Pa Tho Physiology of M.I

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Pathophysiology of Myocardial Infarction

Causes:
 Coronary Artherosclerotic Heart Disease
 Coronary Thrombosis
 Decreased blood flow with Shock and or
Hemorrhage
 Direct Trauma

Myocardial Ischemia Myocardial Cellular Hypoxia


Oxygen Supply

Altered Cell
Cardiac Myocardial Membrane
Output Contractility Integrity

Atrial Stimulation of Stimulation of


Pressure Baroreceptors Sympathetic
Receptors

Peripheral Afterload
Vasoconstriction

Myocardial Heart Rate Diastolic Coronary


Contractility Filling Tissue
Perfusion

Myocardial
Oxygen Demand

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