(Q34718183)

4 August 2017

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title

Core-binding factors in haematopoiesis and leukaemia (English)

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4 August 2017

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Nancy A Speck

1

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4 August 2017

D Gary Gilliland

series ordinal

2

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4 August 2017

language of work or name

English

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publication date

1 July 2002

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4 August 2017

published in

Nature Reviews Cancer

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4 August 2017

volume

2

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4 August 2017

issue

7

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4 August 2017

page(s)

502-513

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t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1

4 August 2017

cites work

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Leukaemia/Drosophila homology

31 March 2020

1 reference

The Runt domain identifies a new family of heteromeric transcriptional regulators.

31 March 2020

1 reference

Purification of core-binding factor, a protein that binds the conserved core site in murine leukemia virus enhancers

31 March 2020

1 reference

Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha

31 March 2020

1 reference

PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene

31 March 2020

1 reference

Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor

31 March 2020

1 reference

Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia

31 March 2020

1 reference

Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation

31 March 2020

1 reference

Cloning and expression pattern of a novel PEBP2 beta-binding protein (charged amino acid rich leucine zipper-1[Crl-1]) in the mouse

31 March 2020

1 reference

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

31 March 2020

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Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

31 March 2020

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The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo

31 March 2020

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Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta

31 March 2020

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Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions

31 March 2020

1 reference

Identification of human granzyme B promoter regulatory elements interacting with activated T-cell-specific proteins: implication of Ikaros and CBF binding sites in promoter activation.

31 March 2020

1 reference

Structural and functional characterization of the human CD36 gene promoter: identification of a proximal PEBP2/CBF site

31 March 2020

1 reference

A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia

31 March 2020

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Emergence of multipotent hemopoietic cells in the yolk sac and paraaortic splanchnopleura in mouse embryos, beginning at 8.5 days postcoitus.

31 March 2020

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Definitive hematopoietic stem cells first develop within the major arterial regions of the mouse embryo

31 March 2020

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Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyomavirus enhancer binding protein 2/core binding factor

31 March 2020

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Haploinsufficiency of AML1 affects the temporal and spatial generation of hematopoietic stem cells in the mouse embryo

31 March 2020

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Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11.

31 March 2020

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The AML1 transcription factor functions to develop and maintain hematogenic precursor cells in the embryonic aorta-gonad-mesonephros region.

31 March 2020

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Requirement of Runx1/AML1/PEBP2alphaB for the generation of haematopoietic cells from endothelial cells

31 March 2020

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Tracing the progeny of the aortic hemangioblast in the avian embryo

31 March 2020

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Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryo

31 March 2020

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Runx1 is essential for hematopoietic commitment at the hemangioblast stage of development in vitro

31 March 2020

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Diminution of the AML1 transcription factor function causes differential effects on the fates of CD4 and CD8 single-positive T cells

31 March 2020

1 reference

Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

31 March 2020

1 reference

In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: implications for mechanisms of pathogenesis

31 March 2020

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Amplification of AML1 in childhood acute lymphoblastic leukemias

31 March 2020

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Spectral karyotyping and fluorescence in situ hybridization detect novel chromosomal aberrations, a recurring involvement of chromosome 21 and amplification of the MYC oncogene in acute myeloid leukaemia M2

31 March 2020

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Multicolor spectral karyotyping identifies novel translocations in childhood acute lymphoblastic leukemia

31 March 2020

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Amplification of the AML1(CBFA2) gene on ring chromosomes in a patient with acute myeloid leukemia and a constitutional ring chromosome 21

31 March 2020

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Proviral insertions induce the expression of bone-specific isoforms of PEBP2alphaA (CBFA1): evidence for a new myc collaborating oncogene

31 March 2020

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Sensitivity to myc-induced apoptosis is retained in spontaneous and transplanted lymphomas of CD2-mycER mice

31 March 2020

1 reference

Runx2: a novel oncogenic effector revealed by in vivo complementation and retroviral tagging

31 March 2020

1 reference

Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions

31 March 2020

1 reference

Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia

31 March 2020

1 reference

Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia

31 March 2020

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Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations

31 March 2020

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The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation

31 March 2020

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The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription

31 March 2020

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The inv(16) encodes an acute myeloid leukemia 1 transcriptional corepressor

31 March 2020

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Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.

