Scribd Logo
Upload

Welcome to Scribd!

  • 24 views

    Staphylococcus Aureus (Toxin-Mediated) : Clinical Presentation

    Uploaded by

    ridin007
    This document summarizes toxic shock syndrome (TSS), scalded skin syndrome, Ritter's disease in newborns, and food poisoning. It describes the clinical presentation and pathobiology of each, including how certain bacteria can release toxins that diffuse systemically and promote excessive cytokine release, fever, rash, organ dysfunction and possible death. It also discusses diagnosis via in vitro culture and treatment involving fluid replacement, antibiotics and future blocking of cytokines. Certain conditions like scalded skin syndrome have high mortality rates from complications.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    Staphylococcus Aureus (Toxin-Mediated) : Clinical Presentation

    Uploaded by

    ridin007
    24 views1 page
    This document summarizes toxic shock syndrome (TSS), scalded skin syndrome, Ritter's disease in newborns, and food poisoning. It describes the clinical presentation and pathobiology of each, including how certain bacteria can release toxins that diffuse systemically and promote excessive cytokine release, fever, rash, organ dysfunction and possible death. It also discusses diagnosis via in vitro culture and treatment involving fluid replacement, antibiotics and future blocking of cytokines. Certain conditions like scalded skin syndrome have high mortality rates from complications.

    Original Title

    MicroCards Ex 23

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    This document summarizes toxic shock syndrome (TSS), scalded skin syndrome, Ritter's disease in newborns, and food poisoning. It describes the clinical presentation and pathobiology of each, including how certain bacteria can release toxins that diffuse systemically and promote excessive cytokine release, fever, rash, organ dysfunction and possible death. It also discusses diagnosis via in vitro culture and treatment involving fluid replacement, antibiotics and future blocking of cytokines. Certain conditions like scalded skin syndrome have high mortality rates from complications.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    24 views1 page

    Staphylococcus Aureus (Toxin-Mediated) : Clinical Presentation

    Uploaded by

    ridin007
    This document summarizes toxic shock syndrome (TSS), scalded skin syndrome, Ritter's disease in newborns, and food poisoning. It describes the clinical presentation and pathobiology of each, including how certain bacteria can release toxins that diffuse systemically and promote excessive cytokine release, fever, rash, organ dysfunction and possible death. It also discusses diagnosis via in vitro culture and treatment involving fluid replacement, antibiotics and future blocking of cytokines. Certain conditions like scalded skin syndrome have high mortality rates from complications.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 1

    CLINICAL PRESENTATION

    Toxic Shock Syndrome (TSS)


    Scalded Skin Syndrome
    Ritters disease in newborn
    food poisoning
    PATHOBIOLOGY
    Toxic Shock Syndrome: tampon use, trauma/surgery introduce bacteria bacteria colonize toxic shock syndrome
    toxin-1 (TSST-1) released and diffuses systemically TSST-1 is a superantigen promotes excess cyto-
    kines released (e.g., IL-1, TNF) acute fever, rash, desquamation on palms and soles, hypotensive shock
    organ hypoperfusion and dysfunction possible death
    Scalded Skin Syndrome: skin wound or cutting umbilicus in neonates promotes local epidermal infection exfolia-
    tive toxins (e.g., ET-A,B) released and diffuse systemically epidermis separates and skin sloughs off
    fluid loss and potential secondary infection possible death
    food poisoning: bacteria release toxin in food such as custards heat-stable toxins (e.g., Enterotoxin SE-A)
    ingested gastroenteritis self-limited, 8- to 24-hour nausea, vomiting, diarrhea, and abdominal pain
    DIAGNOSIS
    detection of toxin production by in vitro culture (blood cultures negative because organism does not invade bloodstream)
    TREATMENT
    removal of foreign bodies, drainage of purulent collections; fluid replacement; penicillinase-resistant penicillins hasten
    recovery; (future) blocking effects of IL-1 and TNF with antibodies
    QUICK FACTS
    Antibiotics are not curativethey kill bacteria but do not remove already-released exotoxin.
    Scalded skin syndrome has a 50% mortality rate among adults due to complications from hypovolemia and secondary
    infection.
    Ritters syndrome is the most severe form of scalded skin syndrome in neonates. It occurs after S. aureus colonizes the
    cut umbilicus and releases ET-A,B systemically.
    Staphylococcus aureus (toxin-mediated)
    (TSS)
    011-033_Harpavat_CoreCards_GramPosBacteria.indd 12b 7/10/11 1:15 AM

    You might also like