Papers by Thibaut Fraisse
Thérapie, 2005
ABSTRACT Aim: The aim of the study was to evaluate drug use amongst French scuba divers. Methods:... more ABSTRACT Aim: The aim of the study was to evaluate drug use amongst French scuba divers. Methods: An anonymous questionnaire was distributed to 220 people, out of which 106 responded. Results: Fifteen percent of respondents were receiving long-term medication whereas 60.33% of respondents reported taking medication only occasionally when diving. Thirty-seven percent of respondents were taking prescribed medicines. Drugs consumed occasionally included analgesics (43.5%), corticosteroids (14.5%) and antiemetics. A detailed study of aspirin and steroid consumption revealed their misuse for performance-enhancing purposes, the level of risk varying with the type of diving activity. The influence of drug use on personal performance was recognised by 72.6% of divers, but only 59.4% considered that they were putting themselves at risk by self-medicating. Contexte : Une étude descriptive de l'automédication a été réalisée chez les plongeurs en scaphandre autonome français. Matériels et méthodes : Sur 220 plongeurs interrogés par autoquestionnaire anonyme, nous avons obtenu 106 réponses. Résultats : Quinze pour cent des répondeurs prennent un traitement au long cours, et 60,33 % ponctuellement en cours de plongée, avec un taux de prescription médicale de 37 %. Les antalgiques représentent 43,5 % des médicaments consommés occasionnellement, suivis par la cortisone (14,5 %) et les antinaupathiques. L'étude détaillée de la prise d'aspirine ou de cortisone montre leur détournement à but dopant et la prise de risque liée au profil de plongée pratiquée. La possible influence du médicament sur la plongée est reconnue par 72,6 % mais seulement 59,4 % estiment prendre un risque.
Journal of Clinical Microbiology, 2010
A new clonal complex of Mycobacterium bovis present at high frequency in cattle from west central... more A new clonal complex of Mycobacterium bovis present at high frequency in cattle from west central African countries has been described as the African 1 (Af1) clonal complex. Here, the first intrafamilial cluster of human tuberculosis cases due to M. bovis Af1 clonal complex strains is reported. We discuss hypotheses regarding modes of transmission.
La Revue de Médecine Interne, 2002
La Revue de Médecine Interne
La Revue de Médecine Interne
International journal of STD & AIDS, Jan 30, 2015
In France, almost 30,000 people are unaware of their HIV positive status. Innovative screening st... more In France, almost 30,000 people are unaware of their HIV positive status. Innovative screening strategies are essential to reach this population. The aim of this study was to describe the acceptability of rapid HIV testing (RHT) among French general practitioners (GPs) working in the south of France and barriers for implementing this strategy. We analysed an anonymous questionnaire sent by mail to GPs about demographic data, routine practice, knowledge of RHT and barriers to its use. Between 1 April and 30 September 2013, out of the 165 GPs contacted, 78 sent back the questionnaires. The average GPs' age was 52 years, 49 were men. Fifty-one GPs reported that their registered patients included at least one HIV-infected person and 70 GPs reported taking care of high-risk people. Sixty-three percent of GPs reported being interested in using RHT in their daily practice. The main reasons reported by uninterested GPs were: greater confidence in standard HIV testing, difficulties inclu...
Digestive and Liver Disease, 2015
Faecal microbiota transplantation is effective for treating recurrent forms of Clostridium diffic... more Faecal microbiota transplantation is effective for treating recurrent forms of Clostridium difficile infection and its use in this indication is recommended in the most recent European and North American guidelines. In this context, faecal microbiota transplantation is beginning to be performed in France in clinical practice, while the rules governing this procedure have been defined in France only for clinical trials. To unify, secure, and evaluate practice in this field in France, the French Group of Faecal microbiota Transplantation (FGFT) was created in October 2014 with the support of the French National Society of Gastroenterology, the French Infectious Disease Society, and the National Academy of Pharmacy. We present here the deliberations of this group regarding the use of faecal microbiota transplantation for recurrent Clostridium difficile infection. The issues addressed are the indications, therapeutic sequence, delivery procedures, donor selection, methods and conditions of specimen preparation, and traceability.
