep deprived is much more common, particular-
ly among young drivers. A typical scenario would be an individ-
ual who, perhaps having gone to bed late the previous night, con-
sumes 2 to 3 standard alcohol drinks at a function and drives
home in the early hours of the morning. The individual may be
technically legal to drive but is their safety compromised?
The primary aim of this study, therefore, was to test the effects
of low BAC (< 0.05 g/dL) on driving performance in subjects
who were partially sleep deprived and driving close to the circa-
dian nadir (early hours of the morning).
Low Levels of Alcohol Impair Driving Simulator PerformanceBanks et al SLEEP, Vol. 27, No. 6, 2004 1063
Low Levels of Alcohol Impair Driving Simulator Performance and Reduce
Perception of Crash Risk in Partially Sleep Deprived Subjects
Siobhan Banks, PhD
1
; Peter Catcheside, PhD
2
; Leon Lack, PhD
2,4
; Ron R. Grunstein MD, PhD
5
; R. Doug McEvoy MD
2,3
1
Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine;
2
Adelaide Institute for Sleep Health, Repatriation General HospitalDaw Park, Adelaide;
3
School of Medicine, Flinders University of South Australia,
Adelaide;
4
School of Psychology, Flinders University of South Australia, Adelaide;
5
Woolcock Institute of Medical Research, Sydney, Australia
Study Objectives: Partial sleep deprivation and alcohol consumption are
a common combination, particularly among young drivers. We hypothe-
sized that while low blood alcohol concentration (<0.05 g/dL) may not sig-
nificantly increase crash risk, the combination of partial sleep deprivation
and low blood alcohol concentration would cause significant performance
impairment.
Design: Experimental
Setting: Sleep Disorders Unit Laboratory
Patients or Participants: 20 healthy volunteers (mean age 22.8 years; 9
men).
Interventions: Subjects underwent driving simulator testing at 1 am on 2
nights a week apart. On the night preceding simulator testing, subjects
were partially sleep deprived (5 hours in bed). Alcohol consumption (2-3
standard alcohol drinks over 2 hours) was randomized to 1 of the 2 test
nights, and blood alcohol concentrations were estimated using a calibrat-
ed Breathalyzer. During the driving task subjects were monitored continu-
ously with electroencephalography for sleep episodes and were prompted
every 4.5 minutes for answers to 2 perception scalesperformance and
crash risk.
Measurements and Results: Mean blood alcohol concentration on the
alcohol night was 0.035 0.015g/dL. Compared with conditions during
partial sleep deprivation alone, subjects had more microsleeps, impaired
driving simulator performance, and poorer ability to predict crash risk in
the combined partial sleep deprivation and alcohol condition. Women pre-
dicted crash risk more accurately than did men in the partial sleep depri-
vation condition, but neither men nor women predicted the risk accurate-
ly in the sleep deprivation plus alcohol condition.
Conclusions: Alcohol at legal blood alcohol concentrations appears to
increase sleepiness and impair performance and the detection of crash
risk following partial sleep deprivation. When partially sleep deprived,
women appear to be either more perceptive of increased crash risk or
more willing to admit to their driving limitations than are men. Alcohol elim-
inated this behavioral difference.
Key Words: Sleepiness, crash risk, driving, alcohol
Citation: Banks S; Catcheside P; Lack L et al. Low levels of alcohol
impair driving simulator performance and reduce perception of crash risk
in partially sleep deprived subjects. SLEEP 2004;27(6):1063-7.
Disclosure Statement
This study was sponsored by a grant from the Australian Brewer's Association.
Dr. McEvoy has received support from Cephalon, ResMed, and Massimo. Drs.
Grunstein, Catcheside, Lack, and Banks have indicated no financial conflicts of
interest.
Submitted for publication March 2004
Accepted for publication June 2004
Address correspondence to: Siobhan Banks, Unit for Experimental Psychiatry,
Division of Sleep and Chronobiology, Department of Psychiatry, University of
