(Q37213586)

19 August 2017

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title

Maintaining the silence: reflections on long-term RNAi (English)

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19 August 2017

5

Stefaan C De Smedt

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19 August 2017

Roosmarijn Vandenbroucke

series ordinal

2

object named as

Roosmarijn E Vandenbroucke

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19 August 2017

3

Joseph Demeester

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19 August 2017

1

Koen Raemdonck

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19 August 2017

Niek N Sanders

4

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19 August 2017

publication date

7 August 2008

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19 August 2017

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19 August 2017

volume

13

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19 August 2017

issue

21-22

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19 August 2017

page(s)

917-931

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In vivo activity of nuclease-resistant siRNAs

19 August 2017

cites work

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12 December 2020

Intracellular distribution of low molecular weight RNA species in HeLa cells

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12 December 2020

Human immunodeficiency virus type 1 escape from RNA interference

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12 December 2020

Development of resistance to RNAi in mammalian cells

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12 December 2020

Chemically modified siRNA prolonged RNA interference in renal disease

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12 December 2020

RNA interference is mediated by 21- and 22-nucleotide RNAs

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12 December 2020

Molecular biology. Amplified silencing

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12 December 2020

The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells

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12 December 2020

Chemical modifications rescue off-target effects of RNAi

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12 December 2020

Design of active small interfering RNAs

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12 December 2020

Progress towards in vivo use of siRNAs

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12 December 2020

Gene therapy for severe combined immunodeficiency: are we there yet?

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12 December 2020

Second-generation shRNA libraries covering the mouse and human genomes

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12 December 2020

Inhibition of RNAse A family enzymes prevents degradation and loss of silencing activity of siRNAs in serum

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12 December 2020

Nucleoplasmic organization of small nuclear ribonucleoproteins in cultured human cells.

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12 December 2020

Hydrophobization and bioconjugation for enhanced siRNA delivery and targeting

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12 December 2020

Polymer brush-stabilized polyplex for a siRNA carrier with long circulatory half-life

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12 December 2020

Inhibiting gene expression at transcription start sites in chromosomal DNA with antigene RNAs

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12 December 2020

Mathematical models of RNA silencing: unidirectional amplification limits accidental self-directed reactions

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12 December 2020

Dynamics of gene silencing by RNA interference

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12 December 2020

Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

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12 December 2020

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

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12 December 2020

Induction of stable RNA interference in mammalian cells

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12 December 2020

Transport of dsRNA into cells by the transmembrane protein SID-1.

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12 December 2020

Long-term inhibition of hepatitis B virus in transgenic mice by double-stranded adeno-associated virus 8-delivered short hairpin RNA.

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12 December 2020

MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies

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12 December 2020

Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha

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12 December 2020

Short hairpin RNA-directed cytosine (CpG) methylation of the RASSF1A gene promoter in HeLa cells

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12 December 2020

RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo

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12 December 2020

Kinetic analysis of the RNAi enzyme complex

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12 December 2020

Comparison of antisense oligonucleotides and siRNAs in cell culture and in vivo.

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12 December 2020

Competition for RISC binding predicts in vitro potency of siRNA.

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12 December 2020

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

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12 December 2020

A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells.

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12 December 2020

RNA-directed de novo methylation of genomic sequences in plants.

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12 December 2020

A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans.

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12 December 2020

Prolonged transcriptional silencing and CpG methylation induced by siRNAs targeted to the HIV-1 promoter region

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12 December 2020

Occurrence of leukaemia following gene therapy of X-linked SCID.

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12 December 2020

Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA.

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12 December 2020

Polycation-based nanoparticle delivery for improved RNA interference therapeutics.

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12 December 2020

Silencing of HIV-1 with RNA interference: a multiple shRNA approach

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12 December 2020

Emerging significance of plasmid DNA nuclear import in gene therapy

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12 December 2020

Progress and problems with the use of viral vectors for gene therapy

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12 December 2020

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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12 December 2020

Structural analyses of the 7SK ribonucleoprotein (RNP), the most abundant human small RNP of unknown function

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12 December 2020

Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

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12 December 2020

Long-lasting RNAi activity in mammalian neurons

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12 December 2020

Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways

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12 December 2020

The silent treatment: siRNAs as small molecule drugs

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12 December 2020

Vector-based RNAi approaches for stable, inducible and genome-wide screens

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12 December 2020

MicroRNA biogenesis: coordinated cropping and dicing

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12 December 2020

Inhibition of MDR1 expression with altritol-modified siRNAs

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12 December 2020

Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication

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12 December 2020

Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells

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12 December 2020

shRNAs targeting hepatitis C: effects of sequence and structural features, and comparision with siRNA.

