Papers by alfinda novi kristanti
RSC Advances
A combination of computational techniques has been carried out to predict the binding of nordenta... more A combination of computational techniques has been carried out to predict the binding of nordentatin derivatives based on pyranocoumarin semi-synthesis with the target protein from the expression of the PDE4B gene.
Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Komplek Kampus... more Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Komplek Kampus C UNAIR, Jl. Mulyorejo, Surabaya, Indonesia Department of Chemistry, Taunggyi University, Shan State (South), Myanmar Faculty of Pharmacy, Meijo University, Tempaku, Nagoya, Japan Department of Chemistry, Mandalay University, Mandalay, Myanmar E-mail: [email protected] Manuscript received online 21 November 2019, revised and accepted 02 December 2019 Three quaiane-type sesquiterpenes named curcumenol (<strong>1</strong>), zedoarondiol (<strong>2</strong>), and (1S,4S,5S,10R)-isozedoarondiol (<strong>3</strong>) were isolated from the rhizomes of Curcuma comosa. Their structures were elucidated on the basis of extensive spectroscopic analysis. The cytotoxic activities of all isolated compounds were tested by MTT assay. Compounds <strong>2</strong> and <strong>3</strong> showed the most potent activities against T47D cell...
Rasayan Journal of Chemistry, 2021
From stem bark of Syzygium aqueum, oleanolic acid, and b-sitosterol were isolated successfully. T... more From stem bark of Syzygium aqueum, oleanolic acid, and b-sitosterol were isolated successfully. Their structure was identified using spectroscopic methods such as UV-Visible, Fourier Transform Infrared and Nuclear Magnetic Resonance. The isolated compounds were then tested for their anticancer activity against cervical, and breast cancer cell lines using the MTT method. The presence of these two compounds isolated from the stem bark of S. aqueum is the first to be reported.
Journal of the Saudi Society of Agricultural Sciences, 2020
Sargassum duplicatum and Padina tetrastromatica seaweed species collected from oil and a non-oil ... more Sargassum duplicatum and Padina tetrastromatica seaweed species collected from oil and a non-oil extraction site at Madura Island were investigated in this study for selected bioactivities, heavy metals and toxicity effects. The collected seaweeds were evaluated for their phytochemical constituents, total phenolic contents (TPC), antioxidant activities, antidiabetic activities, anticancer activities, toxicities and heavy metals using Folin-Ciocalteus method, the 2,2-diphernyl-1 picrylhydrazyl (DPPH), a-glucosidase enzyme, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), Brine Shrimp Lethality Test (BSLT) and atomic absorption spectrophotometer, respectively. The crude extracts (C), normal hexane (N), ethyl acetate (E), and methanol residue fractions (M) were studied. The highest TPC (589.79 ± 7.14 mg GAE/g) was observed in ethyl acetate fraction of P. tetrastromatica from the non-oil extraction site. Meanwhile, the crude extracts and all fractions showed potent antioxidant, antidiabetic, and cytotoxic activities with ethyl acetate fraction of P. tetrastromatica from non-oil extraction site displaying the highest effects (IC 50 25.25 ± 5.15, 249.12 ± 1.77 and 70.56 ± 2.56 mg/mL: antioxidant, antidiabetic, cytotoxic activities respectively). In the brine shrimp assay, the crude extracts and all fractions of both species from the two sites were non-toxic with exception of the hexane fraction of P. tetrastromatica from oil site which was very toxic after 24 h incubation. However, the crude extract of S. duplicatum and ethyl acetate fraction of P. tetrastromatica from oil extraction site were mildly toxic except the hexane fraction of P. tetrastromatica from oil site which was very toxic after 48 h incubation while samples of both species from the non-oil site were nontoxic. In each species, the concentration of Cd from the oil extraction site was higher than those of the non-oil site with the values of P. tetrastromatica leading and a similar observation occurred Cu in P. tetrastromatica but the same Cu was negligible in S. duplicatum as Pb was negligible in both species. According to the findings of this current study, it is safe to conclude that both S. duplicatum and P. tetrastromatica from Madura Island have antioxidant, antidiabetic and cytotoxic activity, we therefore recommend these species from the non-oil extraction site for drug candidates against the various health abnormally they seem to inhibit.