Médecine et Maladies Infectieuses, 2014
European Geriatric Medicine, 2013
Revue du Rhumatisme, 2009
La Revue de Médecine Interne, 2002
Les amyloses paran6oplasiques non dysglobulin6miques, sont exceptionnelles. Nous rapportons le ca... more Les amyloses paran6oplasiques non dysglobulin6miques, sont exceptionnelles. Nous rapportons le cas d'un syndrome n6phrotique par amylose sans d6p6ts de cha3nes 16g~res prdc6dant la d6couverte d'un carcinome neuroendocrine multim6tastatiqne. Monsieur X, 33 ans, est hospitalis6 en avril 2000 pour des eed6mes des membres inf6rieurs de survenue r6cente. On ne note pas d'ant6c6dent saul un tabagisme important. A l'examen, hormis les 0ed~mes il existe un hippocratisme digital. La biologie est en faveur d'un syndrome n6phrotique pur. Les histologies r6nale et de la muqueuse jugale montrent une amylose sans d6p6ts de chaines 16g~res. L'immunofixation sanguine est normale ainsi que la bronchoscopie et le scanner thoraco-abdominal, en dehors d'un emphys~me apical. II n'y a pas d'argument pour une amylose familiale. La recherche des mutations cormues du g~ne de la fi~vre m6diterran6enne est n6gative. I1 est trait6 par furos6mide, r6gime et 6nalapril. En d6cembre 2000 il se plaint de douleurs ~t type de radiculalgies D6. L'IRM montre une infiltration tumo-rale de la vert6bre D6. Le nouveau scanner complet r6v~le une tumeur du segment IV h6patique dont l'histologie est : carcinome neuroendocrine indiff6renci6. La gastroscopie et une nouvelle bronchoscopie sont normales. Les amyloses paran6oplasiques, en dehors des amyloses AL associ6es anx dysglobulin6mies des h6mopathies malignes, ont 6t6 que tr~s rarement d6crites. La glom~rulon6phrite extramembraneuse est 1' atteinte r6nale paran6oplasique la plus fr6quemment associ6e aux carcinomes. Une amylose r6nale non AL a 6t6 trouv6e associ6e h des tumeurs carcinoi'des m6tastatiques ou du rein. La physiopathologie et la nature exacte du d6p6t amyloide restent encore hypoth6tiques : m6diateurs endocrines s6cr6t6s par la tumeur ? En cas de ddcouverte d'une amylose dont l'6tiologie est incertaine, une cause paran6oplasique ne peut ~tre 6car-t6e, marne en 1' absence initiale de tumeur d6teetable.
Médecine et maladies infectieuses, 2014
We wanted to compare the first line intravenous administration of ceftriaxone to a subcutaneous a... more We wanted to compare the first line intravenous administration of ceftriaxone to a subcutaneous administration in patients more than 75 years of age. We performed a retrospective monocentric study on all patients more than 75 years of age admitted to the Ales hospital between January 1 and December 31, 2011, having received at least two doses of ceftriaxone intravenously (IV) or subcutaneously (SC). One hundred and forty-eight patients (70 females/78 males patients) were included, 110 received ceftriaxone IV and 38 SC. They were a mean age of 84.7 years, older in the SC group (86.9 years) than in the IV group (83.9 years) (P = 0.0052). The SC group patients presented more frequently with dementia (57% vs. 25% P = 0.001), were more often bedridden (22% vs. 7% P = 0.023), had a higher mean World Health Organization status (3.13 vs. 2.76, P = 0.0181), and higher ADL score (7.79 vs. 5.76, P = 0.0056). There was no statistical difference for isolated bacteria, site of infection, death ra...
Médecine et maladies infectieuses, 2008
La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne, 2002
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Papers by Thibaut Fraisse