Irritable Bowel Syndrome

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Irritable Bowel Syndrome Irritable bowel syndrome (IBS) is a functional bowel disorder characterized by abdominal pain or discomfort and

altered bowel habits in the absence of detectable structural abnormalities. No clear diagnostic markers exist for IBS, thus the diagnosis of the disorder is based on clinical presentation. Diagnostic Criteria for Irritable Bowel Syndrome: Recurrent abdominal pain or discomfortb at least 3 days per month in the last 3 months associated with two or more of the following: Improvement with defecation Onset associated with a change in frequency of stool Onset associated with a change in form (appearance) of stool Criteria fulfilled for the last 3 months with symptom onset at least 6 months prior to diagnosis. Pathophysiology: The pathogenesis of IBS is poorly understood, although roles of abnormal gut motor and sensory activity, central neural dysfunction, psychological disturbances, mucosal inflammation, stress, and luminal factors have been proposed. Treatments include gut-acting pharmacologic agents such as antispasmodics, antidiarrheals, fiber supplements, and the newer gut serotonin modulators Courtesy: Harrison's, Hopkins

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