PD-0298029

PD-0298029
IUPAC ime
	etil 3,6a,11,14-tetrahidro-9-metoksi-2-propil-3,5-dimetil-(12H)-izohino[1,2-b]pirolo[3,2-f][1,3]benzoksazin-1-karboksilat
Identifikatori
ATC kod	none
ChemSpider	26233369
Hemijski podaci
Formula	C27H32N2O4
Molarna masa	448,56 g·mol−1
	SMILES CCCc1c(c2c(n1C)cc(c3c2CN4CCc5cc(ccc5C4O3)OC)C)C(=O)OCC; ;
	InChI InChI=1S/C27H32N2O4/c1-6-8-21-24(27(30)32-7-2)23-20-15-29-12-11-17-14-18(31-5)9-10-19(17)26(29)33-25(20)16(3)13-22(23)28(21)4/h9-10,13-14,26H,6-8,11-12,15H2,1-5H3 ; Key:MTMZSGQXRVRKSY-UHFFFAOYSA-N ;

PD-0298029 je lek koji deluje kao selektivni antagonist za muskarinski acetilholinski receptor M₄. On je razvijen za lečenje Parkinsonove bolesti, ali je zbog slabe biodostupnosti i brzog metabolizma njegova primena u životinjskim studijama ograničena. On se prvenstveno koristi u in vitro istraživanjima M₄ i drugih muskarinskih receptora.^[1]^[2]^[3]

Reference

^ Böhme TM, Augelli-Szafran CE, Hallak H, Pugsley T, Serpa K, Schwarz RD (2002). „Synthesis and pharmacology of benzoxazines as highly selective antagonists at M(4) muscarinic receptors”. Journal of Medicinal Chemistry. 45 (14): 3094—102. PMID 12086495. doi:10.1021/jm011116o.
^ Boehme TM, Angelli-Szafran CE, Corinne E, Hallak H and Schwarz RD. Analogs of M4 selective synthetic muscarinic receptor antagonists: Synthesis, binding and pharmacokinetic properties. Medicinal Chemistry Research. 2002; 11(8):423–433.
^ Progress in Medicinal Chemistry 43. (2005). Chapter 4, Muscarinic Receptor Subtype Pharmacology and Physiology, by Richard M Eglen. pp 128-129. ISBN 0-444-51572-0