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    Symbol: Physiologic Effects of Arsenic Exposure

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    Monica Sario Policina
    Arsenic is a metalloid found naturally in small amounts in the earth's crust. It is used in wood preservatives, pesticides, and other applications. Arsenic exposure can occur through ingestion of contaminated food, water or air. Both acute and chronic arsenic exposure have serious health effects, including headaches, diarrhea, skin lesions, cancers, and reproductive harm. Long term ingestion is linked to skin, liver, lung and bladder cancers.

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    Symbol: Physiologic Effects of Arsenic Exposure

    Uploaded by

    Monica Sario Policina
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    Arsenic is a metalloid found naturally in small amounts in the earth's crust. It is used in wood preservatives, pesticides, and other applications. Arsenic exposure can occur through ingestion of contaminated food, water or air. Both acute and chronic arsenic exposure have serious health effects, including headaches, diarrhea, skin lesions, cancers, and reproductive harm. Long term ingestion is linked to skin, liver, lung and bladder cancers.

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    Arsenic

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    Arsenic is a metalloid found naturally in small amounts in the earth's crust. It is used in wood preservatives, pesticides, and other applications. Arsenic exposure can occur through ingestion of contaminated food, water or air. Both acute and chronic arsenic exposure have serious health effects, including headaches, diarrhea, skin lesions, cancers, and reproductive harm. Long term ingestion is linked to skin, liver, lung and bladder cancers.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    29 views2 pages

    Symbol: Physiologic Effects of Arsenic Exposure

    Uploaded by

    Monica Sario Policina
    Arsenic is a metalloid found naturally in small amounts in the earth's crust. It is used in wood preservatives, pesticides, and other applications. Arsenic exposure can occur through ingestion of contaminated food, water or air. Both acute and chronic arsenic exposure have serious health effects, including headaches, diarrhea, skin lesions, cancers, and reproductive harm. Long term ingestion is linked to skin, liver, lung and bladder cancers.

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    Arsenic Symbol: As metalloid 1.5-2.

    -2.0mg/kg content in earths crust Sources: volcanoes, weathering of minerals Anthropologic sources:production of metals,burning of coil, fossil fuels, timber Main use:wood preservative Other uses: pesticides, pigments, poison gases, ammunition manufacturing, semiconductor Health effects Arsenic trioxide-treatment of acute promyelocytic leukemia;1:500 Routes of exposure:ingestion of arsenic containing foods, water, beverages or inhalation of contaminated air Arsenobetaine-main arsenic spp. found in sea food;common cause for increased total arsenic concentration in urine Toxic forms:Pentavalent (AsV), trivalent(AsIII) and methylated forms Symptoms may be evident:35ug/L Physiologic Effects of Arsenic Exposure Symptoms of arsenic poisoning: -Headaches, confusion, severe diarrhea, and drowsiness. -convulsions and changes in fingernail pigmentation called leukonychia may occur. -When the poisoning becomes acute, symptoms may include diarrhea, vomiting, blood in the urine, cramping muscles, hair loss, stomach pain, and more convulsions. -Chronic arsenic ingestion may cause cancers of the skin, kidney, liver, lungs, prostate, bladder. Dermal effect (skin) Skin pimentation, keratosis, skin cancer Delayed effects of acute or chronic exposure may be seen as Mees lines in nails. Skin Cancer

    -Due to ingestion of arsenic over a prolonged period of time from a contaminated well. Respiratory Effects Inhalation of high concentrations of arsenic compounds produces irritation of the respiratory mucosa. prolonged exposures to high concentrations of airborne arsenic may have inflammatory and erosive lesions of the respiratory mucosa, including nasal septum perforation. Gastrointestinal and Hepatic Effects Extensive inflammation and necrosis of the mucosa and submucosa of the stomach and intestine may occur and progress to perforation of the gut wall. (Bloody diarhea) associated with hepatic necrosis and elevated levels of liver enzymes. Chronic arsenic ingestion may lead to cirrhotic portal hypertension Renal Effects severe acute arsenic poisoning may include acute tubular necrosis with acute renal failure. Glomerular damage can result in proteinuria. Reproductive Effects Arsenic is a reproductive toxicant and a teratogen. It is readily transferred across the placenta, and concentrations in cord blood are similar to those in maternal blood. acute arsenic ingestion during the third trimester of pregnancy, leading to delivery of a live infant that died within 12 hours. (Autopsy revealed intra alveolar hemorrhage and high levels of arsenic in the brain, liver, and kidneys)

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