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Objectives. We have created a pediatric sedation unit (PSU) in response to the need for uniform, safe, and appropriately monitored sedation and/or anal-gesia for children undergoing invasive and noninvasive studies or procedures in a large tertiary care medical center. The operational characteristics of the PSU are described in this report, as is our clinical experience in the first 8 months of operation. Methods. A retrospective review of quality assurance data was performed. These data included patient demo-graphics and chronic medical diagnoses, procedure, or study performed; sedative or analgesic medication given; complications (defined prospectively); and sedation and monitoring time. Patient-specific medical records related to the procedure and sedation were reviewed if a complication was noted in the quality assurance data. Results. Briefly, the PSU was staffed with an inten-sivist and pediatric intensive care unit nurses. Patients were admitted to the PSU and assessed medically for risk factors during sedation. Continuous heart rate, respiratory rate, and pulse oximetry monitoring were used, and blood pressure was determined every 5 minutes. After sedation and stabilization, with monitoring continued, the patient was transported to the site to undergo the procedure or study. The pediatric intensive care unit nurse remained with the patient at all times. All necessary emergency equipment was transported with the patient. After the procedure or study was completed, the patient was returned to the PSU for recovery to predetermined parameters. We were able to analyze 458 episodes of sedation for this review. Procedures and studies included radiologic examinations, cardiac catheterization, orthopedic manipulations , solid organ and bone marrow biopsy, gastroin-testinal endoscopy, bronchoscopy, evoked potential measurements , and others. Patients were 2 weeks to 32 years of age. The average time from initiation of sedation to last dose of medication administered was 84 minutes. The average time from initiation of sedation to full recovery was 120 minutes. Sedative and analgesia medications use was not standardized; however, the majority of children needing sedation received propofol or midazo-lam. For patients requiring analgesia, ketamine or fenta-nyl was added. In 79 of 458 (12%) sedation episodes, complications were documented. Mild hypotension (4.4%), pulse oximetry <93% (2.6%), apnea (1.5%), and transient airway obstruction (1.3%) were the most common complications noted. Cancellation of 11 (2.4%) procedures was attributable to complications. No long-term morbidity or mortality was seen. Conclusions. Many children require sedation or anal-gesia during procedures or studies. Safe sedation is best ensured by appropriate presedation risk assessment and with monitoring by a care provider trained in resuscita-tive measures who is not involved in performing the procedure itself. Uniformity of care in a large institution is a standard met by the creation of a centralized service, with active input from the department of anesthesiology. We present the PSU as a model for achieving these goals. Pediatrics 1998;102(3). URL: http://www.pediatrics.org/ cgi/content/full/102/3/e30; conscious sedation, child, propofol, anesthesia.
International Journal of Pediatrics, 2012
Sedation and/or analgesia are standard of care for pediatric patients during painful intervention or medical imaging requiring immobility. Physician availability is frequently insufficient to allow for all procedural sedation. A nurse-led sedation program was created at the Centre Hospitalier Universitaire de Sherbrooke (CHUS) to address this problem.Objective. To evaluate the effectiveness and the safety of our program.Methods. A retrospective study of all the procedural sedations done over one year was performed. Complications were separated in four categories: (1) major complications (call for help; unexpected admission, aspiration, and code); (2) reportable sedation events (oxygen saturation <90%, bradycardia (more than 2 SD below normal for the age of the child), and hypotension (more than 2 SD below normal for the age of the child); (3) difficult sedation (agitation, inadequate sedation, and failure to perform the procedure), (4) minor complications.Results. 448 patients, 2...
Indian pediatrics, 1994
Sedation is a frequently overlooked but an important aspect of care of pediatric patients. It serves an important role in reducing distress or anxiety in sick children and is also a prerequisite to facilitate diagnostic and therapeutic procedures. The degree of anxiety and co-operation for these depend on the child's apprehension of pain, from his understanding of, and previous experiences with the procedure and the child's cognitive maturational status. The goal of sedation and analgesia is to minimize suffering and achieve a calm and co-operative
Pediatric Critical Care Medicine, 2016
Background: Despite the fact that almost all critically ill children experience some degree of pain or anxiety, there is a lack of highquality evidence to inform preferred approaches to sedation, analgesia, and comfort measures in this environment. We conducted this survey to better understand current comfort and sedation practices among Canadian pediatric intensivists. Methods: The survey was conducted after a literature review and initial focus groups. The survey was then pretested and validated. The final survey was distributed by email to 134 intensivists from 17 PICUs across Canada using the Research Electronic Data Capture system. Results: The response rate was 73% (98/134). The most commonly used sedation scores are Face, Legs, Activity, Cry, and Consolability (42%) and COMFORT (41%). Withdrawal scores are commonly used (65%). In contrast, delirium scores are used by only 16% of the respondents. Only 36% of respondents have routinely used sedation protocols. The majority (66%) do not use noise reduction methods, whereas only 23% of respondents have a protocol to promote day/night cycles. Comfort measures including music, swaddling, soother, television, and sucrose solutions are frequently used. The drugs most commonly used to provide analgesia are morphine and acetaminophen. Midazolam and chloral hydrate were the most frequent sedatives. Conclusion: Our survey demonstrates great variation in practice in the management of pain and anxiety in Canadian PICUs. Standardized strategies for sedation, delirium and withdrawal, and sleep promotion are lacking. There is a need for research in this field and the development of evidence-based, pediatric sedation and analgesia guidelines.
