Basal cell carcinoma (BCC) is one of the most common skin neoplasms in humans and is usually char... more Basal cell carcinoma (BCC) is one of the most common skin neoplasms in humans and is usually characterized by local aggressiveness with little metastatic potential, although deep invasion, recurrence, and regional and distant metastases may occur. Here, we studied the mechanism of BCC invasion. We found that human BCC tissues and a BCC cell line had significant expression of CXCR4,
Colophonium (rosin) is a complex mixture of over 100 compounds derived from pine trees of the Pin... more Colophonium (rosin) is a complex mixture of over 100 compounds derived from pine trees of the Pinaceae family (1). There are 3 major types, gum, wood and tall oil, distinguished by their different methods of recovery (2). Gum rosin, the most common form, is tapped from the sap of living trees, wood rosin is extracted from pine stumps and tall oil is obtained as a by-product from paper pulp production. Colophonium has numerous applications both at home and in the workplace. In medicine, derivatives of colophonium are found in plasters, bandages, and medicated creams and ointments. Patients with leg ulcers may come into contact with a modified form of colophony, ester gum resin, in Granuflex A hydrocolloid dressing (3, 4) and Lestreflex bandages. Patients with leg ulcers are usually patch tested to colophonium in the European standard series but are not routinely tested to ester gum resin. At Amersham Hospital, we have been patch testing leg ulcer patients to both colophonium and ester gum resin since 1972. Some patients have had positive patch test reactions to ester gum resin but not to colophony. It this test had not been included, an important relevant allergen would have been missed.
ABSTRACT Treatment of advanced cutaneous melanoma is still challenging and new data on melanoma b... more ABSTRACT Treatment of advanced cutaneous melanoma is still challenging and new data on melanoma biology are required. MicroRNAs (miRNAs) represent an emerging field in melanoma understanding. These small regulators of gene expression, involved in melanoma development and progression (Da cruz et al., 2012), showed promising results as biomarkers (Nair et al., 2012). As each miRNA could regulate multiple protein-coding genes and conversely, one gene could be targeted by different miRNAs (Bartel et al., 2009), the dysregulation of miRNAs could significantly impact various pathways and cells behavior. This article is protected by copyright. All rights reserved.
Basal cell carcinoma (BCC) is one of the most common skin neoplasms in humans and is usually char... more Basal cell carcinoma (BCC) is one of the most common skin neoplasms in humans and is usually characterized by local aggressiveness with little metastatic potential, although deep invasion, recurrence, and regional and distant metastases may occur. Here, we studied the mechanism of BCC invasion. We found that human BCC tissues and a BCC cell line had significant expression of CXCR4,
Colophonium (rosin) is a complex mixture of over 100 compounds derived from pine trees of the Pin... more Colophonium (rosin) is a complex mixture of over 100 compounds derived from pine trees of the Pinaceae family (1). There are 3 major types, gum, wood and tall oil, distinguished by their different methods of recovery (2). Gum rosin, the most common form, is tapped from the sap of living trees, wood rosin is extracted from pine stumps and tall oil is obtained as a by-product from paper pulp production. Colophonium has numerous applications both at home and in the workplace. In medicine, derivatives of colophonium are found in plasters, bandages, and medicated creams and ointments. Patients with leg ulcers may come into contact with a modified form of colophony, ester gum resin, in Granuflex A hydrocolloid dressing (3, 4) and Lestreflex bandages. Patients with leg ulcers are usually patch tested to colophonium in the European standard series but are not routinely tested to ester gum resin. At Amersham Hospital, we have been patch testing leg ulcer patients to both colophonium and ester gum resin since 1972. Some patients have had positive patch test reactions to ester gum resin but not to colophony. It this test had not been included, an important relevant allergen would have been missed.
ABSTRACT Treatment of advanced cutaneous melanoma is still challenging and new data on melanoma b... more ABSTRACT Treatment of advanced cutaneous melanoma is still challenging and new data on melanoma biology are required. MicroRNAs (miRNAs) represent an emerging field in melanoma understanding. These small regulators of gene expression, involved in melanoma development and progression (Da cruz et al., 2012), showed promising results as biomarkers (Nair et al., 2012). As each miRNA could regulate multiple protein-coding genes and conversely, one gene could be targeted by different miRNAs (Bartel et al., 2009), the dysregulation of miRNAs could significantly impact various pathways and cells behavior. This article is protected by copyright. All rights reserved.
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