Papers by Prof Dr Shashank Tiwari
Today, the tablet is the most popular dosage form, covering around 50% of total oral drug deliver... more Today, the tablet is the most popular dosage form, covering around 50% of total oral drug delivery system and accounting 75% of all pharmaceutical preparation produced .It promotes statbility, portability and acceptable patient compliance .The quality of solid dosage form is primarily influenced by micromeritic characteristics such as the shape and size of drug crystal, especially in the case of poorly soluble drugs. To improve the dissolution rate of poorly soluble drugs, fine crystals are referred and this micronisation can change drug powder properties such as wettability, compressibility, packability and flow. Further, it is more beneficial to convert micro crystalline drugs into an agglomerated form using spherical crystallization technique. The resulting spherically agglomerated crystals can be directly prepared into a tablet, thus direct tabletting saves time and reduces cost .General methods of spherical crystallization are spherical agglomeration, emulsion, solvent diffusio...
The preparation of microsphere by solvent evaporati on method has been studied extensively to pre... more The preparation of microsphere by solvent evaporati on method has been studied extensively to prepare a microsphere using biodegradable polymer. The properties of biodegradable microsphere of poly (lactic a cid) (PLA) and (acid lactic- co-glycolic) (PLGA) have been ext ensively investigated. The encapsulation of highly water soluble compounds including proteins and peptides is provid ing challenges to the pharmaceutics person. The suc cessful encapsulation of such entities requires high drug l oading in the microsphere, prevention of protein de gradation by the encapsulation method, and predictable release o f the drug compound from the microsphere. Multiple emulsion techniques and some other innovative modifications have been made to the conventional solvent evaporat ion process. A several process variable affecting the q uality of product has been studies in this review.
International Journal of Pharmacy, Apr 1, 2012
Well said that research is a never ending field but still is always motivates to one & all for th... more Well said that research is a never ending field but still is always motivates to one & all for thinking beyond in order to create miracles. And the 2020 will be miracles world for pharma sector. At that time the time will be OTC medicines. The Indian pharmaceutical sector is the highly organized sector; it ranks very high amongst all the thirds world countries in the term of technology, quality and the vast range of medicines that are manufactured.
Well said that research is a never ending field but still is always motivates to one & all for th... more Well said that research is a never ending field but still is always motivates to one & all for thinking beyond in order to create miracles. And the 2020 will be miracles world for pharma sector...
Journal of Pharmaceutical Research International, 2024
The Solanaceae plant family is a large clade that includes Datura, a genus of plants with many sp... more The Solanaceae plant family is a large clade that includes Datura, a genus of plants with many species recognized for their severe pharmacological effects via tropane alkaloids like atropine, hyoscyamine and scopolamine. These alkaloids act as antagonists of muscarinic acetylcholine receptors with leading to a truly diverse pharmacological action, ranging from anticholinergic effects all the way through hallucinogenic properties. Datura plants have been used historically in traditional medicine and rituals worldwide but are infamous for poisoning due to the risk of severe anticholinergic toxicity, including death. Nevertheless, their pharmacology has become of interest for research due to potential therapeutic applications: specifically in controlling nauseousness and perhaps neurological disorders. In this review, we provide a summary of the botanical description and cultivation methods in addition to those on traditional use practices concerning phytochemistry, pharmacology and toxicology as compared with evidence-based information together emphasizing cautions against availability without stringent regulatory consideration for its modern medical uses or ritualistic purposes.
International Journal of Science and Research, 2024
Centella asiatica commonly known as Indian pennywort belong to family Apiaceae known as gotu kola... more Centella asiatica commonly known as Indian pennywort belong to family Apiaceae known as gotu kola. It is found in Southest Asia and traditionally used as brain stimulating in ayurvedic medicine. Generally, Centella asiatica use in treating skin problem like wound healing, revatilized nerve and brain cell. It has potential antimicrobial, antioxidant, neuroprotective, antiinflammatory, hepatoprotective, immunostimulant, cardio protective and other activities widely claimed in many reports. These review paper aims to cover up the pharmacological properties with their mechanism of action and traditional uses of Centella asiatica have been discussed to provide information on its multipurpose commercial values.