Pennsylvania School of Medicine, 1013 Blockley Hall, 423 Guardian Drive,
Philadelphia, PA, USA 19104-6021, Phone: (215) 898-9665, FAX: (215) 573-
6410, E-mail: [email protected]
A second aim was to examine subjects perception of impair-
ment. Previous studies have shown that alcohol affects percep-
tion of crash and traffic hazard risk.
14,15
If perception of impair-
ment is affected, the individuals ability to know when they are at
risk is reduced. This is of critical importance in determining
whether the driver is likely to take countermeasures to avoid an
accident (for example a power nap or caffeine drink). We
hypothesized that consumption of alcohol to a low BAC in the
presence of partial sleep deprivation would limit subjects ability
to recognize their level of impairment.
METHODS
The ethics committee at the Repatriation General Hospital,
Adelaide, approved this study. All subjects gave written informed
consent.
Participants
Advertisements were posted at Flinders University of South
Australia campus. Young people were recruited for this study due
to the high number of 18- to 30-year-olds who have sleep-related
car accidents in the early hours of the morning. Subjects were
excluded if they had a sleep disorder (eg, self-reported snoring or
difficulty sleeping), if they were taking any forms of medication,
and if they suffered motion sickness. All subjects received an
honorarium of $100.
Procedure
Familiarization Session
At the first visit to the laboratory, the subjects were introduced
to the testing equipment and driving simulator. They underwent
three, 10-minute practice sessions on the driving simulator and
perception exercise and were randomly assigned to condition
order. They then completed the Epworth Sleepiness Scale.
16
The
subjects took home an activity monitor and a sleep diary to be
completed in the week prior to testing. Subjects were not required
to obtain a specific amount of sleep during the testing period
(except on the partial sleep-deprivation night). They were
instructed to keep to their normal sleep-wake pattern.
AusEd Driving Simulator
The AusEd driving simulation task used in this study was a
computer program devised to monitor a number of performance
variables. These included position on the road and speed devia-
tion over time, reaction time to a braking task (appearance of
trucks), and crashes (driving off the road, stoppage events, and
crashing into the back of a truck). Early work suggests that this
test is sensitive to varying degrees of sleep deprivation and
sleepiness.
17-19
Subjects were required to drive the AusEd sim-
ulator using a steering wheel and pedals. The view, seen from a
front-seat perspective, was of a dual-carriage rural road at night,
with the usual lane divisions and the road edges marked by
reflective posts. Aspeedometer was displayed in the top left cor-
ner of the computer screen. Subjects were asked to maintain their
position in the left-hand lane on the road (in accordance with
Australian driving code), to keep their speed within 60 to 80 kilo-
meters per hour, and to react by braking firmly and as quickly as
possible to any trucks that appeared ahead in the driving lane.
The simulator was programmed to present 4 trucks at approxi-
mately 10-minute intervals during the 70-minute task.
Perception Probes
The perception exercise required subjects to respond to an
audio tone, played every 4.5 minutes, by rating their perceived
level of driving simulator performance and indicating whether
they felt they should stop driving to avoid an accident. The 4.5-
minute time gap between each probe was chosen because this
length of time made it less possible for subjects to predict the
next tone. However, it was also frequent enough to provide mul-
tiple data points for analysis (15 over the 70-minute driving task).
All responses were spoken and recorded for later analysis. Acue
card of the perception scales was attached to the bottom of the
computer screen. The perception scales and their anchors were:
