Zsolt Unoka
I am the head of Psychotherapy ward at the Department of Psychiatry and Psychotherapy, Semmelweis University Budapest. I am psychiatrist and psychotherapist. My research interest is personality disorders, affect- and self-regulation, social cognition, and core cognitive schemas.
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has also suggested that BPD patients have impairments in neuropsychological functioning, as seen in a previous
meta-analysis (Ruocco, 2005). This meta-analysis showed that neuropsychological functioning are marked
areas of concern in BPD; however, this meta-analytic research did not assess the effects of co-occurring disorders
on neuropsychological functioning in BPD patients. The current meta-analysis takes this into consideration and a
systematic review of cross-sectional studies comparing neuropsychological performance of individuals with BPD
with age-matched healthy comparison subjects was carried out. Potential moderators (i.e., age, gender, education
level, and co-morbid mental disorders) were analyzed. Significant deficits were observed in the decision
making, memory, executive functioning, processing speed, verbal intelligence, and visuospatial abilities. BPD patients
with more education and with parents of a higher educational level had better neuropsychological functioning.
Globally, BPD samples with a higher percentage of co-morbid personality disorders, major depression,
eating disorders, or any substance abuse disorders performed worse than patients with a less percentage; however,
anxiety disorders and PTSD co-morbidity did not affect the cognitive performance of the BPD group. Differences
are seen dependent on neuropsychological domain and specific co-morbidity. These findings highlight the
clinical relevance of characterizing cognitive functioning in BPD and the importance of considering demographic
and clinical moderators in future analyses.
Aims To examine, using meta-analysis, whether mental state decoding abilities in patients with major depression and borderline personality disorder differ from those of healthy controls.
Method A systematic review of 13 cross-sectional studies comparing Reading in the Mind of the Eyes Test (RMET) accuracy performance of patients with major depression or borderline personality disorder and healthy age-matched controls (n=976). Valence scores, where reported, were also assessed.
Results Large significant deficits were seen for global RMET performance in patients with major depression (d=70.751). The positive RMET valence scores of patients with depression were significantly worse; patients with borderline
personality disorder had worse neutral scores. Both groups were worse than controls. Moderator analysis revealed that individuals with comorbid borderline personality disorder and major depression did better than those with borderline personality disorder alone on accuracy. Those with comorbid borderline personality disorder and any cluster B or C personality disorder did worse than borderline personality disorder alone. Individuals with both borderline personality disorder and major depression performed better then those with borderline personality disorder without major depression for positive valence.
Conclusions These findings highlight the relevance of RMET performance in patients with borderline personality disorder and major depression, and the importance of considering comorbidity in future analysis.
has also suggested that BPD patients have impairments in neuropsychological functioning, as seen in a previous
meta-analysis (Ruocco, 2005). This meta-analysis showed that neuropsychological functioning are marked
areas of concern in BPD; however, this meta-analytic research did not assess the effects of co-occurring disorders
on neuropsychological functioning in BPD patients. The current meta-analysis takes this into consideration and a
systematic review of cross-sectional studies comparing neuropsychological performance of individuals with BPD
with age-matched healthy comparison subjects was carried out. Potential moderators (i.e., age, gender, education
level, and co-morbid mental disorders) were analyzed. Significant deficits were observed in the decision
making, memory, executive functioning, processing speed, verbal intelligence, and visuospatial abilities. BPD patients
with more education and with parents of a higher educational level had better neuropsychological functioning.
Globally, BPD samples with a higher percentage of co-morbid personality disorders, major depression,
eating disorders, or any substance abuse disorders performed worse than patients with a less percentage; however,
anxiety disorders and PTSD co-morbidity did not affect the cognitive performance of the BPD group. Differences
are seen dependent on neuropsychological domain and specific co-morbidity. These findings highlight the
clinical relevance of characterizing cognitive functioning in BPD and the importance of considering demographic
and clinical moderators in future analyses.
Aims To examine, using meta-analysis, whether mental state decoding abilities in patients with major depression and borderline personality disorder differ from those of healthy controls.
Method A systematic review of 13 cross-sectional studies comparing Reading in the Mind of the Eyes Test (RMET) accuracy performance of patients with major depression or borderline personality disorder and healthy age-matched controls (n=976). Valence scores, where reported, were also assessed.
Results Large significant deficits were seen for global RMET performance in patients with major depression (d=70.751). The positive RMET valence scores of patients with depression were significantly worse; patients with borderline
personality disorder had worse neutral scores. Both groups were worse than controls. Moderator analysis revealed that individuals with comorbid borderline personality disorder and major depression did better than those with borderline personality disorder alone on accuracy. Those with comorbid borderline personality disorder and any cluster B or C personality disorder did worse than borderline personality disorder alone. Individuals with both borderline personality disorder and major depression performed better then those with borderline personality disorder without major depression for positive valence.
Conclusions These findings highlight the relevance of RMET performance in patients with borderline personality disorder and major depression, and the importance of considering comorbidity in future analysis.