Papers by Bogdan Ioan Coculescu
Romanian Journal of Medical Practice
Background: Patients with chronic pancreatitis can suffer from a range of intense pain, as well a... more Background: Patients with chronic pancreatitis can suffer from a range of intense pain, as well as problems related to the functioning of the digestive organs, the evaluation of the quality of life can provide valuable information about the level of physical and emotional discomfort felt by the patients after the surgical intervention. Methods: A prospective study was carried out in the period 2014-2020 in which 113 patients with benign pancreatic pathology treated surgically admitted to the CF2 Clinical Hospital in Bucharest were included. For this study, the statistical method of simple linear regression was applied. Results: Patients' quality of life can also be influenced by the level of social support and medical care they receive. A strong support network, which can provide emotional and practical support, as well as access to appropriate and specialist medical care, can play an important role in managing symptoms and improving patients' quality of life. Conclusions: A...
Journal of Medicine and Life, 2015
The orientation towards one of the marketing policies with a major impact in organizations provid... more The orientation towards one of the marketing policies with a major impact in organizations providing healthcare services, requires a careful analysis of the needs and aspirations of customers, targeting those patients whose needs the service organization can achieve through the existing resources at the respective health facility, finding the most effective way of achieving benefits associated with reduced costs to maximizing profits, placing the offers for medical services required by the patients on the market, as well as promptly reacting and acting to the changes of health services market which is constantly evolving through a flexible organizing and functioning structure, connected to the financial needs of the patients.
International Journal of Immunopathology and Pharmacology
Burn healing should be regarded as a dynamic process consisting of two main, interrelated phases:... more Burn healing should be regarded as a dynamic process consisting of two main, interrelated phases: (a) the inflammatory phase when neutrophils and monocytes infiltrate the injury site, through localized vasodilation and fluid extravasation, and (b) the proliferative-remodeling phase, which represents a key event in wound healing. In the skin, both canonical autophagy (induced by starvation, oxidative stress, and environmental aggressions) and non-canonical or selective autophagy have evolved to play a discrete, but, essential, “housekeeping” role, for homeostasis, immune tolerance, and survival. Experimental data supporting the pro-survival roles of autophagy, highlighting its Yang, luminous and positive feature of this complex but insufficient explored molecular pathway, have been reported. Autophagic cell death describes an “excessive” degradation of important cellular components that are necessary for normal cell function. This deadly molecular mechanism brings to light the darker...
International Journal of Immunopathology and Pharmacology
At the level of the genital system, ovarian neoplasm is the most frequent cause of morbidity and ... more At the level of the genital system, ovarian neoplasm is the most frequent cause of morbidity and mortality. In the specialized literature, the coexistence of an inflammatory process is admitted from the early stages of the evolution of this pathology. Starting from the importance of this process, both in determinism and in the evolution of carcinogenesis and summarizing the field of knowledge, for this study we considered two objectives: the first was the presentation of the pathogenic mechanism, through which chronic +ovarian inflammation is involved in the process of carcinogenesis, and the second is the justification of the clinical utility of the three parameters, accepted as biomarkers of systemic inflammation: neutrophil-lymphocyte ratio, platelet lymphocyte ratio, and lymphocyte-monocyte ratio in the assessment of prognosis. The study highlights the acceptance of these hematological parameters, with practical utility, as prognostic biomarkers in ovarian cancer, based on the i...
Advances in Cancer Research & Clinical Imaging
This work is licensed under Creative Commons Attribution 4.0 License ACRCI.MS.ID.000562.
Romanian Journal of Medical Practice
Burning mouth syndrome (BMS) has been admitted relatively recently as a condition/syndrome within... more Burning mouth syndrome (BMS) has been admitted relatively recently as a condition/syndrome within oral pathology, bordering various other medical specialities, which may collaborate to determine the diagnosis and especially to achieve therapeutic success. From a clinical point of view, BMS can present itself in 2 forms: the primary/essential form, whose etiopathogenesis is unexplained, justifying the permanent concern as a topic of research at the international level, and the secondary form, in which the causes of the syndrome can be identified and treated/ removed, allowing healing. Particular to the primary form of BMS is the discrepancy between the extent of subjective pain felt by the patient as “burning” and the lack of any objective (clinical) signs in the oral mucosa. In this form of BMS, the pathogenesis of pain can be explained by invoking the role and importance of the field and some favourable factors. In recent years it has been noticed that changes in taste perception a...