Rate your driving performance since the last tone (1 =
Excellent to 9 = Terrible) and If you were driving a real car
would you now stop to avoid an accident? (Yes or No).
Preliminary trials were conducted to ensure the tones played
were not physiologically arousing (eg, significantly increasing
heart rate above baseline). The tones were 60 dB at 1 meter from
source, including background noise.
Each subjects ability to identify crash risk was determined
from the proportion of all 4.5-minute periods containing a crash
in which the subjects reported they would have stopped driving
prior to the commencement of that period.
Experimental Conditions
The subjects were required to keep a detailed diary of their
sleep habits and to wear an activity monitor (Gaehwiler
Electronic, Hombrechtikon, Switzerland), which measured their
sleep-wake activity for 1 week prior to the experimental condi-
tions. This was done to verify the subjects had regular sleep
habits in the week prior to testing, that they followed the sleep
deprivation protocols, and that they did not nap during the day of
testing. Subjects participated in the 2 experimental conditions in
a repeated-measures design, attending the laboratory twice, with
a week separating each visit.
In the partial sleep-deprivation condition, subjects were
restricted to 5 hours time in bed on the night prior to testing (1
AM-6 AM). They were required to telephone a time- and date-
stamped answering machine before going to bed and after rising
in the morning to ensure compliance.
In the combined partial sleep-deprivation and alcohol condi-
tion, subjects were also required to restrict sleep according to the
protocol above. As the legal BAC limit for driving in Australia is
0.05 g/dL, BAC below this level were targeted. At 10:30 PM,
subjects consumed 1 mL of 50% alcohol per kg of body weight,
in a carbonated noncaffeinated beverage, to produce a BAC of
approximately 0.04 g/kg. At 12:15 AM, they consumed another
drink with 0.5 mL of 50% alcohol per kg of body weight. Blood
alcohol levels were estimated using a calibrated Breathalyzer
(Drger, Lbeck, Germany, Alcotest 7410
Plus
) accurate to 0.005
g/dL. Subjects were not blinded to alcohol presentation, as our
aim in this study was to test the subjects in a common real-world
situation where the subjects would be aware of alcohol con-
sumption.
Low Levels of Alcohol Impair Driving Simulator PerformanceBanks et al SLEEP, Vol. 27, No. 6, 2004 1064
Experimental Procedure
Subjects arrived at the laboratory at 9:00 PM. They immedi-
ately analysis with the Breathalyzer, a urine sample was taken to
test for habitual drugs of abuse (eg, opioids, cannabiniods,
amphetamine), and activity monitors were downloaded to ensure
that subjects had complied with the study protocol requirements.
Timepieces were removed so there were no external time cues.
Standard surface electrodes were applied for monitoring: elec-
troencephalogram (EEG)(C
3
/A
2
, C
4
/A
1
), submental electromyo-
gram, left and right eye movements, and electrocardiogram. All
parameters were recorded using the Sleepwatch (Compumedics,
Melbourne, Australia) data-acquisition system. Subjects then
completed the Stanford Sleepiness Scale.
20
Subjects were
allowed a short practice run on the driving simulator and given a
standardized snack (150 calories; dry biscuits and cheese) and
alcohol or an equivalent volume of the carbonated noncaffeinat-
ed beverage at 10:30 PM and at 12:15 AM.
Subjects started the 70-minute driving simulation at 1:00 AM,
and they were prompted every 4.5 minutes during the driving
task to answer the perception probes. Subjects were told the
probes would sound at random intervals. The driving task took
place in a private semidark (10 lux) and sound-attenuated room.
The experiment protocol concluded at approximately 3 AM, and
subjects were taken home by taxicab.
Data Analysis
In order to assess the relationship between the perception
scores and actual performance, the driving simulator and EEG
were analyzed in fifteen 4.5-minute bins. The first tone was
