The hydroxamate siderophore ferricrocin was identified in Cladosporium cladosporioides growth med... more The hydroxamate siderophore ferricrocin was identified in Cladosporium cladosporioides growth medium by solid phase extraction and ultra high pressure liquid chromatography coupled to a time of flight mass spectrometer (UHPLC/QTOF-MS). Both desferricrocin and ferricrocin were detected in the extracellular medium assisted by high resolution mass spectrometry. This is the first identification of a hydroxamate siderophore in Cladosporium cladosporioides. This finding emphasizes the common meaning of ferricrocin in fungi.
ROBERT CRENEVERT, RENE GAGNON, DANIEL CHAMBERLAND, and MICHEL SIMARD. Can. J. Chem. 71, 1225Chem.... more ROBERT CRENEVERT, RENE GAGNON, DANIEL CHAMBERLAND, and MICHEL SIMARD. Can. J. Chem. 71, 1225Chem. 71, (1993. The macrocyclic polyether 18-crown-6 forms crystalline complexes with methyl sulfonates. Most complexes have a 2: 1 (su1fonate:crown) stoichiometry whereas small aliphatic sulfonates give a 1 : 1 ratio. In the 2: 1 ratio complexes, the guest molecules are coordinated above and below the crown in such a way that the dipoles are compensated. In the 1 : 1 ratio complexes, there is a polymeric type association with the two ends of the sulfonate interacting with different crown molecules. A crystal structure is reported for each type of complex. The complex 18-crown-6. CH3S03CH3 crystallizes in the monoclinic system, space group P2,/c with Z = 4. The unit cell dimensions are as follows: a = 8.525(4), b = 16.401(7), c = 15.071(6) A, P = 113.92(3)". Final R,,, = 0.064 for 3650 reflections. The complex 18-crown 6 . (C6H5S03Me)2 (I) crystallizes in the monoclinic systemo, space group P2,/c with Z = 2. The unit cell dimensions are as follows: a = 8.101(3), b = 17.136(5), c = 12.990(5) A, P = 121.30(3)". Final R,, = 0.048 for 2913 reflections. ROBERT CHENEVERT, RENE GAGNON, DANIEL CHAMBERLAND et MICHEL SIMARD. Can. J. Chem. 71, 1225 (1993).
Journal of the Chemical Society, Perkin Transactions 1, 1994
Page 1. J. CHEM. SOC. PERKIN TRANS. 1 1994 2537 Biological Baeyer-Villiger Oxidation of Some Mono... more Page 1. J. CHEM. SOC. PERKIN TRANS. 1 1994 2537 Biological Baeyer-Villiger Oxidation of Some Monocyclic and Bicyclic Ketones using Monooxygenases from Acinetobacter calcoaceticus NCIM B 9871 and Pseudomonas putida N CI M B 10007 ...
Background: It has been proposed that abnormal postprandial plasma nonesterified fatty acid (NEFA... more Background: It has been proposed that abnormal postprandial plasma nonesterified fatty acid (NEFA) metabolism may participate in the development of tissue lipotoxicity and type 2 diabetes (T2D). We previously found that non-diabetic offspring of two parents with T2D display increased plasma NEFA appearance and oxidation rates during intravenous administration of a fat emulsion. However, it is currently unknown whether plasma NEFA appearance and oxidation are abnormal during the postprandial state in these subjects at high-risk of developing T2D.
A sequence of ®ve chemical steps on solid support yields hydroxy-acids in a very straightforward ... more A sequence of ®ve chemical steps on solid support yields hydroxy-acids in a very straightforward and ecient manner. The resulting compounds can be cyclized in solution phase by forming an ester bond to produce macrolactones. #
ROBERT CRENEVERT, RENE GAGNON, DANIEL CHAMBERLAND, and MICHEL SIMARD. Can. J. Chem. 71, 1225Chem.... more ROBERT CRENEVERT, RENE GAGNON, DANIEL CHAMBERLAND, and MICHEL SIMARD. Can. J. Chem. 71, 1225Chem. 71, (1993. The macrocyclic polyether 18-crown-6 forms crystalline complexes with methyl sulfonates. Most complexes have a 2: 1 (su1fonate:crown) stoichiometry whereas small aliphatic sulfonates give a 1 : 1 ratio. In the 2: 1 ratio complexes, the guest molecules are coordinated above and below the crown in such a way that the dipoles are compensated. In the 1 : 1 ratio complexes, there is a polymeric type association with the two ends of the sulfonate interacting with different crown molecules. A crystal structure is reported for each type of complex. The complex 18-crown-6. CH3S03CH3 crystallizes in the monoclinic system, space group P2,/c with Z = 4. The unit cell dimensions are as follows: a = 8.525(4), b = 16.401(7), c = 15.071(6) A, P = 113.92(3)". Final R,,, = 0.064 for 3650 reflections. The complex 18-crown 6 . (C6H5S03Me)2 (I) crystallizes in the monoclinic systemo, space group P2,/c with Z = 2. The unit cell dimensions are as follows: a = 8.101(3), b = 17.136(5), c = 12.990(5) A, P = 121.30(3)". Final R,, = 0.048 for 2913 reflections. ROBERT CHENEVERT, RENE GAGNON, DANIEL CHAMBERLAND et MICHEL SIMARD. Can. J. Chem. 71, 1225 (1993).