Egyptian Journal of Chemistry, 2018
T HIS study reported the isolation of 7-hydroxy-5,3',4'-trimethoxyflavone (1) from stem bark of A... more T HIS study reported the isolation of 7-hydroxy-5,3',4'-trimethoxyflavone (1) from stem bark of Aquilaria microcarpa, a species belonging to Thymelaeaceae family. This report is our continuation study about this plant. Previously, we reported the presence of 5,3',4'-trihydroxy-7-methoxyflavon and 6-hydroxy-2-(2-phenylethyl) chromon The chemical structure of compound (1) has been elucidated based on spectroscopy method including FTIR, NMR and HRESI-MS analysis.
Research for synthesis of calixarenes from eugenol using inorganic bases,such as NaOH and KOH, ha... more Research for synthesis of calixarenes from eugenol using inorganic bases,such as NaOH and KOH, had been done. The objectives of the research were to know the result of calixarenes product from eugenol, the influence of different inorganic bases (NaOH and KOH) in synthesis product, and its application in separating homologous organic compounds based on its capability in host-guest interaction. The synthesis was done by reacting eugenol with formaldehyde and inorganic base solution. The synthesis product was characterized by infrared spectrophotometre and mass spectrometre in order to determine what kind of synthesis product it was. In this research, the synthesis product was not calixarenes, but a kind of methylenebisphenol, and it was 6-6’-methylenebis(4-allyl-2-methoxyphenol). Both of inorganic bases produced same products. The difference was only in the yield of products. The yield of synthesis using KOH was higher than NaOH.
Artocarpus dasyphylla with the local name “cempedak utan” is a member of Artocarpus Genus from Mo... more Artocarpus dasyphylla with the local name “cempedak utan” is a member of Artocarpus Genus from Moraceae family. It is a rare and endemic plant from east region of Indonesia. The purpose of this study was to determine the antihypercholesterolemic effect of ethyl acetate extract from A. dasyphylla toward the level of total cholesterol, LDL, and HDL of hypercholesterolemic Rattus norvegicus as the prevention effort of atheroschlerosis and CVD. It was due to antioxidant activities of phenolic compounds. The powder of stem bark of Artocarpus dasyphylla was extracted by maceration and partition method. Phenolic total of ethyl acetate extract from stem bark of A. dasyphylla was determined with Folin Ciocalteu reagent, it was 9,86 mg GAE/g of extract. In vivo experiment toward Rattus norvegicus with hypercholesterol diet used randomized post test only control group design. Ethyl acetate extract with the treatment doses 75, 150, 225 mg/kg body weight showed antioxidant activity by decreasing...
South African journal of chemistry, 2021
This review highlights recent improvements, and present situations concerning the practical appli... more This review highlights recent improvements, and present situations concerning the practical application of, natural productsbased carbon nanodots (CNDs) in nanomedicine, sensors, drug delivery, bio-imaging, solar cells, photocatalysis and nanoencapsulation. CNDs are zero-dimensional carbonaceous nanomaterials that have recently drawn much attention because of their unique physicochemical properties, such as excellent biocompatibility and tunable photoluminescence, easy functionalization, solubility in water, dispersibility, and low toxicity. Additionally, they are environmentally friendly, abundant, easily accessible, and rich in multiple elements. Since CNDs derived from organic products have unique properties, we explored and found that the properties of CNDs may depend on the preparation method and the used precursors. This study also informs on the positioning of natural products in nanotechnology.
Three flavonoid compounds have been isolated from the leaves of Macaranga gigantea (Euphorbiaceae... more Three flavonoid compounds have been isolated from the leaves of Macaranga gigantea (Euphorbiaceae) namely as glyasperin A (1), broussoflavonol F (2), apigenin (3). Their structures were elucidated by spectroscopic methods including UV, IR, HRESIMS, 1D and 2D NMR analysis. Compounds 1–3 were evaluated for their radical scavenging against 2,2-diphenyl-1-picrylhydrazyl (DPPH), showing their IC50 were 125.10, 708.54, and 518.01 μM, respectively. The results indicate that as glyasperin A (1) more active than ascorbic acid (329.01 μM).