31 March 2020

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Synergistic up-regulation of the myeloid-specific promoter for the macrophage colony-stimulating factor receptor by AML1 and the t(8;21) fusion protein may contribute to leukemogenesis

31 March 2020

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The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells

31 March 2020

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ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors

31 March 2020

1 reference

Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.

31 March 2020

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Both TEL and AML-1 contribute repression domains to the t(12;21) fusion protein

31 March 2020

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The leukemic protein core binding factor beta (CBFbeta)-smooth-muscle myosin heavy chain sequesters CBFalpha2 into cytoskeletal filaments and aggregates

31 March 2020

1 reference

Cytoplasmic sequestration of the polyomavirus enhancer binding protein 2 (PEBP2)/core binding factor alpha (CBFalpha) subunit by the leukemia-related PEBP2/CBFbeta-SMMHC fusion protein inhibits PEBP2/CBF-mediated transactivation

31 March 2020

1 reference

PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors

31 March 2020

1 reference

The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein

31 March 2020

1 reference

Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation.

31 March 2020

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Acquisition of oncogenic potential by RAR chimeras in acute promyelocytic leukemia through formation of homodimers.

31 March 2020

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Oligomerization of ETO is obligatory for corepressor interaction

31 March 2020

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The t(8;21) Fusion Product, AML-1–ETO, Associates with C/EBP-α, Inhibits C/EBP-α-Dependent Transcription, and Blocks Granulocytic Differentiation

31 March 2020

1 reference

Prenatal origin of acute lymphoblastic leukaemia in children

31 March 2020

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Fetal origins of the TEL-AML1 fusion gene in identical twins with leukemia

31 March 2020

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Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

31 March 2020

1 reference

The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia

31 March 2020

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Function of the inv(16) fusion gene CBFB-MYH11.

31 March 2020

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Multiple clones with (3;21) translocation in a case of Ph-positive chronic myelogenous leukemia during relapse after allogeneic bone marrow transplantation

31 March 2020

1 reference

Additional translocation (8;21)(q22;q22) in a patient with Philadelphia-positive chronic myelogenous leukaemia in the blastic phase

31 March 2020

1 reference

Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation

31 March 2020

1 reference

Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome

31 March 2020

1 reference

Fatal myeloproliferation, induced in mice by TEL/PDGFbetaR expression, depends on PDGFbetaR tyrosines 579/581

31 March 2020

1 reference

Biological characteristics and prognosis of adult acute myeloid leukemia with internal tandem duplications in the Flt3 gene

31 March 2020

1 reference

The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the Unite

31 March 2020

1 reference

Clonal analysis of multiple point mutations in the N-ras gene in patients with acute myeloid leukemia.

31 March 2020

1 reference

Patients with t(8;21)(q22;q22) and acute myeloid leukemia have superior failure-free and overall survival when repetitive cycles of high-dose cytarabine are administered

31 March 2020

1 reference

Molecular and clinical advances in core binding factor primary acute myeloid leukemia: a paradigm for translational research in malignant hematology

31 March 2020

1 reference

Clinical importance of cytogenetics in acute myeloid leukaemia

31 March 2020

1 reference

TEL gene rearrangement in acute lymphoblastic leukemia: a new genetic marker with prognostic significance

31 March 2020

1 reference

Significance of the TEL-AML fusion gene in childhood AML

31 March 2020

1 reference

Biology and clinical significance of the TEL/AML1 rearrangement

31 March 2020

1 reference

Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

31 March 2020

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Development of hematopoietic stem cell activity in the mouse embryo

31 March 2020

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Definitive hematopoiesis is autonomously initiated by the AGM region

31 March 2020

1 reference

In vitro generation of lymphohematopoietic cells from endothelial cells purified from murine embryos

31 March 2020

1 reference

Intrinsic transcriptional activation-inhibition domains of the polyomavirus enhancer binding protein 2/core binding factor alpha subunit revealed in the presence of the beta subunit

31 March 2020

1 reference

Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF-alpha transcription factors