The hydroxamate siderophore ferricrocin was identified in Cladosporium cladosporioides growth med... more The hydroxamate siderophore ferricrocin was identified in Cladosporium cladosporioides growth medium by solid phase extraction and ultra high pressure liquid chromatography coupled to a time of flight mass spectrometer (UHPLC/QTOF-MS). Both desferricrocin and ferricrocin were detected in the extracellular medium assisted by high resolution mass spectrometry. This is the first identification of a hydroxamate siderophore in Cladosporium cladosporioides. This finding emphasizes the common meaning of ferricrocin in fungi.
ROBERT CRENEVERT, RENE GAGNON, DANIEL CHAMBERLAND, and MICHEL SIMARD. Can. J. Chem. 71, 1225Chem.... more ROBERT CRENEVERT, RENE GAGNON, DANIEL CHAMBERLAND, and MICHEL SIMARD. Can. J. Chem. 71, 1225Chem. 71, (1993. The macrocyclic polyether 18-crown-6 forms crystalline complexes with methyl sulfonates. Most complexes have a 2: 1 (su1fonate:crown) stoichiometry whereas small aliphatic sulfonates give a 1 : 1 ratio. In the 2: 1 ratio complexes, the guest molecules are coordinated above and below the crown in such a way that the dipoles are compensated. In the 1 : 1 ratio complexes, there is a polymeric type association with the two ends of the sulfonate interacting with different crown molecules. A crystal structure is reported for each type of complex. The complex 18-crown-6. CH3S03CH3 crystallizes in the monoclinic system, space group P2,/c with Z = 4. The unit cell dimensions are as follows: a = 8.525(4), b = 16.401(7), c = 15.071(6) A, P = 113.92(3)". Final R,,, = 0.064 for 3650 reflections. The complex 18-crown 6 . (C6H5S03Me)2 (I) crystallizes in the monoclinic systemo, space group P2,/c with Z = 2. The unit cell dimensions are as follows: a = 8.101(3), b = 17.136(5), c = 12.990(5) A, P = 121.30(3)". Final R,, = 0.048 for 2913 reflections. ROBERT CHENEVERT, RENE GAGNON, DANIEL CHAMBERLAND et MICHEL SIMARD. Can. J. Chem. 71, 1225 (1993).
Journal of the Chemical Society, Perkin Transactions 1, 1994
Page 1. J. CHEM. SOC. PERKIN TRANS. 1 1994 2537 Biological Baeyer-Villiger Oxidation of Some Mono... more Page 1. J. CHEM. SOC. PERKIN TRANS. 1 1994 2537 Biological Baeyer-Villiger Oxidation of Some Monocyclic and Bicyclic Ketones using Monooxygenases from Acinetobacter calcoaceticus NCIM B 9871 and Pseudomonas putida N CI M B 10007 ...
Background: It has been proposed that abnormal postprandial plasma nonesterified fatty acid (NEFA... more Background: It has been proposed that abnormal postprandial plasma nonesterified fatty acid (NEFA) metabolism may participate in the development of tissue lipotoxicity and type 2 diabetes (T2D). We previously found that non-diabetic offspring of two parents with T2D display increased plasma NEFA appearance and oxidation rates during intravenous administration of a fat emulsion. However, it is currently unknown whether plasma NEFA appearance and oxidation are abnormal during the postprandial state in these subjects at high-risk of developing T2D.
A sequence of ®ve chemical steps on solid support yields hydroxy-acids in a very straightforward ... more A sequence of ®ve chemical steps on solid support yields hydroxy-acids in a very straightforward and ecient manner. The resulting compounds can be cyclized in solution phase by forming an ester bond to produce macrolactones. #
ROBERT CRENEVERT, RENE GAGNON, DANIEL CHAMBERLAND, and MICHEL SIMARD. Can. J. Chem. 71, 1225Chem.... more ROBERT CRENEVERT, RENE GAGNON, DANIEL CHAMBERLAND, and MICHEL SIMARD. Can. J. Chem. 71, 1225Chem. 71, (1993. The macrocyclic polyether 18-crown-6 forms crystalline complexes with methyl sulfonates. Most complexes have a 2: 1 (su1fonate:crown) stoichiometry whereas small aliphatic sulfonates give a 1 : 1 ratio. In the 2: 1 ratio complexes, the guest molecules are coordinated above and below the crown in such a way that the dipoles are compensated. In the 1 : 1 ratio complexes, there is a polymeric type association with the two ends of the sulfonate interacting with different crown molecules. A crystal structure is reported for each type of complex. The complex 18-crown-6. CH3S03CH3 crystallizes in the monoclinic system, space group P2,/c with Z = 4. The unit cell dimensions are as follows: a = 8.525(4), b = 16.401(7), c = 15.071(6) A, P = 113.92(3)". Final R,,, = 0.064 for 3650 reflections. The complex 18-crown 6 . (C6H5S03Me)2 (I) crystallizes in the monoclinic systemo, space group P2,/c with Z = 2. The unit cell dimensions are as follows: a = 8.101(3), b = 17.136(5), c = 12.990(5) A, P = 121.30(3)". Final R,, = 0.048 for 2913 reflections. ROBERT CHENEVERT, RENE GAGNON, DANIEL CHAMBERLAND et MICHEL SIMARD. Can. J. Chem. 71, 1225 (1993).
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