Proceedings of the 1st International Conference on Chemical Science and Technology Innovation, 2019
Exploration of secondary metabolites was the focus of this research, especially of Artocarpus cal... more Exploration of secondary metabolites was the focus of this research, especially of Artocarpus calophylla species to look for a potential cytotoxic agent. An arylbenzofuran derivative compound, namely heterophyllene A was isolated from the stem bark of Artocarpus calophylla. Structure determination of this compound has been elucidated using UV-Vis spectroscopy, 1D, and 2D NMR analysis. This compound has a lower IC50 than ethyl acetate extract. The IC50 of this compound (57,54 μg/mL) to HeLa and (25,80 μg/mL) to T47D cells, ethyl acetate extract (>100 μg/mL) to HeLa and (84,16 μg/mL) to T47D cells.
Terpenes and Terpenoids [Working Title], 2020
Curcuma comosa (Zingiberaceae) is widely grown in tropical and subtropical areas of Asia, like Th... more Curcuma comosa (Zingiberaceae) is widely grown in tropical and subtropical areas of Asia, like Thailand, Indonesia, Malaysia, and Myanmar. In Myanmar, the rhizome of Curcuma comosa is called Sa-nwin-ga, and local people had used it as a traditional medicine for stomach ache, diabetes mellitus, and hypertension. This species produces secondary metabolites of phenolic and nonphenolic groups. Phenolic groups like diarylheptanoids and flavonoids. While nonphenolics are terpenoids, especially sesqui- and monoterpenes. In this chapter, the group of sesquiterpene compounds from Curcuma comosa starts from the isolation technique, followed by the elucidation of the molecular structure, and their activity tests have been discussed.
Indonesian Journal of Chemistry, 2020
Carbon nanodots (CNDs) have widely received great attention as a result of favorable optical, ele... more Carbon nanodots (CNDs) have widely received great attention as a result of favorable optical, electrical, optoelectrical, biocompatible, and non-toxic properties these nanoparticles possess. However, the exploration of nanoparticle from natural raw material was limited. In present work, the carbon dots were produced from catechin isolated from Uncaria gambir through a simple and facile process. Carbon nanodots were further produced by the pyrolysis process of catechin, which allowed it for carbonization. Owing to its unique properties such as photoluminescence with an emission peak at 500 nm (lex = 380 nm), average size diameter about 5 nm and non-toxic; Cat-CNDs were incredibly potential for staining targeted tumor cells. The staining ability by confocal microscopy observations showed their green fluorescence images which meant that the CNDs easily penetrated HeLa cells via endocytosis. The resulting CNDs which were analyzed using some significant techniques approved that the prepa...
Open Chemistry, 2020
New derivatives were obtained from natural nordentatin (1) previously isolated from the methanol ... more New derivatives were obtained from natural nordentatin (1) previously isolated from the methanol fraction of Clausena excavata by an acylation method. Herein, we report ten new pyranocoumarin derivatives 1a–1j. Their structures were elucidated based on UV-vis, FT-IR, NMR, and DART-MS data. The α-glucosidase inhibition and anticancer activities of nordentatin (1) and its derivatives were also evaluated. The α-glucosidase inhibition assay exhibited that the derivatives 1b, 1d, 1e, 1f, 1h, 1i, and 1j possess higher inhibitory activity for α-glucosidase with IC50 values of 1.54, 9.05, 4.87, 20.25, 12.34, 5.67, and 2.43 mM, whereas acarbose was used as the positive control, IC50 = 7.57 mM. All derivatives exhibited a weak cytotoxicity against a cervical cancer (HeLa) cell line with the IC50 between 0.25 and 1.25 mM. They also showed moderate to low growth inhibition of a breast cancer (T47D) cell line with IC50 values between 0.043 and 1.5 mM, but their activity was lower than that of th...
THE 14TH JOINT CONFERENCE ON CHEMISTRY 2019, 2020
Natural Product Communications, 2020
The genus Micromelum belongs to the Rutaceae family. As its rich bioactive constituents its stems... more The genus Micromelum belongs to the Rutaceae family. As its rich bioactive constituents its stems, flowers, leaves, and roots have been used in traditional medicine, for the treatment of various diseases from ancient time. Phytochemically, many bioactive compounds, including coumarins, polyoxygenated flavonoids, phenylpropanoic acid derivatives, quinolone alkaloids, and also carbazole alkaloids, have been reported as secondary metabolites of the Micromelum spp. including many new compounds. Therefore, Micromelum spp. are considered potential for drug leads. In this article, we present an overview of secondary metabolites isolated from genus Micromelum and their bioactivities that have been reported between 1982 and 2019.