International Journal of Scientific Research Updates, 2024
Herbal face scrubs have become increasingly popular in recent years due to their ability to impro... more Herbal face scrubs have become increasingly popular in recent years due to their ability to improve skin health and are available at a low cost. These scrubs contain natural ingredients such as rice powder and orange peel powder, ficus riligiosa etc. Which work to exfoliate, whiten, and prevent free radical damage. Vitamin E, rose Oil, and almonds are used to hydrate and exfoliate the skin. Neutralizers and herbal preservatives like neem, and rosemary are used in the variuos formulations. The preparation was evaluated for various parameters, such as colour, odour consistency, pH, spreadability, viscosity, and foamability. The results from the evaluation indicated that the scrub was satisfactory after application and was non-irritating to the skin. Ficus religiosa L., commonly known as Peepal tree known to be a native Indian is a medicinally important tree species belonging to the Moraceae family. It is a large evergreen tree found throughout the India. This tree is popular indigenous system of medicine like Ayurveda, Siddha, Unani, and Homeopathy. Ficus religiosa is sacred tree, which is having great traditional uses as well as pharmacological activities. Almost all parts of the tree are useful in traditional system. The various parts like leaf, bark, fruit, and seeds are beneficial in treatment of gastrointestinal diseases, healing and curative, heart diseases, constipation, mumps and boils, gynaecological problems, fever and joint pains, respiratory problems, skin diseases orodental and ear problems. Ficus religiosa tree shows pharmacological activities analgesic, antioxidant, anticonvulsant, antimicrobial, wound healing, ant amnesic, anti-acetyl cholinesterase, proteolytic activity. The present review is hence an effort to give detailed survey of the literature on its pharmacognosy, photochemistry and medicinal applications.
International Journal of Biological and Pharmaceutical Sciences Archive, 2024
Due to their bioactive compounds with beneficial properties, seaweeds have high potential in cosm... more Due to their bioactive compounds with beneficial properties, seaweeds have high potential in cosmetics science and they are highly appreciated not only because of variability but due to a multitude sources. In this review, we have elaborated on the multifaceted roles of seaweed-derived ingredients used in skin and hair care formulations focusing both on their biological components as well as extraction processes resulting in therapeutic properties. Here, the effectiveness of seaweed extracts in moisturising, anti-ageing and sun protection applications are discussed as well as sustainability and suggestions for future directions. This review highlights the importance of seaweeds establishment as a natural ingredient, effective properties and expected sustainability on contemporary cosmetic formulations through state-of-art scientific evidence providing promising ways to modernizing processes in the beauty industry.
International Journal of Pharmacy & Pharmaceutical Sciences, 2024
Extraction technologies for the recovery of bioactive compounds from natural sources are also imp... more Extraction technologies for the recovery of bioactive compounds from natural sources are also important and represent a significant share in different industries such as pharmaceuticals, food or cosmetics. The present review have discussed about various extraction techniques, their principle and merits in noble compounds extractions. The following methodologies are explained in detail including their ability to selectively extract the bioactive compounds with lesser quantity of solvent and environmental friendly viz., Liquid-liquid extraction, Solid Liquid Extraction (SLE) as well as Super Critical Fluid Extraction, SFE), Ultrasound Assisted Extractions. The use of these processes for selective extraction of bioactive compounds such as polyphenols, alkaloids and essential oils is also discussed with special focus on improving the quality and activity of final products. Finally, prospective trends and challenges of such extraction technologies are discussed to provide some future directions for improvements in this field.
Global Journal of Research in Medical Sciences, 2024
This work aims at presenting a comparative analysis of Flibanserin an agent used to treat sexual ... more This work aims at presenting a comparative analysis of Flibanserin an agent used to treat sexual dysfunction in women and Sildenafil an agent used to treat erectile dysfunction in men. Flibanserin is used to treat female sexual dysfunction that is known as hypoactive sexual desire disorder in women of the premenopausal age group while Sildenafil is mostly used in men to facilitate erectile dysfunction. It analyses their pharmacodynamics and pharmacokinetics, effectiveness, risk-benefit balance, tolerability, and effects upon patients. Neural inhibition of serotonin has also been seen to increase the intensity of sexual desire and libido, slightly improved with some side effects flirting with flibanserin. Sildenafil acts through enhancing the smooth muscle relaxation through inhibition of PDE5 and thus causing an increase in blood flow to the penis, and overall sildenafil has been reported to have high effectiveness coupled with relative safety in most of the male population. Awareness of the differences and specifics of these products may assist healthcare professionals in their choice of approaches to sexual dysfunction.