played 30 seconds after the driving simulator task started. As the
perception questions were phrased with since the last tone, this
initial tone did not provide useful information for analysis but
was a starting point for the following perception probes.
Therefore, 16 tones were played, but only 15 were used in the
analysis. The last tone was played approximately 2 minutes
before the end of the driving task, and data from these 2 minutes
was not used in the analysis.
AusEd Driving Simulator
This study examined mean steering deviation (deviation from
the subjects median position on the road averaged every 40 mil-
liseconds, excluding crashes), mean speed deviation (deviation
from the safe speed zone 60-80 km), braking reaction time (in
response to trucks on the road ahead), and mean number of driv-
ing-simulator crashes (off-road, truck collision, or stoppage
events). The mean number of crashes was determined for each
4.5-minute bin.
EEG Microsleep Analysis
The EEG (C
3
-A
2
) during the driving simulation task was
assessed for the appearance of microsleeps. A microsleep was
defined as a burst of EEG theta activity greater than 3-seconds in
length.
21,22
The cumulative theta time and number of discrete
microsleeps were determined for each 4.5-minute bin.
Statistics
Analysis of variance for repeated measures was conducted to
investigate the effects of condition (alcohol vs no alcohol), sex,
and time on performance and perception variables. Group data
are expressed as means SD of the mean, and P < .05 was con-
sidered significant.
RESULTS
Twenty healthy subjects (11 women, mean age 21.9 2.2; 9
men, mean age 23.8 4.8) participated. The mean Epworth
Sleepiness Scale and Stanford Sleepiness Scale scores at famil-
iarization for the whole group were 6.4 3.9 and 1.7 0.57,
respectively. All subjects had a regular sleep-wake cycle in the
week prior to testing, with activity-monitor data showing sub-
jects were inactive for an average of 411 37 minutes per night.
They subjectively reported (sleep diary kept for 7 days) that they
obtained an average of 423.59 45.8 minutes of sleep per night.
No subjects were excluded on the basis of the amount of sleep
obtained in the week before testing. All subjects had 0 BAC and
a negative urine drug test on arrival at the laboratory on experi-
mental nights. Data from the activity monitors showed subjects
complied with the sleep-restriction protocol. They were inactive
for 270 20 minutes on the night before testing. Subjects rated
themselves as moderately sleepy according to the Stanford
Sleepiness Scale on both experimental nights (partial sleep depri-
vation condition mean 4.0 1.2, and partial sleep deprivation
plus alcohol condition mean 4.0 1.3).
The subjects mean BAC on the alcohol night at the start and
end of the 70-minute driving simulation were 0.037 0.011 g/dL
and 0.021 0.009 g/dL. These values are well below the
Australian legal limit for driving of 0.05 g/dL. Two subjects, 1
man and 1 woman, had a BAC of > 0.05 g/dLjust before the driv-
ing simulation task. Their BAC were 0.054 g/dL and 0.056 g/dL,
respectively.
Table 1 shows the driving-simulator and microsleep results for
both conditions. The consumption of alcohol significantly
increased mean steering deviation (P = .05) and the number of
driving-simulator crashes (P = .02; see Figure 1). Both variables
showed a significant increase with time on task (P < .001 and P
= .02, respectively). Speed variability was not affected by alco-
hol (P = .07) but increased with time on task (P < .001). Braking
reaction time to trucks increased after alcohol (P = .01) but not
with time on task (P = .09). Figure 2 shows that the duration of
microsleeps subjects experienced during the driving simulation
Low Levels of Alcohol Impair Driving Simulator PerformanceBanks et al SLEEP, Vol. 27, No. 6, 2004 1065
Table 1Driving-Simulator Parameters and Microsleeps by
Condition
Parameter Condition
Partial Sleep Partial Sleep
Deprivation Deprivation + Alcohol
Mean SD Mean SD
Microsleep, sec* 4.8 6.6 8.9 12.1
Braking reaction time, msec

