Alendronic Acid

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Drug name: ALENDRONIC ACID General details Bisphosphonates are absorbed onto hydroxyapatite crystals in bone slowing both

growth rate and dissolution and reduce the increased rate of bone turnover associated with disease. Alendronic acid can help steroid induced osteoporosis. Primarily it can also be used in the treatment of Pagets disease of bone, for treating osteoporosis in postmenopausal women; however, it is also used to treat osteoporosis in men. It is a calcium supplement and vitamin D may be prescribed with the drug if dietary amounts are not adequate, however calcium should not be taken at the same time. How taken Tablet Dosage Duration of action

Drug class Bisphosphonates Trade names Fosamax

Availability

10mg/day (men) Prescription Only 70mg weekly 24hrs-1 week (postmenopausal women 5mg/day) Side effects Considerations Symptom Occurrence Obviously with any individual being Headache Common treated with osteoporosis should be Diarrhoea or constipation Common treated with caution. SMT should only Dyspepsia Common be carried out after full bone scan with Oesophageal reactions Common full knowledge of bone strength. Other Abdominal pain Common methods of treatment such as Nausea Rare mobilisation should be considered Vomiting Rare Peptic ulcerations Rare Dietary advice Skin reactions (Rash) Rare Erythema Rare No specific advice Photosensitivity Rare

Other drug interactions Antacids and calcium and iron salts reduce the absorption of Alendronic acid.

Special precautions Should be taken on an empty stomach with large amount of water 30 minutes before breakfast

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