A-84543 je lek koji je razvilo preduzeće Abbott. Ovaj molekul je agonist neuronskog nikotinskog acetilholinskog receptora koji je visoko selektivan za α4β2 receptor. On nalazi široku primenu u naučnim israživanjima strukture i funkcije tog receptora. Ovaj ligand je bio polazno jedinjenje u razvoji velike familije srodnih derivata.[1][2][3][4]
^Abreo, M.; Lin, N.; Garvey, D.; Gunn, D.; Hettinger, A.; Wasicak, J.; Pavlik, P.; Martin, Y.; Donnelly-Roberts, D. (1996). „Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors”. Journal of Medical Chemistry. 39 (4): 817—825. PMID8632405. doi:10.1021/jm9506884.
^Lin, N. H.; Gunn, D. E.; Li, Y.; He, Y.; Bai, H.; Ryther, K. B.; Kuntzweiler, T.; Donnelly-Roberts, D. L.; Anderson, D. J. (1998). „Synthesis and structure-activity relationships of pyridine-modified analogs of 3-2-((S)-pyrrolidinyl)methoxypyridine, A-84543, a potent nicotinic acetylcholine receptor agonist”. Bioorganic & Medicinal Chemistry Letters. 8 (3): 249—254. PMID9871663. doi:10.1016/S0960-894X(98)00019-5.
^Wei, Z.; Xiao, Y.; Yuan, H.; Baydyuk, M.; Petukhov, P.; Musachio, J.; Kellar, K.; Kozikowski, A. (2005). „Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits”. Journal of Medicinal Chemistry. 48 (6): 1721—1724. PMID15771418. doi:10.1021/jm0492406.
^Carreras, J.; Avenoza, A.; Busto, J.; Peregrina, J. (2007). „Synthesis of azabicyclo2.2.nalkane systems as analogues of 3-1-methyl-2-(S)-pyrrolidinyl- methoxypyridine (A-84543)”. The Journal of Organic Chemistry. 72 (8): 3112—3115. PMID17371077. doi:10.1021/jo0700732.
