EMR receptor

EGF modul sadržavajući, mucinu sličan, hormonski receptor 3
EGF modul sadržavajući, mucinu sličan, hormonski receptor 3
Identifikatori
Simbol	EMR3
IUPHAR	EMR3
Entrez	84658
HUGO	23647
OMIM	606101
RefSeq	NM_032571
UniProt	Q9BY15
Ostali podaci
Lokus	Hromozom 19 p13.1

EGF modul sadržavajući, mucinu sličan, hormonski receptor 2
EGF modul sadržavajući, mucinu sličan, hormonski receptor 2
Identifikatori
Simbol	EMR2
IUPHAR	EMR2
Entrez	30817
HUGO	3337
OMIM	606100
RefSeq	NM_152916
UniProt	Q9UHX3
Ostali podaci
Lokus	Hromozom 19 p13.1

EGF modul sadržavajući, mucinu sličan, hormonski receptor 1
EGF modul sadržavajući, mucinu sličan, hormonski receptor 1
Identifikatori
Simbol	EMR1
Alt. simboli	TM7LN3
IUPHAR	EMR1
Entrez	2015
HUGO	3336
OMIM	600493
RefSeq	NM_001974
UniProt	Q14246
Ostali podaci
Lokus	Hromozom 19 p13.3

EGF modul sadržavajući, mucinu sličan, hormonski receptori (EMR) su blisko srodna grupa G protein spregnutih receptora. Ti receptori imaju jedinstvene hibridne strukture u kojima su ekstracelularni domeni slični epidermalnom faktoru rasta spojeni sa GPCR domenom putem mucinu sličnog segmenta.^[1]^[2]^[3]^[4]

Postoje četiri varijante EMR receptora, koje se obležavanju sa 1-4. One su kodirane zasebnim genima. Ti receptori su predominatno izraženi u ćelijama ljudskog imunskog sistema i za njih se vezuju ligandi poput CD55.^[5]

EGF modul sadržavajući, mucinu sličan, hormonski receptor 4 pseudogen
Identifikatori
Simbol	EMR4P
Alt. simboli	GPR127
Entrez	326342
HUGO	19240
RefSeq	XM_940358
UniProt	Q86SQ3
Ostali podaci
Lokus	Hromozom 19 p13.3

Reference

^ Baud V, Chissoe SL, Viegas-Péquignot E, Diriong S, N'Guyen VC, Roe BA, Lipinski M (1995). „EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments”. Genomics. 26 (2): 334—44. PMID 7601460. doi:10.1016/0888-7543(95)80218-B.
^ Lin HH, Stacey M, Hamann J, Gordon S, McKnight AJ (2000). „Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97”. Genomics. 67 (2): 188—200. PMID 10903844. doi:10.1006/geno.2000.6238.
^ Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ (2001). „Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils”. J. Biol. Chem. 276 (22): 18863—70. PMID 11279179. doi:10.1074/jbc.M101147200.
^ Caminschi I, Vandenabeele S, Sofi M, McKnight AJ, Ward N, Brodnicki TC, Toy T, Lahoud M, Maraskovsky E, Shortman K, Wright MD (2006). „Gene structure and transcript analysis of the human and mouse EGF-TM7 molecule, FIRE”. DNA Seq. 17 (1): 8—14. PMID 16753812. doi:10.1080/10425170500355737.
^ Kwakkenbos MJ, Kop EN, Stacey M, Matmati M, Gordon S, Lin HH, Hamann J (2004). „The EGF-TM7 family: a postgenomic view”. Immunogenetics. 55 (10): 655—66. PMID 14647991. doi:10.1007/s00251-003-0625-2.

Spoljašnje veze

EMR1+protein,+human на US National Library of Medicine Medical Subject Headings (MeSH)
EMR2+protein,+human на US National Library of Medicine Medical Subject Headings (MeSH)
EMR3+protein,+human на US National Library of Medicine Medical Subject Headings (MeSH)
EMR4+protein,+human на US National Library of Medicine Medical Subject Headings (MeSH)

[pmid7601460-1] Baud V, Chissoe SL, Viegas-Péquignot E, Diriong S, N'Guyen VC, Roe BA, Lipinski M (1995). „EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments”. Genomics. 26 (2): 334—44. PMID 7601460. doi:10.1016/0888-7543(95)80218-B.

[pmid10903844-2] Lin HH, Stacey M, Hamann J, Gordon S, McKnight AJ (2000). „Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97”. Genomics. 67 (2): 188—200. PMID 10903844. doi:10.1006/geno.2000.6238.

[pmid11279179-3] Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ (2001). „Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils”. J. Biol. Chem. 276 (22): 18863—70. PMID 11279179. doi:10.1074/jbc.M101147200.

[pmid16753812-4] Caminschi I, Vandenabeele S, Sofi M, McKnight AJ, Ward N, Brodnicki TC, Toy T, Lahoud M, Maraskovsky E, Shortman K, Wright MD (2006). „Gene structure and transcript analysis of the human and mouse EGF-TM7 molecule, FIRE”. DNA Seq. 17 (1): 8—14. PMID 16753812. doi:10.1080/10425170500355737.

[pmid14647991-5] Kwakkenbos MJ, Kop EN, Stacey M, Matmati M, Gordon S, Lin HH, Hamann J (2004). „The EGF-TM7 family: a postgenomic view”. Immunogenetics. 55 (10): 655—66. PMID 14647991. doi:10.1007/s00251-003-0625-2.

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