1512.1 355.7 2041.5 778.5

Steering deviation, cm* 82.0 36.2 92.9 33.1
Speed variability, km/h

8.9 9.3 10.5 7.3

Crashes, no.

1.0 1.2 4.3 4.9

Data are presented as mean SD in 20 subjects.
*P < .05

P < .01

Deviation from safe 60- to 80-km/h zone.

task increased with alcohol (P = .04) but not with time on task (P
= .13). There were no significant sex differences in any driving
performance variable.
Overall, subjects showed less insight about crash risk in the
combined partial sleep deprivation and alcohol condition (38%
compared to 64% in the partial sleep deprivation alone condition,
P = .04; see Table 2). Women more accurately anticipated crash-
es than did men in the partial sleep-deprivation condition (85% to
37%, P = .03) but not after consuming alcohol (38% to 33%, P
= .12). Womens ability to accurately anticipate crashes dropped
from 85% to 38% following the consumption of alcohol (P =
.03).
DISCUSSION
The principal finding of this study was that the addition of a
low BAC to the presence of partial sleep deprivation caused
increased sleepiness (microsleeps) while driving and impaired
driving performance, without subjects appreciating the extent of
their impairment. Even a small amount of alcohol combined with
sleep loss appears to be sufficient to dramatically impair subjects
ability to drive safely. These findings may have important road-
safety implications.
This study aimed to simulate the real-life combination of
alcohol and partial sleep deprivation on driving performance and
perception. The amount of sleep deprivation and alcohol con-
sumed are not only within the legal driving limits for most coun-
tries, but also at a level that many individuals would consider safe
to drive. This is the first study to assess such a combination. A
previous study by Horne et al,
12
examined performance in the
afternoon during the post lunch dip in circadian rhythm but
focused primarily on only 1 aspect of driving-simulator perfor-
mance and subjects assessment of sleepiness. Additionally, they
recruited only men and thus no sex comparisons were made. The
current study extends this previous work by examining sex dif-
ferences and driving performance in the early hours of the morn-
ing and by investigating subjects perceptions of driving-perfor-
mance impairment and assessment of crash risk. The driving-
simulation task commenced at 1 AM to coincide with the time
that many individuals drive home from social events and a time
that also approaches the subjects circadian nadir and greatest
sleep pressure. We believed that it was also important to investi-
gate subjects perceptions of their driving performance and crash
risk, since perception of ability likely influences the decision-
making process to stop driving or engage in sleepiness counter-
measures (eg, caffeine or nap).
Overall subjects did not realize the full extent of their perfor-
mance impairment and were poorer at assessing crash risk in the
partial sleep deprivation and alcohol condition. This is consistent
with previous studies showing that alcohol impairs comprehen-
sion of cognitive impairment. Astudy by Deery et al
15
found that
subjects with a BAC of 0.05 who watched a video of typical road
traffic took longer to detect traffic hazards and accident risk and
tended to respond to these hazards abruptly. Subjects ability to
accurately assess potentially dangerous situations was affected
by alcohol, and this may in part explain the increased accident
risk associated with drunk driving.
It has been found previously that young men are much more
likely to have an accident in the early hours of the morning than
are women.
23
Mens ability to assess crash risk was substantially
less than that of the women in the sleep-deprivation condition.
Women appeared to be perhaps more perceptive of increased
crash risk or more willing to admit their limitations. This ability
however was markedly reduced following the consumption of
alcohol when womens crash-risk assessment was the same as
mens. It was found in a previous study that men tend to be more
optimistic, particularly regarding their driving skill and ability.
24
Subjects in this earlier study held similar perceptions concerning
the frequency and accident likelihood of risky behaviors, but men
perceived the behaviors generally less serious and less likely to
result in accidents.
24
Mens attitudes could be potentially affect-
Low Levels of Alcohol Impair Driving Simulator PerformanceBanks et al SLEEP, Vol. 27, No. 6, 2004 1066
Figure 1Mean number of driving-simulator crashes in 11 women
and 9 men for each 4.5-minute bin during the 70-minute task under the
conditions of partial sleep deprivation alone and partial sleep depriva-
tion combined with alcohol consumption (blood alcohol concentration
< 0.05 g/dL).
Figure 2Mean cumulative microsleeps (sum of all 3-second or
longer episodes of theta activity on the electroencephalogram) in 11
women and 9 men for each 4.5-minute bin during the 70-minute task
under the conditions of partial sleep deprivation alone and partial sleep
deprivation combined with alcohol consumption (blood alcohol con-
centration < 0.05 g/dL).
Table 2Percentage of 4.5-minute time periods containing crashes in
which subjects had reported they would have stopped driving prior to
crash
Sex Condition
Partial Sleep Partial Sleep
Deprivation Deprivation + Alcohol
All subjects, n = 20 64 37 38 36
Men, n = 9 37 41 33 42
Women, n =11 85 23 38 24
Data are presented as mean SD.
ed by the nature of the test situation and the tools used. When a
computer game-like simulator is used, the inevitable knowledge
that that this is not a real-life situation might encourage false con-
fidence or even arrogance in their abilities.
An inherent limitation of simulator studies is of course the fact
that it is a simulation. While subjects may be less motivated and
cautious in the laboratory, studies have found a strong association
between laboratory simulator studies and on-road driving behav-
ior.
25
Furthermore, simulator studies allow for control of relevant
variables that is otherwise difficult or impossible in on-road
research, particularly for the assessment of crash risk. Laboratory
driving-simulator research shows trends in behavioral response,
which can aid the development of more complex and costly on-
road real-car research.
In conclusion, in this study, alcohol consumption to a BAC
considered in most jurisdictions to be safe, when combined with
sleep loss, increased EEG-defined sleepiness, impaired driving-
simulator performance, and reduced subjects ability to detect
impairment in driving performance and assess crash risk. Women
appeared to be more perceptive of increased crash risk or more
willing to admit to their driving limitations under partial sleep-
deprivation conditions. These results have may have implications
for policy, including reduction in permissible BAC for drivers
under 25 years of age and restricting young drivers to daytime
driving (which has been successfully implemented in some
areas
26,27
).
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