Drug hypersensitivity
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Recent papers in Drug hypersensitivity
The introduction of highly active antiretroviral therapy (also known as combination therapy) has transformed the nature of HIV infection from a severe and ultimately fatal disease to that of a manageable chronic condition. HIV drugs are... more
Background: Most epidemiologic studies of anaphylaxis have been on Western populations, leaving the clinical and demographic pattern of this acute allergic condition in Asia unclear. Objective: To investigate the clinical characteristics... more
We report a case of severe contact urticaria with systemic involvement resembling an anaphylactic reaction, following the application of a topical corticosteroid. This was caused by hexylene glycol, an excipient in the formulation.... more
Drug fever is a common condition that is frequently misdiagnosed. It is a febrile response that coincides temporally with the administration of a drug and disappears after discontinuation of the offending agent. Drug fever is usually... more
and betalactamase inhibitors permit the effective use of amino-and ureido-penicillins in highly significant infections.
Perhaps the phrase "until the cows come home," which first appeared in 1829, applies to preterm infants. More evidence is mounting that cow's milk can induce an inflammatory reaction resulting in NEC and is eerily similar based on... more
Dentists are aware of contraindications to the use of vasoconstrictors in patients with cardiovascular diseases. However, there are some other noncardiac conditions we should know. This article discusses the absolute contraindications to... more
We report a 39-year-old female who underwent a total thyroidectomy as treatment for a thyroid papillary cancer. She suffered several episodes of mild angioedema in lips and tongue, after using different commercial Levothyroxine... more
Betalactams are the most frequent cause of hypersensitivity reactions to drugs mediated by a specific immune mechanism. Immediate reactions occur within 1 to 6 hours after betalactam administration, and are generally IgE-mediated. They... more
When drug reactions resembling allergy occur, they are called drug hypersensitivity reactions (DHRs) before showing the evidence of either drug-specific antibodies or T cells. DHRs may be allergic or nonallergic in nature, with drug... more
Desensitization for drug allergy is the induction of temporary clinical unresponsiveness to drug antigens. Gradual reintroduction of small doses of drug antigen at fixed time intervals allows for the delivery of full therapeutic doses,... more
and betalactamase inhibitors permit the effective use of amino-and ureido-penicillins in highly significant infections.
Measles is an acute, febrile, viral exanthema of childhood associated with high morbidity and grave sequelae. Live measles vaccines are routinely administered to all infants as a prophylactic measure. We describe a child with severe local... more
BLZ-100 is a single intravenous use, fluorescent imaging agent that labels tumor tissue to enable more complete and precise surgical resection. It is composed of a chlorotoxin peptide covalently bound to the near-infrared fluorophore... more
Chromium is a naturally occurring heavy metal found commonly in the environment in trivalent, Cr(III), and hexavalent, Cr(VI), forms. Cr(VI) compounds have been declared as a potent occupational carcinogen among workers in chrome plating,... more
Reacţii de hipersensibilitate la antiinflamatorii nesteroidiene: scurtă actualizare Reacțiile de hipersensibilitate induse de aspirină și alte AINS reprezintă o provocare pentru clinician, din cauza severității potențiale. La indivizi... more
Allergic contact dermatitis (ACD) from salicylates present in topical products is uncommon. Most publications about ACD from salicylates are case reports describing only a few patients. Cross-reactivity between salicylates is not commonly... more
The development of rapid desensitizations for the treatment of drug hypersensitivities is aimed at providing essential medications while protecting patients from IgE and non-IgE hypersensitivity reactions. Serious adverse drug reactions... more
Colophonium (rosin) is a complex mixture of over 100 compounds derived from pine trees of the Pinaceae family (1). There are 3 major types, gum, wood and tall oil, distinguished by their different methods of recovery (2). Gum rosin, the... more
We reported an anaphylaxis after oral intake and contact urticaria due to polyethylene glycols.
