Papers by Peterson Menezes Terrazas
Garcinia achachairu (GAC) is a native plant from Bolivia that has been used in folk medicine for ... more Garcinia achachairu (GAC) is a native plant from Bolivia that has been used in folk medicine for the treatment of gastric disorders, rheumatism, inflammation and as a healing. The phytochemical characterization of this plant extract revealed that the benzophenone guttiferone A (GA) is one of its major compounds, which according to recent studies, has important antioxidant and antimicrobial activity. Considering the interest in deepening the analysis of the pharmacological potential of GA and the lack of studies assessing its genetic toxicity, the present study was designed in order to investigate the genotoxic and mutagenic effects of GA in different cells of mice in vivo, using some of the traditional tests in the mutagenesis area, the Comet Assay (CA) for genotoxicity evaluation and the Micronucleus Test (MT) for the mutagenicity assessment. The experiment was conducted in Swiss albino male mice (Mus musculus) with 12 weeks, divided into five groups with six animals each. The nega...
PLoS ONE, 2013
Benzophenones from natural sources and those of synthetic analogues present several reports of po... more Benzophenones from natural sources and those of synthetic analogues present several reports of potent biological properties, and Guttiferone A represents a promising medicinal natural compound with analgesic and gastroprotective profiles. Considering that there are no reports that assess the genetic toxicity of Guttiferone A, the present study was undertaken to investigate the genotoxic potential of this benzophenone isolated from seeds of Garcinia achachairu in terms of DNA damage in different cells of Swiss albino mice using the comet assay, and its clastogenic/aneugenic effects in bone marrow cells in vivo by the micronucleus test. Cytotoxicity was assessed by scoring polychromatic (PCE) and normochromatic (NCE) erythrocytes ratio. Guttiferone A was administered by oral gavage at doses of 15, 30 and 60 mg/kg. The results showed that Guttiferone A produced genotoxic effects in leukocytes, liver, bone marrow, brain and testicle cells and clastogenic/aneugenic effects in bone marrow erythrocytes of mice. The PCE/NCE ratio indicated no cytotoxicity. Since guttiferone A is harmful to the genetic material we suggest caution in its use by humans.
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Papers by Peterson Menezes Terrazas