Preformulation Research Papers

Procedimiento Normalizado de Operacion para realizar la prueba de Transparencia.

Solid state investigation and polymorphic screening of indapamide, a diuretic drug generally used for the treatment of hypertension was carried out. Substantial differences were obtained in the solid state properties of crystals... more

Preformulation studies carried out by various research scientists are reviewed. Preformulation begins after literature search of similar type of compounds to provide and understand (i) the degradation process, (ii) any adverse conditions... more

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- by gopinath rongala
- •
- Preformulation

The expanded role of pharmacists uplifts them to patient care, industrial marketing, regulatory affairs from dispensing and manufacturing of drugs. The sector is emerging in both developed and under-developed countries. Furthermore,... more

The purpose of the present study was to systematically investigate some of the important physicochemical properties of loxoprofen loaded microspheres. Loxoprofen, 2-[4-(2-oxocyclopentylmethyl) phenyl]propionate with two chiral centers, is... more

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- by Riyasat patwe
- •
- 6
  Pharmacology, Chemistry, Pharmacy, Sustained Drug Release

Among the various research works going on nowadays, designing of controlled release dosage form is of great importance. For the development of suitable controlled release dosage form, a proper matrix needs to be formed from which the drug... more

In diesem Artikel geht es um Verbphraseme wie dt. einen trinken, jemandem eine runterhauen, sich einen ablachen und frz. ne pas en râter une, en coller une à quelqu’un, s’en jeter un, die ein Indefinitpronomen enthalten, das sich weder... more

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- by Vincent BALNAT
- •
- 10
  German Studies, Languages and Linguistics, Pronouns, Phraseology

Purpose: The goal of the present study is to develop polymeric matrix films loaded with a combination of free diclofenac sodium (DFSfree) and DFS:Ion exchange resin complexes (DFS:IR) for immediate and sustained release profiles,... more

Purpose: The goal of the present study is to develop polymeric matrix films loaded with a combination of free diclofenac sodium (DFSfree) and DFS:Ion exchange resin complexes (DFS:IR) for immediate and sustained release profiles, respectively.

Methods: Effect of ratio of DFS and IR on the DFS:IR complexation efficiency was studied using batch processing. DFS:IR complex, DFSfree, or a combination of DFSfree + DFS:IR loaded matrix films were prepared by melt-cast technology. DFS content was 20% w/w in these matrix films. In vitro transcorneal permeability from the film formulations were compared against DFS solution, using a side-by-side diffusion apparatus, over a 6 h period. Ocular disposition of DFS from the solution, films and corresponding suspensions were evaluated in conscious New Zealand albino rabbits, 4 h and 8 h post-topical administration. All in vivo studies were carried out as per the University of Mississippi IACUC approved protocol.

Results: Complexation efficiency of DFS:IR was found to be 99% with a 1:1 ratio of DFS:IR. DFS release from DFS:IR suspension and the film were best-fit to a Higuchi model. In vitro transcorneal flux with the DFSfree + DFS:IR(1:1)(1 + 1) was twice that of only DFS:IR(1:1) film. In vivo, DFS solution and DFS:IR(1:1) suspension formulations were not able to maintain therapeutic DFS levels in the aqueous humor (AH). Both DFSfree and DFSfree + DFS:IR(1:1)(3 + 1) loaded matrix films were able to achieve and maintain high DFS concentrations in the AH, but elimination of DFS from the ocular tissues was much faster with the DFSfree formulation.

Conclusion: DFSfree + DFS:IR combination loaded matrix films were able to deliver and maintain therapeutic DFS concentrations in the anterior ocular chamber for up to 8 h. Thus, free drug/IR complex loaded matrix films could be a potential topical ocular delivery platform for achieving immediate and sustained release characteristics.

Keywords: Ion exchange resins, immediate release formulations, ocular drug delivery, diclofenac sodium and polymeric matrix films

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- by Sai Prachetan Balguri and +1
  Goutham adelli
- •
- 2
  Formulation development, Preformulation

The use of medicinal plants as raw material in the production of drugs is again gaining popularity. Monechma ciliatum has many traditional uses and applications in African folk's medicines, e.g. the seed's powder macerated in water and... more

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- by Laura Oshin Román Orozco
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- Preformulation

Preformulation

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