Recently it was found that drugs causing drug hypersensitivities do not only rely on the formation of hapten-carrier conjugates but can stimulate T cells directly via their T cell receptors for antigen. This new mechanism was termed... more
W e report on a patient with renal cystic dysplasia, whose mother was given gentamicin and corticosteroids early in preg nancy. We speculate that these drugs may be implicated in abnormal nephrogenesis in humans. This speculation is based... more
The aim of this study was to assess whether chemically intolerant women are at greater risk for having a child with autism spectrum disorders (ASD) or attention deficit hyperactivity disorder (ADHD). We conducted a case-control study of... more
Background: The prevalence of asthma of varying severity and associated risk factors are unknown in Turkey. Objective: The study investigated the distribution of asthma severity, the factors having roles in asthma severity, and the... more
were performed as previously described (3). The patient responded positively to prick testing with ceftriaxone (wheal 20 • 25 mm) at a concentration of 2 mg/ml, 10 min after application. Urticarial rash appeared on her arm, face and neck,... more
Background: Allergic reactions to antibiotics are common in daily clinical allergy practice. Oral drug provocation tests (ODPT) are used to determine safe alternative antibiotics in addition to diagnostic purposes. In one of our previous... more
Background: We examined demographic and clinical factors associated with same-day discharge and unplanned readmission following shoulder arthroplasty in adult patients. Methods: Utilizing data from the American College of Surgeons... more
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The airway responses to methacholine and to exercise challenges were compared in 45 young adults with asthma. The spirometric response to jive minutes of treadmill exercise was jirst documented. On a separate day methacholine... more
Background Poorly documented self-reported drug allergy (DAll) is a frequent problem in daily clinical practice and has a considerable impact on prescription choices. The diagnostic work-up of drug hypersensitivity (DHs) allows a better... more
Delayed drug allergy reactions (DDAR) are potentially fatal. Certain human leukocyte antigen (HLA) alleles have been associated with delayed allergy reactions following the administration of particular drugs. Examples are HLA-B * 57: 01... more
Most immune-mediated adverse drug reactions (IM-ADRs) involve the skin, and many have additional systemic features. Severe cutaneous adverse drug reactions (SCARs) are an uncommon, potentially life-threatening, and challenging subgroup of... more
Background: Momordica charantia (MC) is a tropical plant that is extensively used in folk medicine. However, the knowledge about side effects of this plant is relatively little according to knowledge about its therapeutic effects. The aim... more
A 53 year old female who was maintained on long-term warfarin therapy due to history of pulmonary embolism, repeatedly presents with an abnormally prolonged Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT). After... more
Tableau 1 Concentrations recommandé es des curares pour les prick-tests. Curare Concentration Prick-test Atracurium 1 mg/mL 1/10 e sol mè re Mivacurium 0,2 mg/mL 1/10 e sol. mè re Cisatracurium 2 mg/mL Sol. mè re Suxamé thonium 10 mg/mL... more
THE TREATMENT of infections in patients with suspected allergy to penicillin has become a very common and taxing problem in modern medical practice. [l-3] Unfortunately, the magnitude of this problem probably will increase in the future... more
The nomenclature proposed in the October 2003 report of the Nomenclature Review Committee of the World Allergy Organization is an update of the European Academy of Allergology and Clinical Immunology Revised Nomenclature for Allergy... more
Several reports emphasize the adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs) on renal function. We have observed over the last 10 years seven cases of acute renal failure (ARF) due to immune interstitial nephritis in... more
Adverse drug reactions have a significant impact on public health, clinical practice, and drug development. A widely used classification divides adverse drug reactions into two major types (1). Type A reactions are common (80%) and are... more
The antiplatelet drug clopidogrel is an oral thienopyridine derivative that has been extensively used for the treatment and secondary prevention of a variety of cardiovascular diseases. Although clopidogrel is well tolerated by most... more
With the exception of Ber e 1 reactivity, the allergenic profile was quite similar to that observed in patients in a previous study on Brazil nut allergy (3). Pre-absorption of patients' serum with Brazil nut did not modify the... more
Iodinated contrast media (CM) are highly concentrated solutions of iodinated benzene derivatives, used to enhance X-ray procedures (1). Although these products are regarded as relatively safe, they are known to cause both immediate (£ 1... more