(Q35058575)

6 August 2017

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title

Disruption of differentiation in human cancer: AML shows the way. (English)

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6 August 2017

Daniel G Tenen

1

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6 August 2017

language of work or name

English

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publication date

1 February 2003

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6 August 2017

published in

Nature Reviews Cancer

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6 August 2017

volume

3

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6 August 2017

issue

2

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6 August 2017

page(s)

89-101

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Purification and characterization of mouse hematopoietic stem cells

6 August 2017

cites work

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A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

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Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment

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AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations

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Dichotomy of AML1-ETO functions: growth arrest versus block of differentiation

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Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocation

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Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation

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Distinct domains of the GATA-1 cofactor FOG-1 differentially influence erythroid versus megakaryocytic maturation

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AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

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Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

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Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages.

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PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors

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Granulocyte inducer C/EBPalpha inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions

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CCAAT/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors

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PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene.

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The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor

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Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPalpha

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Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice

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CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein

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C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4

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c-Myc is a critical target for c/EBPalpha in granulopoiesis.

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E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo

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Activation of the erythropoietin receptor promoter by transcription factor GATA-1

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Autoregulation of the human C/EBP alpha gene by stimulation of upstream stimulatory factor binding

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Cooperation between C/EBPalpha TBP/TFIIB and SWI/SNF recruiting domains is required for adipocyte differentiation

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Upregulation of interleukin 6 and granulocyte colony-stimulating factor receptors by transcription factor CCAAT enhancer binding protein alpha (C/EBP alpha) is critical for granulopoiesis

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McBindall--a better name for CCAAT/enhancer binding proteins?

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The effects of Bcr-Abl on C/EBP transcription-factor regulation and neutrophilic differentiation are reversed by the Abl kinase inhibitor imatinib mesylate

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Expression of the AML-1 oncogene shortens the G(1) phase of the cell cycle

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AML1 stimulates G1 to S progression via its transactivation domain

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t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1

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Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

21 January 2018

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In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: implications for mechanisms of pathogenesis

21 January 2018

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The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo

21 January 2018

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Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta

21 January 2018

1 reference

C/EBP-beta, C/EBP-delta, PU.1, AML1 genes: mutational analysis in 381 samples of hematopoietic and solid malignancies

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Heterozygous PU.1 mutations are associated with acute myeloid leukemia.

21 January 2018

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The t(8;21) Fusion Product, AML-1–ETO, Associates with C/EBP-α, Inhibits C/EBP-α-Dependent Transcription, and Blocks Granulocytic Differentiation

21 January 2018

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Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia

21 January 2018

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Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias

21 January 2018

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Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome

21 January 2018

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The C-terminal zinc finger of GATA-1 or GATA-2 is sufficient to induce megakaryocytic differentiation of an early myeloid cell line.

21 January 2018

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Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line

21 January 2018

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In vivo requirements for GATA-1 functional domains during primitive and definitive erythropoiesis

21 January 2018

1 reference

AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia.

21 January 2018

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Molecular classification of cancer: class discovery and class prediction by gene expression monitoring

21 January 2018

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CCAAT/enhancer binding protein epsilon is a potential retinoid target gene in acute promyelocytic leukemia treatment

21 January 2018

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CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia

21 January 2018

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Loss of PU.1 expression following inhibition of histone deacetylases

21 January 2018

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Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors

21 January 2018

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Intercellular trafficking and protein delivery by a herpesvirus structural protein

21 January 2018

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In vivo protein transduction: delivery of a biologically active protein into the mouse

21 January 2018

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Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

21 January 2018

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Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

21 January 2018

1 reference

AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation

21 January 2018

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Multipotent hematopoietic cell lines derived from C/EBPalpha(-/-) knockout mice display granulocyte macrophage-colony-stimulating factor, granulocyte- colony-stimulating factor, and retinoic acid-induced granulocytic differentiation

21 January 2018

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Induction of granulocytic differentiation by 2 pathways

21 January 2018

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Lessons from hereditary colorectal cancer

21 January 2018

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Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

21 January 2018

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Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia

21 January 2018

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Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells

21 January 2018

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BCL-2 cooperates with promyelocytic leukemia retinoic acid receptor alpha chimeric protein (PMLRARalpha) to block neutrophil differentiation and initiate acute leukemia

21 January 2018

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Receptor- and mitochondrial-mediated apoptosis in acute leukemia: a translational view

21 January 2018

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Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1

21 January 2018

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c-Jun is a JNK-independent coactivator of the PU.1 transcription factor.

21 January 2018

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Differential regulation of the human and murine CD34 genes in hematopoietic stem cells.

21 January 2018

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CCAAT/enhancer binding protein gene promoter: binding of nuclear factors during differentiation of 3T3-L1 preadipocytes

21 January 2018

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High level activity of the mouse CCAAT/enhancer binding protein (C/EBP alpha) gene promoter involves autoregulation and several ubiquitous transcription factors

21 January 2018

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AML1 and AML1 fusion protein AML1-ETO in myeloid gene regulation and leukemogenesis

21 January 2018

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Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia

21 January 2018

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Causal relationship between the loss of RUNX3 expression and gastric cancer

21 January 2018

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Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein alpha

21 January 2018

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C/EBPbeta, but not C/EBPalpha, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland.

21 January 2018

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Identification of two polypeptide segments of CCAAT/enhancer-binding protein required for transcriptional activation of the serum albumin gene

21 January 2018

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Regulation of the PU.1 gene by distal elements

21 January 2018

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The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia

21 January 2018

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Heparan sulphate bound growth factors: a mechanism for stromal cell mediated haemopoiesis

21 January 2018

1 reference

Upregulation of lineage specific receptors and ligands in multipotential progenitor cells is part of an endogenous program of differentiation

21 January 2018

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Proliferative status of primitive hematopoietic progenitors from patients with acute myelogenous leukemia (AML)

21 January 2018

1 reference

Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA)

21 January 2018

1 reference

Unlike AML1, CBFbeta gene is not deregulated by point mutations in acute myeloid leukemia and in myelodysplastic syndromes

21 January 2018

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PU.1 exhibits partial functional redundancy with Spi-B, but not with Ets-1 or Elf-1

21 January 2018

1 reference

Overexpression of C/EBP -LIP, a Naturally Occurring, Dominant-Negative Transcription Factor, in Human Breast Cancer

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1038/NRC989

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6 August 2017

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