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12 December 2020

Slicer and the argonautes

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12 December 2020

Defining the optimal parameters for hairpin-based knockdown constructs

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12 December 2020

Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma

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12 December 2020

Nuclear accumulation of plasmid DNA can be enhanced by non-selective gating of the nuclear pore

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12 December 2020

Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages

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12 December 2020

RNA interference: a mammalian SID-1 homologue enhances siRNA uptake and gene silencing efficacy in human cells

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12 December 2020

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

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12 December 2020

Kinetics and synergistic effects of siRNAs targeting structural and replicase genes of SARS-associated coronavirus.

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12 December 2020

Combinatorial RNAi: a winning strategy for the race against evolving targets?

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12 December 2020

Cellular delivery of small interfering RNA by a non-covalently attached cell-penetrating peptide: quantitative analysis of uptake and biological effect

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12 December 2020

Small dsRNAs induce transcriptional activation in human cells

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12 December 2020

Cell cycle arrest drastically extends the duration of gene silencing after transient expression of short hairpin RNA.

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12 December 2020

ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation

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12 December 2020

Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells

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12 December 2020

In situ analysis of single-stranded and duplex siRNA integrity in living cells

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12 December 2020

DNA-dependent PK inhibits adeno-associated virus DNA integration

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12 December 2020

Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation

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12 December 2020

Biomembrane-permeable and Ribonuclease-resistant siRNA with enhanced activity

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12 December 2020

Inhibition of HIV-1 infection by small interfering RNA-mediated RNA interference

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12 December 2020

Inhibition of respiratory viruses by nasally administered siRNA.

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12 December 2020

Synthetic shRNAs as potent RNAi triggers

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12 December 2020

RNAi-mediated gene silencing in non-human primates.

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12 December 2020

Induction of DNA methylation and gene silencing by short interfering RNAs in human cells

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12 December 2020

Impact of tumor-specific targeting and dosing schedule on tumor growth inhibition after intravenous administration of siRNA-containing nanoparticles

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12 December 2020

Activation of the mammalian immune system by siRNAs.

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12 December 2020

siRNAs: applications in functional genomics and potential as therapeutics

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12 December 2020

Effect of siRNA nuclease stability on the in vitro and in vivo kinetics of siRNA-mediated gene silencing

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12 December 2020

Knocking down disease with siRNAs

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12 December 2020

Systemic RNAi in C. elegans requires the putative transmembrane protein SID-1.

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12 December 2020

Chemical modification: the key to clinical application of RNA interference?

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12 December 2020

The gene-silencing effect of siRNA in cationic lipoplexes is enhanced by incorporating pDNA in the complex

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12 December 2020

Strategies for silencing human disease using RNA interference

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12 December 2020

Novel Pol II fusion promoter directs human immunodeficiency virus type 1-inducible coexpression of a short hairpin RNA and protein.

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12 December 2020

Fusogenic peptides enhance endosomal escape improving siRNA-induced silencing of oncogenes

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12 December 2020

Overcoming the innate immune response to small interfering RNA.

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12 December 2020

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

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12 December 2020

RNA interference as potential therapy--not so fast

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12 December 2020

Potential applications for RNAi to probe pathogenesis and develop new treatments for ocular disorders

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12 December 2020

RETRACTED: Secondary siRNAs result from unprimed RNA synthesis and form a distinct class

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12 December 2020

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

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12 December 2020

Interfering with disease: a progress report on siRNA-based therapeutics

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12 December 2020

Nuclear export of microRNA precursors

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12 December 2020

RNA learns from antisense

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12 December 2020

RNAi: mammalian oocytes do it without RNA-dependent RNA polymerase

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12 December 2020

Transcriptional silencing and promoter methylation triggered by double-stranded RNA

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12 December 2020

Moment analysis for kinetics of gene silencing by RNA interference

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12 December 2020

Small interfering RNA-induced transcriptional gene silencing in human cells

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12 December 2020

A protocol for designing siRNAs with high functionality and specificity

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12 December 2020

Prolonged gene silencing in hepatoma cells and primary hepatocytes after small interfering RNA delivery with biodegradable poly(beta-amino esters).

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12 December 2020

A fast and sensitive method for measuring the integrity of siRNA-carrier complexes in full human serum

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12 December 2020

Overcoming HIV-1 resistance to RNA interference

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12 December 2020

Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes

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12 December 2020

Mechanisms and optimization of in vivo delivery of lipophilic siRNAs.

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12 December 2020

Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors

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12 December 2020

Tumor-targeted delivery of siRNA by self-assembled nanoparticles

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12 December 2020

Prolonged down regulation of specific gene expression in nucleus pulposus cell mediated by RNA interference in vitro

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12 December 2020

Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging

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12 December 2020

Photochemical internalization enhances silencing of epidermal growth factor receptor through improved endosomal escape of siRNA.

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12 December 2020

Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo.

