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    Albendazole Drug Interactions

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    sonypardeep
    The document discusses potential drug interactions with albendazole, an anthelmintic drug used to treat parasitic worm infections. It notes that carbamazepine, phenobarbital, and phenytoin can each reduce albendazole levels by around half, so higher doses of albendazole may be needed for systemic infections when used with these drugs. It also recommends women use non-hormonal contraception during and after albendazole treatment due to a theoretical risk of interaction and potential teratogenic effects. Finally, it states that taking albendazole with food, especially fatty meals, can increase levels of its active metabolite.

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    Albendazole Drug Interactions

    Uploaded by

    sonypardeep
    152 views2 pages
    The document discusses potential drug interactions with albendazole, an anthelmintic drug used to treat parasitic worm infections. It notes that carbamazepine, phenobarbital, and phenytoin can each reduce albendazole levels by around half, so higher doses of albendazole may be needed for systemic infections when used with these drugs. It also recommends women use non-hormonal contraception during and after albendazole treatment due to a theoretical risk of interaction and potential teratogenic effects. Finally, it states that taking albendazole with food, especially fatty meals, can increase levels of its active metabolite.

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    Albendazole Drug Interactions

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    AlbendazoleDrugInteractions

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    The document discusses potential drug interactions with albendazole, an anthelmintic drug used to treat parasitic worm infections. It notes that carbamazepine, phenobarbital, and phenytoin can each reduce albendazole levels by around half, so higher doses of albendazole may be needed for systemic infections when used with these drugs. It also recommends women use non-hormonal contraception during and after albendazole treatment due to a theoretical risk of interaction and potential teratogenic effects. Finally, it states that taking albendazole with food, especially fatty meals, can increase levels of its active metabolite.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    152 views2 pages

    Albendazole Drug Interactions

    Uploaded by

    sonypardeep
    The document discusses potential drug interactions with albendazole, an anthelmintic drug used to treat parasitic worm infections. It notes that carbamazepine, phenobarbital, and phenytoin can each reduce albendazole levels by around half, so higher doses of albendazole may be needed for systemic infections when used with these drugs. It also recommends women use non-hormonal contraception during and after albendazole treatment due to a theoretical risk of interaction and potential teratogenic effects. Finally, it states that taking albendazole with food, especially fatty meals, can increase levels of its active metabolite.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
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    Albendazole Drug Interactions | Drug - Drug Interactions

    Albendazole Drug Interactions

    Albendazole + Carbamazepine

    Carbamazepine approximately halves the levels of albendazole.

    For systemic infections it may be necessary to increase the albendazole dosage. Monitor
    the outcome of concurrent use. This interaction is of no importance in the treatment of
    intestinal worm infections.

    Albendazole + Contraceptives

    The manufacturer of albendazole recommends that women should use non-hormonal


    methods of contraception during and for one month after stopping albendazole. This
    is because there is a theoretical risk of an interaction (albendazole is a liver enzyme
    inducer) and because albendazole is potentially teratogenic.

    Counsel patients on additional/alternative contraception.

    Albendazole + Food

    Giving albendazole with a meal (especially fatty meals) markedly increases the levels of
    its active metabolite.

    Albendazole absorption is poor, and if it is being used for systemic infections, it is


    advisable to take it with a meal.

    Albendazole + Phenobarbital

    Phenobarbital (and therefore probably primidone) approximately halves the levels of


    albendazole.

    For systemic infections it may be necessary to increase the albendazole dosage. Monitor
    the outcome of concurrent use. This interaction is of no importance in the treatment of
    intestinal worm infections.

    Albendazole + Phenytoin

    Phenytoin approximately halves the levels of albendazole. Fosphenytoin, a prodrug of


    phenytoin, may interact similarly.

    For systemic infections it may be necessary to increase the albendazole dosage. Monitor
    the outcome of concurrent use. This interaction is of no importance in the treatment of
    intestinal worm infections.
    1
    Download More Drug Actions www.ebooksearn.blogspot.com
    Albendazole Drug Interactions | Drug - Drug Interactions

    Refer: Stockley’s Drug Interactions

    1
    Download More Drug Actions www.ebooksearn.blogspot.com

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