Open Chemistry, 2019
All around the world, patients with diabetes and the prevalence of its disease are currently grow... more All around the world, patients with diabetes and the prevalence of its disease are currently growing. Due to these side effects of oral hypoglycemic agents and oxidative stress in complicating diabetes, there is growing interest in drugs, which possess dual function as both type II diabetes mellitus treatment and oxidative stress treatment. The objective of this research is to search effective antidiabetes and antioxidant bioactive compounds from the Myanmar medicinal plantClausena excavata. The root part ofC. excavatawas successfully extracted with 95% ethanol and followed by column chromatographic separation technique. The structure of isolated pure compounds was elucidated by using methods of spectroscopic such as UV-Vis, IR, NMR and HRFABMS spectrometry. The α-glucosidase inhibition assay was performed against baker’s yeast and rat intestine (sucrose and maltase) α-glucosidases. The activity of isolated compounds’ antioxidant was measured by using DPPH assay. Among the tested en...
Rasayan Journal of Chemistry, 2019
Biosciences, Biotechnology Research Asia, 2019
Gynura procumbens (Lour) Merr is a medicinal plant that has been widely used as an ingredient of ... more Gynura procumbens (Lour) Merr is a medicinal plant that has been widely used as an ingredient of herbal medicine. G. procumbens is known to contains secondary metabolite compounds namely flavonoids. The aim of this study was to investigate the effect of carbon sources on biomass and flavonoid content of G. procumbens adventitious root culture grown in agitated liquid medium. Adventitious roots were induced from leaf explants on Murashige and Skoog (MS) medium supplemented with 3% sucrose and 8 g/Lagar. G. procumbens adventitious root cultures were performed in MS liquid medium containing different carbon source of 3% sucrose, 5% sucrose, 3% glucose and 4% fructose, and supplemented with5 mg/L IBA. Two grams of adventitious roots as the initial inoculum were cultured in1000 mL Erlenmeyer flask containing 250 mL MS medium and agitated at 70 rpm in dark conditions for 28 days.The results showed that medium with the addition of 5% sucrose produced the highest fresh weight (10.23 ± 0.86 ...
Jurnal Kimia Riset, 2019
AbstrakTelah berhasil diisolasi senyawa golongan fenil propanoid dengan nama “skopoletin” dari e... more AbstrakTelah berhasil diisolasi senyawa golongan fenil propanoid dengan nama “skopoletin” dari ekstrak etil asetat umbi Ubi Jalar (Ipomoea batatas L.). Ekstraksi senyawa fenolik dilakukan dengan metode maserasi menggunakan pelarut metanol, dilanjutkan partisi menggunakan n-heksana dan etilasetat. Pemurnian dilakukan dengan kromatografi kolom gravitasi dan ktomatografi radial menghasilkan senyawa golongan fenil propanoid. Struktur skopoletin diidentifikasi berdasarkan data spektrum UV, 1D dan 2D NMR.Kata kunci : fenil propanoid, skopoletin, dan Ipomoea batatas L. Phenylpropanoid group compound has been isolated as “scopoletin” from ethylacetate extract of tuber flesh Sweet potatoes (Ipomoea batatas L.). Extraction of phenolic compound was done by maceration method using methanol solvent, then partition with n-hexana and ethylacetate, respectively. The process of purification using various chromatographic techniques yielded compound of phenylpropanoid group. Structure of scopoletin...
Molbank, 2017
A one-pot multicomponent reaction has been used to synthesize the title compound, ethyl 4-[5-(met... more A one-pot multicomponent reaction has been used to synthesize the title compound, ethyl 4-[5-(methoxymethyl)furan-2-yl]-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate by PTSA catalyzed Biginelli reaction. The chemical structure of the product was confirmed by spectroscopic evidence, FTIR, HRESI-MS, 1D-, and 2D NMR.
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Papers by alfinda novi kristanti