Romanian Journal of Military Medicine, Apr 1, 2018
Gingival conditions are frequently encountered in dental clinical practice and they can raise dia... more Gingival conditions are frequently encountered in dental clinical practice and they can raise diagnosis and treatment problems. The diagnostic is variable from normal conditions to autoimmune diseases or even malignancy. Some of them cause disturbances such as pain, burning sensation and have an impact on patient’s quality of life.
Romanian Journal of Medical Practice
Strokes are very serious neurological disorders, most often with sudden onset, unpredictable evol... more Strokes are very serious neurological disorders, most often with sudden onset, unpredictable evolution and very high mortality. According to the World Health Organization, about 15 million people survive a stroke each year, and 5-6 million die each year from it. Globally, strokes are one of the leading causes of morbidity and mortality. Relatively recent clinical data show that strokes are the second leading cause of death worldwide. Thus, in Europe, new strokes occur annually in 100-200 cases per 100,000 inhabitants. For Romania, the epidemiological analysis of the data of our study shows that strokes are the leading cause of death in vascular diseases, i.e. cerebrovascular and cardiovascular diseases put together.
Romanian Journal of Military Medicine
Unlike the therapy of primary BMS, the treatment of secondary BMS benefits, in addition to sympto... more Unlike the therapy of primary BMS, the treatment of secondary BMS benefits, in addition to symptomatic therapy, from the possibility of using means and methods to correct biological disturbances and/or morphological, psycho-emotional changes respectively. The use of these therapeutic means in secondary BMS is recommended to be established as a first step of therapeutic conduct. Their success is reflected in homeostasis restoring, correcting morphological and functional changes of the field, which frequently leads to no longer use prescription of symptomatic treatment.
Revista de Chimie, 2019
The study is motivated by the existence of a still controversial etiopathogen on Burning Mouth Sy... more The study is motivated by the existence of a still controversial etiopathogen on Burning Mouth Syndrome. The objective of the study, which is carried out on a group of 103 sick of both sexes, presenting the Burning Mouth Disorder - the primary form, is to identify the prevalence of the disease and establish possible correlations with coexistence of age, gender and dyslipidemia as factors that can be considered as favoring the installation non-specific oral allergy. The conclusions of the research constitute an argument for admitting the hypothesis of the existence of a neuronal irrigation deficiency, manifested both at the conductive sensory fibers of the influx and, more preferably, at the sensory-sensorial cortex for pain and taste, or only at one of these levels. According to the hypothesis, neuronal suffering consists in a deficiency of energy production and use, induced by excessively local reactive oxygen species, through irrigation, developed by the presence of arteriosclerosis.
Journal of Enzyme Inhibition and Medicinal Chemistry
Modern Research in Dentistry, 2021
Burning mouth syndrome (BMS) in its primary clinical form has controversial etiopathogenesis, whi... more Burning mouth syndrome (BMS) in its primary clinical form has controversial etiopathogenesis, which explains the frequency of therapeutic failures. On the other hand, the characteristics of the oral pain that allow it to be identified as a particular form of pain are an impediment to its classification in a certain category: through functional lesion/disruption of receptors, of neuropathy or cortical type. Based on their professional experience and the scientific data from the specialized medical literature, the authors raise the hypothesis of the existence of a neuronal irrigation deficiency, manifested both at the conductive sensory fibers of the influx and, preferably, in the sensory-sensorial cortex for pain and taste, or their association. According to the hypothesis, neural irrigation is responsible for installing a shortage of energy production and use, as well as the local synthesis of excess reactive oxygen species that engages the disruption of conduction of the thermoalgesic nervous influx generated in the oral/lingual mucosa.
Academic Journal of Economic Studies, 2020
In this article, we set out to highlight the advantages of prevention in the field of dental medi... more In this article, we set out to highlight the advantages of prevention in the field of dental medicine and what the minimum costs are in this case, as well as how they increase the more a condition is not detected in time and resolved quickly when it occurs, if the patient does not go to the dentist for a consultation once every six months or at least once a year. We will then exemplify by presenting specific cases encountered with different patients, depending on the severity of the disease and what the costs are for solving the problems that appeared in the oral cavity. For the study of the activities in the dentist’s office we chose the cluster analysis mathematical model.
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Papers by Bogdan Ioan Coculescu