31 March 2020

1 reference

Intranuclear targeting of AML/CBFα regulatory factors to nuclear matrix-associated transcriptional domains

31 March 2020

1 reference

Negative regulation of granulocytic differentiation in the myeloid precursor cell line 32Dcl3 byear-2, a mammalian homolog ofDrosophila seven-up, and a chimeric leukemogenic gene,AML1/ETO(MTG8)

31 March 2020

1 reference

ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function

31 March 2020

1 reference

Multiple functional domains of AML1: PU.1 and C/EBPalpha synergize with different regions of AML1

31 March 2020

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A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator

31 March 2020

1 reference

CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter

31 March 2020

1 reference

AML1 (CBFalpha2) cooperates with B cell-specific activating protein (BSAP/PAX5) in activation of the B cell-specific BLK gene promoter

31 March 2020

1 reference

Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias

31 March 2020

1 reference

Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation

31 March 2020

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Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors

31 March 2020

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Groucho-Dependent and -Independent Repression Activities of Runt Domain Proteins

31 March 2020

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The capacity of polyomavirus enhancer binding protein 2alphaB (AML1/Cbfa2) to stimulate polyomavirus DNA replication is related to its affinity for the nuclear matrix

31 March 2020

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Core-binding factor beta (CBFbeta), but not CBFbeta-smooth muscle myosin heavy chain, rescues definitive hematopoiesis in CBFbeta-deficient embryonic stem cells

31 March 2020

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Energetic and functional contribution of residues in the core binding factor beta (CBFbeta ) subunit to heterodimerization with CBFalpha.

31 March 2020

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Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain

31 March 2020

1 reference

The Ig fold of the core binding factor alpha Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains

31 March 2020

1 reference

The leukemia-associated AML1 (Runx1)--CBF beta complex functions as a DNA-induced molecular clamp

31 March 2020

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DNA-binding by Ig-fold proteins

31 March 2020

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Solution structure of core binding factor beta and map of the CBF alpha binding site

31 March 2020

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Molecular insights into PEBP2/CBF beta-SMMHC associated acute leukemia revealed from the structure of PEBP2/CBF beta

31 March 2020

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Biophysical characterization of interactions between the core binding factor alpha and beta subunits and DNA.

31 March 2020

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Mutations of the AML1 gene in acute myeloid leukemia of FAB types M0 and M7.

31 March 2020

1 reference

A novel CBFA2 single-nucleotide mutation in familial platelet disorder with propensity to develop myeloid malignancies.

31 March 2020

1 reference

The common TEL/AML1 rearrangement does not represent a frequent event in acute lymphoblastic leukaemia occuring in children with Down syndrome

31 March 2020

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Prognostic significance of TEL/AML1 fusion transcript in childhood B-precursor acute lymphoblastic leukemia

31 March 2020

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TEL-AML1 fusion transcript designates a favorable outcome with an intensified protocol in childhood acute lymphoblastic leukemia

31 March 2020

1 reference

Determinants of outcome after intensified therapy of childhood lymphoblastic leukaemia: results from Medical Research Council United Kingdom acute lymphoblastic leukaemia XI protocol

31 March 2020

1 reference

TEL/AML1 fusion is not a prognostic factor in Dutch childhood acute lymphoblastic leukaemia

31 March 2020

1 reference

TEL/AML1 rearrangement and the prognostic significance in childhood acute lymphoblastic leukemia in Hong Kong

31 March 2020

1 reference

Expression of TEL-AML1 Fusion Transcripts and Response to Induction Therapy in Standard Risk Acute Lymphoblastic Leukemia

31 March 2020

1 reference

Low frequency of TEL-AML1 in relapsed acute lymphoblastic leukemia supports a favorable prognosis for this genetic subgroup

31 March 2020

1 reference

Significantly lower relapse rate for TEL/AML1-positive ALL

31 March 2020

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Potential roles for RUNX1 and its orthologs in determining hematopoietic cell fate

31 March 2020

1 reference

Sex, segments, and the central nervous system: common genetic mechanisms of cell fate determination.

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Purification of a mouse nuclear factor that binds to both the A and B cores of the polyomavirus enhancer

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRC840

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Dimensions Publication ID

4 August 2017

1053102883

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