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12 December 2020

Gene expression: long-term gene silencing by RNAi

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12 December 2020

Silencing of transgene transcription precedes methylation of promoter DNA and histone H3 lysine 9.

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12 December 2020

Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway

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12 December 2020

Focal adhesion kinase targeting using in vivo short interfering RNA delivery in neutral liposomes for ovarian carcinoma therapy.

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12 December 2020

Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery

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12 December 2020

Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy

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12 December 2020

Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing

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12 December 2020

Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans

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12 December 2020

A species of small antisense RNA in posttranscriptional gene silencing in plants

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12 December 2020

Distinct populations of primary and secondary effectors during RNAi in C. elegans

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12 December 2020

Reversible methylation and inactivation of marker genes in sequentially transformed tobacco plants.

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12 December 2020

RNA interference in vitro and in vivo using a novel chitosan/siRNA nanoparticle system.

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12 December 2020

Transvascular delivery of small interfering RNA to the central nervous system.

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12 December 2020

Chemical modification of siRNAs to improve serum stability without loss of efficacy.

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12 December 2020

Two classes of short interfering RNA in RNA silencing

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12 December 2020

Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1.

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12 December 2020

Long-term inhibition of HIV-1 infection in primary hematopoietic cells by lentiviral vector delivery of a triple combination of anti-HIV shRNA, anti-CCR5 ribozyme, and a nucleolar-localizing TAR decoy

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12 December 2020

Silencing Viral Infection

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12 December 2020

Absolute configuration of the diastereomers of adenosine 5'-O-(1-thiotriphosphate): consequences for the stereochemistry of polymerization by DNA-dependent RNA polymerase from Escherichia coli

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12 December 2020

Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging

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12 December 2020

Delivering silence: advancements in developing siRNA therapeutics.

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12 December 2020

Maintaining inhibition: siRNA double expression vectors against coxsackieviral RNAs

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12 December 2020

RNAi in human cells: basic structural and functional features of small interfering RNA.

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12 December 2020

Nonviral delivery vehicles for use in short hairpin RNA-based cancer therapies

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12 December 2020

Argonaute2 is the catalytic engine of mammalian RNAi

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12 December 2020

Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs

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12 December 2020

Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo

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12 December 2020

Transcriptional and posttranscriptional gene silencing are mechanistically related

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12 December 2020

Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC

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12 December 2020

Effect of adenovirus-mediated RNA interference on endogenous microRNAs in a mouse model of multidrug resistance protein 2 gene silencing

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12 December 2020

Activating gene expression in mammalian cells with promoter-targeted duplex RNAs

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12 December 2020

Involvement of AGO1 and AGO2 in mammalian transcriptional silencing

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12 December 2020

MicroRNAs: genomics, biogenesis, mechanism, and function

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12 December 2020

Targeted delivery of siRNA.

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12 December 2020

A system for stable expression of short interfering RNAs in mammalian cells

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12 December 2020

Combinational antitumor effect of siRNA against midkine and paclitaxel on growth of human prostate cancer xenografts

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12 December 2020

siRNA function in RNAi: a chemical modification analysis

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12 December 2020

Improvements in siRNA properties mediated by 2'-deoxy-2'-fluoro-beta-D-arabinonucleic acid (FANA)

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12 December 2020

Current developments in HIV chemotherapy

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12 December 2020

Tuning silence: conditional systems for RNA interference

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12 December 2020

Toxicity in mice expressing short hairpin RNAs gives new insight into RNAi

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12 December 2020

Approaches for chemically synthesized siRNA and vector-mediated RNAi

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12 December 2020

Optimization and functional effects of stable short hairpin RNA expression in primary human lymphocytes via lentiviral vectors.

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12 December 2020

Chromatin inactivation precedes de novo DNA methylation during the progressive epigenetic silencing of the RASSF1A promoter

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12 December 2020

Specific and potent RNAi in the nucleus of human cells

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12 December 2020

The micro RNA target paradigm: a fundamental and polymorphic control layer of cellular expression

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12 December 2020

Role of Arabidopsis ARGONAUTE4 in RNA-directed DNA methylation triggered by inverted repeats.

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12 December 2020

Therapeutic potential of siRNA-mediated transcriptional gene silencing.

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12 December 2020

Fully 2'-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA.

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12 December 2020

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

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12 December 2020

DNA methylation and chromatin - unraveling the tangled web.

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12 December 2020

RNA interference in human cells is restricted to the cytoplasm

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12 December 2020

The RNA silencing pathway: the bits and pieces that matter

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12 December 2020

A short history of a short RNA.

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7 October 2024

https://opencitations.net/index/api/v1/citations/10.1016/S0092-8674(04)00035-2

Identifiers

DOI

10.1016/J.DRUDIS.2008.06.008

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19 August 2017

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