
Robi Polikar
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Papers by Robi Polikar
Methods: 36 MCI patients were stratified into amyloid positive (MCI-AD, n=17) and negative (MCI-Other, n=19) groups using CSF levels of Aβ42. All amyloid positive patients were also
p-Tau positive. P50s were elicited with an auditory oddball paradigm.
Results: MCI-AD patients yielded larger P50s than MCI-Other. The best amyloid-statuspredictor model showed 94.7% sensitivity, 94.1% specificity and 94.4% total accuracy.
Discussion: P50 predicted amyloid status in MCI patients, thereby showing a relationship with AD pathology versus MCI from an other etiology. The P50 may have clinical utility for
inexpensive prescreening and assessment of Alzheimer's pathology.
nonstationary environments, where the underlying
phenomena change over time, are becoming increasingly
prevalent. Examples of these applications include making
inferences or predictions based on financial data, energy demand
and climate data analysis, web usage or sensor network monitoring, and
malware/spam detection, among many others. In nonstationary environments,
particularly those that generate streaming or multi-domain data, the probability
density function of the data-generating process may change (drift) over time.
Therefore, the fundamental and rather naïve assumption made by most computational
intelligence approaches – that the training and testing data are sampled from the same fixed,
albeit unknown, probability distribution – is simply not true. Learning in nonstationary
environments requires adaptive or evolving approaches that can monitor and track the
underlying changes, and adapt a model to accommodate those changes accordingly.
In this effort, we provide a comprehensive survey and tutorial of established as
well as state-of-the-art approaches, while highlighting two primary perspectives,
active and passive, for learning in nonstationary environments.
Finally, we also provide an inventory of existing real and
synthetic datasets, as well as tools and software for getting
started, evaluating and comparing different approaches.
Methods: 36 MCI patients were stratified into amyloid positive (MCI-AD, n=17) and negative (MCI-Other, n=19) groups using CSF levels of Aβ42. All amyloid positive patients were also
p-Tau positive. P50s were elicited with an auditory oddball paradigm.
Results: MCI-AD patients yielded larger P50s than MCI-Other. The best amyloid-statuspredictor model showed 94.7% sensitivity, 94.1% specificity and 94.4% total accuracy.
Discussion: P50 predicted amyloid status in MCI patients, thereby showing a relationship with AD pathology versus MCI from an other etiology. The P50 may have clinical utility for
inexpensive prescreening and assessment of Alzheimer's pathology.
nonstationary environments, where the underlying
phenomena change over time, are becoming increasingly
prevalent. Examples of these applications include making
inferences or predictions based on financial data, energy demand
and climate data analysis, web usage or sensor network monitoring, and
malware/spam detection, among many others. In nonstationary environments,
particularly those that generate streaming or multi-domain data, the probability
density function of the data-generating process may change (drift) over time.
Therefore, the fundamental and rather naïve assumption made by most computational
intelligence approaches – that the training and testing data are sampled from the same fixed,
albeit unknown, probability distribution – is simply not true. Learning in nonstationary
environments requires adaptive or evolving approaches that can monitor and track the
underlying changes, and adapt a model to accommodate those changes accordingly.
In this effort, we provide a comprehensive survey and tutorial of established as
well as state-of-the-art approaches, while highlighting two primary perspectives,
active and passive, for learning in nonstationary environments.
Finally, we also provide an inventory of existing real and
synthetic datasets, as well as tools and software for getting
started, evaluating and comparing different approaches.