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES, 2024
Cosmetic ingredients and dust remain on facial are difficult to remove by normal cleansers or wat... more Cosmetic ingredients and dust remain on facial are difficult to remove by normal cleansers or water because consist high water proof elements. Therefore, producing of natural makeup remover products in needed for the proper removing of cosmetic without irritation to the skin. The Makeup remover oil was prepared by using the W/O emulsion in which the water phase ingredients is Aloe-Vera extract, Strawberry, Carbopol, Methyl paraben, Distilled water, and the oil phase ingredient is Castor oil, Olive oil, Limonene and Almond oil. Different parameters were evaluated i.e., organoleptic properties, pH, Spreadbility, homogeneity, etc. The formulation is showed a good appearance, and adequate pH, Spreadability, homogeneity, and compatibility were observed. Also, the formulation showed no irritancy and they were easily washable. The formulation were stable at room temperature. All herbal ingredients showed significantly different activities.
Journal of Pharmacognosy & Phytochemistry, 2024
Aconitum novoluridum Munz, belonging to the Ranunculaceae family, is a perennial herb known for i... more Aconitum novoluridum Munz, belonging to the Ranunculaceae family, is a perennial herb known for its toxic and medicinal properties. This review provides a comprehensive overview of A. novoluridum, covering its botanical characteristics, phytochemistry, pharmacological activities, toxicology, and potential therapeutic applications. The primary bioactive compounds in A. novoluridum are diterpenoid alkaloids, notably aconitine, mesaconitine, and hypaconitine, which contribute to its analgesic, antiinflammatory, cardiovascular, and neuroprotective effects. However, these compounds also account for the plant's high toxicity, presenting challenges for safe medicinal use. Advances in phytochemical analysis, pharmacological studies, and toxicology are essential to unlocking the therapeutic potential of A. novoluridum while ensuring safety. This review aims to guide future research and applications of this intriguing species.
Plants Journal, 2024
Cannabis A Novel (Old) Herbal with many applications, the dried leaves to be used for medicinal p... more Cannabis A Novel (Old) Herbal with many applications, the dried leaves to be used for medicinal purposes is derived from the hemp plant marijuana and has been considered a wonder weapon in all diseases. purpose of this review is to look at the current scientific literature on marijuana and its overall effects in different medical areas (neurological disorders, psychiatric conditions, pain management/cancer-related symptoms/cardiovascular/metabolic diseases). While we know that compounds like THC and CBD interact with the endocannabinoid system in ways which produce positive outcomes, their complete impact on human health is a chapter of history still being written. However, there are also emerging concerns regarding adverse digestive effects and the regulatory headache around marijuana. Further work is needed to define appropriate safety profiles, optimal dosing, and successful integration into clinical practice. This review highlights marijuana's emergent role in contemporary medicine and the need for clinical trials to further its therapeutic use within patient safety and regulatory criterion.
International Journal of Life Science Research Archive, 2024
Flavonoids are secondary plant metabolites involved in biological activity that are present in pl... more Flavonoids are secondary plant metabolites involved in biological activity that are present in plentiful proportions in many plant origin foods and beverages. Owing to their chemical difference and qualities that make them beneficial for human health, they have received a lot of focus in research. This review therefore presents an account on the chemical structure of flavonoids, food sources and their metabolism with emphasis on bioavailability. And they also examine their antioxidant, anti-inflammatory, anticancer, cardiovascular protective, neuroprotective, and antimicrobial properties and reveal related molecular processes. In addition, it overviews the clinical data concerning their possible use in the prevention and treatment of chronic diseases. Some of the problems that attend current flavonoid research are also dealt with; such issues as variation in the bioactivity of flavonoids and scarcity of clinical studies. This review is designed to present current state of knowledge and to provoke further research concerning the further potential of flavonoids in enhancing human health.