Jornal de Pediatria, 2007
Objectives: To review the most frequent recommendations, doses and routes of administration of sedatives, analgesics, and muscle relaxants in children, as well as the methods for monitoring the level of sedation. Sources: Review of the literature using the MEDLINE database and review of the experience in pediatric intensive care units. Summary of the findings: The continuous administration of analgesics and sedatives prevents the development of undersedation and is less demanding in terms of care than intermittent administration. Midazolam is the most commonly used drug for continuous sedation of critically ill children. Opioid derivatives and nonsteroidal anti-inflammatory drugs are the most widely used analgesics in critically ill children. Opioids combined with benzodiazepines, given in continuous infusion, are the drugs of choice in mechanically ventilated children, especially morphine and fentanyl. The use of protocols and monitoring through clinical scores and objective methods (e.g. bispectral index) allow adjusting medication more appropriately, preventing oversedation, undersedation, and the withdrawal syndrome. Non-pharmacological interventions, such as music therapy, noise control, adequate use of light, massage, conversation with the patient, are ancillary measures that help children to adapt to the adverse hospital environment. Conclusions: Sedation should be tailored to each child for each specific situation. Protocols that facilitate the correct selection of drugs, their appropriate administration and careful monitoring improve the quality of sedation and analgesia and avoid their adverse effects.
International Journal of Emergency Medicine, 2008
Background Although young age is considered a risk factor for adverse events related to procedural sedation and analgesia (PSA), data in very young children (<2 years of age) are lacking. Aims The main objective of our study is to describe PSA in children <2 years of age in an inner city tertiary care pediatric emergency department (PED). Methods We conducted a retrospective chart review from January 2005 to June 2007 of children <2 years of age who received PSA in our PED. We collected demographic variables, indication for and medications used for PSA, adverse events (AE) related to PSA, and interventions performed to treat them. Results Of the children who received PSA, 14.5% (180/ 1,235) were <2 years of age of whom 173 were included for the analysis; 73% (126/173) of the study subjects were between 1 and 2 years of age, 54.3% (94/173) were male, and 96.5% (167/173) belonged to American Society of Anesthesiologists class 1. Incision and drainage (45.0%, 78/173) and laceration repair (32.4%, 56/173) were the two most common indications for PSA. Ketamine and midazolam was the most common combination medication used for PSA (62.4%, 108/173). Sedation was deemed ineffective in 5.8% (10/173) of the children. There were only two failed sedations; 5.8% (10/173) of the children experienced AE with most being minor [oxygen desaturations 1.7% (3/173), emesis 2.3% (4/173), and others 1.2% (2/173)]. One child experienced serious AE in the form of apnea and bradycardia requiring intubation. Conclusions Our data suggest that children under 2 years of age can be sedated effectively without increased risk of AE in a PED.
Clinical Pediatric Emergency Medicine, 2007
The practice of procedural sedation and analgesia in pediatrics is evolving rapidly. Some of our practices are backed by substantial supporting data, whereas for others, the evidence base is less well developed, leading to substantial differences in provider preferences. In addition, the multidisciplinary nature of providing sedation and differences in local custom and regulatory requirements all contribute to a certain amount of practice variability: the art of sedation. To provide a forum for exploring this, we invited experts in pediatric procedural sedation to share their practices and pearls, combining anecdotal experience with evidence from the literature. Clin Ped Emerg Med 8:268-278 C 2007 Elsevier Inc. All rights reserved.
Verbum Vitae, 2024
This essay is an attempt to explore different contexts of the phrase "you are the salt of the earth" found in Matt 5:13, one of the most confusing expressions used in the whole of the New Testament. The author deals with its original meaning, exposing in the process the earliest layers of transmission of Jesus' sayings. Versed in the Hebrew scriptures, Jesus combined the meanings of MLḤ in Exod 30:35 (incense salted is potent/good/pure/holy) with that in Isa 51:6 and Jer 38:11-12 (something MLḤ might vanish away/wax old/become rotten) and put it in a new context. Jesus' pun-loaded with multiple layers of meanings and shades of meanings-was lost in translation as simply "salt."
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