Review article , 2024
B. acutangula is the species of Barringtonia from Bangladesh, India (Southern States), Sri Lanka ... more B. acutangula is the species of Barringtonia from Bangladesh, India (Southern States), Sri Lanka up to Australia known by such names as freshwater mangrove and itchy tree. Herein, the present review attempts to synthesize and consolidate such information on B. acutangula with respect to its botanical description, ecological importance, phytochemical content, medicinal uses especially mentions in historical texts, wound-healing property as well economic potential of this species. It is known botanically for angular branches, elliptical leaves and white or pinkish flowers with an Odor of orange followed by spherical fruits. In ecological terms, it is critical to revegetate river banks, support biodiversity and help in salt environment adaptation of mangrove areas. Phytochemical investigation of different parts of the plant attributes antioxidant, anti-inflammatory and antimicrobial properties to bioactive phytoconstituents as saponins, flavonoids & alkaloids. B. acutangula has a great importance in traditional medicine systems employed to cure pain, inflammation as well digestive disorders. Its seeds also provide an oil that is used in soap making and its wood for construction. This review opens up with B. acutangula, a plant of immense significance on multiple fronts and subsequently discusses untapped areas for future endeavours along with its sustainable exploitation opportunities.
International Journal of Pharmaceutical Sciences, 2024
The lotion is a semisolid liquid dosage form that contains one or more active ingredients in an a... more The lotion is a semisolid liquid dosage form that contains one or more active ingredients in an appropriate vehicle. Perfume lotions are liquids for a external application that are intended to be applied to the unbroken skin without friction. They are aqueous, alcohol, or polyols based solutions or suspensions containing topically active therapeutic agents. A lotion is a low viscosity topical preparation intended for application to the skin. By contrast, creams and gels have a higher viscosity, typically due to lower water content. Perfume lotion is applied to external skin with bare hands, a brush, a clean cloth, or cotton wool. Lotions may contain antimicrobial preservatives and another appropriate excipients such as stabilizers etc. Perfume lotions are used for their cooling, soothing, protective, and moisturizing effect and also therapeutic effect depending on ingredients used. They are applied directly to skin with the help of some absorbent material, such as, cotton wool or gauze soaked in it. The herbal cosmetics are those when natural herbs and their products used for their aromatic value in cosmetic preparation among consumers for herbal products triggered the demand for natural products and natural extracts in cosmetics preparations. Aloevera is oldest medicinal plant ever known and the most applied medicinal plant worldwide.
Zenodo (CERN European Organization for Nuclear Research), Jun 28, 2023
Zenodo (CERN European Organization for Nuclear Research), Jul 19, 2023
From ancient times to the present, there has always been an expanding market for cosmetics. There... more From ancient times to the present, there has always been an expanding market for cosmetics. There are a wide variety of cosmetic products on the market, including lipstick, kajal, mascara, and eye liner. Applying lipstick has several purposes, including improving one's appearance, making one more appealing, and protecting the lips. The market stocks it in a range of colours and shapes, including liquid and stick. Synthetic colourants included in lipstick are really bad for our skin since they are composed of chemicals. It causes a wide range of problems, including allergy, discomfort, rashes, chapped lips, and even cancer in extreme cases. For this reason, the demand for herbal cosmetics has expanded worldwide and the popularity of using herbs for beauty purposes has increased rapidly in recent years. Herbal lipsticks do not include any potentially harmful ingredients. Because of its various benefits, herbal lipstick should prevent lip dryness and cracking. The purpose of this research was to create and evaluate many formulations of a herbal lipstick made from extracts of the beetroot, rose petal and using papaya petiole as a mould. Prepared herbal lipstick was evaluated for a variety of characteristics, including smoothness, greatness, melting point, breaking point, and pH, etc. This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
Acta Scientific Pharmaceutical Sciences
In the field of analytical chemistry and various pharmaceutical fields the separation techniques ... more In the field of analytical chemistry and various pharmaceutical fields the separation techniques are widely used to study specific compounds from a mixture or a complex material. One such separation technique is called Chromatography. It takes place on the basis of the relative volume of each solute present in the moving fluid stream. The discovery of chromatography was done by Mikhail S. Tsvet, who was a Russian botanist in the year 1901. The separation is done through stationary phase and a mobile phase. Chromatography is used for separation, analysis, and purification of various components which can include food, pesticides, pharmaceuticals, tissue extracts etc. In this paper 2 major types of chromatography are discussed; these include Paper Chromatography and Thin Layer Chromatography. The principles of both the types will be discussed and the contrast will be established between the two in a tabular format.
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Papers by Prof Dr Shashank Tiwari